LOCUS       NM_001106105            3365 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus glial cells missing transcription factor 2
            (Gcm2), mRNA.
ACCESSION   NM_001106105 XM_001061843 XM_225247
VERSION     NM_001106105.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3365)
  AUTHORS   Guan B, Welch JM, Sapp JC, Ling H, Li Y, Johnston JJ, Kebebew E,
            Biesecker LG, Simonds WF, Marx SJ and Agarwal SK.
  TITLE     GCM2-Activating Mutations in Familial Isolated Hyperparathyroidism
  JOURNAL   Am J Hum Genet 99 (5), 1034-1044 (2016)
   PUBMED   27745835
REFERENCE   2  (bases 1 to 3365)
  AUTHORS   Grigorieva IV, Mirczuk S, Gaynor KU, Nesbit MA, Grigorieva EF, Wei
            Q, Ali A, Fairclough RJ, Stacey JM, Stechman MJ, Mihai R, Kurek D,
            Fraser WD, Hough T, Condie BG, Manley N, Grosveld F and Thakker RV.
  TITLE     Gata3-deficient mice develop parathyroid abnormalities due to
            dysregulation of the parathyroid-specific transcription factor Gcm2
  JOURNAL   J Clin Invest 120 (6), 2144-2155 (2010)
   PUBMED   20484821
REFERENCE   3  (bases 1 to 3365)
  AUTHORS   Bowl MR, Mirczuk SM, Grigorieva IV, Piret SE, Cranston T, Southam
            L, Allgrove J, Bahl S, Brain C, Loughlin J, Mughal Z, Ryan F, Shaw
            N, Thakker YV, Tiosano D, Nesbit MA and Thakker RV.
  TITLE     Identification and characterization of novel parathyroid-specific
            transcription factor Glial Cells Missing Homolog B (GCMB) mutations
            in eight families with autosomal recessive hypoparathyroidism
  JOURNAL   Hum Mol Genet 19 (10), 2028-2038 (2010)
   PUBMED   20190276
REFERENCE   4  (bases 1 to 3365)
  AUTHORS   Simmonds CS, Karsenty G, Karaplis AC and Kovacs CS.
  TITLE     Parathyroid hormone regulates fetal-placental mineral homeostasis
  JOURNAL   J Bone Miner Res 25 (3), 594-605 (2010)
   PUBMED   19968565
REFERENCE   5  (bases 1 to 3365)
  AUTHORS   Liu Z, Yu S and Manley NR.
  TITLE     Gcm2 is required for the differentiation and survival of
            parathyroid precursor cells in the parathyroid/thymus primordia
  JOURNAL   Dev Biol 305 (1), 333-346 (2007)
   PUBMED   17382312
REFERENCE   6  (bases 1 to 3365)
  AUTHORS   Baumber,L., Tufarelli,C., Patel,S., King,P., Johnson,C.A.,
            Maher,E.R. and Trembath,R.C.
  TITLE     Identification of a novel mutation disrupting the DNA binding
            activity of GCM2 in autosomal recessive familial isolated
            hypoparathyroidism
  JOURNAL   J Med Genet 42 (5), 443-448 (2005)
   PUBMED   15863676
REFERENCE   7  (bases 1 to 3365)
  AUTHORS   Thomee C, Schubert SW, Parma J, Le PQ, Hashemolhosseini S, Wegner M
            and Abramowicz MJ.
  TITLE     GCMB mutation in familial isolated hypoparathyroidism with residual
            secretion of parathyroid hormone
  JOURNAL   J Clin Endocrinol Metab 90 (5), 2487-2492 (2005)
   PUBMED   15728199
REFERENCE   8  (bases 1 to 3365)
  AUTHORS   Iwasaki Y, Hosoya T, Takebayashi H, Ogawa Y, Hotta Y and Ikenaka K.
  TITLE     The potential to induce glial differentiation is conserved between
            Drosophila and mammalian glial cells missing genes
  JOURNAL   Development 130 (24), 6027-6035 (2003)
   PUBMED   14573516
REFERENCE   9  (bases 1 to 3365)
  AUTHORS   Ding C, Buckingham B and Levine MA.
