LOCUS       NM_133293               3867 bp    mRNA    linear   ROD 24-SEP-2023
DEFINITION  Rattus norvegicus GATA binding protein 3 (Gata3), mRNA.
ACCESSION   NM_133293 XM_006254253
VERSION     NM_133293.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3867)
  AUTHORS   Su L, Nian Y and Zhu T.
  TITLE     Circ_PWWP2A promotes lung fibroblast proliferation and fibrosis via
            the miR-27b-3p/GATA3 axis, thereby aggravating idiopathic pulmonary
            fibrosis
  JOURNAL   Acta Biochim Pol 70 (3), 525-532 (2023)
   PUBMED   37672715
  REMARK    GeneRIF: Circ_PWWP2A promotes lung fibroblast proliferation and
            fibrosis via the miR-27b-3p/GATA3 axis, thereby aggravating
            idiopathic pulmonary fibrosis.
REFERENCE   2  (bases 1 to 3867)
  AUTHORS   He F, Wang N, Yu X, Zheng Y, Liu Q, Chen Q, Pu J, Li N, Zou W, Li B
            and Ran P.
  TITLE     GATA3/long noncoding RNA MHC-R regulates the immune activity of
            dendritic cells in chronic obstructive pulmonary disease induced by
            air pollution particulate matter
  JOURNAL   J Hazard Mater 438, 129459 (2022)
   PUBMED   35780733
  REMARK    GeneRIF: GATA3/long noncoding RNA MHC-R regulates the immune
            activity of dendritic cells in chronic obstructive pulmonary
            disease induced by air pollution particulate matter.
REFERENCE   3  (bases 1 to 3867)
  AUTHORS   Guida N, Mascolo L, Serani A, Cuomo O, Anzilotti S, Brancaccio P,
            Pignataro G, Molinaro P, Annunziato L and Formisano L.
  TITLE     GATA3 (GATA-Binding Protein 3)/KMT2A (Lysine-Methyltransferase-2A)
            Complex by Increasing H3K4-3me (Trimethylated Lysine-4 of
            Histone-3) Upregulates NCX3 (Na+-Ca2+ Exchanger 3) Transcription
            and Contributes to Ischemic Preconditioning Neuroprotection
  JOURNAL   Stroke 52 (11), 3680-3691 (2021)
   PUBMED   34694864
REFERENCE   4  (bases 1 to 3867)
  AUTHORS   Grigorieva IV, Oszwald A, Grigorieva EF, Schachner H, Neudert B,
            Ostendorf T, Floege J, Lindenmeyer MT, Cohen CD, Panzer U, Aigner
            C, Schmidt A, Grosveld F, Thakker RV, Rees AJ and Kain R.
  TITLE     A Novel Role for GATA3 in Mesangial Cells in Glomerular Development
            and Injury
  JOURNAL   J Am Soc Nephrol 30 (9), 1641-1658 (2019)
   PUBMED   31405951
  REMARK    GeneRIF: we identified a novel, nonredundant role for GATA3 in MCs
            from their first appearance in embryonic kidney to mature glomeruli
            in health and disease. Furthermore, GATA3 expression increases
            inMCs in mesangial proliferative GN and haploinsufficiency of GATA3
            results in MC defects, suggesting its importance for glomerular
            homeostasis and response to injury.
REFERENCE   5  (bases 1 to 3867)
  AUTHORS   Wang L, Song G, Tan W, Qi M, Zhang L, Chan J, Yu J, Han J and Han
            B.
  TITLE     MiR-573 inhibits prostate cancer metastasis by regulating
            epithelial-mesenchymal transition
  JOURNAL   Oncotarget 6 (34), 35978-35990 (2015)
   PUBMED   26451614
REFERENCE   6  (bases 1 to 3867)
  AUTHORS   Siegel MD, Zhang DH, Ray P and Ray A.
  TITLE     Activation of the interleukin-5 promoter by cAMP in murine EL-4
            cells requires the GATA-3 and CLE0 elements
  JOURNAL   J Biol Chem 270 (41), 24548-24555 (1995)
   PUBMED   7592673
REFERENCE   7  (bases 1 to 3867)
  AUTHORS   Pandolfi PP, Roth ME, Karis A, Leonard MW, Dzierzak E, Grosveld FG,
            Engel JD and Lindenbaum MH.
  TITLE     Targeted disruption of the GATA3 gene causes severe abnormalities
            in the nervous system and in fetal liver haematopoiesis
  JOURNAL   Nat Genet 11 (1), 40-44 (1995)
   PUBMED   7550312
REFERENCE   8  (bases 1 to 3867)
  AUTHORS   Ng YK, George KM, Engel JD and Linzer DI.
  TITLE     GATA factor activity is required for the trophoblast-specific
            transcriptional regulation of the mouse placental lactogen I gene
  JOURNAL   Development 120 (11), 3257-3266 (1994)
   PUBMED   7720565
REFERENCE   9  (bases 1 to 3867)
  AUTHORS   Marine J and Winoto A.
