LOCUS       NM_033442               3411 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus GATA binding protein 2 (Gata2), mRNA.
ACCESSION   NM_033442
VERSION     NM_033442.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3411)
  AUTHORS   Whigham,C.A., MacDonald,T.M., Walker,S.P., Pritchard,N.,
            Hannan,N.J., Cannon,P., Nguyen,T.V., Hastie,R., Tong,S. and
            Kaitu'u-Lino,T.J.
  TITLE     Circulating GATA2 mRNA is decreased among women destined to develop
            preeclampsia and may be of endothelial origin
  JOURNAL   Sci Rep 9 (1), 235 (2019)
   PUBMED   30659233
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3411)
  AUTHORS   Hartmann,D., Fiedler,J., Sonnenschein,K., Just,A., Pfanne,A.,
            Zimmer,K., Remke,J., Foinquinos,A., Butzlaff,M., Schimmel,K.,
            Maegdefessel,L., Hilfiker-Kleiner,D., Lachmann,N., Schober,A.,
            Froese,N., Heineke,J., Bauersachs,J., Batkai,S. and Thum,T.
  TITLE     MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease
  JOURNAL   Circulation 134 (24), 1973-1990 (2016)
   PUBMED   27780851
REFERENCE   3  (bases 1 to 3411)
  AUTHORS   Peters,I., Dubrowinskaja,N., Tezval,H., Kramer,M.W., von Klot,C.A.,
            Hennenlotter,J., Stenzl,A., Scherer,R., Kuczyk,M.A. and Serth,J.
  TITLE     Decreased mRNA expression of GATA1 and GATA2 is associated with
            tumor aggressiveness and poor outcome in clear cell renal cell
            carcinoma
  JOURNAL   Target Oncol 10 (2), 267-275 (2015)
   PUBMED   25230694
REFERENCE   4  (bases 1 to 3411)
  AUTHORS   Hou,H.A., Lin,Y.C., Kuo,Y.Y., Chou,W.C., Lin,C.C., Liu,C.Y.,
            Chen,C.Y., Lin,L.I., Tseng,M.H., Huang,C.F., Chiang,Y.C., Liu,M.C.,
            Liu,C.W., Tang,J.L., Yao,M., Huang,S.Y., Ko,B.S., Hsu,S.C.,
            Wu,S.J., Tsay,W., Chen,Y.C. and Tien,H.F.
  TITLE     GATA2 mutations in patients with acute myeloid leukemia-paired
            samples analyses show that the mutation is unstable during disease
            evolution
  JOURNAL   Ann Hematol 94 (2), 211-221 (2015)
   PUBMED   25241285
REFERENCE   5  (bases 1 to 3411)
  AUTHORS   Choi,M., Wang,S.E., Ko,S.Y., Kang,H.J., Chae,S.Y., Lee,S.H.,
            Kim,Y.S., Duman,R.S. and Son,H.
  TITLE     Overexpression of human GATA-1 and GATA-2 interferes with spine
            formation and produces depressive behavior in rats
  JOURNAL   PLoS One 9 (10), e109253 (2014)
   PUBMED   25340772
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3411)
  AUTHORS   Zhou,Y., Lim,K.C., Onodera,K., Takahashi,S., Ohta,J., Minegishi,N.,
            Tsai,F.Y., Orkin,S.H., Yamamoto,M. and Engel,J.D.
  TITLE     Rescue of the embryonic lethal hematopoietic defect reveals a
            critical role for GATA-2 in urogenital development
  JOURNAL   EMBO J 17 (22), 6689-6700 (1998)
   PUBMED   9822612
REFERENCE   7  (bases 1 to 3411)
  AUTHORS   Gordon,D.F., Lewis,S.R., Haugen,B.R., James,R.A., McDermott,M.T.,
            Wood,W.M. and Ridgway,E.C.
  TITLE     Pit-1 and GATA-2 interact and functionally cooperate to activate
            the thyrotropin beta-subunit promoter
  JOURNAL   J Biol Chem 272 (39), 24339-24347 (1997)
   PUBMED   9305891
REFERENCE   8  (bases 1 to 3411)
  AUTHORS   Ma,G.T., Roth,M.E., Groskopf,J.C., Tsai,F.Y., Orkin,S.H.,
            Grosveld,F., Engel,J.D. and Linzer,D.I.
