LOCUS       NM_001191634            6369 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus golgi brefeldin A resistant guanine nucleotide
            exchange factor 1 (Gbf1), mRNA.
ACCESSION   NM_001191634 XM_219953
VERSION     NM_001191634.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6369)
  AUTHORS   Hansen,M.D., Johnsen,I.B., Stiberg,K.A., Sherstova,T., Wakita,T.,
            Richard,G.M., Kandasamy,R.K., Meurs,E.F. and Anthonsen,M.W.
  TITLE     Hepatitis C virus triggers Golgi fragmentation and autophagy
            through the immunity-related GTPase M
  JOURNAL   Proc Natl Acad Sci U S A 114 (17), E3462-E3471 (2017)
   PUBMED   28389568
REFERENCE   2  (bases 1 to 6369)
  AUTHORS   Lowery,J., Szul,T., Styers,M., Holloway,Z., Oorschot,V.,
            Klumperman,J. and Sztul,E.
  TITLE     The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane
            recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to
            the trans-Golgi network (TGN)
  JOURNAL   J Biol Chem 288 (16), 11532-11545 (2013)
   PUBMED   23386609
REFERENCE   3  (bases 1 to 6369)
  AUTHORS   Mao,L., Li,N., Guo,Y., Xu,X., Gao,L., Xu,Y., Zhou,L. and Liu,W.
  TITLE     AMPK phosphorylates GBF1 for mitotic Golgi disassembly
  JOURNAL   J Cell Sci 126 (Pt 6), 1498-1505 (2013)
   PUBMED   23418352
REFERENCE   4  (bases 1 to 6369)
  AUTHORS   Mazaki,Y., Nishimura,Y. and Sabe,H.
  TITLE     GBF1 bears a novel phosphatidylinositol-phosphate binding module,
            BP3K, to link PI3Kgamma activity with Arf1 activation involved in
            GPCR-mediated neutrophil chemotaxis and superoxide production
  JOURNAL   Mol Biol Cell 23 (13), 2457-2467 (2012)
   PUBMED   22573891
REFERENCE   5  (bases 1 to 6369)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 6369)
  AUTHORS   Szul,T., Grabski,R., Lyons,S., Morohashi,Y., Shestopal,S., Lowe,M.
            and Sztul,E.
  TITLE     Dissecting the role of the ARF guanine nucleotide exchange factor
            GBF1 in Golgi biogenesis and protein trafficking
  JOURNAL   J Cell Sci 120 (Pt 22), 3929-3940 (2007)
   PUBMED   17956946
REFERENCE   7  (bases 1 to 6369)
  AUTHORS   Garcia-Mata,R., Szul,T., Alvarez,C. and Sztul,E.
  TITLE     ADP-ribosylation factor/COPI-dependent events at the endoplasmic
            reticulum-Golgi interface are regulated by the guanine nucleotide
            exchange factor GBF1
  JOURNAL   Mol Biol Cell 14 (6), 2250-2261 (2003)
   PUBMED   12808027
REFERENCE   8  (bases 1 to 6369)
  AUTHORS   Kawamoto,K., Yoshida,Y., Tamaki,H., Torii,S., Shinotsuka,C.,
            Yamashina,S. and Nakayama,K.
  TITLE     GBF1, a guanine nucleotide exchange factor for ADP-ribosylation
            factors, is localized to the cis-Golgi and involved in membrane
            association of the COPI coat
  JOURNAL   Traffic 3 (7), 483-495 (2002)
   PUBMED   12047556
REFERENCE   9  (bases 1 to 6369)
  AUTHORS   Zhao,X., Lasell,T.K. and Melancon,P.
