LOCUS       NM_001107897            3902 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ganglioside-induced
            differentiation-associated-protein 1 (Gdap1), mRNA.
ACCESSION   NM_001107897 XM_001062260 XM_232577
VERSION     NM_001107897.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3902)
  AUTHORS   Pepaj M, Bredahl MK, Gjerlaugsen N, Bornstedt ME and Thorsby PM.
  TITLE     Discovery of novel vitamin D-regulated proteins in INS-1 cells: a
            proteomic approach
  JOURNAL   Diabetes Metab Res Rev 31 (5), 481-491 (2015)
   PUBMED   25449168
REFERENCE   2  (bases 1 to 3902)
  AUTHORS   da Silva AF, Mariotti FR, Maximo V and Campello S.
  TITLE     Mitochondria dynamism: of shape, transport and cell migration
  JOURNAL   Cell Mol Life Sci 71 (12), 2313-2324 (2014)
   PUBMED   24442478
  REMARK    Review article
REFERENCE   3  (bases 1 to 3902)
  AUTHORS   Niemann A, Huber N, Wagner KM, Somandin C, Horn M, Lebrun-Julien F,
            Angst B, Pereira JA, Halfter H, Welzl H, Feltri ML, Wrabetz L,
            Young P, Wessig C, Toyka KV and Suter U.
  TITLE     The Gdap1 knockout mouse mechanistically links redox control to
            Charcot-Marie-Tooth disease
  JOURNAL   Brain 137 (Pt 3), 668-682 (2014)
   PUBMED   24480485
REFERENCE   4  (bases 1 to 3902)
  AUTHORS   Palmer CS, Osellame LD, Stojanovski D and Ryan MT.
  TITLE     The regulation of mitochondrial morphology: intricate mechanisms
            and dynamic machinery
  JOURNAL   Cell Signal 23 (10), 1534-1545 (2011)
   PUBMED   21683788
  REMARK    Review article
REFERENCE   5  (bases 1 to 3902)
  AUTHORS   Zimon M, Baets J, Fabrizi GM, Jaakkola E, Kabzinska D, Pilch J,
            Schindler AB, Cornblath DR, Fischbeck KH, Auer-Grumbach M, Guelly
            C, Huber N, De Vriendt E, Timmerman V, Suter U,
            Hausmanowa-Petrusewicz I, Niemann A, Kochanski A, De Jonghe P and
            Jordanova A.
  TITLE     Dominant GDAP1 mutations cause predominantly mild CMT phenotypes
  JOURNAL   Neurology 77 (6), 540-548 (2011)
   PUBMED   21753178
REFERENCE   6  (bases 1 to 3902)
  AUTHORS   Pedrola L, Espert A, Wu X, Claramunt R, Shy ME and Palau F.
  TITLE     GDAP1, the protein causing Charcot-Marie-Tooth disease type 4A, is
            expressed in neurons and is associated with mitochondria
  JOURNAL   Hum Mol Genet 14 (8), 1087-1094 (2005)
   PUBMED   15772096
REFERENCE   7  (bases 1 to 3902)
  AUTHORS   Nelis E, Erdem S, Van Den Bergh PY, Belpaire-Dethiou MC, Ceuterick
            C, Van Gerwen V, Cuesta A, Pedrola L, Palau F, Gabreels-Festen AA,
            Verellen C, Tan E, Demirci M, Van Broeckhoven C, De Jonghe P,
            Topaloglu H and Timmerman V.
  TITLE     Mutations in GDAP1: autosomal recessive CMT with demyelination and
            axonopathy
  JOURNAL   Neurology 59 (12), 1865-1872 (2002)
   PUBMED   12499475
REFERENCE   8  (bases 1 to 3902)
  AUTHORS   Cuesta A, Pedrola L, Sevilla T, Garcia-Planells J, Chumillas MJ,
            Mayordomo F, LeGuern E, Marin I, Vilchez JJ and Palau F.
  TITLE     The gene encoding ganglioside-induced differentiation-associated
            protein 1 is mutated in axonal Charcot-Marie-Tooth type 4A disease
  JOURNAL   Nat Genet 30 (1), 22-25 (2002)
   PUBMED   11743580
REFERENCE   9  (bases 1 to 3902)
  AUTHORS   Baxter RV, Ben Othmane K, Rochelle JM, Stajich JE, Hulette C,
            Dew-Knight S, Hentati F, Ben Hamida M, Bel S, Stenger JE, Gilbert
            JR, Pericak-Vance MA and Vance JM.
