LOCUS       NP_062058                587 aa            linear   ROD 28-APR-2025
DEFINITION  transcription factor GATA-6 [Rattus norvegicus].
ACCESSION   NP_062058 XP_346507
VERSION     NP_062058.2
DBSOURCE    REFSEQ: accession NM_019185.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 587)
  AUTHORS   Li,A., Gu,L., He,C., Li,Y., Peng,M., Liao,J., Xiao,R., Xu,L. and
            Guo,S.
  TITLE     GATA6 promotes fibrotic repair of tracheal injury through NLRP3
            inflammasome-mediated epithelial pyroptosis
  JOURNAL   Int Immunopharmacol 123, 110657 (2023)
   PUBMED   37531826
  REMARK    GeneRIF: GATA6 promotes fibrotic repair of tracheal injury through
            NLRP3 inflammasome-mediated epithelial pyroptosis.
REFERENCE   2  (residues 1 to 587)
  AUTHORS   Fan,W., Rong,J., Shi,W., Liu,W., Wang,J., Tan,J., Yu,B. and Tong,J.
  TITLE     GATA6 Inhibits Neuronal Autophagy and Ferroptosis in Cerebral
            ischemia-reperfusion Injury Through a miR-193b/ATG7 axis-dependent
            Mechanism
  JOURNAL   Neurochem Res 48 (8), 2552-2567 (2023)
   PUBMED   37059928
  REMARK    GeneRIF: GATA6 Inhibits Neuronal Autophagy and Ferroptosis in
            Cerebral ischemia-reperfusion Injury Through a miR-193b/ATG7
            axis-dependent Mechanism.
REFERENCE   3  (residues 1 to 587)
  AUTHORS   Feng,F., Wu,X., Shi,X., Gao,Q., Wu,Y., Yu,Y., Cheng,Q., Li,B.,
            Yi,B., Liu,C., Hao,Q., Zhang,L., Gao,C. and Jiang,X.
  TITLE     Comprehensive analysis of genomic alterations of Chinese hilar
            cholangiocarcinoma patients
  JOURNAL   Int J Clin Oncol 26 (4), 717-727 (2021)
   PUBMED   33387086
REFERENCE   4  (residues 1 to 587)
  AUTHORS   Yoshida,T., Takizawa,N., Matsuda,T., Yamada,H., Kitada,M. and
            Tanaka,S.
  TITLE     GATA4/6 regulate DHH transcription in rat adrenocortical autografts
  JOURNAL   Sci Rep 10 (1), 446 (2020)
   PUBMED   31949236
  REMARK    GeneRIF: GATA4/6 regulate DHH transcription in rat adrenocortical
            autografts.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 587)
  AUTHORS   Salehi Jahromi,M., Hill,J.W., Ramezani Tehrani,F. and
            Zadeh-Vakili,A.
  TITLE     Hypomethylation of specific CpG sites in the promoter region of
            steroidogeneic genes (GATA6 and StAR) in prenatally androgenized
            rats
  JOURNAL   Life Sci 207, 105-109 (2018)
   PUBMED   29859221
  REMARK    GeneRIF: GATA6 and StAR steroidogeneic genes are hypomethylated at
            specific CpG sites in prenatally androgenized rats
REFERENCE   6  (residues 1 to 587)
  AUTHORS   Nakagawa,R., Sato,R., Futai,M., Yokosawa,H. and Maeda,M.
  TITLE     Gastric GATA-6 DNA-binding protein: proteolysis induced by cAMP
  JOURNAL   FEBS Lett 408 (3), 301-305 (1997)
   PUBMED   9188781
REFERENCE   7  (residues 1 to 587)
  AUTHORS   Morrisey,E.E., Ip,H.S., Lu,M.M. and Parmacek,M.S.
  TITLE     GATA-6: a zinc finger transcription factor that is expressed in
            multiple cell lineages derived from lateral mesoderm
  JOURNAL   Dev Biol 177 (1), 309-322 (1996)
   PUBMED   8660897
REFERENCE   8  (residues 1 to 587)
  AUTHORS   Laverriere,A.C., MacNeill,C., Mueller,C., Poelmann,R.E., Burch,J.B.
            and Evans,T.
