LOCUS       NM_019185               3044 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Rattus norvegicus GATA binding protein 6 (Gata6), mRNA.
ACCESSION   NM_019185 XM_346506
VERSION     NM_019185.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3044)
  AUTHORS   Li,A., Gu,L., He,C., Li,Y., Peng,M., Liao,J., Xiao,R., Xu,L. and
            Guo,S.
  TITLE     GATA6 promotes fibrotic repair of tracheal injury through NLRP3
            inflammasome-mediated epithelial pyroptosis
  JOURNAL   Int Immunopharmacol 123, 110657 (2023)
   PUBMED   37531826
  REMARK    GeneRIF: GATA6 promotes fibrotic repair of tracheal injury through
            NLRP3 inflammasome-mediated epithelial pyroptosis.
REFERENCE   2  (bases 1 to 3044)
  AUTHORS   Fan,W., Rong,J., Shi,W., Liu,W., Wang,J., Tan,J., Yu,B. and Tong,J.
  TITLE     GATA6 Inhibits Neuronal Autophagy and Ferroptosis in Cerebral
            ischemia-reperfusion Injury Through a miR-193b/ATG7 axis-dependent
            Mechanism
  JOURNAL   Neurochem Res 48 (8), 2552-2567 (2023)
   PUBMED   37059928
  REMARK    GeneRIF: GATA6 Inhibits Neuronal Autophagy and Ferroptosis in
            Cerebral ischemia-reperfusion Injury Through a miR-193b/ATG7
            axis-dependent Mechanism.
REFERENCE   3  (bases 1 to 3044)
  AUTHORS   Feng,F., Wu,X., Shi,X., Gao,Q., Wu,Y., Yu,Y., Cheng,Q., Li,B.,
            Yi,B., Liu,C., Hao,Q., Zhang,L., Gao,C. and Jiang,X.
  TITLE     Comprehensive analysis of genomic alterations of Chinese hilar
            cholangiocarcinoma patients
  JOURNAL   Int J Clin Oncol 26 (4), 717-727 (2021)
   PUBMED   33387086
REFERENCE   4  (bases 1 to 3044)
  AUTHORS   Yoshida,T., Takizawa,N., Matsuda,T., Yamada,H., Kitada,M. and
            Tanaka,S.
  TITLE     GATA4/6 regulate DHH transcription in rat adrenocortical autografts
  JOURNAL   Sci Rep 10 (1), 446 (2020)
   PUBMED   31949236
  REMARK    GeneRIF: GATA4/6 regulate DHH transcription in rat adrenocortical
            autografts.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3044)
  AUTHORS   Salehi Jahromi,M., Hill,J.W., Ramezani Tehrani,F. and
            Zadeh-Vakili,A.
  TITLE     Hypomethylation of specific CpG sites in the promoter region of
            steroidogeneic genes (GATA6 and StAR) in prenatally androgenized
            rats
  JOURNAL   Life Sci 207, 105-109 (2018)
   PUBMED   29859221
  REMARK    GeneRIF: GATA6 and StAR steroidogeneic genes are hypomethylated at
            specific CpG sites in prenatally androgenized rats
REFERENCE   6  (bases 1 to 3044)
  AUTHORS   Nakagawa,R., Sato,R., Futai,M., Yokosawa,H. and Maeda,M.
  TITLE     Gastric GATA-6 DNA-binding protein: proteolysis induced by cAMP
  JOURNAL   FEBS Lett 408 (3), 301-305 (1997)
   PUBMED   9188781
REFERENCE   7  (bases 1 to 3044)
  AUTHORS   Morrisey,E.E., Ip,H.S., Lu,M.M. and Parmacek,M.S.
  TITLE     GATA-6: a zinc finger transcription factor that is expressed in
            multiple cell lineages derived from lateral mesoderm
  JOURNAL   Dev Biol 177 (1), 309-322 (1996)
   PUBMED   8660897
REFERENCE   8  (bases 1 to 3044)
  AUTHORS   Laverriere,A.C., MacNeill,C., Mueller,C., Poelmann,R.E., Burch,J.B.
            and Evans,T.
  TITLE     GATA-4/5/6, a subfamily of three transcription factors transcribed
            in developing heart and gut
  JOURNAL   J Biol Chem 269 (37), 23177-23184 (1994)
   PUBMED   8083222
REFERENCE   9  (bases 1 to 3044)
  AUTHORS   Tamura,S., Wang,X.H., Maeda,M. and Futai,M.
