LOCUS       NM_031031               2297 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Rattus norvegicus glycine amidinotransferase (Gatm), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_031031 XM_342508
VERSION     NM_031031.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2297)
  AUTHORS   Lai,Q., Yuan,G., Wang,H., Liu,Z., Kou,J., Yu,B. and Li,F.
  TITLE     Metabolomic profiling of metoprolol-induced cardioprotection in a
            murine model of acute myocardial ischemia
  JOURNAL   Biomed Pharmacother 124, 109820 (2020)
   PUBMED   31972362
REFERENCE   2  (bases 1 to 2297)
  AUTHORS   Ellery,S.J., Murthi,P., Gatta,P.A.D., May,A.K., Davies-Tuck,M.L.,
            Kowalski,G.M., Callahan,D.L., Bruce,C.R., Wallace,E.M.,
            Walker,D.W., Dickinson,H. and Snow,R.J.
  TITLE     The Effects of Early-Onset Pre-Eclampsia on Placental Creatine
            Metabolism in the Third Trimester
  JOURNAL   Int J Mol Sci 21 (3), 806 (2020)
   PUBMED   31991880
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2297)
  AUTHORS   Kazak,L., Chouchani,E.T., Lu,G.Z., Jedrychowski,M.P., Bare,C.J.,
            Mina,A.I., Kumari,M., Zhang,S., Vuckovic,I., Laznik-Bogoslavski,D.,
            Dzeja,P., Banks,A.S., Rosen,E.D. and Spiegelman,B.M.
  TITLE     Genetic Depletion of Adipocyte Creatine Metabolism Inhibits
            Diet-Induced Thermogenesis and Drives Obesity
  JOURNAL   Cell Metab 26 (4), 660-671 (2017)
   PUBMED   28844881
  REMARK    Erratum:[Cell Metab. 2017 Oct 3;26(4):693. PMID: 28978428]
REFERENCE   4  (bases 1 to 2297)
  AUTHORS   DesRoches,C.L., Bruun,T., Wang,P., Marshall,C.R. and
            Mercimek-Mahmutoglu,S.
  TITLE     Arginine-Glycine Amidinotransferase Deficiency and Functional
            Characterization of Missense Variants in GATM
  JOURNAL   Hum Mutat 37 (9), 926-932 (2016)
   PUBMED   27233232
REFERENCE   5  (bases 1 to 2297)
  AUTHORS   Stockler-Ipsiroglu,S., Apatean,D., Battini,R., DeBrosse,S.,
            Dessoffy,K., Edvardson,S., Eichler,F., Johnston,K., Koeller,D.M.,
            Nouioua,S., Tazir,M., Verma,A., Dowling,M.D., Wierenga,K.J.,
            Wierenga,A.M., Zhang,V. and Wong,L.J.
  TITLE     Arginine:glycine amidinotransferase (AGAT) deficiency: Clinical
            features and long term outcomes in 16 patients diagnosed worldwide
  JOURNAL   Mol Genet Metab 116 (4), 252-259 (2015)
   PUBMED   26490222
REFERENCE   6  (bases 1 to 2297)
  AUTHORS   Tormanen,C.D.
  TITLE     Comparison of the properties of purified mitochondrial and
            cytosolic rat kidney transamidinase
  JOURNAL   Int J Biochem 22 (11), 1243-1250 (1990)
   PUBMED   2257950
REFERENCE   7  (bases 1 to 2297)
  AUTHORS   Hirata,M.
  TITLE     [Study of impaired metabolism of guanidinoacetic acid in
            uremia--the compensatory role of the pancreas in guanidinoacetic
            acid synthesis]
  JOURNAL   Nihon Jinzo Gakkai Shi 31 (9), 951-961 (1989)
   PUBMED   2685430
REFERENCE   8  (bases 1 to 2297)
  AUTHORS   Kuwagaki,Y. and Sudo,J.
  TITLE     Interrelation of urinary and plasma levels of guanidinoacetic acid
            with alteration in renal activity of glycine amidinotransferase in
            acute renal failure rats
  JOURNAL   Chem Pharm Bull (Tokyo) 37 (3), 781-784 (1989)
   PUBMED   2752493
REFERENCE   9  (bases 1 to 2297)
  AUTHORS   Karelin,A.A.
  TITLE     [Creatine biosynthesis enzymes in the postnatal development of
            rats: the role of cyclo-3',5'-AMP and glucagon in the postnatal
            induction of liver guanidine acetate-N-methyltransferase]
  JOURNAL   Ontogenez 9 (2), 154-159 (1978)
   PUBMED   205820
REFERENCE   10 (bases 1 to 2297)
  AUTHORS   Magri,E., Baldoni,G. and Grazi,E.
  TITLE     On the biosynthesis of creatine. Intramitochondrial localization of
            transamidinase from rat kidney
  JOURNAL   FEBS Lett 55 (1), 91-93 (1975)
   PUBMED   1140432
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC081785.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_031031.3.