  TITLE     Ganglioside-induced differentiation-associated protein-1 is mutant
            in Charcot-Marie-Tooth disease type 4A/8q21
  JOURNAL   Nat Genet 30 (1), 21-22 (2002)
   PUBMED   11743579
REFERENCE   10 (bases 1 to 3902)
  AUTHORS   Liu H, Nakagawa T, Kanematsu T, Uchida T and Tsuji S.
  TITLE     Isolation of 10 differentially expressed cDNAs in differentiated
            Neuro2a cells induced through controlled expression of the GD3
            synthase gene
  JOURNAL   J Neurochem 72 (5), 1781-1790 (1999)
   PUBMED   10217254
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473984.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001062260.1, XM_232577.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ087676.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3902
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..3902
                     /gene="Gdap1"
                     /note="ganglioside-induced
                     differentiation-associated-protein 1"
                     /db_xref="GeneID:312890"
                     /db_xref="RGD:1309005"
     exon            1..208
                     /gene="Gdap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1168
                     /gene="Gdap1"
                     /codon_start=1
                     /product="ganglioside-induced differentiation-associated
                     protein 1"
                     /protein_id="NP_001101367.1"
                     /db_xref="GeneID:312890"
                     /db_xref="RGD:1309005"
                     /translation="MARKQDEARSGVPLRAQGPPAAEVRLILYHWTHSFSSQKVRLVI
                     AEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLIHGENIICEATQIIDYLEQTFL
                     DERTPRLMPDEGSMYYPRVQHYRELLDSLPMDAYTHGCILHPELTVDSMIPAYATTRI
                     RGQIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDELEKVLDQ
                     VETELQRRNEETPDEGNQPWLCGESFTLADVSLAVTLHRLKFLGFARRNWGHGKRPNL
                     ESYYERVLKRKTFNKVLGHVNNILISAVLPTAFRVAKKRAPKVLGSTLVVGLLVGMGY
                     FAFMLFRRRLGNMILSLRPRPNYF"
     exon            209..401
                     /gene="Gdap1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..575
                     /gene="Gdap1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..670
                     /gene="Gdap1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..785
                     /gene="Gdap1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..3902
                     /gene="Gdap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacagggggc cctgcgaaac caaaggacgg ctctaagcct ctgcagcaag caggccaacc
       61 gacaaggctg gctgagtccc tgcatcccgc aatggctcgg aagcaagacg aggcgcggtc
      121 cggcgtgccc ctgagggcgc aaggcccgcc ggccgcagag gtccgcctca ttctgtacca
      181 ctggacgcac tccttcagct ctcaaaaggt gcgcttggta attgctgaaa aggcactgaa
      241 gtgtgaggaa catgatgtaa gtctgcccct gagtgagcac aatgagcctt ggtttatgcg
      301 tttgaactca actggagaag tgcctgtcct tatccacggg gaaaacataa tttgtgaggc
      361 cacccagatc attgattatc ttgagcagac tttcctggat gaaagaacac ccaggttaat
      421 gcctgatgaa ggaagcatgt attacccacg ggtgcagcat taccgagagc ttcttgactc
      481 cttgccgatg gatgcttaca cacatggctg cattttgcat cctgagctca ctgtggattc
      541 catgatccca gcttatgcaa ccacaaggat tcgcggccag attggtaaca cggagtctga
      601 actgaagaaa cttgctgaag aaaaccctga cttacaagag gcttacattg ccaagcagaa
      661 gcgactgaag tcaaagctgc ttgatcacga caatgtcaaa tacttgaaga aaattcttga
      721 tgagttggag aaggtcttag atcaggtgga aactgagtta caaagaagaa atgaagaaac
      781 tccagatgag ggcaaccagc cttggctctg tggagaatcc tttacactgg cagatgtctc
      841 attggctgtc acattgcatc ggctgaagtt cctggggttt gcaaggagaa actggggaca
      901 tggaaagaga ccaaacttgg aaagctatta tgagcgtgtc ttgaagagaa aaacatttaa