  TITLE     The human enhancer-binding protein Gata3 binds to several T-cell
            receptor regulatory elements
  JOURNAL   Proc Natl Acad Sci U S A 88 (16), 7284-7288 (1991)
   PUBMED   1871134
REFERENCE   10 (bases 1 to 3867)
  AUTHORS   Ko LJ, Yamamoto M, Leonard MW, George KM, Ting P and Engel JD.
  TITLE     Murine and human T-lymphocyte GATA-3 factors mediate transcription
            through a cis-regulatory element within the human T-cell receptor
            delta gene enhancer
  JOURNAL   Mol Cell Biol 11 (5), 2778-2784 (1991)
   PUBMED   2017177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000294.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_133293.3.
            
            On or before Sep 28, 2022 this sequence version replaced
            XM_006254253.4, NM_133293.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY024364.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132261, SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               JACYVU010000294.1  7219835-7220052
            219-870             JACYVU010000294.1  7220464-7221115
            871-1407            JACYVU010000294.1  7223472-7224008
            1408-1553           JACYVU010000294.1  7229591-7229736
            1554-1679           JACYVU010000294.1  7235138-7235263
            1680-3867           JACYVU010000294.1  7239775-7241962
FEATURES             Location/Qualifiers
     source          1..3867
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..3867
                     /gene="Gata3"
                     /note="GATA binding protein 3"
                     /db_xref="GeneID:85471"
                     /db_xref="RGD:621250"
     exon            1..218
                     /gene="Gata3"
                     /inference="alignment:Splign:2.1.0"
     exon            219..870
                     /gene="Gata3"
                     /inference="alignment:Splign:2.1.0"
     CDS             630..1964
                     /gene="Gata3"
                     /codon_start=1
                     /product="trans-acting T-cell-specific transcription
                     factor GATA-3"
                     /protein_id="NP_579827.1"
                     /db_xref="GeneID:85471"
                     /db_xref="RGD:621250"
                     /translation="MEVTTDQPRWVSHHHPAVLNGQHPDTHHPGLGHSYMDPAQYPLT
                     EEVDVLFNIDGQGNHVPSYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKA
                     LSSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLAAGHSSPHLFTFPPTPPKD
                     VSPDPSLSTPGSAGSARQDEKECLKYQVQLPDSMKLETSHSRGSMTTLGGASSSAHHP
                     ITTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWR
                     RDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNAN
                     GDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDALEDFPKSSSF
                     NPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSGLSFGPHHPSSMVTAMG"
     exon            871..1407
                     /gene="Gata3"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1553
                     /gene="Gata3"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1679
                     /gene="Gata3"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..3867
                     /gene="Gata3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacactgag ctgcctggcg ccgtcttgat agtttcagaa agaatgcatt ccctgtaaaa
       61 aaaaaaaaat actgagagag ggagaggaaa ccagagagag agagagagag agagactgag
      121 agagagagac tgagagagag agagacatag agagctacgc aatctgaccg ggcaggtcac
      181 acgtctcctc ctcctcctct ccgctccttg ctacccaggt gatcagagga gcaaccgtct
      241 ctgagcgcca aggaaccagt gtgcactgtg gccacacttg gattcgtctc tctttctcgc
      301 tccttttttt tttttttttt tttttgcccc tttattcctc cgtgtttgct tttttttttt
      361 ttggaggggg tctccctctt tcttcattct ttcccttttc tttctttctt tccttctttt
      421 gctaagctat cccgcaaaga attttctttc ctccctaaac cctctccttt gctcaccttt
      481 tctatccact tcactacaaa caaaccttta agcgactccc tctcctgggc ctccgacggc
      541 aggactccgc ggacctccca ggccgacagc cctccctcta cccgcgaggg ttccgggccc