  TITLE     Gastric DNA-binding proteins recognize upstream sequence motifs of
            parietal cell-specific genes
  JOURNAL   Proc Natl Acad Sci U S A 91 (10), 4609 (1994)
   PUBMED   8183957
  REMARK    Correction to:[Proc Natl Acad Sci U S A. 1993 Nov
            15;90(22):10876-80. doi: 10.1073/pnas.90.22.10876.. PMID: 8248184]
REFERENCE   10 (bases 1 to 3044)
  AUTHORS   Tamura,S., Wang,X.H., Maeda,M. and Futai,M.
  TITLE     Gastric DNA-binding proteins recognize upstream sequence motifs of
            parietal cell-specific genes
  JOURNAL   Proc Natl Acad Sci U S A 90 (22), 10876-10880 (1993)
   PUBMED   8248184
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 May 10;91(10):4609. doi:
            10.1073/pnas.91.10.4609.. PMID: 8183957]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1, AI712574.1 and L22760.1.
            
            On May 5, 2015 this sequence version replaced NM_019185.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.3547288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                JAXUCZ010000018.1  2460909-2461005
            98-697              JAXUCZ010000018.1  2461606-2462205
            698-706             AI712574.1         29-37
            707-2127            L22760.1           254-1674
            2128-3044           JAXUCZ010000018.1  2491406-2492322
FEATURES             Location/Qualifiers
     source          1..3044
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..3044
                     /gene="Gata6"
                     /note="GATA binding protein 6"
                     /db_xref="GeneID:29300"
                     /db_xref="RGD:2666"
     exon            1..97
                     /gene="Gata6"
                     /inference="alignment:Splign:2.1.0"
     exon            98..1251
                     /gene="Gata6"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1898
                     /gene="Gata6"
                     /note="GATA-binding factor 6; DNA-binding protein
                     GATA-GT2"
                     /codon_start=1
                     /product="transcription factor GATA-6"
                     /protein_id="NP_062058.2"
                     /db_xref="GeneID:29300"
                     /db_xref="RGD:2666"
                     /translation="MALTDGGWCLPKRFGAAAADAGDSGPFPAREPSSPLSPISSSSS
                     SCSRGGDRGPCGASNCRTPQLDTEAVAGPPGRSLLLSPYTSHPFAAAHGAAAPGVAGP
                     GSALSTWEDLLLFTDLDQAATASKLLWSSRGAKLSPFAAEQPEEMYQTLAALSSQGPA
                     AYDGAPGGFVHSAAAAAAAAAAASSPVYVPTTRVGSMLPGLPYLQGAGSGPSNHAGGA
                     GAHPGWPQASADSPPYGGGGAAGGGAAGPGGAGSATAHASARFPYSPSPPMANGAARD
                     PGGYVAAGGAGAGSVSGGGGSLAAMGGREHQYSSLSAARPLNGTYHHHHHHHPTYSPY
                     MGAPLTPAWPAGPFETPVLHSLQSRAGAPLPVPRGPSADLLEDLSESRECVNCGSIQT
                     PLWRRDGTGHYLCNACGLYSKMNGLSRPLIKPQKRVPSSRRLGLSCANCHTTTTTLWR
                     RNAEGEPVCNACGLYMKLHGVPRPLAMKKEGIQTRKRKPKNINKSKACSGNSSVPMTP
                     TSSSSNSDDCTKNTSPPTQSTASGVGASVMSAVGESANPENSDLKYSGQDGLYIGVSL
                     SSPAEVTSSVRQDSWCALALA"
     exon            1252..1418
                     /gene="Gata6"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1544
                     /gene="Gata6"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1632
                     /gene="Gata6"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1730
                     /gene="Gata6"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..3044
                     /gene="Gata6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggttgtg aggcggtctg tgtttaaggt gtaccgttgg cctggacgtg gttggacgtg
       61 aggttttgcc gagtgggttt ccagcactgt ttcctaggaa ccaaaagtca ggttggagca
