LOCUS       NM_012564               1684 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus GC, vitamin D binding protein (Gc), mRNA.
ACCESSION   NM_012564
VERSION     NM_012564.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1684)
  AUTHORS   Obaid,A.A., Almasmoum,H., Almaimani,R.A., El-Boshy,M., Aslam,A.,
            Idris,S., Ghaith,M.M., El-Readi,M.Z., Ahmad,J., Farrash,W.F.,
            Mujalli,A., Eid,S.Y., Elzubier,M.E. and Refaat,B.
  TITLE     Vitamin D and calcium co-therapy mitigates pre-established cadmium
            nephropathy by regulating renal calcium homeostatic molecules and
            improving anti-oxidative and anti-inflammatory activities in rat
  JOURNAL   J Trace Elem Med Biol 79, 127221 (2023)
   PUBMED   37244046
REFERENCE   2  (bases 1 to 1684)
  AUTHORS   Martin,C.B., Oshiro,B.T., Sands,L.D., Kabir,S., Thorpe,D.,
            Clark,T.C., Yao,R. and Mata-Greenwood,E.
  TITLE     Vitamin-D dysregulation in early- and late-onset preeclampsia: A
            gestational-age matched study
  JOURNAL   J Steroid Biochem Mol Biol 203, 105729 (2020)
   PUBMED   32682061
REFERENCE   3  (bases 1 to 1684)
  AUTHORS   Pavlikova,N., Daniel,P., Sramek,J., Jelinek,M., Sramkova,V.,
            Nemcova,V., Balusikova,K., Halada,P. and Kovar,J.
  TITLE     Upregulation of vitamin D-binding protein is associated with
            changes in insulin production in pancreatic beta-cells exposed to
            p,p'-DDT and p,p'-DDE
  JOURNAL   Sci Rep 9 (1), 18026 (2019)
   PUBMED   31792309
  REMARK    GeneRIF: Upregulation of vitamin D-binding protein is associated
            with changes in insulin production in pancreatic beta-cells exposed
            to p,p'-DDT and p,p'-DDE.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1684)
  AUTHORS   Kwak,S.Y., Cho,Y., Oh,H. and Shin,M.J.
  TITLE     Association of circulating 25-hydroxyvitamin D levels with
            hypertension and blood pressure values in Korean adults: A
            Mendelian randomization study on a subset of the Korea National
            Health and Nutrition Survey 2011-2012 population
  JOURNAL   Nutr Res Pract 13 (6), 498-508 (2019)
   PUBMED   31814925
REFERENCE   5  (bases 1 to 1684)
  AUTHORS   Peng,Q., Yang,S., Lao,X., Li,R., Chen,Z., Wang,J., Qin,X. and Li,S.
  TITLE     Association of single nucleotide polymorphisms in VDR and DBP genes
            with HBV-related hepatocellular carcinoma risk in a Chinese
            population
  JOURNAL   PLoS One 9 (12), e116026 (2014)
   PUBMED   25541958
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1684)
  AUTHORS   Ray,K., Wang,X.K., Zhao,M. and Cooke,N.E.
  TITLE     The rat vitamin D binding protein (Gc-globulin) gene. Structural
            analysis, functional and evolutionary correlations
  JOURNAL   J Biol Chem 266 (10), 6221-6229 (1991)
   PUBMED   2007578
REFERENCE   7  (bases 1 to 1684)
  AUTHORS   McLeod,J.F. and Cooke,N.E.
  TITLE     The vitamin D-binding protein, alpha-fetoprotein, albumin multigene
            family: detection of transcripts in multiple tissues
  JOURNAL   J Biol Chem 264 (36), 21760-21769 (1989)
   PUBMED   2480956
REFERENCE   8  (bases 1 to 1684)
  AUTHORS   Cooke,N.E.
  TITLE     Rat vitamin D binding protein. Determination of the full-length
            primary structure from cloned cDNA
  JOURNAL   J Biol Chem 261 (7), 3441-3450 (1986)
   PUBMED   2419332
REFERENCE   9  (bases 1 to 1684)
  AUTHORS   Bouillon,R., Vandoren,G., Van Baelen,H. and De Moor,P.
  TITLE     Immunochemical measurement of the vitamin D-binding protein in rat
            serum
  JOURNAL   Endocrinology 102 (6), 1710-1715 (1978)
   PUBMED   217634
REFERENCE   10 (bases 1 to 1684)
  AUTHORS   Daiger,S.P., Schanfield,M.S. and Cavalli-Sforza,L.L.
  TITLE     Group-specific component (Gc) proteins bind vitamin D and
            25-hydroxyvitamin D
  JOURNAL   Proc Natl Acad Sci U S A 72 (6), 2076-2080 (1975)
   PUBMED   49052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC078891.1.
