LOCUS       NM_024356               1016 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus GTP cyclohydrolase 1 (Gch1), mRNA.
ACCESSION   NM_024356
VERSION     NM_024356.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1016)
  AUTHORS   Mehri,M., Gheitasi,R., Pourbagher,R., Ranaee,M., Nayeri,K.,
            Rahimi,S.M., Khorasani,H.R., Hossein-Nattaj,H., Sabour,D.,
            Akhavan-Niaki,H., Fattahi,S., Kalali,B. and Mostafazadeh,A.
  TITLE     Ninety-six-hour starved peripheral blood mononuclear cell
            supernatant inhibited LA7 breast cancer stem cells induced tumor
            via reduction in angiogenesis and alternations in Gch1 and Spr
            expressions
  JOURNAL   Front Immunol 13, 1025933 (2023)
   PUBMED   36908807
  REMARK    GeneRIF: Ninety-six-hour starved peripheral blood mononuclear cell
            supernatant inhibited LA7 breast cancer stem cells induced tumor
            via reduction in angiogenesis and alternations in Gch1 and Spr
            expressions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1016)
  AUTHORS   Zhao,Z., Zhang,C., Lin,J., Zheng,L., Li,H., Qi,X., Huo,H., Lou,X.,
            Hammock,B.D., Hwang,S.H., Bao,Y. and Luo,M.
  TITLE     COX-2/sEH Dual Inhibitor PTUPB Alleviates CCl 4 -Induced Liver
            Fibrosis and Portal Hypertension
  JOURNAL   Front Med (Lausanne) 8, 761517 (2021)
   PUBMED   35004731
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1016)
  AUTHORS   Ezrokhi,M., Zhang,Y., Luo,S. and Cincotta,A.H.
  TITLE     Time-of-Day-Dependent Effects of Bromocriptine to Ameliorate
            Vascular Pathology and Metabolic Syndrome in SHR Rats Held on High
            Fat Diet
  JOURNAL   Int J Mol Sci 22 (11), 6142 (2021)
   PUBMED   34200262
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1016)
  AUTHORS   Yan,T., Guo,S., Zhang,T., Zhang,Z., Liu,A., Zhang,S., Xu,Y., Qi,Y.,
            Zhao,W., Wang,Q., Shi,L. and Liu,L.
  TITLE     Ligustilide Prevents Radiation Enteritis by Targeting Gch1/BH4/eNOS
            to Improve Intestinal Ischemia
  JOURNAL   Front Pharmacol 12, 629125 (2021)
   PUBMED   33967762
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1016)
  AUTHORS   Wang,Z., Cheng,C., Yang,X. and Zhang,C.
  TITLE     L-phenylalanine attenuates high salt-induced hypertension in Dahl
            SS rats through activation of GCH1-BH4
  JOURNAL   PLoS One 16 (4), e0250126 (2021)
   PUBMED   33857222
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1016)
  AUTHORS   Hatakeyama,K., Inoue,Y., Harada,T. and Kagamiyama,H.
  TITLE     Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I.
            The first enzyme of the tetrahydrobiopterin biosynthetic pathway
  JOURNAL   J Biol Chem 266 (2), 765-769 (1991)
   PUBMED   1985963
REFERENCE   7  (bases 1 to 1016)
  AUTHORS   Hatakeyama,K., Harada,T., Suzuki,S., Watanabe,Y. and Kagamiyama,H.
  TITLE     Purification and characterization of rat liver GTP cyclohydrolase
            I. Cooperative binding of GTP to the enzyme
  JOURNAL   J Biol Chem 264 (36), 21660-21664 (1989)
   PUBMED   2557335
REFERENCE   8  (bases 1 to 1016)
  AUTHORS   Schoedon,G., Redweik,U. and Curtius,H.C.
  TITLE     Purification of GTP cyclohydrolase I from human liver and
            production of specific monoclonal antibodies
  JOURNAL   Eur J Biochem 178 (3), 627-634 (1989)
   PUBMED   2463916
REFERENCE   9  (bases 1 to 1016)
  AUTHORS   Schoedon,G., Curtis,H.C. and Niederwieser,A.