  TITLE     Localization of large ADP-ribosylation factor-guanine nucleotide
            exchange factors to different Golgi compartments: evidence for
            distinct functions in protein traffic
  JOURNAL   Mol Biol Cell 13 (1), 119-133 (2002)
   PUBMED   11809827
REFERENCE   10 (bases 1 to 6369)
  AUTHORS   Claude,A., Zhao,B.P., Kuziemsky,C.E., Dahan,S., Berger,S.J.,
            Yan,J.P., Armold,A.D., Sullivan,E.M. and Melancon,P.
  TITLE     GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide
            exchange factor that displays specificity for ADP-ribosylation
            factor 5
  JOURNAL   J Cell Biol 146 (1), 71-84 (1999)
   PUBMED   10402461
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 17, 2010 this sequence version replaced XM_219953.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.6953.1,
                                           SRR26643429.5862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JAXUCZ010000001.1  254960065-254960260
            197-302             JAXUCZ010000001.1  254971065-254971170
            303-369             JAXUCZ010000001.1  254978690-254978756
            370-501             JAXUCZ010000001.1  255048061-255048192
            502-620             JAXUCZ010000001.1  255053680-255053798
            621-729             JAXUCZ010000001.1  255055570-255055678
            730-790             JAXUCZ010000001.1  255056150-255056210
            791-845             JAXUCZ010000001.1  255057258-255057312
            846-993             JAXUCZ010000001.1  255060666-255060813
            994-1217            JAXUCZ010000001.1  255061098-255061321
            1218-1383           JAXUCZ010000001.1  255062208-255062373
            1384-1595           JAXUCZ010000001.1  255063221-255063432
            1596-1694           JAXUCZ010000001.1  255063987-255064085
            1695-1889           JAXUCZ010000001.1  255069136-255069330
            1890-2079           JAXUCZ010000001.1  255069541-255069730
            2080-2220           JAXUCZ010000001.1  255069954-255070094
            2221-2309           JAXUCZ010000001.1  255070390-255070478
            2310-2512           JAXUCZ010000001.1  255071464-255071666
            2513-2636           JAXUCZ010000001.1  255072193-255072316
            2637-2762           JAXUCZ010000001.1  255072589-255072714
            2763-2845           JAXUCZ010000001.1  255072981-255073063
            2846-3082           JAXUCZ010000001.1  255073935-255074171
            3083-3176           JAXUCZ010000001.1  255074448-255074541
            3177-3353           JAXUCZ010000001.1  255074797-255074973
            3354-3418           JAXUCZ010000001.1  255075722-255075786
            3419-3542           JAXUCZ010000001.1  255075873-255075996
            3543-3614           JAXUCZ010000001.1  255076149-255076220
            3615-3709           JAXUCZ010000001.1  255076331-255076425
            3710-3863           JAXUCZ010000001.1  255076801-255076954
            3864-4089           JAXUCZ010000001.1  255081461-255081686
            4090-4250           JAXUCZ010000001.1  255082250-255082410
            4251-4497           JAXUCZ010000001.1  255082513-255082759
            4498-4703           JAXUCZ010000001.1  255082874-255083079
            4704-4854           JAXUCZ010000001.1  255085207-255085357
            4855-4985           JAXUCZ010000001.1  255085463-255085593
            4986-5087           JAXUCZ010000001.1  255085758-255085859
            5088-5201           JAXUCZ010000001.1  255086114-255086227
            5202-5382           JAXUCZ010000001.1  255086358-255086538
