LOCUS       NM_012764               1860 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus GATA binding protein 1 (Gata1), mRNA.
ACCESSION   NM_012764
VERSION     NM_012764.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1860)
  AUTHORS   Gao,Y., Xu,W., Guo,C. and Huang,T.
  TITLE     GATA1 regulates the microRNA-328-3p/PIM1 axis via circular RNA
            ITGB1 to promote renal ischemia/reperfusion injury in HK-2 cells
  JOURNAL   Int J Mol Med 50 (2) (2022)
   PUBMED   35674159
  REMARK    GeneRIF: GATA1 regulates the microRNA3283p/PIM1 axis via circular
            RNA ITGB1 to promote renal ischemia/reperfusion injury in HK2
            cells.
REFERENCE   2  (bases 1 to 1860)
  AUTHORS   Wu,Y.Y., Zhang,H.L., Lu,X., Du,H., Li,Y.C., Zhang,P.A. and Xu,G.Y.
  TITLE     Targeting GATA1 and p2x7r Locus Binding in Spinal Astrocytes
            Suppresses Chronic Visceral Pain by Promoting DNA Demethylation
  JOURNAL   Neurosci Bull 38 (4), 359-372 (2022)
   PUBMED   34890016
  REMARK    GeneRIF: Targeting GATA1 and p2x7r Locus Binding in Spinal
            Astrocytes Suppresses Chronic Visceral Pain by Promoting DNA
            Demethylation.
REFERENCE   3  (bases 1 to 1860)
  AUTHORS   Yu,J., Liu,M., Liu,H. and Zhou,L.
  TITLE     GATA1 promotes colorectal cancer cell proliferation, migration and
            invasion via activating AKT signaling pathway
  JOURNAL   Mol Cell Biochem 457 (1-2), 191-199 (2019)
   PUBMED   31069596
REFERENCE   4  (bases 1 to 1860)
  AUTHORS   Akimova,T., Zhang,T., Negorev,D., Singhal,S., Stadanlick,J.,
            Rao,A., Annunziata,M., Levine,M.H., Beier,U.H., Diamond,J.M.,
            Christie,J.D., Albelda,S.M., Eruslanov,E.B. and Hancock,W.W.
  TITLE     Human lung tumor FOXP3+ Tregs upregulate four 'Treg-locking'
            transcription factors
  JOURNAL   JCI Insight 2 (16), 94075 (2017)
   PUBMED   28814673
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1860)
  AUTHORS   Liu,F., Wei,W., Ding,J., Chen,Y., Feng,T.T., Ji,L.H. and Shi,J.Y.
  TITLE     [Influence of HIF- 2alpha on the expression of GATA- 1 in bone
            marrow CD71(+) cell of high altitude polycythemia rat model]
  JOURNAL   Zhonghua Xue Ye Xue Za Zhi 37 (8), 696-701 (2016)
   PUBMED   27587253
REFERENCE   6  (bases 1 to 1860)
  AUTHORS   Shimamoto,T., Ohyashiki,K., Ohyashiki,J.H., Kawakubo,K.,
            Fujimura,T., Iwama,H., Nakazawa,S. and Toyama,K.
  TITLE     The expression pattern of erythrocyte/megakaryocyte-related
            transcription factors GATA-1 and the stem cell leukemia gene
            correlates with hematopoietic differentiation and is associated
            with outcome of acute myeloid leukemia
  JOURNAL   Blood 86 (8), 3173-3180 (1995)
   PUBMED   7579412
REFERENCE   7  (bases 1 to 1860)
  AUTHORS   Weiss,M.J. and Orkin,S.H.
  TITLE     Transcription factor GATA-1 permits survival and maturation of
            erythroid precursors by preventing apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9623-9627 (1995)
   PUBMED   7568185
REFERENCE   8  (bases 1 to 1860)
  AUTHORS   Simon,M.C., Pevny,L., Wiles,M.V., Keller,G., Costantini,F. and
            Orkin,S.H.
  TITLE     Rescue of erythroid development in gene targeted GATA-1- mouse
            embryonic stem cells
  JOURNAL   Nat Genet 1 (2), 92-98 (1992)
   PUBMED   1302015
  REMARK    Review article
REFERENCE   9  (bases 1 to 1860)
  AUTHORS   Pevny,L., Simon,M.C., Robertson,E., Klein,W.H., Tsai,S.F.,
            D'Agati,V., Orkin,S.H. and Costantini,F.
  TITLE     Erythroid differentiation in chimaeric mice blocked by a targeted
            mutation in the gene for transcription factor GATA-1
  JOURNAL   Nature 349 (6306), 257-260 (1991)
   PUBMED   1987478
REFERENCE   10 (bases 1 to 1860)
  AUTHORS   Martin,D.I., Tsai,S.F. and Orkin,S.H.
