LOCUS       NM_001001511            3847 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus glucosaminyl (N-acetyl) transferase 2 (Gcnt2),
            transcript variant 2, mRNA.
ACCESSION   NM_001001511 XM_225233 XM_225234
VERSION     NM_001001511.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3847)
  AUTHORS   Zhang,H., Meng,F., Wu,S., Kreike,B., Sethi,S., Chen,W., Miller,F.R.
            and Wu,G.
  TITLE     Engagement of I-branching {beta}-1,
            6-N-acetylglucosaminyltransferase 2 in breast cancer metastasis and
            TGF-{beta} signaling
  JOURNAL   Cancer Res 71 (14), 4846-4856 (2011)
   PUBMED   21750175
REFERENCE   2  (bases 1 to 3847)
  AUTHORS   Pras,E., Raz,J., Yahalom,V., Frydman,M., Garzozi,H.J., Pras,E. and
            Hejtmancik,J.F.
  TITLE     A nonsense mutation in the glucosaminyl (N-acetyl) transferase 2
            gene (GCNT2): association with autosomal recessive congenital
            cataracts
  JOURNAL   Invest Ophthalmol Vis Sci 45 (6), 1940-1945 (2004)
   PUBMED   15161861
REFERENCE   3  (bases 1 to 3847)
  AUTHORS   Zhang,T., Haws,P. and Wu,Q.
  TITLE     Multiple variable first exons: a mechanism for cell- and
            tissue-specific gene regulation
  JOURNAL   Genome Res 14 (1), 79-89 (2004)
   PUBMED   14672974
REFERENCE   4  (bases 1 to 3847)
  AUTHORS   Twu,Y.C., Chou,M.L. and Yu,L.C.
  TITLE     The molecular genetics of the mouse I
            beta-1,6-N-acetylglucosaminyltransferase locus
  JOURNAL   Biochem Biophys Res Commun 303 (3), 868-876 (2003)
   PUBMED   12670491
REFERENCE   5  (bases 1 to 3847)
  AUTHORS   Yu,L.C., Twu,Y.C., Chou,M.L., Reid,M.E., Gray,A.R., Moulds,J.M.,
            Chang,C.Y. and Lin,M.
  TITLE     The molecular genetics of the human I locus and molecular
            background explain the partial association of the adult i phenotype
            with congenital cataracts
  JOURNAL   Blood 101 (6), 2081-2088 (2003)
   PUBMED   12424189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jan 28, 2022 this sequence version replaced NM_001001511.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099796.1, AY435153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1153              JAXUCZ010000017.1  24043495-24044647   c
            1154-1246           JAXUCZ010000017.1  24007888-24007980   c
            1247-3847           JAXUCZ010000017.1  24002592-24005192   c
FEATURES             Location/Qualifiers
     source          1..3847
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..3847
                     /gene="Gcnt2"
                     /gene_synonym="Gcnt6; Ignt"
                     /note="glucosaminyl (N-acetyl) transferase 2"
                     /db_xref="GeneID:306860"
                     /db_xref="RGD:1303198"
     exon            1..1153
                     /gene="Gcnt2"
                     /gene_synonym="Gcnt6; Ignt"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1437
                     /gene="Gcnt2"
                     /gene_synonym="Gcnt6; Ignt"
                     /EC_number="2.4.1.150"
                     /note="isoform 2 is encoded by transcript variant 2;
                     N-acetyllactosaminide
                     beta-1,6-N-acetylglucosaminyl-transferase; I-branching
