LOCUS       NP_001019448             416 aa            linear   ROD 20-MAR-2023
DEFINITION  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [Rattus
            norvegicus].
ACCESSION   NP_001019448
VERSION     NP_001019448.1
DBSOURCE    REFSEQ: accession NM_001024277.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 416)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   2  (residues 1 to 416)
  AUTHORS   Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA and
            Martinou JC.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092591.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092591.1, FQ210112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132267
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     Protein         1..416
                     /product="2-amino-3-ketobutyrate coenzyme A ligase,
                     mitochondrial"
                     /EC_number="2.3.1.29"
                     /note="glycine C-acetyltransferase
                     (2-amino-3-ketobutyrate-coenzyme A ligase)"
                     /calculated_mol_wt=45092
     Region          24..415
                     /region_name="AAT_I"
                     /note="Aspartate aminotransferase (AAT) superfamily (fold
                     type I) of pyridoxal phosphate (PLP)-dependent enzymes.
                     PLP combines with an alpha-amino acid to form a compound
                     called a Schiff base or aldimine intermediate, which
                     depending on the reaction, is the...; cl18945"
                     /db_xref="CDD:450240"
     Site            order(70,130..132,156,199,203..204,228,230..231,259,262,
                     386)
                     /site_type="active"
                     /note="substrate-cofactor binding pocket [active]"
                     /db_xref="CDD:99747"
     Site            order(130..132,156,199,203,228,230..231,259,262)
                     /site_type="other"
                     /note="pyridoxal 5'-phosphate binding site [chemical
                     binding]"
                     /db_xref="CDD:99747"
     Site            262
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:99747"
     CDS             1..416
                     /gene="Gcat"
                     /coded_by="NM_001024277.1:2..1252"
                     /db_xref="GeneID:366959"
                     /db_xref="RGD:1307291"
ORIGIN      
        1 mwvnflwraa lspgrrahsa laqlrcvldr elegirgagt wkservitsr qgpcirvegi
       61 sggilnfcan nylglsshpe viqaglqale efgaglistr ficgtqsihk nleakiarfh
      121 qredailyps cfdantglfe alltpedavl sdelnhasvi dgirlckahk yryrhldmad
      181 leaklkeaqk hrlrlvatdg afsmdgdvap lqeicrlaaq ygalvfvdec hatgflgptg
      241 rgtdellgvm dqvtiinstl gkalggasgg yttgpeplis lmrqrsrpyl fsnslppavv
      301 gcaskaldll mesntivqsm aaktrrfrsk meaagftisg adhpicpvml gdarlssqma
      361 edmlkkgifv igfsypvvpk gkarirvqis avhseedidr cveafvevgk lhgalp
//