  TITLE     Familial isolated hypoparathyroidism caused by a mutation in the
            gene for the transcription factor GCMB
  JOURNAL   J Clin Invest 108 (8), 1215-1220 (2001)
   PUBMED   11602629
REFERENCE   10 (bases 1 to 3365)
  AUTHORS   Kim J, Jones BW, Zock C, Chen Z, Wang H, Goodman CS and Anderson
            DJ.
  TITLE     Isolation and characterization of mammalian homologs of the
            Drosophila gene glial cells missing
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12364-12369 (1998)
   PUBMED   9770492
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473977.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_225247.4, XM_001061843.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760434
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3365
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..3365
                     /gene="Gcm2"
                     /note="glial cells missing transcription factor 2"
                     /db_xref="GeneID:291047"
                     /db_xref="RGD:1311127"
     exon            1..270
                     /gene="Gcm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1695
                     /gene="Gcm2"
                     /note="glial cells missing homolog 2"
                     /codon_start=1
                     /product="chorion-specific transcription factor GCMb"
                     /protein_id="NP_001099575.1"
                     /db_xref="GeneID:291047"
                     /db_xref="RGD:1311127"
                     /translation="MPADSMQDPDPVLSYGMKLTWDINDPQMPQEPAHFDHFREWPDG
                     YVRFIYSSQEKKAQRHLSGWAMRNTNNHNGHILKKSCLGVVVCARACALKDGSHLQLR
                     PAICDKARLKQQKKACPNCHSALELVPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHP
                     RPESKSETEGRRSALKRQMASFYQPQKRRSEEPEAGSTQDTRGHSNSTPVPEPSELFA
                     MPADTSFPISGHSSLSFPNSDVHRVTCDLPTFPGDVILPFQKYSNPSIYFPGPPWSYE
                     LASPGVTGSSPYPTLYKDPSIVPDDPDWIHLNSLQYNVSSYGSYERSLDLTARYHGWK
                     PTHGKAGLEEKVDCRPCQAVPTSPYYNLELPCRYLPVAPAGTQALQTVITTTVAYQAY
                     QHPALKHGDSVQEVSSLASCTYASENLPMPIYPQALDPQEGAIQAASPSGRAPGIVPG
                     DCQAARPTLAFPQETDPSRTAGADVWDVCLSGVGSVMAYLDRTGQPFNLDNEDF"
     exon            271..523
                     /gene="Gcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            524..636
                     /gene="Gcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            637..762
                     /gene="Gcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..3365
                     /gene="Gcm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcatctctc tgtttctctc tgtgtctgtg tgtctctctt tctgtctccc tctgtctctg
       61 tctctgtccc ctccctcctc ttcctcctcc tcctttcact cacctctcgc cctacatctc
      121 atttgggaaa aagtcaccct gtgcgctcct tgcttttatt tctctttcag gcccctccag
      181 atgccagcag acagcatgca ggaccccgat cctgtgcttt cctacgggat gaaactcaca
      241 tgggacatca atgacccgca gatgcctcag gaaccagctc acttcgacca cttccgggag
      301 tggcctgatg gctacgtgcg cttcatctac agcagtcagg agaagaaagc tcagcgccac
      361 ctgagcggct gggccatgcg caacaccaac aaccacaatg gccacatcct caaaaagtcc
      421 tgcctgggcg tggtggtgtg cgcacgcgcc tgcgccctga aggatggctc gcacctgcag
      481 ctgaggccag ccatctgcga caaggctcgt ctgaagcaac aaaagaaagc ttgccccaac
      541 tgtcattcag ctttggagct ggtcccttgc cgaggacaca gtggataccc tgtcaccaac
      601 ttctggagac ttgatggcaa tgcaatattt tttcaggcca aaggagttca tgatcatccc
