LOCUS       NM_133598               1273 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus glycine cleavage system protein H (Gcsh), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_133598 XM_346524
VERSION     NM_133598.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1273)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1273)
  AUTHORS   Tibbetts,A.S. and Appling,D.R.
  TITLE     Compartmentalization of Mammalian folate-mediated one-carbon
            metabolism
  JOURNAL   Annu Rev Nutr 30, 57-81 (2010)
   PUBMED   20645850
  REMARK    Review article
REFERENCE   3  (bases 1 to 1273)
  AUTHORS   Tygstrup,N., Bangert,K., Ott,P. and Bisgaard,H.C.
  TITLE     Messenger RNA profiles in liver injury and stress: a comparison of
            lethal and nonlethal rat models
  JOURNAL   Biochem Biophys Res Commun 290 (1), 518-525 (2002)
   PUBMED   11779202
REFERENCE   4  (bases 1 to 1273)
  AUTHORS   Sakata,Y., Owada,Y., Sato,K., Kojima,K., Hisanaga,K., Shinka,T.,
            Suzuki,Y., Aoki,Y., Satoh,J., Kondo,H., Matsubara,Y. and Kure,S.
  TITLE     Structure and expression of the glycine cleavage system in rat
            central nervous system
  JOURNAL   Brain Res Mol Brain Res 94 (1-2), 119-130 (2001)
   PUBMED   11597772
REFERENCE   5  (bases 1 to 1273)
  AUTHORS   Koyata,H. and Hiraga,K.
  TITLE     The glycine cleavage system: structure of a cDNA encoding human
            H-protein, and partial characterization of its gene in patients
            with hyperglycinemias
  JOURNAL   Am J Hum Genet 48 (2), 351-361 (1991)
   PUBMED   1671321
REFERENCE   6  (bases 1 to 1273)
  AUTHORS   Hampson,R.K., Barron,L.L. and Olson,M.S.
  TITLE     Regulation of the glycine cleavage system in isolated rat liver
            mitochondria
  JOURNAL   J Biol Chem 258 (5), 2993-2999 (1983)
   PUBMED   6402507
REFERENCE   7  (bases 1 to 1273)
  AUTHORS   Hayasaka,K., Narisawa,K., Satoh,T., Tateda,H., Metoki,K., Tada,K.,
            Hiraga,K., Aoki,T., Kawakami,T., Akamatsu,H. and Matsuo,N.
  TITLE     Glycine cleavage system in ketotic hyperglycinemia: a reduction of
            H-protein activity
  JOURNAL   Pediatr Res 16 (1), 5-7 (1982)
   PUBMED   7070876
REFERENCE   8  (bases 1 to 1273)
  AUTHORS   Hayasaka,K., Kochi,H., Hiraga,K. and Kikuchi,G.
  TITLE     Purification and properties of glycine decarboxylase, a component
            of the glycine cleavage system, from rat liver mitochondria and
            immunochemical comparison of this enzyme from various sources
  JOURNAL   J Biochem 88 (4), 1193-1199 (1980)
   PUBMED   6778858
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB609750.1 and BC088114.1.
            
            On Mar 8, 2007 this sequence version replaced NM_133598.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088114.1, Y17321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                CB609750.1         27-89
            64-1273             BC088114.1         1-1210
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1273
                     /gene="Gcsh"
                     /note="glycine cleavage system protein H"
                     /db_xref="GeneID:171133"
                     /db_xref="RGD:619946"
     exon            1..229
                     /gene="Gcsh"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..603
                     /gene="Gcsh"
                     /note="glycine cleavage system H protein, mitochondrial;
                     lipoic acid-containing protein; glycine cleavage system
                     protein H (aminomethyl carrier)"
                     /codon_start=1
                     /product="glycine cleavage system H protein, mitochondrial
                     precursor"
                     /protein_id="NP_598282.2"
                     /db_xref="GeneID:171133"
                     /db_xref="RGD:619946"
                     /translation="MSLRVVRSVRAVACSLRIALASCPPRPWAPSAAAVRSLRTGSAL
                     LSVRKFTEKHEWVTAKDGIGTVGISNFAQEALGDVVYCSLPEVGTKLKKQEEFGALES
                     VKAASELYSPLSGEVTEVNEALAENPGLVNKSCYEDGWLIKMTLSDPSELDELMSEEA
                     YEKYVKSIEE"
     exon            230..309
                     /gene="Gcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            310..373
                     /gene="Gcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            374..505
                     /gene="Gcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            506..1247
                     /gene="Gcsh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcctcggt gctccgctta ctctggccca cctcgtcccc gccggcccgg tggcggaggc
       61 gaagcgcagt taccctcgga accttggatc atgtcgctgc gagtggtaag gagtgtgcgg
      121 gctgtggcct gcagcctgcg catcgccctg gcctcctgcc cgccaaggcc ctgggcgccg
      181 agcgctgccg ctgtccgctc gctgcgcacc ggatctgctt tgctctcggt gcgtaaattc
      241 acagagaagc acgaatgggt aacagcaaag gatggtattg gaacagtggg aatcagcaac
      301 tttgcacagg aagctttggg agatgttgtt tactgcagtc tgcctgaagt tgggacaaaa
      361 ctgaaaaaac aagaggagtt tggtgctttg gaaagcgtga aggctgccag tgaactctac
      421 tctcctctgt caggagaagt aactgaagtc aatgaagcac ttgccgaaaa cccagggctt
      481 gtcaacaaat catgttacga agacggttgg ctgatcaaga tgacactgag tgacccttct
      541 gagctggatg aattaatgag tgaagaagcg tatgagaaat atgtgaagtc cattgaggag
      601 tgaccatggc ttccacatag aactgggacg tgccctgttc cagcatgctt gtcttaaact
      661 agtggagaat agaggacttg acataactta gcaatagtga aggaaaggaa ctcttcttga
      721 cagtgctact taaggcccac ccccaacttc ctaatggatg cagataaaca cagtgtacag
      781 atttttgata atcaccgtaa taagtattta gactaggggt taagctctgg tttttagaat
      841 tcttaagatc atctgtggtg aaaagtagtt atgaagctgg gcttggtgac agaccaccat
      901 gggatcccag cactcaacag gcagatgtta gttcaaggtc ggtctacata gcaagttcca
      961 gaccagccac agttacaagg tgggatgcta cctactggtt atgggaattt cataattcag
     1021 gataacagtg gtgtatctta cgtacttttg tgacttgccc atatccacca ctggattttg
     1081 gtccgagact tcgtgtcttc tccttggaaa tgctgggcct gtggggaggt gttgtgcagt
     1141 gtcagatgca ggagattccc gtctttgtct cgtcttgtgc tgttctccca cggtgaagca
     1201 ctggctttgc aacactgaga aataaataaa acactcatgt ccttgttaaa aaaaaaaaaa
     1261 aaaaaaaaaa aaa
//
