LOCUS       NM_001305261            2560 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus guanylate binding protein 4 (Gbp4), mRNA.
ACCESSION   NM_001305261 XM_001078892 XM_227762
VERSION     NM_001305261.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2560)
  AUTHORS   Kim,B.H., Shenoy,A.R., Kumar,P., Das,R., Tiwari,S. and
            MacMicking,J.D.
  TITLE     A family of IFN-gamma-inducible 65-kD GTPases protects against
            bacterial infection
  JOURNAL   Science 332 (6030), 717-721 (2011)
   PUBMED   21551061
REFERENCE   2  (bases 1 to 2560)
  AUTHORS   Degrandi,D., Konermann,C., Beuter-Gunia,C., Kresse,A., Wurthner,J.,
            Kurig,S., Beer,S. and Pfeffer,K.
  TITLE     Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10
            involved in host defense
  JOURNAL   J Immunol 179 (11), 7729-7740 (2007)
   PUBMED   18025219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Mar 6, 2015 this sequence version replaced
            XM_227762.8, XM_001078892.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225190.1, SRR26643290.10231.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000002.1  233978486-233978634
            150-345             JAXUCZ010000002.1  233979598-233979793
            346-473             JAXUCZ010000002.1  233981685-233981812
            474-583             JAXUCZ010000002.1  233982500-233982609
            584-780             JAXUCZ010000002.1  233982800-233982996
            781-1026            JAXUCZ010000002.1  233983905-233984150
            1027-1307           JAXUCZ010000002.1  233985096-233985376
            1308-1520           JAXUCZ010000002.1  233986729-233986941
            1521-1623           JAXUCZ010000002.1  233989445-233989547
            1624-1817           JAXUCZ010000002.1  233989843-233990036
            1818-2560           JAXUCZ010000002.1  233991378-233992120
FEATURES             Location/Qualifiers
     source          1..2560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..2560
                     /gene="Gbp4"
                     /note="guanylate binding protein 4"
                     /db_xref="GeneID:310917"
                     /db_xref="RGD:1310579"
     exon            1..149
                     /gene="Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            150..345
                     /gene="Gbp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2036
                     /gene="Gbp4"
                     /note="guanylate nucleotide binding protein 4; guanylate
                     nucleotide binding protein 3; guanylate-binding protein
                     4-like"
                     /codon_start=1
                     /product="guanylate-binding protein 4"
                     /protein_id="NP_001292190.1"
                     /db_xref="GeneID:310917"
                     /db_xref="RGD:1310579"
                     /translation="MEAPICLVQNWKEQLTVNLEAIGILEQIAQPLVVVAIVGLYRTG
                     KSYLMNRLAGRNHGFSLGSTVQSETKGIWMWCVPHPTKPTHTLVLLDTEGLGDVEKGD
                     PKNDSWIFALAVLLSSTFVYNSMSTINHQALEQLHYVTELTQLIRAKSDPREDKVEDS
                     SEFVGFFPDFIWAVRDFVLELKLDGRPITEDEYLENALKLIPENNPKGQKSNMTRECI
                     RYFFPVRKCFVFDRPTNDKSLLFQIENVPENQLEWNFQVESENFCSYIFANGKTKTLR
                     GGVIVTGNRLGTLVQTYVDAINSGTVPCLENAVTALAQRENSAAVQKAAEHYAEQMAQ
                     RLRLPTDTLQELLEVHSACEKEAIAVFMEHSFKDDEQEFQKRLVATIEKWKEEFMLRN
                     EAASIRHCQAELEKLSESLKESISCGAFSVPGGHSLYLEARKKVELSYEQVPRKGVKA
                     KEVLKSFLQSQATVENSILQSDKALTDGERAVAAERTKKEVAEKERELLKQRQKEQEQ
                     VMEAQERSFQENIAKLQEKMERERVMLLREQEKMMEHKLKVQKELLVEGFRKKSDMLK
                     NEISQLREEIERTRKKPSLFAHILDTVGNAFIMILPGAGKICGAGMKVLSSLMK"
     exon            346..473
                     /gene="Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            474..583
