LOCUS       NM_017186               1500 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus glial cells missing transcription factor 1
            (Gcm1), mRNA.
ACCESSION   NM_017186
VERSION     NM_017186.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1500)
  AUTHORS   Lo,H.F., Tsai,C.Y., Chen,C.P., Wang,L.J., Lee,Y.S., Chen,C.Y.,
            Liang,C.T., Cheong,M.L. and Chen,H.
  TITLE     Association of dysfunctional synapse defective 1 (SYDE1) with
            restricted fetal growth - SYDE1 regulates placental cell migration
            and invasion
  JOURNAL   J Pathol 241 (3), 324-336 (2017)
   PUBMED   27917469
REFERENCE   2  (bases 1 to 1500)
  AUTHORS   Chang,C.W., Cheong,M.L., Chang,G.D., Tsai,M.S. and Chen,H.
  TITLE     Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the
            regulation of placental cell fusion
  JOURNAL   Mol Hum Reprod 19 (11), 745-755 (2013)
   PUBMED   23867755
REFERENCE   3  (bases 1 to 1500)
  AUTHORS   Lu,J., Zhang,S., Nakano,H., Simmons,D.G., Wang,S., Kong,S.,
            Wang,Q., Shen,L., Tu,Z., Wang,W., Wang,B., Wang,H., Wang,Y., van
            Es,J.H., Clevers,H., Leone,G., Cross,J.C. and Wang,H.
  TITLE     A positive feedback loop involving Gcm1 and Fzd5 directs chorionic
            branching morphogenesis in the placenta
  JOURNAL   PLoS Biol 11 (4), e1001536 (2013)
   PUBMED   23610556
REFERENCE   4  (bases 1 to 1500)
  AUTHORS   Kashif,M., Hellwig,A., Kolleker,A., Shahzad,K., Wang,H., Lang,S.,
            Wolter,J., Thati,M., Vinnikov,I., Bierhaus,A., Nawroth,P.P. and
            Isermann,B.
  TITLE     p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium
            formation, placental vascularization and embryonic growth
  JOURNAL   Development 138 (11), 2235-2247 (2011)
   PUBMED   21558372
REFERENCE   5  (bases 1 to 1500)
  AUTHORS   Baczyk,D., Drewlo,S., Proctor,L., Dunk,C., Lye,S. and Kingdom,J.
  TITLE     Glial cell missing-1 transcription factor is required for the
            differentiation of the human trophoblast
  JOURNAL   Cell Death Differ 16 (5), 719-727 (2009)
   PUBMED   19219068
REFERENCE   6  (bases 1 to 1500)
  AUTHORS   Schubert,S.W., Kardash,E., Khan,M.A., Cheusova,T., Kilian,K.,
            Wegner,M. and Hashemolhosseini,S.
  TITLE     Interaction, cooperative promoter modulation, and renal
            colocalization of GCMa and Pitx2
  JOURNAL   J Biol Chem 279 (48), 50358-50365 (2004)
   PUBMED   15385555
REFERENCE   7  (bases 1 to 1500)
  AUTHORS   Iwasaki,Y., Hosoya,T., Takebayashi,H., Ogawa,Y., Hotta,Y. and
            Ikenaka,K.
  TITLE     The potential to induce glial differentiation is conserved between
            Drosophila and mammalian glial cells missing genes
  JOURNAL   Development 130 (24), 6027-6035 (2003)
   PUBMED   14573516
REFERENCE   8  (bases 1 to 1500)
  AUTHORS   Cohen,S.X., Moulin,M., Schilling,O., Meyer-Klaucke,W.,
            Schreiber,J., Wegner,M. and Muller,C.W.
  TITLE     The GCM domain is a Zn-coordinating DNA-binding domain
  JOURNAL   FEBS Lett 528 (1-3), 95-100 (2002)
   PUBMED   12297286
REFERENCE   9  (bases 1 to 1500)
  AUTHORS   Anson-Cartwright,L., Dawson,K., Holmyard,D., Fisher,S.J.,
            Lazzarini,R.A. and Cross,J.C.
  TITLE     The glial cells missing-1 protein is essential for branching
            morphogenesis in the chorioallantoic placenta
  JOURNAL   Nat Genet 25 (3), 311-314 (2000)
   PUBMED   10888880
REFERENCE   10 (bases 1 to 1500)
  AUTHORS   Kim,J., Jones,B.W., Zock,C., Chen,Z., Wang,H., Goodman,C.S. and
            Anderson,D.J.
  TITLE     Isolation and characterization of mammalian homologs of the
            Drosophila gene glial cells missing
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12364-12369 (1998)
   PUBMED   9770492
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF081557.1.
