LOCUS       NP_001001511             400 aa            linear   ROD 31-MAR-2024
DEFINITION  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
            isoform 2 [Rattus norvegicus].
ACCESSION   NP_001001511 XP_225233 XP_225234
VERSION     NP_001001511.1
DBSOURCE    REFSEQ: accession NM_001001511.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 400)
  AUTHORS   Zhang,H., Meng,F., Wu,S., Kreike,B., Sethi,S., Chen,W., Miller,F.R.
            and Wu,G.
  TITLE     Engagement of I-branching {beta}-1,
            6-N-acetylglucosaminyltransferase 2 in breast cancer metastasis and
            TGF-{beta} signaling
  JOURNAL   Cancer Res 71 (14), 4846-4856 (2011)
   PUBMED   21750175
REFERENCE   2  (residues 1 to 400)
  AUTHORS   Pras,E., Raz,J., Yahalom,V., Frydman,M., Garzozi,H.J., Pras,E. and
            Hejtmancik,J.F.
  TITLE     A nonsense mutation in the glucosaminyl (N-acetyl) transferase 2
            gene (GCNT2): association with autosomal recessive congenital
            cataracts
  JOURNAL   Invest Ophthalmol Vis Sci 45 (6), 1940-1945 (2004)
   PUBMED   15161861
REFERENCE   3  (residues 1 to 400)
  AUTHORS   Zhang,T., Haws,P. and Wu,Q.
  TITLE     Multiple variable first exons: a mechanism for cell- and
            tissue-specific gene regulation
  JOURNAL   Genome Res 14 (1), 79-89 (2004)
   PUBMED   14672974
REFERENCE   4  (residues 1 to 400)
  AUTHORS   Twu,Y.C., Chou,M.L. and Yu,L.C.
  TITLE     The molecular genetics of the mouse I
            beta-1,6-N-acetylglucosaminyltransferase locus
  JOURNAL   Biochem Biophys Res Commun 303 (3), 868-876 (2003)
   PUBMED   12670491
REFERENCE   5  (residues 1 to 400)
  AUTHORS   Yu,L.C., Twu,Y.C., Chou,M.L., Reid,M.E., Gray,A.R., Moulds,J.M.,
            Chang,C.Y. and Lin,M.
  TITLE     The molecular genetics of the human I locus and molecular
            background explain the partial association of the adult i phenotype
            with congenital cataracts
  JOURNAL   Blood 101 (6), 2081-2088 (2003)
   PUBMED   12424189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On or before Aug 30, 2004 this sequence version replaced
            XP_225233.2, XP_225234.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099796.1, AY435153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     Protein         1..400
                     /product="N-acetyllactosaminide
                     beta-1,6-N-acetylglucosaminyl-transferase isoform 2"
                     /EC_number="2.4.1.150"
                     /note="N-acetyllactosaminide
                     beta-1,6-N-acetylglucosaminyl-transferase; I-branching
                     beta-1,6-acetylglucosaminyltransferase; glucosaminyl
                     (N-acetyl) transferase 2, I-branching enzyme; glucosaminyl
                     (N-acetyl) transferase 6; N-acetyllactosaminide
                     beta-1,6-N-acetylglucosaminyl-transferase-like;
                     glucosaminyl (N-acetyl) transferase 2 (I blood group)"
                     /calculated_mol_wt=45976
     Region          95..356
                     /region_name="Branch"
                     /note="Core-2/I-Branching enzyme; pfam02485"
                     /db_xref="CDD:426795"
     CDS             1..400
                     /gene="Gcnt2"
                     /gene_synonym="Gcnt6; Ignt"
                     /coded_by="NM_001001511.4:235..1437"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:306860"
                     /db_xref="RGD:1303198"
ORIGIN      
        1 mnlcmkffaf talsvvifvv fyhsqlslpn lyqrfnssse rtsviacdyg lqnhsvfvpg
       61 itsphplekl scsqyqilsh yitsplseee adfplayvmv iykdfdtfer lfraiympqn
      121 vycvhvdska aetfkeavrh llscfpnafl asrmervvyg gfsrlqadln cmrdlvaskv
      181 pwkyvintcg qdfplktnke ivqylkgfkg knltpgvlpp ehvitrtkyv ykerkgrdgy
      241 fmqntntlkt ppphklviyf gtayvaltrd fvnfilndkr aidllewskd tyspdehfwv
      301 tlnripgvpg ampnaswtgn lravkwkdme sqngachghy vhdiciygng dlqwlinsqs
      361 lfankfevnt ypltveclel rlrertlnqs dialqpswhf
//
