LOCUS       NM_001108896            1875 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glutaryl-CoA dehydrogenase (Gcdh), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001108896 XM_001066810 XM_344744
VERSION     NM_001108896.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1875)
  AUTHORS   Gonzalez Melo,M., Remacle,N., Cudre-Cung,H.P., Roux,C., Poms,M.,
            Cudalbu,C., Barroso,M., Gersting,S.W., Feichtinger,R.G., Mayr,J.A.,
            Costanzo,M., Caterino,M., Ruoppolo,M., Rufenacht,V., Haberle,J.,
            Braissant,O. and Ballhausen,D.
  TITLE     The first knock-in rat model for glutaric aciduria type I allows
            further insights into pathophysiology in brain and periphery
  JOURNAL   Mol Genet Metab 133 (2), 157-181 (2021)
   PUBMED   33965309
  REMARK    GeneRIF: The first knock-in rat model for glutaric aciduria type I
            allows further insights into pathophysiology in brain and
            periphery.
REFERENCE   2  (bases 1 to 1875)
  AUTHORS   Biagosch,C., Ediga,R.D., Hensler,S.V., Faerberboeck,M., Kuehn,R.,
            Wurst,W., Meitinger,T., Kolker,S., Sauer,S. and Prokisch,H.
  TITLE     Elevated glutaric acid levels in Dhtkd1-/Gcdh- double knockout mice
            challenge our current understanding of lysine metabolism
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (9), 2220-2228 (2017)
   PUBMED   28545977
REFERENCE   3  (bases 1 to 1875)
  AUTHORS   Braissant,O., Jafari,P., Remacle,N., Cudre-Cung,H.P., Do Vale
            Pereira,S. and Ballhausen,D.
  TITLE     Immunolocalization of glutaryl-CoA dehydrogenase (GCDH) in adult
            and embryonic rat brain and peripheral tissues
  JOURNAL   Neuroscience 343, 355-363 (2017)
   PUBMED   27984186
  REMARK    GeneRIF: GCDH was found widely expressed in embryonic and adult rat
            tissues. In rat embryos GCDH is predominantly expressed in brain
            implying an important role for brain development. Interestingly,
            GCDH was found to be significantly expressed in different other
            organs (e.g. kidney, gut) in adult rats probably explaining the
            evolving phenotype in GA-I patients.
REFERENCE   4  (bases 1 to 1875)
  AUTHORS   Malecki,J., Ho,A.Y., Moen,A., Dahl,H.A. and Falnes,P.O.
  TITLE     Human METTL20 is a mitochondrial lysine methyltransferase that
            targets the beta subunit of electron transfer flavoprotein
            (ETFbeta) and modulates its activity
  JOURNAL   J Biol Chem 290 (1), 423-434 (2015)
   PUBMED   25416781
REFERENCE   5  (bases 1 to 1875)
  AUTHORS   Gao,J., Zhang,C., Fu,X., Yi,Q., Tian,F., Ning,Q. and Luo,X.
  TITLE     Effects of targeted suppression of glutaryl-CoA dehydrogenase by
            lentivirus-mediated shRNA and excessive intake of lysine on
            apoptosis in rat striatal neurons
  JOURNAL   PLoS One 8 (5), e63084 (2013)
   PUBMED   23658800
  REMARK    GeneRIF: GA1-induced striatal degeneration is partially
            caspase-dependent
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1875)
  AUTHORS   Keyser,B., Muhlhausen,C., Dickmanns,A., Christensen,E., Muschol,N.,
            Ullrich,K. and Braulke,T.
  TITLE     Disease-causing missense mutations affect enzymatic activity,
            stability and oligomerization of glutaryl-CoA dehydrogenase (GCDH)
  JOURNAL   Hum Mol Genet 17 (24), 3854-3863 (2008)
   PUBMED   18775954
REFERENCE   7  (bases 1 to 1875)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1875)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 1875)
  AUTHORS   Reichmann,H., Maltese,W.A. and DeVivo,D.C.
  TITLE     Enzymes of fatty acid beta-oxidation in developing brain
  JOURNAL   J Neurochem 51 (2), 339-344 (1988)
   PUBMED   2899130
REFERENCE   10 (bases 1 to 1875)
  AUTHORS   Goodman,S.I.