      661 agaccagaga gcaagtcaga gacagaaggc agaagaagtg ccctcaagag acagatggcc
      721 tctttctacc aaccccagaa aaggagatca gaggagcctg aggcaggaag cactcaggac
      781 accaggggac actccaatag cacgcctgtc ccagaaccct cagaactgtt tgctatgcct
      841 gctgacacca gcttccctat ttcagggcat tcttcccttt ccttcccaaa ctctgatgtc
      901 cacagagtta cctgtgacct gcccaccttt ccaggagatg taatacttcc ctttcagaaa
      961 tattcaaatc caagcattta tttccctggg ccaccttgga gctatgaatt ggcaagtcct
     1021 ggagttacgg gttcaagtcc atatcctacc ctgtataaag acccctccat tgtccccgat
     1081 gaccctgact ggatccatct aaactcacta caatataatg tgagttcata cggcagctat
     1141 gagagaagct tggatctcac agctagatat catggctgga aacctacaca tgggaaagct
     1201 ggccttgagg agaaggttga ctgtaggcca tgccaggctg tgcccacatc gccttattac
     1261 aacctagagc tgccctgcag gtacctgcca gtggccccgg caggtaccca ggccctgcag
     1321 acagtgatca ccaccacagt ggcttatcag gcttaccagc accctgctct gaaacacggc
     1381 gacagcgtgc aggaggttag cagccttgcc agttgcacct acgcttctga aaacctccca
     1441 atgcccatct atccgcaagc cttagaccct caagagggag ccatccaggc agcctcccct
     1501 tcagggagag cccctgggat agtccctgga gattgccagg cagccagacc tactctggct
     1561 ttccctcaag aaacagatcc ctccaggaca gctggagcag atgtgtggga tgtgtgtctg
     1621 tctggggtgg gctctgtgat ggcttacttg gataggacag ggcaaccctt taacctcgac
     1681 aatgaggact tttaggaggg tcccaggata cacacaccat gacaatgaag tacatgctag
     1741 ataacccatg cccaggggca acgacttgct tgggtggttc atacacatac aggactggag
     1801 ttgagtgtaa aggcacctgg ggagttataa gttgggaatg ataggtgctg gaagttagca
     1861 cagcactttg aaacctgcca caccgcatag gctagtagca gtgcgagcat cccagatgaa
     1921 caaataaagg agcgggaggg acctgcaatg ccctggcctg cccttcctta gcttgcctgc
     1981 taaggatgct agttccattc ttaacctttg ccctttagac ttttagagaa tttcacacag
     2041 ctgtgaatag catcaagagg ctatgtaagc agcatgggtg tggaagcctg gagagaaaca
     2101 tatgaaacgt atgaaatgta gcaagtgttt tattgccctg caggcttttc cattcatcag
     2161 ctgaaaattc tgtaagccaa gaggaaccct acataacttg gggtgctatg acatctgtga
     2221 actgaagctc cccccaccct gggggggagc ctcctctgtg ttaaagattc ctcaatgtgg
     2281 actgattggc aagaatttct gtgatgttga gagctggaat gttgcaggtc tgaggccaga
     2341 tctgtgactt taacccttta atagccatgt ctcacctatt aagtgattaa gtggatccct
     2401 ttgggatgca caaacaaacc ccaagtttct atttccccca aaggctaaaa atgtcatcaa
     2461 gtagcatctt aggctactat atggaaaaag aaaatatata tatatattta tatatataat
     2521 cctgtcttcc tggttttacc actaatgaat ttttcacata ccttgattta tgagttcctt
     2581 tgttctatta ctataaaaac gttatgaact tgctccctcc atgtttgaac atgttttcaa
     2641 atctatgttc cctactccgt gatcaactaa tgttcagctc cataataaaa tctctcgttt
     2701 cctttgaggt aagagctatg gttcttgtgt ccacacacct cagtaatccc agcactctga
     2761 aggctaaggc aggaggattt gcctatggca cttgctgtag atggcttttc aaatatcaat
     2821 ttctaccaga cagtttctgt gtctcgtgag tcactgagga cagttcaggc ctgttacttg
     2881 ctggtgagac acaactcagt atatgaacac tttaaaactg tcaccaattt agacacaatt
     2941 taactaacct agccttactg gtttctatgc tgacaaaact gaacttaatc tatattttat
     3001 ggcttttttt aaacttttta ttatatattt ctttacttac atttcaaagg ttactcccct
     3061 tcctggtttc ctgtccataa gcccccattc cctcccctcc ctctccccca tacaggtatt
     3121 ccccctatac atctgcctta ttgccctccc ccatattccc ttgcactggg ggtccaacct
     3181 tggcaagacc aagggctttc ccttccattg gtgcccaaca aggctattct ctgctacata
     3241 tccagttgga gccctgggtc agtccgtgta tagtctttcg gtagtggttt agtccctgga
     3301 agctctgatt ggttggcatt gttgttttct atattttaat aaaagacaat tgatattgtt
     3361 ctatg
//
