LOCUS       NM_013120               2296 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus glucokinase regulator (Gckr), mRNA.
ACCESSION   NM_013120
VERSION     NM_013120.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2296)
  AUTHORS   Ram,R., Wakil,S.M., Muiya,N.P., Andres,E., Mazhar,N., Hagos,S.,
            Alshahid,M., Meyer,B.F., Morahan,G. and Dzimiri,N.
  TITLE     A common variant association study in ethnic Saudi Arabs reveals
            novel susceptibility loci for hypertriglyceridemia
  JOURNAL   Clin Genet 91 (3), 371-378 (2017)
   PUBMED   27599772
REFERENCE   2  (bases 1 to 2296)
  AUTHORS   Pautsch,A., Stadler,N., Lohle,A., Rist,W., Berg,A., Glocker,L.,
            Nar,H., Reinert,D., Lenter,M., Heckel,A., Schnapp,G. and
            Kauschke,S.G.
  TITLE     Crystal structure of glucokinase regulatory protein
  JOURNAL   Biochemistry 52 (20), 3523-3531 (2013)
   PUBMED   23621087
REFERENCE   3  (bases 1 to 2296)
  AUTHORS   Bourbonais,F.J., Chen,J., Huang,C., Zhang,Y., Pfefferkorn,J.A. and
            Landro,J.A.
  TITLE     Modulation of glucokinase by glucose, small-molecule activator and
            glucokinase regulatory protein: steady-state kinetic and cell-based
            analysis
  JOURNAL   Biochem J 441 (3), 881-887 (2012)
   PUBMED   22044397
  REMARK    GeneRIF: When GK is pre-incubated with glucose and compound A, the
            inhibition observed by GKRP is time dependent, but independent of
            GKRP concentration, reflecting the GKA-controlled transition
            between closed and open GK conformations.
REFERENCE   4  (bases 1 to 2296)
  AUTHORS   Boger,C.A., Gorski,M., Li,M., Hoffmann,M.M., Huang,C., Yang,Q.,
            Teumer,A., Krane,V., O'Seaghdha,C.M., Kutalik,Z., Wichmann,H.E.,
            Haak,T., Boes,E., Coassin,S., Coresh,J., Kollerits,B., Haun,M.,
            Paulweber,B., Kottgen,A., Li,G., Shlipak,M.G., Powe,N., Hwang,S.J.,
            Dehghan,A., Rivadeneira,F., Uitterlinden,A., Hofman,A.,
            Beckmann,J.S., Kramer,B.K., Witteman,J., Bochud,M., Siscovick,D.,
            Rettig,R., Kronenberg,F., Wanner,C., Thadhani,R.I., Heid,I.M.,
            Fox,C.S. and Kao,W.H.
  CONSRTM   CKDGen Consortium
  TITLE     Association of eGFR-Related Loci Identified by GWAS with Incident
            CKD and ESRD
  JOURNAL   PLoS Genet 7 (9), e1002292 (2011)
   PUBMED   21980298
REFERENCE   5  (bases 1 to 2296)
  AUTHORS   Bonetti,S., Trombetta,M., Boselli,M.L., Turrini,F., Malerba,G.,
            Trabetti,E., Pignatti,P.F., Bonora,E. and Bonadonna,R.C.
  TITLE     Variants of GCKR affect both beta-cell and kidney function in
            patients with newly diagnosed type 2 diabetes: the Verona newly
            diagnosed type 2 diabetes study 2
  JOURNAL   Diabetes Care 34 (5), 1205-1210 (2011)
   PUBMED   21411509
REFERENCE   6  (bases 1 to 2296)
  AUTHORS   Fernandez-Novell,J.M., Castel,S., Bellido,D., Ferrer,J.C.,
            Vilaro,S. and Guinovart,J.J.
  TITLE     Intracellular distribution of hepatic glucokinase and glucokinase
            regulatory protein during the fasted to refed transition in rats
  JOURNAL   FEBS Lett 459 (2), 211-214 (1999)
   PUBMED   10518020
REFERENCE   7  (bases 1 to 2296)
  AUTHORS   Volpe,C.M., Koo,J., Miloro,S.M., Driscoll,D.L., Nava,H.R. and
            Douglass,H.O. Jr.