                     /gene="Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            584..780
                     /gene="Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1026
                     /gene="Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1307
                     /gene="Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1520
                     /gene="Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1623
                     /gene="Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1817
                     /gene="Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2560
                     /gene="Gbp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttcccttt atctcaattt gtatgtgggt ggctgttact ttgacacttc taacagtggc
       61 tgcttcaagg gagcctggag cagtaggaag ctcagtgaat gaaccaagtt ggctgaggac
      121 tgtcagggtt ttggagccag agcgcctggg gagctgtggt gtctgagtct accatggagg
      181 cacccatttg tctggtgcaa aactggaaag agcagctgac agtaaatctg gaggccatag
      241 ggattcttga gcagatagca cagcctctgg tggtggtggc cattgttggt ttatatcgga
      301 cagggaagtc ctacctcatg aatcgccttg caggacggaa ccacggcttc tccttgggct
      361 ccacagtgca atcagagacc aagggcatct ggatgtggtg tgtgccccat cccaccaagc
      421 caacccacac cctggtcctt ctggacactg agggtcttgg cgatgtagaa aagggtgacc
      481 ctaagaatga ctcatggatc ttcgccttgg ccgtgcttct gagcagcacc tttgtctaca
      541 acagcatgag caccatcaac caccaggccc tggagcagct gcactatgtg actgaattaa
      601 cacaactaat ccgagcaaaa tcagacccca gggaggataa agtggaggac tctagtgagt
      661 ttgtaggttt cttcccagac ttcatctggg ctgttcgaga ttttgttctg gagttgaagt
      721 tagatggtcg gcccatcaca gaagatgagt acctggagaa tgccctgaag ctgatcccag
      781 aaaacaatcc caaaggccaa aagtccaaca tgaccagaga atgtatcaga tattttttcc
      841 cggtacggaa gtgctttgtc tttgataggc ccacaaacga caaaagttta ttattccaaa
      901 ttgaaaacgt tccagaaaac caactagagt ggaatttcca agttgaatca gaaaatttct
      961 gttcctatat ctttgccaat ggcaagacca agacgctgag agggggagtc attgtcacag
     1021 gaaatcggct ggggactttg gtgcagacct atgtggatgc catcaacagt ggaactgtgc
     1081 catgtttgga gaacgcagtg acggccctgg cccaacgtga gaactctgca gctgtgcaga
     1141 aggcagctga gcactacgct gagcagatgg cccagagact aaggctcccc acagacactc
     1201 tccaggagct gctggaggtg cactcagcct gtgagaagga agccattgct gtcttcatgg
     1261 agcactcctt caaggatgat gaacaggagt ttcagaagag gctggtggcc accatagaga
     1321 aatggaagga agagttcatg ctacggaatg aagcagcatc catccggcac tgccaggctg
     1381 agctggagaa gctttcagag tccctgaagg aaagcatctc atgtggagct ttctctgttc
     1441 cgggggggca cagcctctac ttagaagcca ggaagaaggt tgagctgagc tacgagcaag
     1501 tgccgaggaa gggagtgaag gcaaaagaag tccttaagag tttcctacag tcacaggcta
     1561 ctgtggagaa ctccatcctg cagtcagaca aagctcttac agatggagag agggccgtag
     1621 cagctgagcg gaccaagaag gaggtggctg agaaggaaag agagctgctg aaacagagac
     1681 agaaggagca agagcaagtg atggaggctc aggagagaag tttccaagaa aacattgcta
     1741 agcttcagga gaagatggag agggaaaggg tgatgctgct cagggagcag gagaagatga
     1801 tggagcacaa gctgaaggtc caaaaagaac tgcttgttga aggattcaga aagaaatctg
     1861 atatgttaaa gaatgaaata agtcaactga gagaagagat cgaaagaaca agaaagaaac
     1921 cctcactgtt tgcacacatc cttgacacag ttggcaatgc attcattatg attttaccag
     1981 gagctggtaa aatatgtggt gcggggatga aagtccttag ctcacttatg aagtagtctg
     2041 aagagtttct gggacggaat atataaaaac caagcttcta tcattttgat accaactgtg
     2101 ttttttaata catgtgcttt ggattttaaa tacatgtgct actttagtaa ctcatattac
     2161 aacgaagtca gaactctcgt taatagctag ataatcagat acagcttcat tggagttgag
     2221 ttctgtgtcc gttcattgcc agttatattc aaggttaaag atacaaacca atgaagaata
     2281 taaggatcat gcatacataa ataccaccaa atttcattgc cacaatctct gtaataaaga
     2341 gggaaaccag tcagaatata gtgaaattgt taatagaaaa ggtgtaaaat aaatcaaaca
     2401 gaaatatggc cacatggaga cacattggca attgtatccc agtcttacag gacagataat
     2461 ttgttacaaa gatctcttgt aaaaactgac aagtgggttt tcataggacc ggaagtatga
     2521 gaaaaatgat tgataataaa agcagtgcat attaaattta
//
