LOCUS       NM_144730               3313 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus GATA binding protein 4 (Gata4), mRNA.
ACCESSION   NM_144730
VERSION     NM_144730.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3313)
  AUTHORS   Huang,Z., Zeng,Z., Li,J., Cai,R., He,W. and Hu,S.
  TITLE     [High expression of Circ-PALLD in heart failure is
            transcriptionally regulated by the transcription factor GATA4]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (8), 1371-1378 (2023)
   PUBMED   37712274
  REMARK    GeneRIF: [High expression of Circ-PALLD in heart failure is
            transcriptionally regulated by the transcription factor GATA4].
REFERENCE   2  (bases 1 to 3313)
  AUTHORS   Ma,C.X., Wei,Z.R., Sun,T., Yang,M.H., Sun,Y.Q., Kai,K.L., Shi,J.C.,
            Zhou,M.J., Wang,Z.W., Chen,J., Li,W., Wang,T.Q., Zhang,S.F.,
            Xue,L., Zhang,M., Yin,Q. and Zang,M.X.
  TITLE     Circ-sh3rf3/GATA-4/miR-29a regulatory axis in
            fibroblast-myofibroblast differentiation and myocardial fibrosis
  JOURNAL   Cell Mol Life Sci 80 (2), 50 (2023)
   PUBMED   36694058
  REMARK    GeneRIF: Circ-sh3rf3/GATA-4/miR-29a regulatory axis in
            fibroblast-myofibroblast differentiation and myocardial fibrosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3313)
  AUTHORS   Liu,L., Peng,Y., Liu,W., Xu,J., Li,D. and Li,X.
  TITLE     GATA-binding protein 4 promotes neuroinflammation and cognitive
            impairment in Abeta1-42 fibril-infused rats through small nucleolar
            RNA host gene 1/miR-361-3p axis
  JOURNAL   Chin J Physiol 66 (1), 14-20 (2023)
   PUBMED   36814152
  REMARK    GeneRIF: GATA-binding protein 4 promotes neuroinflammation and
            cognitive impairment in Abeta1-42 fibril-infused rats through small
            nucleolar RNA host gene 1/miR-361-3p axis.
REFERENCE   4  (bases 1 to 3313)
  AUTHORS   Wang,X.H., Gao,J.W., Bao,J.P., Zhu,L., Xie,Z.Y., Chen,L., Peng,X.,
            Zhang,C. and Wu,X.T.
  TITLE     GATA4 promotes the senescence of nucleus pulposus cells via
            NF-kappaB pathway
  JOURNAL   Arch Gerontol Geriatr 101, 104676 (2022)
   PUBMED   35286985
  REMARK    GeneRIF: GATA4 promotes the senescence of nucleus pulposus cells
            via NF-kappaB pathway.
REFERENCE   5  (bases 1 to 3313)
  AUTHORS   Duan,X., Miao,Z. and Chen,J.
  TITLE     LncRNA KCNQ1OT1 attenuates myocardial injury induced by hip
            fracture via regulating of miR-224-3p/GATA4 axis
  JOURNAL   Int Immunopharmacol 107, 108627 (2022)
   PUBMED   35217336
  REMARK    GeneRIF: LncRNA KCNQ1OT1 attenuates myocardial injury induced by
            hip fracture via regulating of miR-224-3p/GATA4 axis.
REFERENCE   6  (bases 1 to 3313)
  AUTHORS   Soudais,C., Bielinska,M., Heikinheimo,M., MacArthur,C.A.,
            Narita,N., Saffitz,J.E., Simon,M.C., Leiden,J.M. and Wilson,D.B.
  TITLE     Targeted mutagenesis of the transcription factor GATA-4 gene in
            mouse embryonic stem cells disrupts visceral endoderm
            differentiation in vitro
  JOURNAL   Development 121 (11), 3877-3888 (1995)
   PUBMED   8582296
REFERENCE   7  (bases 1 to 3313)
  AUTHORS   Molkentin,J.D., Kalvakolanu,D.V. and Markham,B.E.
