LOCUS       NM_133624               2395 bp    mRNA    linear   ROD 13-AUG-2024
DEFINITION  Rattus norvegicus guanylate binding protein 2 (Gbp2), mRNA.
ACCESSION   NM_133624
VERSION     NM_133624.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2395)
  AUTHORS   Miao,Q., Ge,M. and Huang,L.
  TITLE     Up-regulation of GBP2 is Associated with Neuronal Apoptosis in Rat
            Brain Cortex Following Traumatic Brain Injury
  JOURNAL   Neurochem Res 42 (5), 1515-1523 (2017)
   PUBMED   28239766
  REMARK    GeneRIF: Neuronal cells overexpressing GBP2 exhibited up-regulation
            of GBP2 in the cerebral cortex following traumatic brain injury.
REFERENCE   2  (bases 1 to 2395)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 2395)
  AUTHORS   Britzen-Laurent,N., Bauer,M., Berton,V., Fischer,N., Syguda,A.,
            Reipschlager,S., Naschberger,E., Herrmann,C. and Sturzl,M.
  TITLE     Intracellular trafficking of guanylate-binding proteins is
            regulated by heterodimerization in a hierarchical manner
  JOURNAL   PLoS One 5 (12), e14246 (2010)
   PUBMED   21151871
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2395)
  AUTHORS   Burckstummer,T., Baumann,C., Bluml,S., Dixit,E., Durnberger,G.,
            Jahn,H., Planyavsky,M., Bilban,M., Colinge,J., Bennett,K.L. and
            Superti-Furga,G.
  TITLE     An orthogonal proteomic-genomic screen identifies AIM2 as a
            cytoplasmic DNA sensor for the inflammasome
  JOURNAL   Nat Immunol 10 (3), 266-272 (2009)
   PUBMED   19158679
REFERENCE   5  (bases 1 to 2395)
  AUTHORS   Degrandi,D., Konermann,C., Beuter-Gunia,C., Kresse,A., Wurthner,J.,
            Kurig,S., Beer,S. and Pfeffer,K.
  TITLE     Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10
            involved in host defense
  JOURNAL   J Immunol 179 (11), 7729-7740 (2007)
   PUBMED   18025219
REFERENCE   6  (bases 1 to 2395)
  AUTHORS   Tripal,P., Bauer,M., Naschberger,E., Mortinger,T., Hohenadl,C.,
            Cornali,E., Thurau,M. and Sturzl,M.
  TITLE     Unique features of different members of the human guanylate-binding
            protein family
  JOURNAL   J Interferon Cytokine Res 27 (1), 44-52 (2007)
   PUBMED   17266443
REFERENCE   7  (bases 1 to 2395)
  AUTHORS   Asundi,V.K., Stahl,R.C., Showalter,L., Conner,K.J. and Carey,D.J.
  TITLE     Molecular cloning and characterization of an isoprenylated 67 kDa
            protein
  JOURNAL   Biochim Biophys Acta 1217 (3), 257-265 (1994)
   PUBMED   8148370
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M80367.1.
            
            On Aug 30, 2012 this sequence version replaced NM_133624.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M80367.1, BC086991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132292, SAMD00132301
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2395              M80367.1           2-2396
FEATURES             Location/Qualifiers
     source          1..2395
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..2395
                     /gene="Gbp2"
                     /note="guanylate binding protein 2"
                     /db_xref="GeneID:171164"
                     /db_xref="RGD:621810"
     exon            1..156
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            157..367
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1947
                     /gene="Gbp2"
                     /note="interferon-induced guanylate-binding protein 2;
                     p67; GBP-2; GTP-binding protein 2; guanine
                     nucleotide-binding protein 2; isoprenylated 67 kDa
                     protein; guanylate nucleotide binding protein 2;
                     guanylate-binding protein 1; guanylate binding protein 2,
                     interferon-inducible"
                     /codon_start=1
                     /product="guanylate-binding protein 2"
                     /protein_id="NP_598308.1"
                     /db_xref="GeneID:171164"
                     /db_xref="RGD:621810"
                     /translation="MDMASEIHMLQPMCLIENTEAHLVINQEALRILSAINQPVVVVA
                     IVGLYRTGKSYLMNKLAGKRTGFSLGSTVQSHTKGIWMWCVPHPKKAGQTLVLLDTEG
                     LEDVEKGDNQNDCWIFALAVLLSSTFVYNSMGTINQQAMDQLHYVTELTDLIKSKSSP