  TITLE     The effect of extended lymphadenectomy on survival in patients with
            gastric adenocarcinoma
  JOURNAL   J Am Coll Surg 181 (1), 56-64 (1995)
   PUBMED   7599772
REFERENCE   8  (bases 1 to 2296)
  AUTHORS   Detheux,M., Vandekerckhove,J. and Van Schaftingen,E.
  TITLE     Cloning and sequencing of rat liver cDNAs encoding the regulatory
            protein of glucokinase
  JOURNAL   FEBS Lett 339 (3), 312 (1994)
   PUBMED   8112473
  REMARK    Correction to:[FEBS Lett. 1993 Apr 26;321(2-3):111-5. doi:
            10.1016/0014-5793(93)80089-d.. PMID: 7682971]
REFERENCE   9  (bases 1 to 2296)
  AUTHORS   Detheux,M., Vandekerckhove,J. and Van Schaftingen,E.
  TITLE     Cloning and sequencing of rat liver cDNAs encoding the regulatory
            protein of glucokinase
  JOURNAL   FEBS Lett 321 (2-3), 111-115 (1993)
   PUBMED   7682971
  REMARK    Erratum:[FEBS Lett. 1994 Feb 21;339(3):312. doi:
            10.1016/0014-5793(94)80437-0.. PMID: 8112473]
REFERENCE   10 (bases 1 to 2296)
  AUTHORS   Nordbrock,E.
  TITLE     Statistical comparison of stability study designs
  JOURNAL   J Biopharm Stat 2 (1), 91-113 (1992)
   PUBMED   1300209
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081843.1.
            
            On Sep 16, 2004 this sequence version replaced NM_013120.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081843.1, X68497.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132262,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2296
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..2296
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /note="glucokinase regulator"
                     /db_xref="GeneID:25658"
                     /db_xref="RGD:2671"
     exon            1..237
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2061
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /note="glucokinase (hexokinase 4) regulator; 68-kDa
                     regulatory protein"
                     /codon_start=1
                     /product="glucokinase regulatory protein"
                     /protein_id="NP_037252.1"
                     /db_xref="GeneID:25658"
                     /db_xref="RGD:2671"
                     /translation="MPGTKRYQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKA
                     DAEKIVKLLGQCDAEIFQEEGQIVPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLV
                     VLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREQTEDSALHGI
                     EELKKVAAGKKRVVVIGISVGLSAPFVAGQMDYCMDNTAVFLPVLVGFNPVSMARNDP
                     IEDWRSTFRQVAERMQKMQEKQEAFVLNPAIGPEGLSGSSRMKGGGATKILLETLLLA
                     AHKTVDQGVVSSQRCLLEILRTFERAHQVTYSQSSKIATLMKQVGISLEKKGRVHLVG
                     WQTLGIIAIMDGVECIHTFGADFQDIRGFLIGDHSDMFNQKDELTNQGPQFTFSQDDF
                     LTSILPSLTETDTVVFIFTLDDNLTEVQALAERVREKCQNIQALVHSTVGQSLPAPLK
                     KLFPSLISITWPLLFFDYEGTYVQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDL
                     RIANSKLFWRALAMLQRFSGQSKARCIESLLQAIHFPQPLSDDVRAAPISCHVQVAHE
                     KEKVIPTALLSLLLRCSISEAKARLSAASSVCEVVRSALSGPGQKRSTQALEDPPACG
                     TLN"
     exon            238..393
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            394..462
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            463..531
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            532..605
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            606..672
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            673..726
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            727..821