  TITLE     Transcription factor GATA-4 regulates cardiac muscle-specific
            expression of the alpha-myosin heavy-chain gene
  JOURNAL   Mol Cell Biol 14 (7), 4947-4957 (1994)
   PUBMED   8007990
REFERENCE   8  (bases 1 to 3313)
  AUTHORS   Tamura,S., Wang,X.H., Maeda,M. and Futai,M.
  TITLE     Gastric DNA-binding proteins recognize upstream sequence motifs of
            parietal cell-specific genes
  JOURNAL   Proc Natl Acad Sci U S A 91 (10), 4609 (1994)
   PUBMED   8183957
  REMARK    Correction to:[Proc Natl Acad Sci U S A. 1993 Nov
            15;90(22):10876-80. doi: 10.1073/pnas.90.22.10876. PMID: 8248184]
REFERENCE   9  (bases 1 to 3313)
  AUTHORS   Tamura,S., Wang,X.H., Maeda,M. and Futai,M.
  TITLE     Gastric DNA-binding proteins recognize upstream sequence motifs of
            parietal cell-specific genes
  JOURNAL   Proc Natl Acad Sci U S A 90 (22), 10876-10880 (1993)
   PUBMED   8248184
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 May 10;91(10):4609. doi:
            10.1073/pnas.91.10.4609. PMID: 8183957]
REFERENCE   10 (bases 1 to 3313)
  AUTHORS   Arceci,R.J., King,A.A., Simon,M.C., Orkin,S.H. and Wilson,D.B.
  TITLE     Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription
            factor expressed in endodermally derived tissues and heart
  JOURNAL   Mol Cell Biol 13 (4), 2235-2246 (1993)
   PUBMED   8455608
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L22761.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L22761.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3313
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..3313
                     /gene="Gata4"
                     /note="GATA binding protein 4"
                     /db_xref="GeneID:54254"
                     /db_xref="RGD:2665"
     exon            1..78
                     /gene="Gata4"
                     /inference="alignment:Splign:2.1.0"
     exon            79..1174
                     /gene="Gata4"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1341
                     /gene="Gata4"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1467
                     /gene="Gata4"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1555
                     /gene="Gata4"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1707
                     /gene="Gata4"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..3311
                     /gene="Gata4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgaggctc cgctgttgct gcagctccgc ggactcacgg agatcgcgcc ggctctctgg
       61 gaaactggag ctggccagga ctgtcgcttc gaagggaacg ggccctcttc gtccttcgct
      121 ggagccgcac tggagccacc aaatgcgcct gggtgtgcag caggcagaaa gcaaggacta
      181 ggcacctcta gcccgtgggt gatccgaagg cctgcgcagg gtgttcgaga ccagtcttga
      241 ctgagttctg ggcatctcca gcctctgggc cctggagtag agtcagccct cctgcagttt
      301 ctggagcaac cacaaatcca atttgggatt tttgttttct tcttgagcaa accagagcct
      361 aaagattgtt gctctgatgc tggatttaat tcgtatatat tttgagcgag ttgggcctgt
      421 cctcattgtt ttttgatctc cgttttcgcg acagttctgc acacctgtat tccaattctt
      481 gtcgctttgg tctgccgcgc ccgcgtgggc tccttgactt gcaaataaag gggagcacac
      541 cgaagctcag agcttggggc gatgtaccaa agcctggcta tggccgccaa ccacgggccc
      601 ccgccgggcg cctacgaagc gggtggacct ggcgccttca tgcacagtgc gggcgccgcg