      121 gcgccggaca gtggatggcc ttgactgacg gcggctggtg cctgccgaag cgtttcgggg
      181 ctgctgctgc ggacgccggc gactctgggc cctttccagc gcgggagccc tcctcgccgc
      241 tctcccccat ctcgtcctct tcctcctcct gctcccgggg tggggatcgt ggtccctgcg
      301 gcgccagcaa ctgcaggacg ccgcagctcg acactgaggc ggtggcggga cctccgggcc
      361 gctcgctctt gctcagcccc tacacttccc atcccttcgc cgctgctcac ggagccgcgg
      421 cgcccggggt cgctggcccc gggagcgccc tgtcgacttg ggaggacctg ttgctcttca
      481 ctgacctcga tcaggccgcg accgccagca agctgctgtg gtccagccgg ggcgccaagc
      541 tgagtccctt cgcggccgag cagccggagg aaatgtacca gacgctcgcc gctctgtcca
      601 gccaggggcc cgccgcttac gacggcgcgc ccggcggctt cgtacactcc gcagctgcgg
      661 cggccgcggc ggccgcggca gccagctctc cggtctacgt gcccaccaca cgcgtgggct
      721 ccatgctgcc cggcctgcct tacctgcagg gggcgggcag cgggcccagc aatcacgcgg
      781 gcggcgcggg cgcccacccg ggctggcccc aggcctccgc cgacagcccc ccgtatggcg
      841 ggggtggtgc agcgggcggc ggcgcggccg gacccggagg tgcgggatca gccacagccc
      901 acgcctctgc acgcttcccc tactcgccca gcccgcccat ggccaacggc gccgcgcggg
      961 accccggggg ctacgtggct gcgggcggcg cgggcgcggg tagcgtgagt ggcggtggcg
     1021 gcagcctggc ggccatgggt ggccgggagc accagtacag ctcgctgtcc gcagccaggc
     1081 cgctgaacgg gacgtaccac caccaccatc atcaccaccc gacctactcg ccctacatgg
     1141 gcgctcctct gactcccgcc tggccagcgg gacccttcga aacgccggtg ctccacagtt
     1201 tacagagccg cgcgggagct ccactcccgg tgccacgagg ccccagcgca gacctgttgg
     1261 aggacctgtc ggagagccgc gagtgcgtga actgtggctc catccagacg ccactgtgga
     1321 gacgagatgg caccggtcat tacctgtgca acgcatgcgg tctctacagt aagatgaacg
     1381 gcctcagcag gcccctcatc aagccacaga agcgcgtgcc ttcatcacga cggcttggac
     1441 tgtcctgtgc caactgtcac accacaacca ctaccttatg gcgtagaaac gctgagggtg
     1501 agcccgtgtg caatgcttgc gggctttata tgaaactcca tggggtgcct cgaccacttg
     1561 ctatgaaaaa agaaggaatt caaaccagga aacgaaaacc taaaaatata aataagtcga
     1621 aagcttgctc cggtaacagc tctgttccta tgactccaac ttcctcctcc tctaattcag
     1681 atgactgcac caaaaatact tctcctccca cacagtcgac tgcctcaggg gtgggtgcat
     1741 cagtgatgtc tgcagtggga gaaagtgcca accctgagaa cagtgacctc aagtattcag
     1801 gtcaagatgg cctctacata ggtgtcagtt tgtcctcccc tgccgaagtt acatcctcgg
     1861 tgcgacagga ttcttggtgt gctctggccc tggcctgagc tggtgctgcc aagggctctg
     1921 aaggcctcat accacttgtg tctgattttg tccagcagtc cagatggcgg caaaaaatgc
     1981 agacataaca ttccttcgat gcgtgatttc tgtgcctttg ttttgaaaga gatatatttc
     2041 ccaagaagct tattgaagta agaagagatg ggtctttgta ggaaggggca gcacagtggg
     2101 cgtgtggcct attcctgtca gcctgggctg cttccagcca gcttgcctct ggctctgctc
     2161 cacaccagtg ggagaaactg tgacaatgac tggggccttg tctgctaagg aagattgaga
     2221 gattaaaaaa aaatagtttg tgtattgctc caaatcatgt gcttcttgtg atcaaccttg
     2281 gttatcccag aattctttca tccctgatct acgtgcacat ttcacaagca ttcgtggaga
     2341 ggagcattgg aggccattag gtccatcctg gaggctgagt gcattcctgg ggtcttgaaa
     2401 agaatattag tttgcaagat cgcattatga cagacactga ctgacttatc tcaacgttta
     2461 ttgtaacgtg gctgatctga ggtcacttgg aatttgtaaa cagggtagca aacaagatat
     2521 ttttcttcca tgtacacaat aattttttta agtgcaattt gcgttgcagc aatcagtgtt
     2581 aaatcatttg cataagattt aacagcattt ttataatgaa tgtaaacatt ttaacttaat
     2641 ggtacttaaa ataatttaaa aaaatgttaa ctttagacat atgcttctta cacccacagc
     2701 ccacttctgt attcccaatt gtttaaaaga aaaacgattt caagaacaaa tcttctctca
     2761 ggaaattgac tttctccatt tatgaatttt tatacaagaa caccaacaca tccccatttc
     2821 ttttactgag gaaaaagtgc tggaaaattg caacaaacct ttactaccta aagaatagca
     2881 tttgtaaata gtttaagcat ctgtaaacac tcgtgacgtc tgtaccgtgt gactaaccca
     2941 caggttggtt tacattatta ttttttttta aagggatatc gtatggaaac ctatttcacc
     3001 agagttttaa aaaaaataaa aagggtattg ttttgtgttc tgta
//
