LOCUS       NM_001271453            1831 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus gastrulation brain homeobox 1 (Gbx1), mRNA.
ACCESSION   NM_001271453 XM_001063850
VERSION     NM_001271453.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1831)
  AUTHORS   Meziane,H., Fraulob,V., Riet,F., Krezel,W., Selloum,M.,
            Geffarth,M., Acampora,D., Herault,Y., Simeone,A., Brand,M.,
            Dolle,P. and Rhinn,M.
  TITLE     The homeodomain factor Gbx1 is required for locomotion and cell
            specification in the dorsal spinal cord
  JOURNAL   PeerJ 1, e142 (2013)
   PUBMED   24010020
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1831)
  AUTHORS   Buckley,D.M., Burroughs-Garcia,J., Lewandoski,M. and Waters,S.T.
  TITLE     Characterization of the Gbx1-/- mouse mutant: a requirement for
            Gbx1 in normal locomotion and sensorimotor circuit development
  JOURNAL   PLoS One 8 (2), e56214 (2013)
   PUBMED   23418536
REFERENCE   3  (bases 1 to 1831)
  AUTHORS   Obinata,A., Osakabe,K., Yamaguchi,M., Morimoto,R. and Akimoto,Y.
  TITLE     Tgm2/Gh, Gbx1 and TGF-beta are involved in retinoic acid-induced
            transdifferentiation from epidermis to mucosal epithelium
  JOURNAL   Int J Dev Biol 55 (10-12), 933-943 (2011)
   PUBMED   22252490
  REMARK    GeneRIF: Tgm2/Gh, Gbx1 and TGF-beta are involved in retinoic
            acid-induced transdifferentiation from epidermis to mucosal
            epithelium
REFERENCE   4  (bases 1 to 1831)
  AUTHORS   Rhinn,M., Lun,K., Werner,M., Simeone,A. and Brand,M.
  TITLE     Isolation and expression of the homeobox gene Gbx1 during mouse
            development
  JOURNAL   Dev Dyn 229 (2), 334-339 (2004)
   PUBMED   14745958
REFERENCE   5  (bases 1 to 1831)
  AUTHORS   Asbreuk,C.H., van Schaick,H.S., Cox,J.J., Kromkamp,M., Smidt,M.P.
            and Burbach,J.P.
  TITLE     The homeobox genes Lhx7 and Gbx1 are expressed in the basal
            forebrain cholinergic system
  JOURNAL   Neuroscience 109 (2), 287-298 (2002)
   PUBMED   11801365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Sep 26, 2012 this sequence version replaced XM_001063850.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates and exon combination used
            for the transcript record were based on alignment to full-length
            mouse mRNAs AF547996.1 and AY319256.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN09345330,
                              SAMN13663605 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1113              JAXUCZ010000004.1  11538402-11539514
            1114-1831           JAXUCZ010000004.1  11564214-11564931
FEATURES             Location/Qualifiers
     source          1..1831
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1831
                     /gene="Gbx1"
                     /note="gastrulation brain homeobox 1"
                     /db_xref="GeneID:246149"
                     /db_xref="RGD:621864"
     exon            1..1113
                     /gene="Gbx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..1664
                     /gene="Gbx1"
                     /note="gastrulation brain homeo box 1"
                     /codon_start=1