            
            On Dec 11, 2007 this sequence version replaced NM_031031.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081785.1, U07971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2297
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..2297
                     /gene="Gatm"
                     /note="glycine amidinotransferase"
                     /db_xref="GeneID:81660"
                     /db_xref="RGD:71090"
     exon            1..125
                     /gene="Gatm"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1328
                     /gene="Gatm"
                     /EC_number="2.1.4.1"
                     /note="glycine amidinotransferase, mitochondrial;
                     l-arginine:glycine amidinotransferase; AT; transamidinase;
                     L-arginine: glycine amidinotransferase"
                     /codon_start=1
                     /product="glycine amidinotransferase, mitochondrial
                     precursor"
                     /protein_id="NP_112293.1"
                     /db_xref="GeneID:81660"
                     /db_xref="RGD:71090"
                     /translation="MLRVRCLRGGSRGAEAVHYIGSRLGGSLTGWVQRTFQSTQAATA
                     SSQNSCAAEDKATHPLPKDCPVSSYNEWDPLEEVIVGRAENACVPPFTVEVKANTYEK
                     YWPFYQKNGGLYFPKDHLKKAVAEVEEMCNILSMEGVTVKRPDPIDWSLKYKTPDFES
                     TGLYSAMPRDILMVVGNEIIEAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTM
                     ADELYDQDYPIHSVEDRHKLAAQGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYL
                     GIEWMRRHLAPDYRVHIISFKDPNPMHIDATFNIIGPGLVLSNPDRPCHQIDLFKKAG
                     WTIVTPPTPVIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANEVPIQKMFEKLGISTIK
                     VNIRNANSLGGGFHCWTCDVRRRGTLQSYFD"
     exon            126..344
                     /gene="Gatm"
                     /inference="alignment:Splign:2.1.0"
     exon            345..540
                     /gene="Gatm"
                     /inference="alignment:Splign:2.1.0"
     exon            541..731
                     /gene="Gatm"
                     /inference="alignment:Splign:2.1.0"
     exon            732..869
                     /gene="Gatm"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1034
                     /gene="Gatm"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1098
                     /gene="Gatm"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1215
                     /gene="Gatm"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..2265
                     /gene="Gatm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgagcttg gcgactagga ccttgtgcac acagagcagc agcagaaacc ggggcgatgc
       61 tacgggtgcg gtgtctgcgc ggcggcagcc gaggcgccga ggcggtgcac tacatcggct
      121 ctcggcttgg aggatcctta acaggatggg tgcagcgaac tttccagagc acccaggcag
      181 ctacagcttc ctcccaaaat tcctgtgcag ctgaagacaa ggccacccac cccctgccca
      241 aggactgccc tgtctcctct tacaacgaat gggacccttt agaggaagtg atagtgggca
      301 gagctgaaaa tgcctgtgtc ccaccattca cagtggaggt gaaggccaat acatatgaaa
      361 agtactggcc gttttaccag aaaaatggag gtctttattt tcccaaagat catctgaaga
      421 aggctgttgc cgaggtcgaa gagatgtgca atattttatc aatggaaggc gtgaccgtga
      481 agcggcctga ccccattgac tggtcactga agtataagac tcctgatttt gagtctacag
      541 gtttatacag cgcgatgcct cgagacatcc tgatggttgt ggggaatgag attatagagg
      601 ctcccatggc atggcgctca cgcttctttg agtaccgcgc atacaggtca attatcaaag
      661 actacttcca ccgtggtgcc aagtggacaa cggcccccaa gcccacaatg gctgacgaac
      721 tgtatgacca ggactatccc atccattctg tggaagacag acacaaattg gccgctcagg
      781 ggaagttcgt gacaaccgag ttcgagcctt gctttgatgc tgctgacttc attcgagctg
      841 gaagagatat ttttgcgcag agaagccagg ttacaaacta cctgggcatc gagtggatgc
      901 gtaggcatct tgccccagac tacagagtgc atatcatctc gtttaaagac cccaatccaa
      961 tgcatattga tgccaccttc aacatcattg gacctggtct tgtgctctcc aaccctgacc
     1021 gtccatgcca tcagattgat cttttcaaga aagcaggatg gaccatagtt acccctccaa
     1081 cacctgtgat ccccgatgat catcccctct ggatgtcatc caagtggctc tccatgaatg
     1141 tcttaatgct agatgagaag cgcgtgatgg tagacgccaa tgaggtccca attcagaaga
     1201 tgtttgagaa gctgggtatc agcaccatta aggttaacat tcgaaatgcc aattccctgg
     1261 gaggaggctt ccactgctgg acctgcgacg tccgccgccg aggcaccctt cagtcctact
     1321 ttgactgagc ggccgtggtg tggcttgggg catagcctca gatataccta agaagcagca
     1381 aggcccttct ctcgctttaa taaatgcatg aactgtagtg ctttgaacaa tcacctcctt
     1441 aacagggttc ccaaacctgg gttacttttc gttgacataa ggaagataac ttttgatagg
     1501 tcttactttc ttctcctaaa gttatttaca atttggcttc aaatataaaa gttgagtaaa
     1561 tgtataccag ggcagaaatt agtcatttga gtaacttggc cgctaatatt taaccatcta
     1621 cctctgtttt taatcttctt tcctaaaggc agcttgaaat gtcggtccta accttgtctt
     1681 cttttcctct ctggtggact tgtgaatgtt catattactt caaagactta ggagaaaaac
     1741 acagacccta agtagaacca gatatttgtc tatttttcaa aaataattgg atgtttttta
     1801 aaattttgtt tttaaataac ctagactatg caaacactgg aaaaaaaatg aagtaacttt
     1861 tccatgaatg cttttaacat tcttgtgtca ccatttggta ctaaactcta gtcctgcctc
     1921 ttacctcatt tcaagtgggt tttccttcct tccttccttc cttccttcct cccttccttc
     1981 tttccttcct ttcttccaaa aacttagaga agtgcttggt ttaatagagt gaaacttgta
     2041 gatcctattc ctaaaggttg atgatgttca gtatctaaca ggtaaaatgg catctttgtt
     2101 aatctgtctt gtttacatat atgcaaatta tttaaggcat agagttttga agcatttttt
     2161 aaaaactaat gcaggtaaaa gaaatacatg tgacatgaaa taattttaat gttggatatt
     2221 gtatatgtat ttttattcta ataaactttt gtgttccaga ttggaaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa aaaaaaa
//