      601 ggcgagaggg cgcgagcaca gcccgggaca tggaggtgac tacggaccag ccgcgctggg
      661 tgagccacca tcacccggcg gtcctcaacg ggcagcaccc agacacgcac cacccgggcc
      721 tcggccattc gtacatggac ccggcacagt accccctgac ggaagaggtg gacgtacttt
      781 ttaacatcga tggtcaaggc aaccacgtcc cgtcctacta cggaaactcg gtcagggcta
      841 cggtgcagag gtatcctccg acccaccacg ggagccaggt atgccgcccg cctctgctgc
      901 acggatctct gccctggctg gatggcggca aagccctgag cagccaccac accgcctcgc
      961 cctggaacct cagccccttc tccaagacgt ccatccacca cggctccccg gggcctctgt
     1021 ccgtctaccc tccggcttca tcctcttctc tggctgcggg ccactccagt ccgcatctct
     1081 tcaccttccc gcccacccct ccgaaggacg tctccccaga cccgtcgctg tccaccccgg
     1141 gatccgccgg gtcggccagg caagatgaga aagagtgcct caagtatcag gtgcagctgc
     1201 ccgatagcat gaagctggag acgtctcatt cccgaggcag catgaccacc ctgggagggg
     1261 cctcgtcttc agcccaccac cccattacca cctatccgcc ctatgtgccc gagtacagct
     1321 ccggactctt ccctcccagc agcctactgg gaggatcccc taccgggttc ggatgtaagt
     1381 cgaggcccaa ggcacgatcc agcacagaag gcagggagtg tgtgaactgc ggggcaacct
     1441 ctaccccact gtggcggcga gatggtactg ggcactacct ttgcaacgcc tgcggactct
     1501 accataaaat gaatgggcag aaccggcccc ttatcaagcc caagcgaagg ctgtcagcag
     1561 cgaggagagc agggacttcc tgtgcgaact gtcagaccac caccaccacc ctctggagga
     1621 ggaacgctaa cggagacccc gtctgcaatg cctgtgggct gtactacaaa ctccacaata
     1681 ttaacagacc cctgactatg aagaaggagg gcatccagac ccgaaaccgt aagatgtcta
     1741 gcaaatcgaa aaagtgcaaa aaggtgcatg atgcgctgga ggacttcccc aagagcagct
     1801 ccttcaaccc ggctgctctc tccagacaca tgtcgtccct gagccacatc tccccgttca
     1861 gccactccag ccacatgctg accacaccga cgcccatgca cccgccctcc ggcctctcct
     1921 tcggacctca ccatccatcc agcatggtca ccgccatggg ttagagaggc agagccctgc
     1981 tccacgtgcg tgaggactct ccgagtctgt ggagaggtcc tccgaccccc ttctacttgc
     2041 gttttcgcag gagcagtatc atgaagcccg aaaagcgaca gatctctgtt tgtgaaggca
     2101 gaaagcaaaa tgttcgcttc tttttcaaag gagctcccgg tggtgtctgc gttccaacca
     2161 ctgaatccgg atcccatttg tgaataagcc attcaattga ctcatatttc cctatttaac
     2221 agggtctcta gtgctgtgaa aaaaaatatt gctgaacatt gcatataact tatattgtaa
     2281 gaaatactgt acattcgagg aagactttat tgtacctgaa tagctgtaag aaaggcatgt
     2341 aagacgccaa gaattttaag ggatagaggg agaataaagt atggagatac agaagaaact
     2401 aagtctgatg tccaaatggg cacgctatca gttttctttc cctttagttg ttcgatgcat
     2461 ttaaaaaaaa aaaaaagaaa aaagaaaaaa aaaagggggg gggcgagaaa aaaagaaatt
     2521 aaaaaaaaaa ggaaagaaaa gaaagaaaaa tccaagaaaa aaaaaaaggt tgtaggcaaa
     2581 tcatttgttt caggctgtga gcctttgcaa aaggaatttc agatgtgggc aatcagtgtg
     2641 tcagctccac cagtcactca tgaggatttg agaatgtccc gtctaggcct acacgctctg
     2701 tgaatcagtc cctgtaactg ttgtttgtat gtataattca gagaagcacc aaaataagaa
     2761 aagatgtaga tttatttcat catattatac agactgaatt gttgtataaa tttatttact
     2821 gctagagtta ggacctgctt tttttttttt tttttttggt ggtttttgtt ttaaattttt
     2881 tctttttttt ttcttttttc tctctggatt tttggttgca taaactagct cgctttcagt
     2941 tgacccaagg tggatgtact ctctggaggg tttattttcc cttttattat tattttttga
     3001 tggtatttat taaatagctt ctatgggccc agcggtacct gtctttttcg tcacttctct
     3061 tgcagcctaa gctatgaagg tagcagtgta tcagctaccg acgtgcatgt cagcgacccg
     3121 gccactccca gacctggtcc tgagagccac ctggctgact gttagcccct gtgtgttctg
     3181 tatttgtgat ctctgccttt aaaccgtcta ttggaataat actataaaaa taaaaataaa
     3241 gttaaagtat tttaaaacaa caaagtaaca ttgtatcaaa atgatggatg gccgagctct
     3301 gatagaattt ggtaacacta gctaattcca gggttgtttt ctctttaagc atcccaaaga
     3361 ggatatggta gttcttcacc aggagatcat gtgaccccac cccgaaggtg aggtccactc
     3421 cttgaatgag agaactgtga gttctactgt tgtttagaga aatctatctc tgggcaggcg
     3481 catctcctgg gtgctcctgt gagatgcttg ctgttctcgg gtgtctccgg ggagacaatc
     3541 ttaaaggaag aatggcaaac tcctggcttg agatttccag gagttactac agtcaggggg
     3601 tggactcttt gacacagcaa gcgggctggg tgctcctcag ttcatttcca cttcgttttg
     3661 ctactgttga ataacactga aatggagggg tgactgggac gtctgtacaa ctcgaagtaa
     3721 cccgttggaa acctgttgta cactcccttt gccctctgac agaacgtgtg actctggcac
     3781 acacttacga atctgttaac ctcctctgct ttcttagcaa atattttaag tctaaagctg
     3841 aatgttgaaa taaaagcgtt aagagaa
//