            
            On Aug 18, 2012 this sequence version replaced NM_012564.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078891.1, FQ210734.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1684
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1684
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /note="GC, vitamin D binding protein"
                     /db_xref="GeneID:24384"
                     /db_xref="RGD:2667"
     exon            1..107
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1480
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /note="vitamin D-binding protein; gc-globulin; group
                     specific component"
                     /codon_start=1
                     /product="vitamin D-binding protein precursor"
                     /protein_id="NP_036696.2"
                     /db_xref="GeneID:24384"
                     /db_xref="RGD:2667"
                     /translation="MKRVLVLLLALAFGHALERGRDYEKDKVCQELSTLGKDDFRSLS
                     LILYSRKFPSSTFEQVSQLVKEVVSLTEECCAEGADPNCYDTRTSELSIKSCESDAPF
                     PVHPGTSECCTKEGLERKLCMAALSHQPQEFPAYVEPTNDEICEAFRKDPKGFADQFL
                     FEYSSNYGQAPLPLLVGYTKSYLSMVGSCCTSAKPTVCFLKERLQMKQLSLLTTMSNR
                     VCSQYAAYGKEKSRMSHLIKLAQKVPTANLEDVLPLAEDLTEILSRCCKSTSEDCMAR
                     ELPEHTLKICGNLSKKNSKFEECCYETTPMGIFMCSYFMPTAEPLQLPAIKLPTSKDL
                     CGQSATQAMDQYTFELSRRTQVPEVFLSKVLDTTLKTLRECCDTQDSVSCFSTQSPLM
                     KRQLTSFIEKGQEMCADYSENTFTEYKKKLAERLRTKMPNASPEELADMVAKHSDFAS
                     KCCSINSPPRYCSSQIDAEMRDILQS"
     exon            108..177
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            178..310
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            311..522
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            523..655
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            656..750
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            751..880
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1083
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1213
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1311
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1444
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1504
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1659
                     /gene="Gc"
                     /gene_synonym="DBP; DBP02; VDB; Vdbp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtgtcctg tgggtgagag gaggtgctgc aggactccct ggacgcaaaa tgaagagggt
       61 tctggttctc ctgctggcct tagcctttgg gcatgcccta gagagaggcc gagattatga
      121 gaaggataaa gtttgccagg aactctccac gctggggaaa gatgacttca gatctctatc
      181 actaatccta tacagcagga agtttcccag tagcaccttt gaacaggtca gtcagcttgt
      241 gaaggaagtt gtctccttaa ctgaggaatg ctgtgctgag ggagcagatc ccaactgcta
      301 tgacaccagg acttcagagc tgtctattaa gtcctgtgaa agtgacgccc cctttcccgt
      361 tcaccccggg acttccgagt gttgcacgaa ggaggggcta gagcggaaac tctgcatggc
      421 tgccctcagt caccagccac aggaatttcc cgcctatgtg gagccgacga atgatgagat
      481 ctgtgaggcg ttcaggaagg atccaaaggg atttgccgat cagtttctat tcgaatattc
      541 cagcaattac ggacaagctc ctctgccact tttagttggt tacaccaaga gttatctctc
      601 tatggttggc tcctgctgta cttctgcaaa accaactgtg tgctttttga aggagagact
      661 ccagatgaaa cagttatcac ttctcaccac tatgtcaaac agagtctgct cacaatatgc
      721 tgcatatgga aaggaaaaat caaggatgag ccatctcata aaactagccc aaaaagtacc
      781 aactgctaac ctggaggatg ttctgccact cgctgaagac cttactgaaa tcctgtccag
      841 atgttgtaag tctacctcag aggactgcat ggccagagag ctgcctgaac acacattaaa
      901 aatctgtgga aacttatcca aaaagaattc aaagtttgaa gagtgctgtt acgaaacaac
      961 acccatgggc atttttatgt gtagctactt catgccaact gctgaaccac ttcaattgcc
     1021 agccatcaag ctgccaacca gcaaagacct ctgtggtcag agtgccacac aagccatgga
     1081 ccagtataca tttgaactaa gcagaaggac ccaggttcca gaagtgttcc tcagcaaagt
     1141 tctggatacg accctgaaaa cccttaggga atgctgcgac actcaggact ctgtctcctg
     1201 tttcagcact cagagtcccc tgatgaagag gcaactaact tctttcattg aaaaggggca
     1261 agaaatgtgt gcagattatt ccgagaacac atttactgag tacaagaaaa aattggcgga
     1321 acgactgagg acaaaaatgc ccaatgcctc cccggaagag ctggcagaca tggtggccaa
     1381 gcactcagac tttgcctcca agtgctgctc cataaactct cctccacgct actgtagctc
     1441 acagattgat gcagaaatga gagacatcct gcagtcctga tgcagggtat atgcaatgcc
     1501 ttggacctag aactggacca ctctggaaaa ttgccagata acaaaatcaa gcaaatacca
     1561 cagagatggc cttccaagaa gaccaccaag ataattccat ttttcccatc tacaatgttt
     1621 tttgatgaat tataaaaata aattgaaata tagtgcaaaa aaaaaaaaaa aaaaaaaaaa
     1681 aaaa
//
