LOCUS       NM_133595                631 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus GTP cyclohydrolase I feedback regulator (Gchfr),
            mRNA.
ACCESSION   NM_133595
VERSION     NM_133595.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 631)
  AUTHORS   Higgins,C.E. and Gross,S.S.
  TITLE     The N-terminal peptide of mammalian GTP cyclohydrolase I is an
            autoinhibitory control element and contributes to binding the
            allosteric regulatory protein GFRP
  JOURNAL   J Biol Chem 286 (14), 11919-11928 (2011)
   PUBMED   21163945
  REMARK    GeneRIF: The N-terminal peptide of mammalian GTP cyclohydrolase I
            is an autoinhibitory control element and contributes to binding the
            allosteric regulatory protein GFRP.
REFERENCE   2  (bases 1 to 631)
  AUTHORS   Chavan,B., Gillbro,J.M., Rokos,H. and Schallreuter,K.U.
  TITLE     GTP cyclohydrolase feedback regulatory protein controls cofactor
            6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus
            of epidermal keratinocytes and melanocytes
  JOURNAL   J Invest Dermatol 126 (11), 2481-2489 (2006)
   PUBMED   16778797
REFERENCE   3  (bases 1 to 631)
  AUTHORS   Kalivendi,S., Hatakeyama,K., Whitsett,J., Konorev,E.,
            Kalyanaraman,B. and Vasquez-Vivar,J.
  TITLE     Changes in tetrahydrobiopterin levels in endothelial cells and
            adult cardiomyocytes induced by LPS and hydrogen peroxide--a role
            for GFRP?
  JOURNAL   Free Radic Biol Med 38 (4), 481-491 (2005)
   PUBMED   15649650
  REMARK    GeneRIF: allosteric regulation of GTPCH-I activity in the
            cardiovascular system maybe an important mechanism regulating BH4
            levels through GTPCH-I feedback regulatory protein signaling
REFERENCE   4  (bases 1 to 631)
  AUTHORS   Maita,N., Hatakeyama,K., Okada,K. and Hakoshima,T.
  TITLE     Structural basis of biopterin-induced inhibition of GTP
            cyclohydrolase I by GFRP, its feedback regulatory protein
  JOURNAL   J Biol Chem 279 (49), 51534-51540 (2004)
   PUBMED   15448133
  REMARK    GeneRIF: conformational analysis of GTP cyclohydrolase I binding
            GFRP, its feedback regulatory protein
REFERENCE   5  (bases 1 to 631)
  AUTHORS   Kolinsky,M.A. and Gross,S.S.
  TITLE     The mechanism of potent GTP cyclohydrolase I inhibition by
            2,4-diamino-6-hydroxypyrimidine: requirement of the GTP
            cyclohydrolase I feedback regulatory protein
  JOURNAL   J Biol Chem 279 (39), 40677-40682 (2004)
   PUBMED   15292175
  REMARK    GeneRIF: GTPCH feedback regulatory protein has a role in GTCPCH
            inhibition by DAHP (2,4-diamino-6-hydroxypyrimidine)
REFERENCE   6  (bases 1 to 631)
  AUTHORS   Maita,N., Okada,K., Hatakeyama,K. and Hakoshima,T.
  TITLE     Crystal structure of the stimulatory complex of GTP cyclohydrolase
            I and its feedback regulatory protein GFRP
  JOURNAL   Proc Natl Acad Sci U S A 99 (3), 1212-1217 (2002)
   PUBMED   11818540
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2003 Aug 22;308(2):408]
REFERENCE   7  (bases 1 to 631)
  AUTHORS   Bader,G., Schiffmann,S., Herrmann,A., Fischer,M., Gutlich,M.,
            Auerbach,G., Ploom,T., Bacher,A., Huber,R. and Lemm,T.
  TITLE     Crystal structure of rat GTP cyclohydrolase I feedback regulatory
            protein, GFRP
  JOURNAL   J Mol Biol 312 (5), 1051-1057 (2001)
   PUBMED   11580249
REFERENCE   8  (bases 1 to 631)
  AUTHORS   Yoneyama,T. and Hatakeyama,K.
  TITLE     Decameric GTP cyclohydrolase I forms complexes with two pentameric
            GTP cyclohydrolase I feedback regulatory proteins in the presence
            of phenylalanine or of a combination of tetrahydrobiopterin and GTP
  JOURNAL   J Biol Chem 273 (32), 20102-20108 (1998)
   PUBMED   9685352
REFERENCE   9  (bases 1 to 631)
  AUTHORS   Milstien,S., Jaffe,H., Kowlessur,D. and Bonner,T.I.
  TITLE     Purification and cloning of the GTP cyclohydrolase I feedback
            regulatory protein, GFRP
  JOURNAL   J Biol Chem 271 (33), 19743-19751 (1996)
   PUBMED   8702680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U53710.1.
            
            On Dec 23, 2009 this sequence version replaced NM_133595.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U53710.1, U85512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-631               U53710.1           1-631
FEATURES             Location/Qualifiers
     source          1..631
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..631
                     /gene="Gchfr"
                     /note="GTP cyclohydrolase I feedback regulator"
                     /db_xref="GeneID:171128"
                     /db_xref="RGD:621746"
     exon            1..76
                     /gene="Gchfr"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..295
                     /gene="Gchfr"
                     /note="p35; GFRP; GTP cyclohydrolase I feedback regulatory
                     protein"
                     /codon_start=1
                     /product="GTP cyclohydrolase 1 feedback regulatory
                     protein"
                     /protein_id="NP_598279.1"
                     /db_xref="GeneID:171128"
                     /db_xref="RGD:621746"
                     /translation="MPYLLISTQIRMEVGPTMVGDEHSDPELMQQLGASKRRVLGNNF
                     YEYYVNDPPRIVLDKLECRGFRVLSMTGVGQTLVWCLHKE"
     exon            77..171
                     /gene="Gchfr"
                     /inference="alignment:Splign:2.1.0"
     exon            172..631
                     /gene="Gchfr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      602..607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gchfr"
     polyA_site      631
                     /gene="Gchfr"
ORIGIN      
        1 taacggggac tgtggtcgcg ggcagcccca gccactcacc atgccctacc tgctcatcag
       61 cactcagatc cgtatggaag tgggtcccac catggtgggt gatgagcact cggatccaga
      121 gctgatgcag cagttggggg cctccaagag acgagtcctg ggaaacaact tttatgaata
      181 ctacgtcaat gaccctcctc gaatagtcct ggacaagctg gaatgcaggg gcttccgagt
      241 gttaagcatg acaggggtgg gccagacgct ggtgtggtgt ctgcacaagg aatgacctgc
      301 ttgagctgac ttgtgcgtag ggtatatatt ctttggaggg atcgccatgt gccctgtcca
      361 taatcttgca tcactgtctc ccctgtcgct ctctttccaa attgtcaact tccttgccca
      421 acactgatgg gctgtgaaca gcctcaggaa ccttgctgcg gttggttggg tacagcaggc
      481 cctgccccgg ctccttcagc ttcccccagc tggacctggc cctgcctctt gctgtaggcc
      541 atgtgcagaa ggcaagctac cctgaggatg gtccctggat cctacacagc taatccaagc
      601 caataaaggg ctctcacaag tgttgttcct c
//