  TITLE     GATA-4/5/6, a subfamily of three transcription factors transcribed
            in developing heart and gut
  JOURNAL   J Biol Chem 269 (37), 23177-23184 (1994)
   PUBMED   8083222
REFERENCE   9  (residues 1 to 587)
  AUTHORS   Tamura,S., Wang,X.H., Maeda,M. and Futai,M.
  TITLE     Gastric DNA-binding proteins recognize upstream sequence motifs of
            parietal cell-specific genes
  JOURNAL   Proc Natl Acad Sci U S A 91 (10), 4609 (1994)
   PUBMED   8183957
  REMARK    Correction to:[Proc Natl Acad Sci U S A. 1993 Nov
            15;90(22):10876-80. doi: 10.1073/pnas.90.22.10876. PMID: 8248184]
REFERENCE   10 (residues 1 to 587)
  AUTHORS   Tamura,S., Wang,X.H., Maeda,M. and Futai,M.
  TITLE     Gastric DNA-binding proteins recognize upstream sequence motifs of
            parietal cell-specific genes
  JOURNAL   Proc Natl Acad Sci U S A 90 (22), 10876-10880 (1993)
   PUBMED   8248184
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 May 10;91(10):4609. doi:
            10.1073/pnas.91.10.4609. PMID: 8183957]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1, AI712574.1 and L22760.1.
            
            On May 5, 2015 this sequence version replaced NP_062058.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.3547288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     Protein         1..587
                     /product="transcription factor GATA-6"
                     /note="GATA-binding factor 6; DNA-binding protein
                     GATA-GT2"
                     /calculated_mol_wt=59037
     Region          17..73
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P46153.2)"
     Region          147..371
                     /region_name="GATA-N"
                     /note="GATA-type transcription activator, N-terminal;
                     pfam05349"
                     /db_xref="CDD:461628"
     Region          209..259
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P46153.2)"
     Site            266
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P46153.2)"
     Region          383..428
                     /region_name="ZnF_GATA"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     cd00202"
                     /db_xref="CDD:238123"
     Site            order(384,387,405,408)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:238123"
     Site            order(393..394,396,405..415)
                     /site_type="DNA binding"
                     /note="DNA-binding region [nucleotide binding]"
                     /db_xref="CDD:238123"
     Region          <437..>582
                     /region_name="GAT1"
                     /note="GATA Zn-finger-containing transcription factor
                     [Transcription]; COG5641"
                     /db_xref="CDD:227928"
     Region          437..488
                     /region_name="ZnF_GATA"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     cd00202"
                     /db_xref="CDD:238123"
     Site            order(438,441,459,462)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:238123"
     Site            order(447..448,450,459..469,485,487..488)
                     /site_type="DNA binding"
                     /note="DNA-binding region [nucleotide binding]"
                     /db_xref="CDD:238123"
     Region          480..532
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P46153.2)"
     CDS             1..587
                     /gene="Gata6"
                     /coded_by="NM_019185.2:135..1898"
                     /db_xref="GeneID:29300"
                     /db_xref="RGD:2666"
ORIGIN      
        1 maltdggwcl pkrfgaaaad agdsgpfpar epssplspis ssssscsrgg drgpcgasnc
       61 rtpqldteav agppgrslll spytshpfaa ahgaaapgva gpgsalstwe dlllftdldq
      121 aataskllws srgaklspfa aeqpeemyqt laalssqgpa aydgapggfv hsaaaaaaaa
      181 aaasspvyvp ttrvgsmlpg lpylqgagsg psnhaggaga hpgwpqasad sppyggggaa
      241 gggaagpgga gsatahasar fpyspsppma ngaardpggy vaaggagags vsggggslaa
      301 mggrehqyss lsaarplngt yhhhhhhhpt yspymgaplt pawpagpfet pvlhslqsra
      361 gaplpvprgp sadlledlse srecvncgsi qtplwrrdgt ghylcnacgl yskmnglsrp
      421 likpqkrvps srrlglscan chtttttlwr rnaegepvcn acglymklhg vprplamkke
      481 giqtrkrkpk ninkskacsg nssvpmtpts sssnsddctk ntspptqsta sgvgasvmsa
      541 vgesanpens dlkysgqdgl yigvslsspa evtssvrqds wcalala
//