      961 caaggtttta ggacatgtca acaatatatt aatctctgcg gtgctgccca cagcattccg
     1021 ggtggccaag aaaagggccc cgaaagttct cggtagcacc cttgtggttg gtttgcttgt
     1081 aggaatggga tattttgcat ttatgctttt cagaaggaga cttggcaaca tgatattatc
     1141 actcagaccc agaccaaatt atttctaggt ttgttgggtt ctgtggtagc agcacatcta
     1201 accactccac tagaccctca tccattcttc cagacccatt gaagatttgt tcttggtaac
     1261 tagtagaaaa catattttat agtattcatt ggggagttca tgtggggaaa ggagctaatg
     1321 atatgttttt tccttccttc cttcgttcct tcgttccttc gttccttcgt tccttcgttc
     1381 cttcgttcct tccttccttc cttccttcct tccttccttc ctttcttaga caacacaact
     1441 tacttctaat ttatccctta aagatcaatg taacttctga cagataggta agggatcttt
     1501 atggagatta taaattcatg tcctcagtta tttcttgaga ggttgtaatt aggagcagac
     1561 agtaataata acccatgact gcttatagtg cttcacctga gagtgactgc aattctgggt
     1621 gttgaacagt tgcaggatcc tcttctggga ctctgaagtc atctttgtta tgctagacag
     1681 gattcagata acaacaggac attgtaatgt ttcatcttcc actagcagct taggcatacg
     1741 taaaggagaa aaatgggaaa ggggagaaag aaaacaagag aatgaagtac atctagaaca
     1801 aagctgtaga tggtaacttc cagtggcttc cactgctgcc catggttgcc tctctccttg
     1861 gaaaacttca catctaccta cttgtggtta tgtcccctcc ttaactgaga actgttaaga
     1921 gggaacagag ggctgggaag tttgtgggga tagtatacca gagagaaacc tacatactgc
     1981 atagaaaaca cttcagttga ccctaattat gaattatact tgttgattta ataagattaa
     2041 gctattatac acttgaccat gagatgccca ttgaaacata tatttctggc aattatatga
     2101 atgtctaaag gaagtcttca tggtgccttc taaagatagg gcagtcttca tggctcccat
     2161 gaccatgaga gatattttcc tgtggacaac agtgctcagt cctgggagcc ttggcctcta
     2221 tagccctctt tatacatata agtaatatgc agatgaatat ctaaggtaaa catcatggct
     2281 tatggcttgt agtggatcat tcaatgagag tcaaatgtgc tcatttttat ttgaggagag
     2341 tggcacattc atgcacaaac cgttggctag gctttgtatt tgtttatgac tatcgacaaa
     2401 gctttacatt gaaggaaaaa ggaaaagcta gcactagata ttgacagtta atttgggaga
     2461 gataaaatat ctagctagtg atgtccaccc atactcatcc atgtgtgttt aagaatttgt
     2521 gggatatctc agtccatgtg gaagagacag ttcccagatg acctagagat caggaaaaac
     2581 ctcatattga agcagggagg cagtcttcct ggagctcgct gtcaaagtct taggagaagc
     2641 ttcgtgaatc tgatgaggag ctcatcctaa gaacgtgagt aaagggaaag tctgcttgga
     2701 tggcttcaag tgaactatgc acatagctaa agaatgtact gatgttttat taataggaaa
     2761 atgttatgag taacaagcaa tggctttctg atggtagaaa caattctgta atcccatttt
     2821 gattctatta tccatttcat aagctagatg tactaaaaat gtatgagcag aatgtgccct
     2881 gtgtgtaaaa acaaaacaac aaaacaaaaa ccctaggaac actccaaagt gaactcagat
     2941 taatgaagat gaaatgtgca cagctctcat gccatctcct ctgcctgtct gtgtcattgc
     3001 taggacattg ttatcattgt atttatacat gtatttatac aacagcccta aaattaactg
     3061 actagtaatt cagaaattct tacaatgttc tgatagaaat aaaaagtcag gtcaaagaag
     3121 taacaataag aattaaaaaa aaaatctaca aagggtattt atttacctat gaaaggattg
     3181 ttaaagagtg acttttcttt cagtatatgt tattatggaa tcaggaaatc actgggaaat
     3241 tataattctc atatgtaact tatttggagg tagatgtgtg gcaatgttaa aggcgaagca
     3301 tctgagcttc ttcaatgttt tctaggtagg tattcttgac attagtgctt taaaaatatt
     3361 tgtctagtga tagcaccata accactagat gtcgttgttc acccagtagt ctattaggtt
     3421 cagcaaatgt gaatgatttc aagtgggcat ctttgtcaag gttagtcatc tttgaaaaag
     3481 cttgcggcaa atctagtatg gattttttat gttttgtgag tgatgacagc actgtatgat
     3541 atcaaactaa ggaggtgcac agccactgtt agccaaagag gcactttaat gcatcttttt
     3601 cttcaggatt tttgacaact gaccaatgtg tttctcatgt gaaaaaaata gtataaattc
     3661 caccactaga gaatgctcaa gtcattaaaa ggttatgttg tctatttctt tcttaacaca
     3721 catgcacact attttattga tactaccatt atatgccttt taattctcaa aattgatgag
     3781 ctgcttactc aagttttcat gattattgct attgatatca aagttgtaat ggtattgtta
     3841 actgtcatag gaaattattg atattattct atctgtaaga tcaataaaat taatttgaaa
     3901 at
//