  TITLE     Localization of GTP cyclohydrolase I in human peripheral blood
            smears using a specific monoclonal antibody and an immune-alkaline
            phosphatase labeling technique
  JOURNAL   Biochem Biophys Res Commun 148 (3), 1232-1236 (1987)
   PUBMED   3318829
REFERENCE   10 (bases 1 to 1016)
  AUTHORS   Blau,N. and Niederwieser,A.
  TITLE     The application of 8-aminoguanosine triphosphate, a new inhibitor
            of GTP cyclohydrolase I, to the purification of the enzyme from
            human liver
  JOURNAL   Biochim Biophys Acta 880 (1), 26-31 (1986)
   PUBMED   3753653
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M58364.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M58364.1, FQ220953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1016
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..1016
                     /gene="Gch1"
                     /gene_synonym="Gch; GTPCH; GTPCH-1"
                     /note="GTP cyclohydrolase 1"
                     /db_xref="GeneID:29244"
                     /db_xref="RGD:61992"
     exon            1..443
                     /gene="Gch1"
                     /gene_synonym="Gch; GTPCH; GTPCH-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..853
                     /gene="Gch1"
                     /gene_synonym="Gch; GTPCH; GTPCH-1"
                     /EC_number="3.5.4.16"
                     /note="GTP cyclohydrolase I; GTP-CH-I; GTP cyclohydrase I"
                     /codon_start=1
                     /product="GTP cyclohydrolase 1 precursor"
                     /protein_id="NP_077332.1"
                     /db_xref="GeneID:29244"
                     /db_xref="RGD:61992"
                     /translation="MEKPRGVRCTNGFPERELPRPGASRPAEKSRPPEAKGAQPADAW
                     KAGRPRSEEDNELNLPNLAAAYSSILRSLGEDPQRQGLLKTPWRAATAMQFFTKGYQE
                     TISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGRVHIGYLPNKQVLGLSKLA
                     RIVEIYSRRLQVQERLTKQIAVAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTVT
                     STMLGVFREDPKTREEFLTLIRS"
     exon            444..553
                     /gene="Gch1"
                     /gene_synonym="Gch; GTPCH; GTPCH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..609
                     /gene="Gch1"
                     /gene_synonym="Gch; GTPCH; GTPCH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..641
                     /gene="Gch1"
                     /gene_synonym="Gch; GTPCH; GTPCH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..726
                     /gene="Gch1"
                     /gene_synonym="Gch; GTPCH; GTPCH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..1016
                     /gene="Gch1"
                     /gene_synonym="Gch; GTPCH; GTPCH-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacttcgaac ctcattcggt gcagaactcc tgtcccggtg acagccacag gtcacggccg
       61 ccggctaagc cgagccgcag cgcttggtag caccttaggg tgtctcggga gcaatcgcgc
      121 cgggtccatg gagaagccgc ggggtgtaag gtgcaccaat gggttccccg agcgggagct
      181 gccgcggccc ggggccagcc gacctgccga gaagtcccgg ccgcccgagg ccaagggcgc
      241 acagccagcc gacgcctgga aggcagggcg gccccgcagc gaggaggata acgagctgaa
      301 cctccccaac ctggcggccg cttactcgtc catcctgcgc tcgctgggcg aggaccccca
      361 gcggcagggg ctgctcaaga cgccctggag ggcggccacc gccatgcagt tcttcaccaa
      421 gggataccag gagaccatct cagatgtcct gaacgatgct atatttgatg aggaccatga
      481 cgagatggtg attgtgaagg acattgacat gttttccatg tgtgagcatc acctggtccc
      541 atttgtggga agggtccata ttggttatct tcctaacaag caagtccttg gtctcagcaa
      601 acttgccagg attgtggaaa tctacagtag aagactacaa gttcaagaac gccttaccaa
      661 acagattgca gtggccatca cagaagcctt gcagcctgct ggcgtcgggg tagtgattga
      721 agcaacacac atgtgtatgg tcatgcgagg tgtgcagaaa atgaacagca agactgtcac
      781 tagcaccatg ctaggcgtgt tccgggaaga cccaaagact cgggaggagt tcctcacact
      841 catcaggagc tgaacttccg tgtgcgagcc ccggtttgca gacccccgct gaggccagcg
      901 ttatctgtct cgattgtaca ttccagttcc agttggtata cttgtcaact ttatttctca
      961 ccatgaattg tatttaataa ttatttatag agatgtcaaa taaaggtgat caactt
//