                     /product="homeobox protein GBX-1"
                     /protein_id="NP_001258382.1"
                     /db_xref="GeneID:246149"
                     /db_xref="RGD:621864"
                     /translation="MSPEGDTPSPPARPLPPYERGSAAPEPHCAEPAPRRYLGPRARS
                     EPCVSAPGARRGPGSAMQRAAGGGAPGGSGGSGGGPGTAFSIDSLIGPPPPRSGHLLY
                     TGYPMFMPYRPLVLPQALAPAPLPAGLPPLAPLASFAGRLSNTFCAGLGQAVPSMVAL
                     TTALPSFAEPPDAYYGPPELAAAAAAAAASTVSRSNPEPPARRTDGALDADELLPARE
                     KVTEPPPPPPPPPPHFSETFPSLPAEGKVYSSDEEKLEPPAGEPAGSEPEEEGSGGDS
                     EDSFLDSSAGGPGALLGPKPKLKGSLGTGAEEGTPVATGVTTPGGKSRRRRTAFTSEQ
                     LLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAGNVSSRSGE
                     PVRNPKIVVPIPVHVNRFAVRSQHQQMEQGARP"
     exon            1114..1831
                     /gene="Gbx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgccgcgtc ctgactccta cggatcgcca ctccgtgcgc cctgagtcgc tcctggcgtc
       61 ccacgcgccc ccgccccgcc ccgccgcgcc cctctcgccc ttcgagccgc gccgagcccg
      121 ggtcctgtgg gctgagccgg gagcaggtcc gggcgcgggg aggggacctg gccagctgcc
      181 gccgccgcct cctcgcccgc cgcaaacttt cacaaagcgg cgggtccggc ctcatcaatc
      241 tgcattaata atagttggtt gggccgcggg gggcgggcgg ggtcccgggc cggccgggcc
      301 actgggaagg cgcggggcgc ggggcgcggg agccgggcgc ggcggcgggc ggagggagca
      361 agtgaagcgt aatttgagga agatggatga gtccggaggg cgacaccccc agcccgcccg
      421 cccgccccct ccctccttat gagcgaggga gcgcggcgcc ggagccacac tgcgccgagc
      481 ccgcgccccg ccgctacctc ggcccgcgcg cccgcagcga gccctgcgtg tccgcgccgg
      541 gcgcacggcg gggcccgggc agcgccatgc agagagcggc gggcggcggc gcccccgggg
      601 gcagcggcgg gagcggcggc ggccccggca ccgccttctc catcgactcg ctcatcgggc
      661 cgccgccgcc gcgctcgggc cacctgctct acactggcta ccccatgttc atgccctacc
      721 ggccgctcgt gctgccgcag gcgctggccc cggcgccgct gcccgccggc ctgccgccgc
      781 tggccccgct cgcctcgttc gcgggccgcc tgagcaacac cttctgcgcg gggctgggcc
      841 aggcggtgcc ctcgatggtg gcgctgacca ctgcactgcc cagcttcgca gagccccccg
      901 acgcctacta cggacccccg gagctcgccg ccgccgccgc cgccgccgcc gcctccaccg
      961 tctcgcgaag caacccggag cccccggccc ggcgcacaga cggagcgctg gatgcggacg
     1021 agctgctgcc tgcgcgcgag aaagtgactg agcctccgcc gcccccgccg cccccgcctc
     1081 cgcacttctc agagactttc ccgagtctgc cggcagaggg gaaggtgtac agctcagatg
     1141 aggagaagct ggagccccca gcaggagagc cagcaggcag cgagccggag gaagaaggct
     1201 caggcggtga cagcgaggac agcttcctgg acagttctgc agggggccca ggggctcttc
     1261 tgggacctaa accgaagcta aagggaagcc tggggactgg cgcagaggag gggacaccag
     1321 tggccacagg ggtcaccacg cctgggggga aaagccgaag gcggcgcaca gccttcacta
     1381 gcgagcagct tttggagctg gagaaggagt ttcactgcaa gaaatacctg agtctgaccg
     1441 agcgctccca gatcgcccac gccctcaagc tcagcgaggt gcaggtgaag atctggtttc
     1501 agaaccgccg ggccaagtgg aagcgaatca aggctggcaa tgtgagcagc cgttctgggg
     1561 agcccgtgag aaaccccaag atcgtagtgc ccatacctgt gcacgtcaac aggtttgctg
     1621 tgcgcagcca gcaccaacag atggagcagg gggcccggcc atgaccaagc tcccggggac
     1681 cgaagtcaac ggatctgaac ctgtgcctgc ccaagactca ctgggtgctg cagcctagag
     1741 gggcctggtg gactctgttc tgggaaagac cagcgtgttc ccaggactgc ggcatgagta
     1801 ttcggccaga gactgttctc gagacctcag g
//