  TITLE     GATA-2 and GATA-3 regulate trophoblast-specific gene expression in
            vivo
  JOURNAL   Development 124 (4), 907-914 (1997)
   PUBMED   9043071
REFERENCE   9  (bases 1 to 3411)
  AUTHORS   Ng,Y.K., George,K.M., Engel,J.D. and Linzer,D.I.
  TITLE     GATA factor activity is required for the trophoblast-specific
            transcriptional regulation of the mouse placental lactogen I gene
  JOURNAL   Development 120 (11), 3257-3266 (1994)
   PUBMED   7720565
REFERENCE   10 (bases 1 to 3411)
  AUTHORS   Tsai,F.Y., Keller,G., Kuo,F.C., Weiss,M., Chen,J., Rosenblatt,M.,
            Alt,F.W. and Orkin,S.H.
  TITLE     An early haematopoietic defect in mice lacking the transcription
            factor GATA-2
  JOURNAL   Nature 371 (6494), 221-226 (1994)
   PUBMED   8078582
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY032734.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY032734.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3411
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..3411
                     /gene="Gata2"
                     /note="GATA binding protein 2"
                     /db_xref="GeneID:25159"
                     /db_xref="RGD:2664"
     exon            1..191
                     /gene="Gata2"
                     /inference="alignment:Splign:2.1.0"
     exon            192..399
                     /gene="Gata2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..672
                     /gene="Gata2"
                     /inference="alignment:Splign:2.1.0"
     CDS             444..1886
                     /gene="Gata2"
                     /note="GATA-bindning protein 2"
                     /codon_start=1
                     /product="endothelial transcription factor GATA-2"
                     /protein_id="NP_254277.1"
                     /db_xref="GeneID:25159"
                     /db_xref="RGD:2664"
                     /translation="MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDE
                     VDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGK
                     AALSAAAAHHHSPWTVSPFSKTPLHPSAAGAPGGPLSVYPGAAGGSGGGSGSSVASLT
                     PTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASPSAGGSVARGEDKDGVKYQVSLS
                     ESMKMEGGSPLRPGLAPMGTQPATHHPIPTYPSYVPASAHEYGSGLFHPGGFLGGPAS
                     SFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIK
                     PKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEG
                     IQTRNRKMSSKSKKSKKGAECFEELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSG
                     HILPTPTPIHPSSSLSFGHPHPSSMVTAMG"
     exon            673..1314
                     /gene="Gata2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1460
                     /gene="Gata2"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1586
                     /gene="Gata2"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..3411
                     /gene="Gata2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagaggtcc caatctcgag actcgtgctg tccagccgat cctaccagcc ccttgcacag
       61 ccagccctga taggaggaca gagggtttgg ggagtcagta ggacttgggc tgaccgtggt
      121 ccgtagcagg ggaggtgggt ctccgcccga gagtgaaaaa tctgtggtac cagcagagag
      181 atacccagaa ggagtcggca gctggcgcca gggcggccgg aggatgcaga ggggccggag
      241 ccgggcgggc cggaggccga gacgcgcgct gtcccccacc tctatcccgt gaatccgcca
      301 gccttgggac gcgctgtcgc tgggcccgcc gtacccgggc tctcctggtg tcccttactc
      361 tctactgctg agccctcccc ttcccgcgcc gctgcgagtg gtcgccccac cttcgcctgg
      421 atcccaagcc gcagtagtgg accatggagg tggcgcctga gcagcctcgc tggatggcgc
      481 accccgccgt attgaatgcg cagcaccccg actcgcacca tccgggcctg gcacacaact