            5383-5511           JAXUCZ010000001.1  255086830-255086958
            5512-6369           JAXUCZ010000001.1  255087622-255088479
FEATURES             Location/Qualifiers
     source          1..6369
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..6369
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="golgi brefeldin A resistant guanine nucleotide
                     exchange factor 1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
     exon            1..196
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            197..302
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..5792
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="golgi-specific brefeldin A-resistance factor 1;
                     golgi-specific brefeldin A resistant guanine nucleotide
                     exchange factor 1"
                     /codon_start=1
                     /product="Golgi-specific brefeldin A-resistance guanine
                     nucleotide exchange factor 1"
                     /protein_id="NP_001178563.1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
                     /translation="MVDKNIYIIQGEINIVVGAIKRNARWSTHIPLDEERDPLLHSFS
                     HLKEVLNSGTELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSCALIDPTH
                     EGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGTHLTNESVCEI
                     MQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKSYVGTNLKKLKMRA
                     GGMSDSSKWKKQKRSPRPPRHTTKVMPGSELPTPNGAALSSNLTGGMPFIEAPTSISS
                     ASSEAASTVVSPCTDSGLELSSQATSKEDLTDLEQAGSPREITTTEPGSTEIGVSDQL
                     DPQEGAHVEKAQSASVESIPEVLEECTSPTDHSDSASVHDMDYVNPRGVRFTQSSQKE
                     GTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQCQTLL
                     GLIKDEMCRHLFQLLSVERLNLYAASLRVCFLLFESMREHLKFQLEMYIKKLMEIITV
                     ENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFEDLTKLLSKNAFPV
                     SGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNTLNQQEKKETARPGFEAVDGSPDTYK
                     SERAASDGKATGVPSDAPGLHFSSGGWLSTEHGKPGCSDLEEAGDSGVDKKTTRKPPR
                     FSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWL
                     RENPRLDKKMIGEFVSDRKNMDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVI
                     HRLLEVFTEHWRSCNGSPFANSDACFALAYAVIMLNTDQHNHNVRKQNAPMTLEEFRK
                     NLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWSVLLHRGATPEGIF
                     LRVPPGSYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSD
                     VFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKTVFHLAHRHGDILREGWKNI
                     MEAMLQLFRAQLLPKAMVEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGP
                     EQSSVRGPSTENQEAKRVALDCIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEE
                     TYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYHLCVQAQDFCFLVERAVVGLL
                     RLAIRLLRREEISGQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDD
                     WATLFTLLECIGSGVKPPDALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDS
                     EVYTDHGRPGKMHRSATDADMANSGWLVVGKDDIDNSKPAAGLSRPGPSPLVNQYSLT
                     VGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQD
                     KRGKSHKYDSKGNRFKKKPKEGSMLRRPRASSQHATRAGHSDEEEDEGVPASYHTVSL
                     QVSQDLLDLMHTLHTRAASIYSSWAEEQRHLETGGRKIEADSRTLWAHCWCPLLQGIA
                     CLCCDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPAD
                     VGGMEETRMRASTLLSKVFLQHLSPLLSLSTFAALWLTILDFMDKYMHAGSSDLLSEA
                     VPESLKNMLLVMDTAEIFHSADARGGSPSALWEITWERIDCFLPHLRDELFKQTVIQD
                     PMPTEPHSQKPLASTHLTPAAGDPRMPGHPPPPEIPSEVGACDPEKPESTRAASSSSP
                     GSPVASSPSKQSPAPEGPPPLAQPPLILQPLTSPLQVGVPPMTLPIILNPALIEATSP
                     VPLLATPRPTDPIPTSEVN"
     exon            303..369
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            370..501
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            502..620
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            621..729
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            730..790
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            791..845
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            846..993
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1217
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1383
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1595
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1694
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1889
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2079
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2220
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2309
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2512
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2636
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2762
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2845
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3082
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3176
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3353
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3418
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3542
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3543..3614
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3709
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3863
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3864..4089
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4090..4250
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4251..4497
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4498..4703
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4854
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4855..4985
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4986..5087
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5088..5201
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5202..5382
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5383..5511
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5512..6369
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcccactt attccggcct gcagtgaggt ctcaccctaa agttagggtc gacttccaga
       61 cgacaggctc cttcccttct ctcactcgct gccggcgccg ggagagtggc tgggagacgc
      121 ctccggggcc aagctggaca tgagctgcgg ctgccggtcc tgggactagg ccccgccatt
      181 ttggatcctc tgacaggttt gtcaggatgg tggataagaa tatttacatc attcaaggag
      241 aaattaacat tgttgttggt gccatcaaac gaaatgcccg atggagcacc catataccac
      301 tggatgaaga gcgggatccc cttttgcaca gtttcagcca tctaaaggag gtcttaaaca
      361 gtgggacaga actctcagag attgagccaa atgtattcct tcgtccattt ctggaagtca
      421 ttcgctctga agacaccact ggtcctatca ccggcctggc actcacctct gtcaacaagt
      481 tcctgtcctg tgcactcata gatccaactc atgagggcac ggcagagggc atggagaaca
      541 tggcagatgc tgtcactcat gcccgttttg tgggcacaga tcctgccagt gatgaagttg
      601 tcctgatgaa aatccttcag gttctccgga ctttgttgct aaccccagtg ggtacccact
      661 taacaaatga atctgtatgt gagattatgc agtcttgctt ccggatttgc tttgaaatga