  TITLE     Organic aciduria in the riboflavin-deficient rat
  JOURNAL   Am J Clin Nutr 34 (11), 2434-2437 (1981)
   PUBMED   6895440
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_344744.3, XM_001066810.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1875
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1875
                     /gene="Gcdh"
                     /note="glutaryl-CoA dehydrogenase"
                     /db_xref="GeneID:364975"
                     /db_xref="RGD:1308829"
     exon            1..126
                     /gene="Gcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            127..256
                     /gene="Gcdh"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1473
                     /gene="Gcdh"
                     /EC_number="1.3.8.6"
                     /note="glutaryl-Coenzyme A dehydrogenase"
                     /codon_start=1
                     /product="glutaryl-CoA dehydrogenase, mitochondrial"
                     /protein_id="NP_001102366.1"
                     /db_xref="GeneID:364975"
                     /db_xref="RGD:1308829"
                     /translation="MVPAMLTGYMSLRGVSAWLLSRKLGLRFSRVPRTWSSAAAHTEK
                     TQIRSVKSSRPVFDWKDPLVLEEQLTADEKLIRDTFRNYCQERLMSRILLANRNEVFH
                     RDIVYEMGELGVLGPTIKGYGCAGVSSVAYGLLTRELERVDSGYRSMMSVQSSLVMHP
                     IYTYGSEEQRQKYLPRLAKGELLGCFGLTEPNHGSDPGSMETRARHNPSNKSYTLSGT
                     KTWITNSPVADLFVVWARCEDNCIRGFLLEKGMRGLSAPRIEGKFSLRASATGMIIMD
                     SVEVPEENVLPNVSSLAGPFGCLNTARYGITWGVLGAAEFCLHTARQYALDRIQFGVP
                     LARNQLVQKKLADMLTEITLGLHACLQLGRLKDQDKATPEMVSLLKRNNCGKALDIAR
                     QARDILGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTVEK"
     exon            257..283
                     /gene="Gcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            284..427
                     /gene="Gcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            428..490
                     /gene="Gcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            491..661
                     /gene="Gcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            662..791
                     /gene="Gcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1008
                     /gene="Gcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1112
                     /gene="Gcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1238
                     /gene="Gcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1399
                     /gene="Gcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1875
                     /gene="Gcdh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcttttaa aaggcagagc cacagagaag gcggtgctct gggaggaacc aaggagaaac
       61 caatgagcag cccctattag gcctaggtca agtgtgctgg tccagaacgc agcctgcaag
      121 caccaggtta tggtccctgc gatgctcacc ggctacatgt ccctgagagg agtctctgcg
      181 tggttgctga gccgcaagct cggcctgcgc ttctcgcgcg ttccacgtac gtggagctcg
      241 gcggccgcgc acacggagaa gacacagatc cgatcggtca aatcctctcg tcctgtgttt
      301 gactggaagg acccactggt cctggaggag cagttgactg ccgatgagaa actcatcagg
      361 gacaccttcc gtaactactg ccaggaacga cttatgtctc gaattctgct ggccaatcga
      421 aatgaagttt ttcacaggga cattgtatat gagatggggg agctgggtgt gctgggaccc
      481 accattaaag ggtatggctg tgctggagtg tcatcggtgg cctatgggct cctgactcga
      541 gagctagaga gggtggacag cggctacagg tcgatgatga gtgttcagtc ctcccttgtc
      601 atgcacccca tctataccta tgggagtgag gagcagcgac agaagtatct gccccgactg
      661 gccaagggtg aacttctggg ctgcttcgga cttacagagc ccaaccatgg gagtgatcca
      721 ggcagcatgg agaccagagc tcgccacaat ccatcaaaca agagctacac tctcagtgga
      781 accaagacct ggatcaccaa ctcccctgtg gctgacctat tcgtagtgtg ggctcggtgt
      841 gaggataact gtatccgggg cttcctgctg gagaagggga tgcggggcct ctcagcccct
      901 aggattgaag gaaagttctc cttgcgggcc tcagctactg gtatgatcat catggacagc
      961 gtggaagtgc ccgaggagaa tgtgctgcct aatgtgtcaa gcctggcggg cccttttggc
     1021 tgccttaaca ctgcccgata tggcatcaca tggggtgtgt tgggagctgc tgagttctgt
     1081 ttgcacacag ctcggcagta tgctctggac aggatccagt ttggagtccc cttggccagg
     1141 aaccagctgg ttcagaagaa gttggcagac atgctcactg agatcacact gggcctccat
     1201 gcatgtttac aacttggccg tctaaaggat caggacaagg ctactccaga aatggtctcc
     1261 ctgttgaaga gaaacaactg tgggaaagcc ctggacatcg cccgccaggc acgagacatc
     1321 ctgggaggaa atgggatttc tgatgagtac catgtgatcc ggcatgctat gaatttagag
     1381 gcagtgaaca cttacgaagg tacacatgac atccatgctc tgatcctggg gagagcaatt
     1441 actgggattc aggcattcac ggttgaaaaa tgaacccact tcaacagaga aatactttgc
     1501 tcaagaagta atggatggac ccagctttta tggttgaaag tgagacactg atttgagact
     1561 taggaaatgt ctttcttcat tcagatatgc tctatagaaa gaagaagaaa ttaattctca
     1621 gtgtggctct tggccctcag tgctttttaa ctgtggatga aatcaaactc catctaccct
     1681 gttttaagtt ttttggaact ggaagagaca aaggggagtg acacagaagc cactgagacg
     1741 gagcagacct tgtgtgagaa ggtgtagtgg actttacagt gagccttcct gcctctatcc
     1801 caggagcagt accttctgtg ttcaacacta agcagataaa agaggaaaat aaagagcctg
     1861 tgccttactc cttgg
//
