LOCUS       NM_172091               1893 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus glucagon receptor (Gcgr), transcript variant 2,
            mRNA.
ACCESSION   NM_172091
VERSION     NM_172091.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1893)
  AUTHORS   Zhang,H., Qiao,A., Yang,D., Yang,L., Dai,A., de Graaf,C.,
            Reedtz-Runge,S., Dharmarajan,V., Zhang,H., Han,G.W., Grant,T.D.,
            Sierra,R.G., Weierstall,U., Nelson,G., Liu,W., Wu,Y., Ma,L.,
            Cai,X., Lin,G., Wu,X., Geng,Z., Dong,Y., Song,G., Griffin,P.R.,
            Lau,J., Cherezov,V., Yang,H., Hanson,M.A., Stevens,R.C., Zhao,Q.,
            Jiang,H., Wang,M.W. and Wu,B.
  TITLE     Structure of the full-length glucagon class B G-protein-coupled
            receptor
  JOURNAL   Nature 546 (7657), 259-264 (2017)
   PUBMED   28514451
REFERENCE   2  (bases 1 to 1893)
  AUTHORS   Selley,E., Kun,S., Szijarto,I.A., Kertesz,M., Wittmann,I. and
            Molnar,G.A.
  TITLE     Vasodilator Effect of Glucagon: Receptorial Crosstalk Among
            Glucagon, GLP-1, and Receptor for Glucagon and GLP-1
  JOURNAL   Horm Metab Res 48 (7), 476-483 (2016)
   PUBMED   26975347
  REMARK    GeneRIF: The vasodilatation due to glucagon evokes via the
            glucagon-receptor, but also via the receptor for GLP-1, and it is
            endothelium-independent.
REFERENCE   3  (bases 1 to 1893)
  AUTHORS   Melancon,A., Gagnon,V., Milot,M., Charest,E., Foucher,D.,
            Peronnet,F., Unson O'Brien,C.G., Asselin,E. and Lavoie,C.
  TITLE     Liver glucagon receptors (GluR): effect of exercise and fasting on
            binding characteristics, GluR-mRNA, and GluR protein content in
            rats
  JOURNAL   Horm Metab Res 45 (10), 716-721 (2013)
   PUBMED   23918690
  REMARK    GeneRIF: Significant higher GluR density (mRNA and proteins)
            following exercise and fasting than in the control group.
REFERENCE   4  (bases 1 to 1893)
  AUTHORS   Berger,J.H., Charron,M.J. and Silver,D.L.
  TITLE     Major facilitator superfamily domain-containing protein 2a (MFSD2A)
            has roles in body growth, motor function, and lipid metabolism
  JOURNAL   PLoS One 7 (11), e50629 (2012)
   PUBMED   23209793
REFERENCE   5  (bases 1 to 1893)
  AUTHORS   Longuet,C., Sinclair,E.M., Maida,A., Baggio,L.L., Maziarz,M.,
            Charron,M.J. and Drucker,D.J.
  TITLE     The glucagon receptor is required for the adaptive metabolic
            response to fasting
  JOURNAL   Cell Metab 8 (5), 359-371 (2008)
   PUBMED   19046568
REFERENCE   6  (bases 1 to 1893)
  AUTHORS   Hager,J., Hansen,L., Vaisse,C., Vionnet,N., Philippi,A., Poller,W.,
            Velho,G., Carcassi,C., Contu,L., Julier,C. et al.
  TITLE     A missense mutation in the glucagon receptor gene is associated
            with non-insulin-dependent diabetes mellitus
  JOURNAL   Nat Genet 9 (3), 299-304 (1995)
   PUBMED   7773293
REFERENCE   7  (bases 1 to 1893)
  AUTHORS   Maget,B., Tastenoy,M. and Svoboda,M.
  TITLE     Sequencing of eleven introns in genomic DNA encoding rat glucagon
            receptor and multiple alternative splicing of its mRNA
  JOURNAL   FEBS Lett 351 (2), 271-275 (1994)
   PUBMED   8082779
REFERENCE   8  (bases 1 to 1893)
  AUTHORS   Svoboda,M., Ciccarelli,E., Tastenoy,M., Robberecht,P. and
            Christophe,J.
  TITLE     A cDNA construct allowing the expression of rat hepatic glucagon
            receptors
  JOURNAL   Biochem Biophys Res Commun 192 (1), 135-142 (1993)
   PUBMED   8386505
REFERENCE   9  (bases 1 to 1893)
  AUTHORS   Svoboda,M., Ciccarelli,E., Tastenoy,M., Cauvin,A., Stievenart,M.
            and Christophe,J.
  TITLE     Small introns in a hepatic cDNA encoding a new glucagon-like
            peptide 1-type receptor
  JOURNAL   Biochem Biophys Res Commun 191 (2), 479-486 (1993)
   PUBMED   8384842
REFERENCE   10 (bases 1 to 1893)
  AUTHORS   Jelinek,L.J., Lok,S., Rosenberg,G.B., Smith,R.A., Grant,F.J.,
            Biggs,S., Bensch,P.A., Kuijper,J.L., Sheppard,P.O., Sprecher,C.A.
            et al.