      661 tcctcgcccg tctacgtgcc cactccgcgg gtgccgtcct ctgtgctggg cctgtcctac
      721 ctgcagggcg gaggcagtgg tgctgcttct ggagccacct cgggtggcag ctccggggcc
      781 ggcccgtcgg gtgctgggcc tgggacccag cagggtagcc cgggctggag ccaggctgga
      841 gctgagggag ccgcttacac cccaccgcct gtgtccccgc gcttctcctt cccggggact
      901 actgggtccc tggcggccgc cgccgccgct gccgcagccc gggaagctgc agcctacagc
      961 agtagcggcg gggcagccgg cgctggcctg gctggccgag agcagtacgg gcgtccgggc
     1021 ttcgcaggct cctactccag cccctaccca gcctacatgg ccgatgtggg cgcatcctgg
     1081 gccgcagccg ctgccgcctc cgccggcccc ttcgacagcc cagtcctgca cagcctacct
     1141 ggccgggcca accctgcgag acaccccaat ctcgatatgt ttgatgactt ctcagaaggc
     1201 agagagtgtg tcaactgcgg ggccatgtcc accccactct ggaggcgaga tgggacagga
     1261 cactacctat gcaacgcctg tggcctctac cacaagatga atggtatcaa ccggcccctc
     1321 atcaagcctc agcgccggct gtctgcctcc cgccgggtag gcctctcctg tgccaactgc
     1381 cagactacca ccaccacact gtggcgccgt aacgctgagg gcgagcctgt ttgcaatgcc
     1441 tgcggcctct acatgaagct ccatggggtt cccaggcctc ttgcaatgcg gaaggagggg
     1501 attcaaacca gaaaacggaa gcccaagaat ctgaataaat ctaagacacc agcaggtcct
     1561 cctggcgaga gcctccctcc ctccagtggt gcctccagca actccagcaa cgccaccagc
     1621 agcagcagca gcagtgaaga gatgcgcccc atcaagacag agcccgggct gtcatctcac
     1681 tatgggcaca gcagctccat gtcccagaca ttcagtactg tgtccggcca tgggtcctcc
     1741 atccatccag tgctgtcggc tctgaagctc tccccacaag gctatccatc tcctgtcact
     1801 cagacatcac aggccagctc caagcaggac tcttggaaca gcctggtcct ggctgacagt
     1861 catggggaca taatcaccgc gtaatcagca cccccttccc tcttcaaatt cctgctcgga
     1921 cttgggacct ggggccagca aagtaaaagg ctggggcacc ctggccagcc cctctgtgtg
     1981 ggaacaactc ctgaagaaca actggtagaa cttgaagttg ttgacaatca cttagggata
     2041 agggtgctgg gtttcttcaa atacctttcc aggtggagca ctggaagaag cctgcattct
     2101 cacagaaaag cccaccttgg ctgcaagcac agcacagtga ggctcttcag tgagcaggag
     2161 acttcttcct ccttctctac ctgcctgtcc aggacagaca cataatcttc accccagctc
     2221 cccaccccag tggctgtggt gatgggtttt tctttgtgat cctagagtgg ctgtagggac
     2281 cgaggcttca agacactgtc tacagccggc gcagggtgtc tacttgtgga ctagacatag
     2341 cagccctgcc cttgtccaac actccccttg aggcatggaa catctcatgt gtcccatacc
     2401 tgatctgact ccaaagcgct gggtgcagtg cagatgttac tgagtgcttc ctggggggtt
     2461 taggtgagga gaaggcacat cacccatcac acagatcgca gcccgtcaga ggtgccttcc
     2521 cttcctctcc caggaacagc aacccccttg ctctccagcc tgaacatctc ctaccctctg
     2581 taaaactaga gcccagttgt acagcaggct aataccacta ggtgctgttc ccagcatcca
     2641 tttccacctc ttcacacaca ggggttccaa ggaggaacaa aacctgctac taaagcaggg
     2701 ttggtgactg tgctcatctg caccttggga ccctctggag gttgtgtcta cagcacaatc
     2761 ctgcccccag gactccagct tacttgctct gagcctgcca agccaagctc tctcaagtca
     2821 gacagttaac tggctctggg actttctcca gcacagatcc tttgtctaga aaatacggac
     2881 tgtttgcaaa acaaattcag agcagaaaca acaaagggaa atttttgaaa ggacaagggt
     2941 gatggatgga agaagatgtc cccaggcctg atgggacagc catgcttgca gttgtgctag
     3001 aactggcaac ccctctccct cctccattac tggggctccc aaagattctt ccttgtcttc
     3061 atcacccaca gagctgtagc caactgtggc attaccttgt tttgccccaa atttccagcc
     3121 ccgcccctaa accttactgg ccgtagcaga gaatagcttt gaaccaagat tctgttgtaa
     3181 tcatttacgc tgtttctccc tcaaggccgc cttcctatgc ctccccctcc tccacaaccc
     3241 gttaacattg tcttaaggtg aaatggctgt aaaatcagta tttaactaat aaatttatct
     3301 gtattactct taa
//