                     beta-1,6-acetylglucosaminyltransferase; glucosaminyl
                     (N-acetyl) transferase 2, I-branching enzyme; glucosaminyl
                     (N-acetyl) transferase 6; N-acetyllactosaminide
                     beta-1,6-N-acetylglucosaminyl-transferase-like;
                     glucosaminyl (N-acetyl) transferase 2 (I blood group)"
                     /codon_start=1
                     /product="N-acetyllactosaminide
                     beta-1,6-N-acetylglucosaminyl-transferase isoform 2"
                     /protein_id="NP_001001511.1"
                     /db_xref="GeneID:306860"
                     /db_xref="RGD:1303198"
                     /translation="MNLCMKFFAFTALSVVIFVVFYHSQLSLPNLYQRFNSSSERTSV
                     IACDYGLQNHSVFVPGITSPHPLEKLSCSQYQILSHYITSPLSEEEADFPLAYVMVIY
                     KDFDTFERLFRAIYMPQNVYCVHVDSKAAETFKEAVRHLLSCFPNAFLASRMERVVYG
                     GFSRLQADLNCMRDLVASKVPWKYVINTCGQDFPLKTNKEIVQYLKGFKGKNLTPGVL
                     PPEHVITRTKYVYKERKGRDGYFMQNTNTLKTPPPHKLVIYFGTAYVALTRDFVNFIL
                     NDKRAIDLLEWSKDTYSPDEHFWVTLNRIPGVPGAMPNASWTGNLRAVKWKDMESQNG
                     ACHGHYVHDICIYGNGDLQWLINSQSLFANKFEVNTYPLTVECLELRLRERTLNQSDI
                     ALQPSWHF"
     exon            1154..1246
                     /gene="Gcnt2"
                     /gene_synonym="Gcnt6; Ignt"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..3847
                     /gene="Gcnt2"
                     /gene_synonym="Gcnt6; Ignt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgcgaac gtgcggtggg aaagctgtcg gattccagcc gttcccggag gatggaccag
       61 actcggcagc accggggacc cacgacttga gaactgggga gcgcgagccc gcatctgttc
      121 gggagaagcc gtcgaatctg gagcagccag gtccgcctct cgctcctggg ctttcagaac
      181 tgtggtcact tctcggtctc cggtgataat tcttcccacc tgggactgga aataatgaac
      241 ctatgtatga aatttttcgc tttcactgcg ctcagcgtgg tgatttttgt ggttttttat
      301 cacagccagc taagcctgcc caacctctac cagcggttca atagctccag cgaaaggacg
      361 tctgtcatcg cctgtgatta cggcttgcaa aatcattcgg tcttcgtgcc ggggatcaca
      421 tcaccacatc ctttagaaaa actctcctgc tctcagtacc agatcctgag ccactatatt
      481 accagtccct tgtccgaaga agaagctgac tttcccttgg cctacgtcat ggtgatctac
      541 aaagacttcg acacctttga aaggctcttc agggccattt acatgcccca gaacgtctac
      601 tgtgtgcacg tggacagtaa ggcggcagag accttcaaag aagcggtgag gcatttactg
      661 agctgtttcc ccaatgcctt cctggcttct aggatggagc gggtggtcta tggtggcttc
      721 tcccggctcc aggctgacct gaactgcatg agagatctgg tggcttccaa agtcccctgg
      781 aaatatgtca tcaacacctg cgggcaggac ttccctctga aaaccaacaa agaaatagtt
      841 cagtacctga aagggtttaa ggggaaaaac ctcactccgg gggtgctccc tcctgagcat
      901 gtaattactc ggactaaata cgtatacaag gaacgtaaag gcagagacgg atattttatg
      961 caaaacacaa atactttgaa gactccgcct cctcacaaac tggtcatcta ctttggaacc
     1021 gcctacgtgg ccctcacccg agactttgtc aactttatcc tgaatgacaa aagggccatt
     1081 gatctcttag agtggtctaa agatacctat agcccggatg aacatttttg ggtgacactc
     1141 aataggattc caggagtccc tggcgccatg cccaatgcat cctggacagg taacctcaga
     1201 gctgtgaagt ggaaggatat ggaatcgcag aatggagcct gccacggtca ctacgtacat
     1261 gacatttgca tctatggaaa cggagacttg caatggctga ttaattcgca gagcctgttt