  TITLE     Expression cloning and signaling properties of the rat glucagon
            receptor
  JOURNAL   Science 259 (5101), 1614-1616 (1993)
   PUBMED   8384375
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB735411.1, BC081700.1 and CV117246.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_172091.3.
            
            On Sep 6, 2012 this sequence version replaced NM_172091.1.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal non-coding exon, therefore, has a different 5' UTR
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L04796.1, X68692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                CB735411.1         212-266
            56-530              BC081700.1         28-502
            531-637             CV117246.1         55-161
            638-1893            BC081700.1         503-1758
FEATURES             Location/Qualifiers
     source          1..1893
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1893
                     /gene="Gcgr"
                     /note="glucagon receptor"
                     /db_xref="GeneID:24953"
                     /db_xref="RGD:2669"
     exon            1..55
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     exon            56..197
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1592
                     /gene="Gcgr"
                     /note="GL-R; glucagon receptor perhaps same as Niddm3"
                     /codon_start=1
                     /product="glucagon receptor precursor"
                     /protein_id="NP_742088.1"
                     /db_xref="GeneID:24953"
                     /db_xref="RGD:2669"
                     /translation="MLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQC
                     HHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCG
                     PDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLA
                     LVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLS
                     DGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSP
                     LLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKL
                     RAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSF
                     QGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCE
                     KLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT"
     exon            198..300
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     exon            301..408
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     exon            409..530
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     exon            531..637
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     exon            638..794
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     exon            795..954
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1015
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1085
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1174
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1313
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1355
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1866
                     /gene="Gcgr"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1866
                     /gene="Gcgr"
ORIGIN      
        1 tgctgttctt ctgtcttgga gacatagaag ggggactctg agctcaccgg agtcgcctga
       61 ggagaggtgc acacaccccc aaggacccag gcacccaacc tctgccagat gtgggggggt
      121 ggctacccag aggcatgctc ctcacccagc tccactgtcc ctacctgctg ctgctgctgg
      181 tggtgctgtc atgtctgcca aaggcaccct ctgcccaggt aatggacttt ttgtttgaga
      241 agtggaagct ctatagtgac cagtgccacc acaacctaag cctgctgccc ccacctactg
      301 agctggtctg caacagaact ttcgacaagt actcctgctg gcctgacacc cctcccaaca
      361 ccactgccaa catttcctgc ccctggtacc taccttggta ccacaaagtg cagcaccgcc
      421 tagtgttcaa gaggtgtggg cctgatgggc agtgggttcg agggccacgg gggcagtcat
      481 ggcgcgacgc ctcccaatgt cagatggatg atgacgagat cgaggtccag aagggggtag
      541 ccaagatgta tagcagctac caggtgatgt acactgtggg ctacagtctg tccctggggg
      601 ccttgctcct ggcgctggtc atcctgctgg gcctcaggaa gctgcactgc acccggaact
      661 acatccacgg gaacctgttc gcgtccttcg tgctcaaggc tggctctgtg ctggtcattg
      721 attggctgct caagacacgc tatagccaga agattggaga tgacctcagt gtgagcgtct
      781 ggctcagtga tggggcggtg gctggctgca gagtggccac agtgatcatg cagtacggca
      841 tcatagccaa ctactgctgg ttgctggtgg agggtgtgta cctgtacagc ctgctgagca
      901 tcaccacctt ctcggagaag agcttcttct ccctctatct gtgcatcggc tggggatctc
      961 ccctgctgtt tgtcatcccc tgggtggtgg tcaagtgtct gtttgagaat gtccagtgct
     1021 ggaccagcaa tgacaatatg ggattctggt ggatcctgcg tatccctgta ctcctggcca
     1081 tactgatcaa ttttttcatc tttgtccgca tcattcatct tcttgtggcc aagctgcgtg
     1141 cccatcagat gcactatgct gattacaagt tccggctagc caggtccacg ctgaccctca
     1201 ttcctctgct gggagtccac gaagtggtct ttgcctttgt gactgatgag catgcccagg
     1261 gcaccctgcg ctccaccaag ctcttttttg acctgttctt cagctccttc cagggtctgc
     1321 tggtggctgt tctctactgt ttcctcaaca aggaggtgca ggcagagcta ctgcggcgtt
     1381 ggaggcgatg gcaagaaggc aaagctcttc aggaggaaag gatggccagc agccatggca
     1441 gccacatggc cccagcaggg acttgtcatg gtgatccctg tgagaaactt cagcttatga
     1501 gtgcaggcag cagcagtggg actggctgtg agccctctgc gaagacctca ttggccagta
     1561 gtctcccaag gctggctgac agccccacct gaatctccac tggactccag ccaagttgga
     1621 ttcagaaagg gcctcacaag acaacccaga aacagatgcc tggccaaggc tgaagaggca
     1681 aagcagcaag acagcagctt gtactatcca cactccccta acctgtcctg gccgggtaca
     1741 ggccacattg atggagtagg ggctggatat gatggagtag ccatgctatg aactatgggt
     1801 gttcccatga gtgttgccat gttccatgca cacagatatg accttcagta aagagctccc
     1861 gtaggaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