                     DQSGIDDSANFVGFFPTFVWALRDFSLELEVNGKLVTPDEYLEHSLTLKKGADKKTKS
                     FNEPRLCIRKFFPKRKCFIFDRPALRKQLCKLETLGEEELCSEFVEQVAEFTSYIFSY
                     SAVKTLSGGIIVNGPRLKSLVQTYVGAISSGSLPCMESAVLTLAQIENSAAVQKAITH
                     YEEQMNQKIQMPTETLQELLDLHRLIEREAIEIFLKNSFKDVDQKFQTELGNLLISKR
                     DAFIKKNSDVSSAHCSDLIEDIFGPLEEEVKQGTFSKPGGYFLFLQMRQELEKKYNQA
                     PGKGLEAEAVLKKYFESKEDIVETLLKTDQSLTEAAKEIEVERIKAETAEAANRELAE
                     KQEKFELMMQQKEESYQEHVRQLTEKMKEEQKKLIEEQDNIIALKLREQEKFLREGYE
                     NESKKLLREIENMKRRQSPGKCTIL"
     exon            368..495
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..605
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            606..802
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1045
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1326
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1539
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1642
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1836
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2395
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2395
                     /gene="Gbp2"
ORIGIN      
        1 taaaagatct aactcttcac aagttctctg gagacaattt ggaacttcct aggttatgac
       61 agggtctttg ccacagagcc cgtgaaaaag gacagagtga tcagcagcct gaccctgaac
      121 ctgtcaggca ttcttctcta aagaatttcg tttaagagac aaaagagcac catggacatg
      181 gcctcggaga tccacatgtt acaacccatg tgcctcattg agaacactga ggctcaccta
      241 gtgatcaacc aggaggctct gaggattttg tctgccatca accagcctgt ggtggtggtg
      301 gcaatcgtgg gcctctaccg cacaggcaaa tcctacctga tgaacaaatt ggctgggaag
      361 agaacaggct tctccctggg ctccactgtg cagtctcaca ccaagggcat ctggatgtgg
      421 tgtgtgcctc accccaagaa ggcagggcaa accctagttc tgcttgacac cgagggcctt
      481 gaagatgttg agaagggaga caaccagaac gactgctgga tctttgcctt ggcagtcctc
      541 ctcagcagca ccttcgtcta caacagcatg ggaaccatca accagcaggc catggaccag
      601 ctgcattatg tgacagagct gactgatctt atcaagtcaa agtcatcacc tgatcagagt
      661 gggatagacg actctgctaa ctttgtgggc ttctttccaa cctttgtgtg ggctctgaga
      721 gatttctccc tggagttgga agtcaatgga aaacttgtca ctcctgatga gtacctggag
      781 cattcgctga ccctgaagaa aggagctgat aagaaaacta aaagctttaa tgagcctcga
      841 ctgtgcatca ggaaattctt tccgaagagg aagtgtttca tctttgacag acctgctctg
      901 aggaagcaac tctgcaaact ggagactctg ggggaggagg agctgtgtag tgagtttgta
      961 gaacaagttg cagaattcac ctcgtatatc ttcagttact ctgctgtcaa aactctgtct
     1021 ggtggcatca tagtcaatgg gccacgtcta aagagcctgg tgcagaccta tgttggtgcc
     1081 atcagcagtg ggtctctccc ctgcatggag agtgcagtcc tgactttggc ccagatagag
     1141 aactcagctg cagtacaaaa ggccatcacc cactatgaag aacagatgaa tcagaaaatc
     1201 cagatgccca cagaaaccct ccaggagctg ctagacctgc acaggctgat tgagagggag
     1261 gccattgaga tcttcctaaa gaattctttc aaggatgtag accagaagtt ccagacagaa
     1321 ttagggaacc tgctgatatc aaagcgagat gcctttatta agaagaactc ggatgtatca
     1381 tcagctcatt gttcagatct gatagaggat atttttggac ctctggaaga agaagtaaaa
     1441 caagggacat tttccaaacc aggaggttac ttcctcttcc ttcagatgag acaagagcta
     1501 gagaagaagt ataaccaggc tcctgggaag gggctcgagg cagaagcggt gctgaaaaag
     1561 tactttgagt ccaaggaaga cattgttgaa acacttctaa agacggatca gtcactcacg
     1621 gaggcagcaa aggagattga agtggaacgg attaaggctg aaactgctga agctgcaaac
     1681 agagagttag cagagaagca ggagaagttt gagctgatga tgcagcagaa ggaagagagt
     1741 taccaggagc acgtgagaca gctgactgag aagatgaagg aggaacagaa aaagttaata
     1801 gaagaacagg acaacatcat agctcttaaa cttcgggaac aggaaaaatt tctcagggaa
     1861 ggatacgaga acgagagcaa gaaacttctt cgagagattg agaacatgaa gagacgacaa
     1921 tcacctggga aatgcaccat actctaaagg tccgaggccc aaacctctct gccaaactct
     1981 tcatcacaga atatgtggac tgacaccttt aggctttgaa acagctgtta tgatactacg
     2041 ttcattttag ctcaaaaatc aatcacatgc aaatccagtt tggggtcacc gtctgaccac
     2101 tgggcagcat cagaagaagt tcgcccagcc acatatgttc ctcctctata atcttaagtt
     2161 ttcctctttc ctacagtaca acttctgcaa ttacagagca ggcaactttt aattaactta
     2221 caaaacaaac tccctttctc tgaggacctt gacattttgc tacagtcctt caaaacctaa
     2281 atcccatctc cattttccct gtgatctttc tccctactat ggcagtgtgt cttgaacttt
     2341 ctcaggacaa atgtcttgca agagcacgag ttaataaaat tgattagcct accat
//
