LOCUS       NP_598308                591 aa            linear   ROD 13-AUG-2024
DEFINITION  guanylate-binding protein 2 [Rattus norvegicus].
ACCESSION   NP_598308
VERSION     NP_598308.1
DBSOURCE    REFSEQ: accession NM_133624.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 591)
  AUTHORS   Miao,Q., Ge,M. and Huang,L.
  TITLE     Up-regulation of GBP2 is Associated with Neuronal Apoptosis in Rat
            Brain Cortex Following Traumatic Brain Injury
  JOURNAL   Neurochem Res 42 (5), 1515-1523 (2017)
   PUBMED   28239766
  REMARK    GeneRIF: Neuronal cells overexpressing GBP2 exhibited up-regulation
            of GBP2 in the cerebral cortex following traumatic brain injury.
REFERENCE   2  (residues 1 to 591)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (residues 1 to 591)
  AUTHORS   Britzen-Laurent,N., Bauer,M., Berton,V., Fischer,N., Syguda,A.,
            Reipschlager,S., Naschberger,E., Herrmann,C. and Sturzl,M.
  TITLE     Intracellular trafficking of guanylate-binding proteins is
            regulated by heterodimerization in a hierarchical manner
  JOURNAL   PLoS One 5 (12), e14246 (2010)
   PUBMED   21151871
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 591)
  AUTHORS   Burckstummer,T., Baumann,C., Bluml,S., Dixit,E., Durnberger,G.,
            Jahn,H., Planyavsky,M., Bilban,M., Colinge,J., Bennett,K.L. and
            Superti-Furga,G.
  TITLE     An orthogonal proteomic-genomic screen identifies AIM2 as a
            cytoplasmic DNA sensor for the inflammasome
  JOURNAL   Nat Immunol 10 (3), 266-272 (2009)
   PUBMED   19158679
REFERENCE   5  (residues 1 to 591)
  AUTHORS   Degrandi,D., Konermann,C., Beuter-Gunia,C., Kresse,A., Wurthner,J.,
            Kurig,S., Beer,S. and Pfeffer,K.
  TITLE     Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10
            involved in host defense
  JOURNAL   J Immunol 179 (11), 7729-7740 (2007)
   PUBMED   18025219
REFERENCE   6  (residues 1 to 591)
  AUTHORS   Tripal,P., Bauer,M., Naschberger,E., Mortinger,T., Hohenadl,C.,
            Cornali,E., Thurau,M. and Sturzl,M.
  TITLE     Unique features of different members of the human guanylate-binding
            protein family
  JOURNAL   J Interferon Cytokine Res 27 (1), 44-52 (2007)
   PUBMED   17266443
REFERENCE   7  (residues 1 to 591)
  AUTHORS   Asundi,V.K., Stahl,R.C., Showalter,L., Conner,K.J. and Carey,D.J.
  TITLE     Molecular cloning and characterization of an isoprenylated 67 kDa
            protein
  JOURNAL   Biochim Biophys Acta 1217 (3), 257-265 (1994)
   PUBMED   8148370
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M80367.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M80367.1, BC086991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132292, SAMD00132301
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     Protein         1..591
                     /product="guanylate-binding protein 2"
                     /note="interferon-induced guanylate-binding protein 2;
                     p67; GBP-2; GTP-binding protein 2; guanine
                     nucleotide-binding protein 2; isoprenylated 67 kDa
                     protein; guanylate nucleotide binding protein 2;
                     guanylate-binding protein 1; guanylate binding protein 2,
                     interferon-inducible"
                     /calculated_mol_wt=67224
     Region          20..282
                     /region_name="GBP"
                     /note="Guanylate-binding protein, N-terminal domain;
                     pfam02263"
                     /db_xref="CDD:460516"
     Region          284..580
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     pfam02841"
                     /db_xref="CDD:460721"
     CDS             1..591
                     /gene="Gbp2"
                     /coded_by="NM_133624.2:172..1947"
                     /db_xref="GeneID:171164"
                     /db_xref="RGD:621810"
ORIGIN      
        1 mdmaseihml qpmcliente ahlvinqeal rilsainqpv vvvaivglyr tgksylmnkl
       61 agkrtgfslg stvqshtkgi wmwcvphpkk agqtlvlldt egledvekgd nqndcwifal
      121 avllsstfvy nsmgtinqqa mdqlhyvtel tdlikskssp dqsgiddsan fvgffptfvw
      181 alrdfslele vngklvtpde ylehsltlkk gadkktksfn eprlcirkff pkrkcfifdr
      241 palrkqlckl etlgeeelcs efveqvaeft syifsysavk tlsggiivng prlkslvqty
      301 vgaissgslp cmesavltla qiensaavqk aithyeeqmn qkiqmptetl qelldlhrli
      361 ereaieiflk nsfkdvdqkf qtelgnllis krdafikkns dvssahcsdl iedifgplee
      421 evkqgtfskp ggyflflqmr qelekkynqa pgkgleaeav lkkyfesked ivetllktdq
      481 slteaakeie verikaetae aanrelaekq ekfelmmqqk eesyqehvrq ltekmkeeqk
      541 klieeqdnii alklreqekf lregyenesk kllreienmk rrqspgkcti l
//