      721 ggctcagtga gttattgaga aaatccgcag agcacactct cgtagacatg gtgcagctgc
      781 tcttcacaag gttaccgcag tttaaagaag aacccaagag ttacgtggga accaacttga
      841 agaagctgaa aatgagagca ggaggcatga gtgactcatc caagtggaag aaacagaagc
      901 gatcccctcg acctccacgt catacaacca aagtcatgcc aggttcagag ctgcccaccc
      961 caaatggagc cgccttatcc tctaacctta ctggtggcat gcccttcatt gaggcaccca
     1021 catccatctc ctctgcaagt tcagaagctg cctccacagt ggtcagtccc tgtacagata
     1081 gtggcctgga attatcctcc caggctacct ccaaggagga cctcaccgac ctggagcaag
     1141 ctggctcccc aagggagatc accaccacag agcctgggag cactgagata ggagtttctg
     1201 atcagcttga ccctcaggaa ggggcccatg tagaaaaggc ccagtcagca tcggtggaat
     1261 ctatccctga agtgctagag gagtgcacat cccctactga ccattctgac tctgcctctg
     1321 tccatgacat ggattatgtc aatcctcggg gcgtgcgctt tacccagtcc tcccagaaag
     1381 aaggcacagc tttggttcct tatggtcttc cttgcatccg tgagctcttc cgcttcctta
     1441 tctccctcac aaatccacat gaccgccata actctgaggt tatgatccac atgggacttc
     1501 atttgctgac agtagctctt gagtcagccc ctgtggccca gtgccagacc ctcttgggtc
     1561 tcatcaagga tgagatgtgc cgacacttat tccagctact cagcgtagag cggctgaacc
     1621 tttacgctgc ttccctacga gtgtgctttt tgctctttga gagcatgcgg gaacacctca
     1681 agttccagtt ggagatgtac atcaaaaagc tcatggagat tatcactgtt gaaaacccca
     1741 agatgcctta tgagatgaag gagatggcgc tggaggccat tgtgcagctc tggcgcatcc
     1801 ccagcttcgt cacggagctc tacatcaact atgactgtga ctactactgc tccaacctct
     1861 tcgaagacct cactaagctg ctgtccaaga atgcctttcc tgtgtctggc cagctttata
     1921 caacacacct gctgtctctt gatgccctat tgacagttat tgacagcact gaggctcatt
     1981 gtcaggccaa agtcctcaac accctcaacc agcaagagaa gaaagagaca gccagacctg
     2041 gctttgaggc agtggatggc agcccagaca cttacaagtc tgagagagca gccagtgatg
     2101 ggaaagccac aggagtgccc tcagatgctc caggccttca tttttcaagt ggagggtggt
     2161 tgtcaacaga acatggaaag ccagggtgca gtgatctgga ggaagctggt gactctgggg
     2221 ttgacaaaaa gaccaccagg aagccacctc gattttcctg tcttctgcca gatccacggg
     2281 aactaattga aattaaaaac aaaaaaaagc tgctgatcac tggtacagag cagttcaacc
     2341 aaaaaccaaa gaaggggatc cagtttctgc aggagaaagg cctcctcacc atcccaatgg
     2401 ataacacaga ggtagcccag tggctccgag aaaaccctcg gctagacaaa aaaatgattg
     2461 gagagtttgt gagtgaccgc aaaaacatgg acctgttgga gagttttgtg agcaccttca
     2521 gcttccaggg tctgaggctt gatgaggctc tccgcctcta cctagaagcc ttccgtctgc
     2581 ctggggaagc gcctgttatt cacaggctgc tggaggtgtt cactgagcac tggaggagtt
     2641 gtaatggctc cccatttgct aatagcgatg cctgctttgc cctggcctat gctgttatca
     2701 tgcttaacac tgaccaacat aaccacaatg ttcgcaagca aaatgcaccc atgaccctgg
     2761 aggagttccg caaaaacctg aaaggtgtga atggaggcaa ggactttgag caagacatcc
     2821 tggaagacat gtaccatgcc atcaagaatg aggaaattgt gatgcctgag gaacaaacag
     2881 gtctggttcg tgagaattat gtgtggagtg tgctgcttca tcgaggtgct acccctgagg
     2941 gcatcttcct tcgtgtaccc cctggcagct atgatcttga cctcttcact atgacctggg
     3001 gccccactat tgctgctctc tcttatgtgt tcgataaaag cctcgaggag accatcatcc
     3061 agaaagccat ctcaggcttc aggaagtgtg ccatgatctc cgcccactat ggcctcagcg
     3121 atgtgtttga caatctcatc atctctctgt gcaaattcac agctctaagt agtgagtcta
     3181 ttgagaacct gcccagtgta ttcggaagca accctaaagc ccacattgca gccaagacag
     3241 tattccattt ggcccatcgt catggtgaca tccttcggga gggctggaag aatatcatgg
     3301 aggccatgct gcagctcttc cgagcccaac ttttaccgaa ggctatggta gaggtagaag
     3361 attttgtgga tcccaatggt aagatctctc tacagcggga ggagacacca tcaaaccgag
     3421 gagagtcaac agtccttagt tttgtaagct ggctgacact gagtggtcct gagcagtcca
     3481 gtgtccgggg cccatcgaca gagaaccaag aggccaagcg agtagccttg gactgcatca
