LOCUS       NM_001108569            2810 bp    mRNA    linear   ROD 15-AUG-2024
DEFINITION  Rattus norvegicus guanylate binding protein 5 (Gbp5), mRNA.
ACCESSION   NM_001108569 XM_001078845 XM_342352
VERSION     NM_001108569.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2810)
  AUTHORS   Haque,M., Singh,A.K., Ouseph,M.M. and Ahmed,S.
  TITLE     Regulation of Synovial Inflammation and Tissue Destruction by
            Guanylate Binding Protein 5 in Synovial Fibroblasts From Patients
            With Rheumatoid Arthritis and Rats With Adjuvant-Induced Arthritis
  JOURNAL   Arthritis Rheumatol 73 (6), 943-954 (2021)
   PUBMED   33615742
  REMARK    GeneRIF: Regulation of Synovial Inflammation and Tissue Destruction
            by Guanylate Binding Protein 5 in Synovial Fibroblasts From
            Patients With Rheumatoid Arthritis and Rats With Adjuvant-Induced
            Arthritis.
REFERENCE   2  (bases 1 to 2810)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 2810)
  AUTHORS   Shenoy,A.R., Wellington,D.A., Kumar,P., Kassa,H., Booth,C.J.,
            Cresswell,P. and MacMicking,J.D.
  TITLE     GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals
  JOURNAL   Science 336 (6080), 481-485 (2012)
   PUBMED   22461501
REFERENCE   4  (bases 1 to 2810)
  AUTHORS   Britzen-Laurent,N., Bauer,M., Berton,V., Fischer,N., Syguda,A.,
            Reipschlager,S., Naschberger,E., Herrmann,C. and Sturzl,M.
  TITLE     Intracellular trafficking of guanylate-binding proteins is
            regulated by heterodimerization in a hierarchical manner
  JOURNAL   PLoS One 5 (12), e14246 (2010)
   PUBMED   21151871
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2810)
  AUTHORS   Wehner,M. and Herrmann,C.
  TITLE     Biochemical properties of the human guanylate binding protein 5 and
            a tumor-specific truncated splice variant
  JOURNAL   FEBS J 277 (7), 1597-1605 (2010)
   PUBMED   20180847
REFERENCE   6  (bases 1 to 2810)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 2810)
  AUTHORS   Degrandi,D., Konermann,C., Beuter-Gunia,C., Kresse,A., Wurthner,J.,
            Kurig,S., Beer,S. and Pfeffer,K.
  TITLE     Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10
            involved in host defense
  JOURNAL   J Immunol 179 (11), 7729-7740 (2007)
   PUBMED   18025219
REFERENCE   8  (bases 1 to 2810)
  AUTHORS   Tripal,P., Bauer,M., Naschberger,E., Mortinger,T., Hohenadl,C.,
            Cornali,E., Thurau,M. and Sturzl,M.
  TITLE     Unique features of different members of the human guanylate-binding
            protein family
  JOURNAL   J Interferon Cytokine Res 27 (1), 44-52 (2007)
   PUBMED   17266443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM048046.1, CO559037.1 and BC168951.1.
            
            On Nov 25, 2008 this sequence version replaced NM_001108569.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-540               FM048046.1         1-540
            541-788             CO559037.1         207-454
            789-2810            BC168951.1         1-2022
FEATURES             Location/Qualifiers
     source          1..2810
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..2810
                     /gene="Gbp5"
                     /note="guanylate binding protein 5"
                     /db_xref="GeneID:362050"
                     /db_xref="RGD:1311040"
     exon            1..192
                     /gene="Gbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            193..433
                     /gene="Gbp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2004
                     /gene="Gbp5"
                     /note="guanylate nucleotide binding protein 5"
                     /codon_start=1
                     /product="guanylate-binding protein 5"
                     /protein_id="NP_001102039.2"
                     /db_xref="GeneID:362050"
                     /db_xref="RGD:1311040"
                     /translation="MAPEIHMPEPICLIANTDEHLVTNQEALEILSAITQPVVVVAIV
                     GLYRTGKSYLMNKLAGKEKGFSVGSTVQSHTKGIWMWCVPHPQKPDHTLVLLDTEGLG
                     DVEKVDEKNDIQIFALAILLSSTFVYNTMSKIDQGAIDLLHSVTELTDLLRTRNTSDP
                     SETKEPDDMSFFPDLVWTLRDFFLGLEVNGQAITSDEYLEKSLMLKQGSDERTQTFNL
                     PRLCIQKFFPVKKCFVFDSPALGSKLSQLQTLNSDELNPDFVQNLSEFCSHIFTHSKT
                     KTLPGGIQVNGPRLESMVQTYVDAINSGALPSMENMVVTLTRRENTAAVQKAIAHYDQ
                     QMSQKVQLPTETLQLLLDLHKTCEKEAIEIFRKRSFKDDDQCFQKELESLLSAKRDEI
                     CRKNEDASAALCSTLLQSTFQPLEQEVARGVYAKPGGHSLFLQRMEQLKAQYRQQPGK