      541 acatggagcc ggcacagctg ctgcctccgg acgaggtgga tgtcttcttc aaccacctcg
      601 actcgcaggg caacccctac tacgccaacc cagcccacgc gcgcgcgcgc gtttcctaca
      661 gtccagcgca tgcccgtctc acaggaggcc agatgtgccg accacacttg ttgcacagcc
      721 caggcttgcc atggctggac gggggcaaag cagctctctc tgccgctgct gcccatcacc
      781 acagcccctg gaccgtcagc ccgttctcca agaccccgct gcacccctca gctgctggag
      841 cacctggagg gcctctgtct gtgtacccag gggctgcggg tgggagcggt ggaggcagcg
      901 ggagctccgt agcctccctc acccccactg cagcccactc aggctcccat ctcttcggct
      961 tcccacccac gccacccaaa gaagtgtctc cagaccccag caccacagga gctgcttccc
     1021 cagcctcacc ttcagcaggg ggtagtgtag cccggggtga ggacaaggat ggcgtcaagt
     1081 atcaagtgtc actgtctgag agcatgaaga tggaaggtgg cagtcccctg cgcccgggcc
     1141 tagctcccat gggcacccag cctgcaacac accacccaat acccacctat ccctcctatg
     1201 tgcctgcctc agctcatgaa tatggcagcg ggctcttcca tcccggaggc ttcctgggtg
     1261 gcccagcctc cagcttcacc cctaagcagc gaagcaaggc tcgctcctgc tcagaaggcc
     1321 gggagtgtgt caactgcggg gccacagcca cccctctctg gcgacgggat ggcacgggcc
     1381 actacctgtg caatgcctgt gggctctacc acaagatgaa tggacagaat cggccgctca
     1441 tcaagcccaa gaggagactg tctgctgcca ggagagcggg cacctgttgt gcaaattgtc
     1501 agacgacaac caccacctta tggcgccgga acgccaacgg ggaccctgtg tgcaacgcct
     1561 gtggcctcta ctacaagctg cacaatgtta acaggccact gaccatgaag aaggaaggga
     1621 tccagacccg gaatcggaag atgtccagca aatccaagaa gagcaagaaa ggagccgaat
     1681 gctttgagga gctatccaag tgcatgcagg agaagtcatc ccccttcagt gcggctgccc
     1741 tggctggaca catggcacct gtgggacacc tcccaccttt tagtcactct ggacacatcc
     1801 tacctacgcc aacgcctatc cacccctcct ccagtctctc ctttggtcac ccccacccgt
     1861 ccagcatggt gactgccatg ggctaggcac agcctccggc tggacagaca tggacatcaa
     1921 gggtggttgg cagaaccaga gcgaggctgg gcactccccg gatgggtgga acgtactctt
     1981 ggctcctgcc catcccaaga gacccacttc ctcctgccag cctagtctgg ctgaagccac
     2041 ctctccttgg aggactccca gccttgtgcc gccattactg tgaatatttc taagtgggct
     2101 gcagcttgtg tgtgccctgg gtgctgccca gaagtgtttt cacggacagt gtttgtttgg
     2161 agagcaaaat ggacaggttt acagatttat agcaagagga ggagactagg gatagaaaaa
     2221 tgaaactttt ttttcttttt tttttttttg aaggagaaag gagtaggcaa aaaaatattt
     2281 attttgctct tatttcttac aagaacgtga agacacagag gcatgggctg tttgtgttct
     2341 ctgggtcctt ccttgggacc tactgccacc agtcagggct cttgggggca gcttacaggt
     2401 cctcaggctg agcctgctcc tccccagcct gccgggaggg tagcccttgc cctgacgcag
     2461 ccccagaggg cagagacaat tgcaggcggt cctgtgcgga ttcccaggcc agggctgggt
     2521 cacaggaagg aagcattctc tggaaagggg aaatgtctcc cagatcattc ccctggcttc
     2581 cagaggccaa aactggtgtg acccaaatgg gccaagctgt agcctgtgct ctaggccagt
     2641 tggacccctg taaatacatc cttttttttc tgctaaaccc ctcaaccccc tcccactcta
     2701 agataaataa gaaaatactc aaatcaaaaa ccaaactgca taagcttaac ccgctgatga
     2761 gtggttttac tttgaaactc gttttgggtc cagtccgttg tacgtcgcca cagaagccac
     2821 accatgaaaa agaataaaac cttaaaaaac aaaacaaaac aaaacaaaac cagggccaag
     2881 cttcacagtt ctttaaatgg ttcttgggtt ccacggccct agcaggagac tggggacaag
     2941 gggcaatctt ctgctcttgg tttctggggg gacagggcgt gggcaggcag tggccctgtg
     3001 gtcccaggct tctgttctgc ggtagccggc tggatccttc aaggtacagc tgtacataaa
     3061 aatgtgtccc aagcttcgat tctgtgtgcg gtggtggcag tggtgcagca gccggcacgg
     3121 ggccccgagc ccagggagac gattgtgcgg actagtcaac caagtgcaat atcggtgccc
     3181 actgctgcag agcgccccaa cagaaagtaa cttattttgt gctagtaccc gcctaagaaa
     3241 agaatcggca gtattttctg tttttatgtt ttgggcttgt tttattttgg attagtgacc
     3301 taagttattg ttaactgtgt acaacattta aatattgtct gtaaaaattg tatgctaccc
     3361 tcttattcct ttaaagtgaa tactgttaaa agtaataaaa tactttttgt g
//