     3541 agcaatgtga cccagaaaag atgatcacag aaagcaagtt cctccagctg gaatctctgc
     3601 aggagctcat gaaggctctg gtctcggtga caccagatga agagacatat gatgaagaag
     3661 atgctgcttt ctgtctggag atgctgctaa ggattgtgtt agaaaacagg gaccgtgtgg
     3721 gctgtgtatg gcagactgtt cgagatcatc tataccacct gtgtgttcag gcacaagatt
     3781 tctgcttcct tgtggagcga gcagtggtag ggctgctacg cctagccatt cggctactcc
     3841 gaagagaaga gattagtggc caggtcctgc tctctctgcg catcttgtta ctgatgaagc
     3901 ccagcgtgct gtccagagtc agccaccagg tcgcttatgg gctgcatgaa ctcctcaaga
     3961 ccaatgctgc caacatccac tcgggtgatg actgggccac tctcttcaca ttgctggagt
     4021 gcattggctc aggcgtgaag cctccagatg ctctacaagc cacagccagg gctgatgctc
     4081 ctgatgctgg agcacaatcc gacagtgagc tcccatccta ccatcaaaat gatgtcagcc
     4141 tagaccgagg gtacacttcc gactcagaag tctacactga ccatggcagg cctggcaaga
     4201 tgcaccgatc agccacagac gctgacatgg ccaacagtgg ttggttagtg gtggggaagg
     4261 atgacattga taactccaaa ccagcagcag gactcagcag gccaggccct tcgcccttgg
     4321 tcaatcagta cagccttaca gtgggcctgg acctgggacc acatgacact aagtccttgc
     4381 ttaagtgtgt ggagtctctg tccttcattg ttcgtgatgc tgctcacatc acccctgaca
     4441 actttgaact ctgcgtcaag accctccgca tctttgtaga agccagtctg aatggtgggt
     4501 gcaagtccca ggataaacgt ggcaagagtc ataaatatga cagcaaaggg aaccggttca
     4561 agaaaaagcc caaggagggc tcgatgcttc ggcggccccg ggcatccagc cagcatgcca
     4621 ctcgggctgg acacagtgat gaagaggagg acgaaggcgt gcctgccagc taccatacgg
     4681 tgtctttaca ggtcagtcag gacttgctag acctgatgca caccctgcac acacgggcag
     4741 cctctatcta cagttcatgg gcagaggagc aacgccacct ggagacaggt ggccggaaga
     4801 ttgaagctga ctcacgtacc ctctgggccc actgctggtg ccctttatta caaggtatcg
     4861 cttgcttatg ctgtgacgcc cggcgccagg tgcggatgca ggccctgaca tatctccagc
     4921 gagcccttct ggtacatgac ctgcaaaagc tagatgccct ggaatgggag tcctgtttta
     4981 acaaggtgct gtttccgcta ctgaccaagc ttttagaaaa tatcagccct gcggatgtgg
     5041 gcgggatgga ggagacccgg atgcgggctt ccacactgct ctcaaaggtc ttcctgcagc
     5101 acctgtcccc actgctgtcc ctgtccacct ttgctgccct gtggctcacc atcctggact
     5161 tcatggacaa gtacatgcac gcaggttcca gtgacttgct gtcagaagct gtccctgagt
     5221 ctctgaagaa catgctcctt gtgatggaca cagcagagat tttccacagt gcagatgcaa
     5281 ggggaggcag cccctctgct ctctgggaga tcacctggga gcgcatcgat tgcttcttac
     5341 cacacctacg tgatgaactc ttcaagcaga ctgtcatcca ggaccccatg cccacagagc
     5401 ctcacagtca aaaacctctg gcttctactc acctgacgcc tgctgctggt gaccccagga
     5461 tgcctggcca tccacctcct ccagagatac cctcagaagt gggagcttgt gacccggaga
     5521 agcccgagag caccagagct gccagcagca gctcccctgg atcgccggtg gcctctagcc
     5581 ccagcaaaca gagtcctgcc ccagagggac ctcccccact ggcccagccc ccactaatcc
     5641 tacagccctt gacctcccca ctgcaggtgg gggtaccacc catgactttg cccatcatcc
     5701 tcaaccctgc actcattgag gccacctctc cagtgcctct cttagccacg ccacgcccta
     5761 cagaccccat ccccacctct gaggtcaact aaggcagcca ctcagaggtc aggaccattc
     5821 cttcctatca ggcattcaag gccctgcttc cagtcccagg ggccacagaa atcttcaggc
     5881 ccaaagcaag ctgctgttac cactgcttga cagggggatg acgatgttta tagtccctgc
     5941 tgggatccac tccaggctgc gaggttcttc ctctgccgtt cagtcctgaa cttccaagct
     6001 gagagtggat gcaggctgaa cctgtagcct ctgcctctgg cctggcagcc ctggggaggc
     6061 atagagccaa ccctgctgtg ccaaccctgc agtgcctgcc atgtgccccc tgccaggttg
     6121 ggcattagga gccaagcccg acctctctgc actttgttcc tctccctatc cagtccatca
     6181 gtcctgggcc actgcctcca gttcttcttc cttcattaaa tagttggtca gtttggagtc
     6241 gcttggcacc atggagggtg gacaggtagg actcgatggg gggtctgccc acaggagcat
     6301 gtacatatgg aaaaataaca ttggactttt tatgatataa taaatgtctt agtaccaaca
     6361 cagttccta
//