            
            On Aug 30, 2012 this sequence version replaced NM_017186.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF081557.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1500              AF081557.1         2-1501
FEATURES             Location/Qualifiers
     source          1..1500
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1500
                     /gene="Gcm1"
                     /gene_synonym="Gcma"
                     /note="glial cells missing transcription factor 1"
                     /db_xref="GeneID:29394"
                     /db_xref="RGD:61852"
     exon            1..49
                     /gene="Gcm1"
                     /gene_synonym="Gcma"
                     /inference="alignment:Splign:2.1.0"
     exon            50..233
                     /gene="Gcm1"
                     /gene_synonym="Gcma"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1469
                     /gene="Gcm1"
                     /gene_synonym="Gcma"
                     /note="GCM motif protein 1; glial cells missing homolog 1"
                     /codon_start=1
                     /product="chorion-specific transcription factor GCMa"
                     /protein_id="NP_058882.1"
                     /db_xref="GeneID:29394"
                     /db_xref="RGD:61852"
                     /translation="MELDDFDPEDKEILSWDINDMKLPQNVKKTDWFQEWPDSYVKHI
                     YSSDDRSAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCSRDCSTEEGRKIYLRPAICD
                     KARQKQQRKSCPNCNGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPRPETK
                     LEAEARRAMKKVHMASASSSLRMKGRPEMKGLPGEIPSQGSLPLTWSFQEGVQLPSGY
                     STPLIANAPQQNSLNDCLSFPKSYDLGGTTELEDPTSTLDPTKLYERYKFSSSKVYSA
                     EDQFQPPVPGVYGDYDEAQTWNKNAVLGRSPTDDTYYPPYPLPVASWPCDYLPSQSSL
                     EHSPQQVPLEPPAAQPGHHPLWTNPGGEPYEEKVPVDFSSYVPSVTYHSPQQDPFLLA
                     YGSHPQQQYALPGKSNRWDFDEEMACMGLDHFNNEMLLNLCSLK"
     exon            234..486
                     /gene="Gcm1"
                     /gene_synonym="Gcma"
                     /inference="alignment:Splign:2.1.0"
     exon            487..599
                     /gene="Gcm1"
                     /gene_synonym="Gcma"
                     /inference="alignment:Splign:2.1.0"
     exon            600..728
                     /gene="Gcm1"
                     /gene_synonym="Gcma"
                     /inference="alignment:Splign:2.1.0"
     exon            729..1500
                     /gene="Gcm1"
                     /gene_synonym="Gcma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaacgagaa ggagggactc aggcctcagg agcactgaag atggaaaggc tttgaaaaac
       61 aagcccttca gctgctctcg tggacagagt tctgagactg cgagctctcg agacatctct
      121 gacgatttga gaagagcctg tgttgagccg acctcatcat ggaactggac gactttgatc
      181 ctgaagacaa agagatactg agctgggata ttaacgacat gaagctgcct cagaatgtga
      241 agaagactga ctggttccag gagtggccag actcctacgt gaaacacatc tacagctcag
      301 acgacaggag cgcacagcgc catctgagca gctgggccat gcgcaacacc aacaaccaca
      361 actcccggat cctcaagaag tcgtgcctgg gggtagtggt gtgcagcagg gactgttcca
      421 cggaggaagg ccgcaagatt tacctgagac ccgccatctg tgacaaagcc aggcagaagc
      481 agcagaggaa aagctgtccc aactgcaatg gacccctgaa actaattccc tgcagaggcc
      541 acggcggctt cccggtcacc aacttctgga ggcatgacgg acgcttcatc tttttccagt
      601 ccaaaggaga gcacgatcat cccaggccgg agaccaagct agaagcagag gcaagaagag
      661 ccatgaagaa agtgcacatg gcctctgcct ccagctcctt acggatgaag gggagaccag
      721 aaatgaaggg tctcccaggt gaaatcccga gtcagggaag tttaccttta acttggtcat
      781 tccaggaagg ggtccaactg cccagcggtt acagcacacc tttaatagct aacgctcccc
      841 agcagaactc cctcaatgat tgcctgtcct tccccaagag ctatgacttg gggggaacca
      901 ctgagctaga agatccaact tccaccttag atcccacgaa gctctatgag agatataagt
      961 tctccagcag taaggtctac agcgctgaag accagttcca gcctcctgtc cccggggtgt
     1021 acggagatta tgatgaagca caaacctgga ataaaaatgc tgtcttaggg agaagtccta
     1081 ctgacgacac ctactatcca ccctatcctc tgcctgtggc cagctggccc tgtgactacc
     1141 ttccctccca gagctctttg gagcactctc cccaacaggt tccactagag ccacctgcag
     1201 ctcaacccgg ccatcatccc ttgtggacca atcccggagg tgagccttac gaagagaaag
     1261 ttcctgtgga tttcagcagc tatgtgcctt ctgtcacgta ccactcccct cagcaggacc
     1321 cctttctgct cgcttacggc tctcatcctc agcagcagta cgcgctgcct ggtaagagca
     1381 acaggtggga tttcgatgaa gagatggcgt gcatgggctt ggatcacttc aacaacgaga
     1441 tgctcctaaa cctctgttct ttaaaataac tcatagcccg cttcctgctc tccccatcat
//