  TITLE     Increased gamma-globin expression in a nondeletion HPFH mediated by
            an erythroid-specific DNA-binding factor
  JOURNAL   Nature 338 (6214), 435-438 (1989)
   PUBMED   2467208
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012764.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13518.1, SRR26643284.21226.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000021.1  17201637-17201729
            94-332              JAXUCZ010000021.1  17205657-17205895
            333-710             JAXUCZ010000021.1  17206359-17206736
            711-856             JAXUCZ010000021.1  17206834-17206979
            857-982             JAXUCZ010000021.1  17208012-17208137
            983-1860            JAXUCZ010000021.1  17208582-17209459
FEATURES             Location/Qualifiers
     source          1..1860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..1860
                     /gene="Gata1"
                     /gene_synonym="Eryf1"
                     /note="GATA binding protein 1"
                     /db_xref="GeneID:25172"
                     /db_xref="RGD:2663"
     exon            1..93
                     /gene="Gata1"
                     /gene_synonym="Eryf1"
                     /inference="alignment:Splign:2.1.0"
     exon            94..332
                     /gene="Gata1"
                     /gene_synonym="Eryf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1354
                     /gene="Gata1"
                     /gene_synonym="Eryf1"
                     /note="GF-1; GATA-1; GATA-binding factor 1; NF-E1
                     DNA-binding protein; GATA-binding protein 1 (globin
                     transcription factor 1)"
                     /codon_start=1
                     /product="erythroid transcription factor"
                     /protein_id="NP_036896.1"
                     /db_xref="GeneID:25172"
                     /db_xref="RGD:2663"
                     /translation="MDFPGLGALGTSEPLPQFVDSALVSSTSDSAGFFSSGPESLDTA
                     SSSTSPNAATAAATALAYYREAEAYRHSPVFQVYPLLNSMEGIPGSSPYASWAYSKTA
                     LYPASTVCPSHEDAPSQTLEDPDGKNNNTFLETLKTERLSPDLLTLGTALPTSLPVTS
                     SAYGGADFPSPFFSPTGSPLSSAAYSSPKFHGSLPLAPCEARECVNCGATATPLWRRD
                     RTGHYLCNACGLYHKMNGQNRPLIRPKKRMIVSKRAGTQCTNCQTTTTTLWRRNASGD
                     PVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKASGKGKKKRGSSLAGAGAAEGPAGGF
                     MVVAGGSSSGNCGEVAPGLTLGTAGTAHLYQGLGPVVLSGPVSHLMSFPGPLLGSPTA
                     SFPTGPVPTTTSTSVVSPLSS"
     exon            333..710
                     /gene="Gata1"
                     /gene_synonym="Eryf1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..856
                     /gene="Gata1"
                     /gene_synonym="Eryf1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..982
                     /gene="Gata1"
                     /gene_synonym="Eryf1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1860
                     /gene="Gata1"
                     /gene_synonym="Eryf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcaaaggcc aaggccagcg aggactcccc ttgggatcac attgacctca ccacaccact
       61 aaggtgctga accttctgca tcaacaagcg caggttaaac cccagtgtcc acatggattt
      121 tcctggtcta ggggccctgg gaacctcaga acccttgccc cagtttgtgg attctgccct
      181 ggtgtcctcg acatcagact cagcgggttt cttttcctct gggcctgaga gtttggatac
      241 agcatcttcc tccacttctc caaatgcagc cacggcagca gccacggcac tggcctacta
      301 cagagaagct gaggcctaca gacactcccc agtctttcag gtgtacccgc tgctcaacag
      361 tatggaggga atcccaggga gctcacctta tgctagctgg gcctatagca agacggcgct
      421 ctaccctgcc tcaactgtat gtcccagtca tgaggatgcc ccttcccaga ccctggaaga
      481 cccagatggg aagaacaaca atacattctt ggaaaccttg aagacggagc ggctgagtcc
      541 agacctcctg accctgggga ctgcactgcc tacatcactc cctgtcacca gcagtgctta
      601 tgggggagct gactttccca gtcctttctt ctctcccact gggagccctc tcagctcagc
      661 agcctattct tcccccaagt ttcatggaag cctaccattg gctccttgtg aggccagaga
      721 gtgtgtgaac tgtggagcaa cggctactcc actgtggcgg agggacagga caggtcacta
      781 cctgtgcaat gcttgtggct tgtatcacaa gatgaatggt cagaaccggc ctctcatccg
      841 gcccaagaag cgaatgattg tcagcaagcg agcaggcacc caatgcacta actgtcaaac
      901 aacaaccacg accctctggc ggaggaatgc cagtggagac ccggtgtgca atgcctgcgg
      961 cctctactac aagctgcacc aggtgaaccg cccactgacc atgaggaaag atggaatcca
     1021 gacgaggaac cgcaaggcat ctggaaaagg gaaaaagaag cggggctcaa gtctggccgg
     1081 agcaggagcg gctgaaggac cagctggtgg attcatggtg gtagctggtg gcagcagtag
     1141 tgggaattgc ggagaggtgg ccccaggctt gacactgggc actgcaggta ctgcccatct
     1201 ctaccagggc ctgggacctg tggtgctgtc agggcctgtc agccatctta tgtctttccc
     1261 tggacctctg ctgggatcgc ctacggcctc cttccccaca ggtcctgtgc ctaccaccac
     1321 cagcactagc gtagtgtctc cactcagttc ttgaaggtac acaaaatggc ctttggcctt
     1381 gtggcagagg agatgctccc ctcctccccc acctttattt tttggagaca ggatcttgtg
     1441 tagctcaggc tgcctgtgaa ctatgtagct aagggtgacc ccaaatttcc cattctcctg
     1501 cctctacctc ctgagattaa aggcatatat caccatgctt gacattttcc tttgtttcag
     1561 ttttgttttt gttttgagac agggtttcac tatgcagccg aggctggctt tgaattccct
     1621 atgtagtcca gactaacctc aaacttgaga ttctcctgcc tcagttcccg agtgctggaa
     1681 tcacaggcat ctgctaccac tcctgtttct ccctcctctt agagccacca gcctttacag
     1741 cccaaccatc tccttgccct gtaccctcaa agattttgta aaataaaacc accaaagacc
     1801 tgaacctgga gactgtgagc tggtatttgg ctaaataaat gtcagtgtca agtggtgtcc
//