                     GTQAEEVLQKYLKAKEPVSATILQTDQDLTAKEKQKKEEQARAEAARAEAQRLEALRV
                     QEEQRRVEQERRHQEHLRQIEFERANFQREQQRKQKQRVQEEMERIKAEQEAQLRALQ
                     QQLQNMRVISHHEHDQCIII"
     exon            434..561
                     /gene="Gbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            562..671
                     /gene="Gbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            672..865
                     /gene="Gbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1108
                     /gene="Gbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1389
                     /gene="Gbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1602
                     /gene="Gbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1705
                     /gene="Gbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1887
                     /gene="Gbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2769
                     /gene="Gbp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagttctct gccagagagc tgagagagga aaggaaattc ccagagctgg tcattatttc
       61 tcaaaaaaaa aataataaaa aaaaaagaag aagaagcaca gataaataag ggcacgagga
      121 gtacgtactc ttgcagagtc ccgtttgaag cgtatcaccg gcacttgctc cagctcttca
      181 gtgtttgtta agaaattcca ggtcattcca cttctgaccc cgaggacaag taacatcgca
      241 gacatggccc cagagattca catgccagaa cccatatgcc tcattgcgaa cacggatgaa
      301 cacctagtga ctaaccagga agccctggag atcctgtcag ccatcacaca gccggtggtg
      361 gtggtggcca ttgttggcct ctaccgcaca ggcaaatcct acctgatgaa caagctggct
      421 gggaaggaga aaggcttttc cgtgggctcc actgttcagt ctcacaccaa gggcatctgg
      481 atgtggtgtg tgccccaccc tcaaaagcca gaccacactt tggttctgtt ggacactgag
      541 ggcctgggag atgtggagaa ggttgatgaa aagaatgata ttcagatctt cgcactggcg
      601 atcctcctca gtagcacctt cgtatacaac accatgagca aaattgacca gggggctatc
      661 gacctactgc acagtgtcac agagctgaca gatctgctcc ggacaaggaa cacctctgat
      721 cccagtgaaa ccaaggaacc tgatgacatg agcttcttcc cagacttggt gtggactctg
      781 agagatttct tcctgggcct ggaagtcaat gggcaagcca tcacatcaga tgaatatctg
      841 gagaagtcgc tgatgctgaa gcaaggtagt gatgaaagga cccaaacatt caatctacct
      901 cggctgtgca tacagaagtt cttcccagta aagaaatgct ttgtttttga ctctcctgct
      961 ctcggaagta aactttctca gcttcaaaca ctcaacagtg atgagctgaa ccctgatttt
     1021 gtgcagaacc tttcagaatt ctgttctcac atcttcacac attctaagac caagactctt
     1081 ccaggaggca tccaggtcaa tggacctcgt ctggaaagca tggtgcagac ctatgtggat
     1141 gctatcaaca gtggggctct tccttccatg gagaacatgg tggtaacctt gacccggaga
     1201 gagaacacag cagcagtgca aaaggccatt gctcactatg accaacagat gagtcagaag
     1261 gtgcagctgc ccacagagac cctccaactg ctgctggacc tgcacaagac ctgtgagaaa
     1321 gaagccatag aaatcttcag gaagcgttct ttcaaggatg atgaccaatg tttccagaaa
     1381 gaattggaga gcctactaag tgcaaagcgg gatgagattt gtaggaagaa cgaggatgct
     1441 tctgcagccc tctgctcaac cctacttcag agtacttttc agcctctgga acaagaagtg
     1501 gcacgggggg tctatgctaa accaggagga cacagtctct tccttcagag gatggaacag
     1561 ttgaaggcac agtaccgcca gcagccgggg aagggaacac aggctgagga agttctgcag
     1621 aaatatctga aagccaagga accagtgagc gctacaattc tacaaacaga ccaggatctc
     1681 acagccaaag agaagcagaa aaaagaggaa caagcaagag cggaggctgc ccgggctgaa
     1741 gcacagaggt tggaggctct tcgagtccag gaagagcaaa ggagagtaga gcaggagaga
     1801 aggcatcaag agcatctgag gcaaatagag tttgagaggg caaacttcca gagagagcaa
     1861 cagaggaagc agaagcagag ggtccaggaa gagatggaaa ggatcaaggc agagcaggaa
     1921 gctcaactca gagcacttca acagcagctc caaaacatga gggtaataag ccaccacgaa
     1981 catgaccagt gtataataat ctaatacacc aaaacctggg tcctcccttt cttattgctt
     2041 ctcattgaag acacagagga acaagagacc gaaggacttc agacaaccaa tagttaagaa
     2101 gccccagcgc cccctgacta actgccacat ctgtctggag atagttactc agggggtgtt
     2161 aatcaaatag aacttggcca atatctgcaa ttgacatggc atccccttta ctggtggaca
     2221 caggaagaag ggttaccaat gagaaatcag aaaaaaattt gtttttctca actgggtgcg
     2281 ggcccctgct ccgtggacag aggggctggc tcctcagtac aatcagctga ccatctgcat
     2341 gatattcctt tccatttctt tgttgcgagc ccaaacacat tatagtcaac cttgtcacgt
     2401 ggctaaggat catgtcactc acacttggag gaaaatttgt tcctcccgat tgtcttttct
     2461 gctgcatcca ccttctatct ttggttacgt gattaatgat aaagaaagtc ttccactaag
     2521 gctttgcttt cgatacacaa aatcaccatc tggccccatc tgtatccatt tttcttcctt
     2581 caagtctatg cttgcccagg catattgctc actttcaatc agattcttaa ccacagtcat
     2641 tatactgacg tttaaatcat tttgatgatt taaaatttaa agtttttaaa cggtttgtga
     2701 ccattctaag cctgaccctg tttctgggtc tatttgcttt atttctttaa aataaaatta
     2761 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