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            822..927
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1046
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1145
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1243
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1320
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1417
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1515
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1599
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1749
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1884
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2273
                     /gene="Gckr"
                     /gene_synonym="GKRP; GLRE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggaaaggg cattgaagag aggggcatag gggtggtgct ctgagaggca gggttcttag
       61 gttaatcatc tccatagctc agataagacc ctgccaactg gaagcaaagt tattgggagc
      121 agaacagttt gtgtgactgc acaggcaggc aggtcggagg gtccacagtg tgggaccatg
      181 ccaggcacca aacgatatca gcatgtgatc gagacccctg agcctggtga atgggagttg
      241 tcagggtatg aagcggctgt gccaatcaca gagaaatcca acccactgac ccgaaacctg
      301 gacaaagcag atgcagagaa aattgtcaaa ctgctggggc agtgtgatgc tgagatattc
      361 caggaggagg ggcagattgt gcccacctac cagcgactat acagcgaatc agttctgacc
      421 accatgttgc aagtggctgg aaaagtccag gaagttctga aggagccaga tgggggtctg
      481 gtagtgctga gtggaggggg aacctctggt cgtatggcat ttctcatgtc tgtgtctttc
      541 aaccagctga tgaaaggcct gggacaaaag cctctttaca cctacctcat tgcaggaggt
      601 gacaggtctg ttgtggcctc tcgtgaacag acagaagata gcgccctaca cgggatcgag
      661 gagctgaaga aggtggctgc tgggaagaag agagtggtcg tcataggcat ctctgtggga
      721 ctctctgcgc cctttgtggc aggtcagatg gactactgca tggataacac agccgtcttc
      781 ttgccggttc tggttggctt caatccagtg agcatggcca gaaatgaccc cattgaagac
      841 tggagatcaa cattccggca agtggcagag cggatgcaaa agatgcagga gaaacaggaa
      901 gcttttgtgc tcaatcctgc catcgggccc gaggggctca gcggctcttc ccgaatgaaa
      961 ggtggaggtg ccaccaagat tctactggaa accctgctac tagcagccca taagactgtg
     1021 gaccagggtg ttgtgtcctc tcaaagatgc cttctggaaa tcctgaggac atttgagcgg
     1081 gctcatcagg tgacctacag tcaaagttcc aaaattgcca cgctgatgaa acaagtcggc
     1141 atcagcctgg agaagaaagg ccgagtgcac ttggttggct ggcagactct cggcatcatt
     1201 gccattatgg acggagtaga gtgcatccac acttttggtg ctgatttcca agatatccgt
     1261 ggctttctta ttggtgacca cagtgacatg tttaaccaga aggatgaact caccaaccag
     1321 ggtccccagt tcaccttctc ccaggatgac ttcctgactt ccatcctgcc atccctcacg
     1381 gagactgaca ccgtggtctt catttttacc ctggatgata acctcacaga agtacaggcc
     1441 ctggcagaaa gagtgagaga gaagtgccag aacatccagg ccctggtgca cagcactgtg
     1501 gggcagtcct tgccggcccc tctaaagaaa ctctttccct cactcatcag tatcacgtgg
     1561 ccacttcttt tcttcgatta tgaagggacc tatgttcaga agttccagcg tgagttaagc
     1621 accaagtggg tgttgaatac agtgagtact ggggcccatg tactgctggg gaagatccta
     1681 cagaaccaca tgctggacct ccgcatcgcc aactccaagc tcttctggag ggcgctggcc
     1741 atgttgcaga ggttctctgg acagtccaag gctcgctgca ttgagagcct ccttcaagca
     1801 atccactttc ctcaaccact gtcggatgat gtccgcgccg ctcccatctc ctgccacgtc
     1861 caggttgccc acgagaagga aaaggtgatc cccacagcct tgctgagcct cctactccgg
     1921 tgctccatct ctgaggctaa ggcacgcctg tctgcagctt cttcagtctg tgaggttgtt
     1981 aggagcgccc tctctgggcc gggtcagaag cgcagcacgc aagcccttga agaccctccc
     2041 gcctgtggga ccctgaattg atatttctag aaccatggag gggcagagtc tccgtccact
     2101 tccaagggga catgtgccag cagtacacgc tgtgggaaga actcagtttc gggtgggtgg
     2161 ggcctaactg cccagaattg gggaagagcc ctgttctcaa ccggattatt tccattttta
     2221 ctggtgtctt ctgaactcag aaataaaact aaatgtcttg ttttggaaca taaaaaaaaa
     2281 aaaaaaaaaa aaaaaa
//