     1321 gctaacaagt ttgaagtcaa cacataccct ctcactgtgg aatgcttgga actgaggctt
     1381 cgagaaagaa cgctcaatca gagtgacatt gccttacagc ccagctggca tttctgatcc
     1441 acagcagctc tggcctgaac ggaaattgaa gacacaagac agagctttct tttccaagag
     1501 actcttgtct tggttatgct gaaggcttaa aaaaaatggt ttcaggaaac catcaggacc
     1561 tggcagcacg gctctgctta aaatatccat cgggcactgg gacacgtttg tcaggatggc
     1621 tgtgtcattt cttttgagtg tcttttgttt tctcctccac ctctccttcc tcctcttttc
     1681 ttttttaaaa gataggtagg gtcttgctat atatctcagg tagcccagga tggccctgaa
     1741 ctctctaatc actcctccta ccttggcctc ctaagggttg ctattacaag tgtgtacaac
     1801 cacacccagc tctgatgtct gacagtcact tgatgtgcat ctgcctctca ggctgcatta
     1861 gagctccgtg ccagatactc atattaacat atccggttag aaaggagaat ggtgggtaat
     1921 actgtctaag aaagtcaaaa cttatttgaa aaggaagctc tttccatatt cctagcaact
     1981 atattctcag gcacacatag gcacagagac agctttctag taactcacca atgccattta
     2041 ttaccaacac cgatcctgaa aagctgtacg gtgcccaagc atttgactga cacttgggca
     2101 tctccagcat cgcgaagggg tctcgtgaac accgacgttt tcagttttct tgtgtctgaa
     2161 gttctgcgta cagtacaaag ccattaacaa gggacctaca gcatgtgccg taagacggga
     2221 tgtgctgcag gaagaggacc tcagggatgc cggacatttc cgtgttctag tccagaatgt
     2281 tctctttggc cagagaacac tgtaacatcc tcacgggaat ggaggaattc tttctttcct
     2341 acaggaaagg tgctactgca tgggtctgga acctgtgaaa gacttgcttc tgcggcttcg
     2401 tttctatatg agagatgggg accgggttct gttgtggaca gctttaaata tatcagggca
     2461 gcctccagct tgtaatgatt ggtactgaca agagcaccta agagcttttt atgacaggtg
     2521 gacatctgtg tcatttttcc ttgttcaccc ttccatccat ccatccatcc atccatccat
     2581 ccatccatcc atccatccat ccatttgcca gcctgcattc agcaaacacc tcttgaatat
     2641 ctgtggccct ccagacatat gctgacagac atgagggaag caagacagat actttctcca
     2701 ctgtagaact ctggagagtg gtatcagctt ttgaaaccct gctctagagt cttacaaaat
     2761 ggctacactt cgcacagacc tggcctggct atatattaca tcaggccata gatatcagca
     2821 gcgtgttgat tgatagacta atccagagac aaggaggaaa tggaaggtag gcctctcatg
     2881 cccccacagc tcctccttgt ctcgttttat tcacacaccc atgcccgccc ctctcgtggg
     2941 ttccatgagt acctgtgtct tgcagatgac gtaacaagcc ttaggatggt tcatgatcac
     3001 taggaagcaa actctaagaa ttcgggttga agataaaata aagccatgct tagtatctcc
     3061 agagaatggc ctcggtgtta tttatgagaa aaaattctgt cattcaaaaa aatgtgaggt
     3121 caggacttgg taggcagggt ttcttgccgc aaagcctgat gacctgagtt caattcctgg
     3181 gatccacatg actaagggag agagcccact accaaaagga actctccaac ctccacacac
     3241 ttgtccttgc actcggacat ctgccgctcc ccccacccca tacgcataca cacaaatgaa
     3301 taactataat tttcaaaatg tgatttgtct ttgctcgctc tatcgcattt agaaatattt
     3361 atttaatcta acaggggaaa aacccatttg ctttaatgac gtcacttacc acagtttcat
     3421 tcttgtgctg taattgtacc tgctgaatgt tacatacctt taaagggaat tacttcgtgt
     3481 aaactttctt gtttcttcta ctgaaaaata aaatagggtt gtatcgggta ggaaagggtt
     3541 gagatataag aagtacttag tcaaggtgaa atctaaaacc gctttctcct ttgttattcg
     3601 gatgagagca cctgaagact aatgttttac actggatcgc tcatggagaa tgagacgatt
     3661 tttctggaga agtttacacg cccattgtcg gtcacctcct tactgtaaat actattggaa
     3721 agagaacagc atttgagctg gcagggaaag tacccgtatc tactgtgtcc agtttggttt
     3781 tgcggatgtt ttctgttttt tttttccctt gggaataaat taatatattg ttttccacct
     3841 tcaaaaa
//
