LOCUS       NM_012849                446 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus gastrin (Gast), mRNA.
ACCESSION   NM_012849
VERSION     NM_012849.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Perez-Arana,G.M., Almorza-Gomar,D., Mayo-Ossorio,M.A.,
            Ramirez,A.C., Castro-Santiago,M.J., Valverde-Martinez,A.,
            Casado-Maestre,M.D., Visiedo,F., Bohorquez-Sierra,J.C. and
            Prada-Oliveira,J.A.
  TITLE     Gastrin: a new branch of the gastropancreatic axis that can explain
            the effect of sleeve gastrectomy on glucose metabolism
  JOURNAL   J Gastrointest Surg 28 (4), 381-388 (2024)
   PUBMED   38583887
  REMARK    GeneRIF: Gastrin: a new branch of the gastropancreatic axis that
            can explain the effect of sleeve gastrectomy on glucose metabolism.
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Skarbaliene,J., Secher,T., Jelsing,J., Ansarullah, Neerup,T.S.,
            Billestrup,N. and Fosgerau,K.
  TITLE     The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in
            ZDF rats
  JOURNAL   Peptides 69, 47-55 (2015)
   PUBMED   25849341
  REMARK    GeneRIF: we examined the chronic effects of a GLP-1-gastrin dual
            agonist ZP3022 on glycemic control and beta cell dysfunction in
            overtly diabetic Zucker Diabetic Fatty
REFERENCE   3  (bases 1 to 446)
  AUTHORS   Cao,Y., Cao,X. and Liu,X.M.
  TITLE     Expression of cholecystokinin2-receptor in rat and human L cells
            and the stimulation of glucagon-like peptide-1 secretion by gastrin
            treatment
  JOURNAL   Acta Histochem 117 (2), 205-210 (2015)
   PUBMED   25601282
  REMARK    GeneRIF: treatment with gastrin, a CCK2R agonist, stimulated the
            secretion of GLP-1, and that this effect was likely due to
            increased expression of proglucagon and PCSK1 (also known as
            prohormone convertase 3 (PC3 gene)).
REFERENCE   4  (bases 1 to 446)
  AUTHORS   Fjeldbo,C.S., Bakke,I., Erlandsen,S.E., Holmseth,J., Laegreid,A.,
            Sandvik,A.K., Thommesen,L. and Bruland,T.
  TITLE     Gastrin upregulates the prosurvival factor secretory clusterin in
            adenocarcinoma cells and in oxyntic mucosa of hypergastrinemic rats
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 302 (1), G21-G33 (2012)
   PUBMED   21995960
  REMARK    GeneRIF: The results suggested that clusterin may contribute to
            gastrin's growth-promoting effect on the oxyntic mucosa.
REFERENCE   5  (bases 1 to 446)
  AUTHORS   Kidd,M., Hauso,O., Drozdov,I., Gustafsson,B.I. and Modlin,I.M.
  TITLE     Delineation of the chemomechanosensory regulation of gastrin
            secretion using pure rodent G cells
  JOURNAL   Gastroenterology 137 (1), 231-241 (2009)
   PUBMED   19208342
  REMARK    GeneRIF: G cells are luminal sampling chemomechanosensory cells
            whose gastrin secretion is regulated by neural, hormonal, luminal,
            and mechanical factors through protein kinase A activation, cAMP
            signaling, and mitogen-activated protein kinase phosphorylation.
REFERENCE   6  (bases 1 to 446)
  AUTHORS   Bjorkqvist,M., Dornonville de la Cour,C., Zhao,C.M.,
            Gagnemo-Persson,R., Hakanson,R. and Norlen,P.
  TITLE     Role of gastrin in the development of gastric mucosa, ECL cells and
            A-like cells in newborn and young rats
  JOURNAL   Regul Pept 108 (2-3), 73-82 (2002)
   PUBMED   12220729
  REMARK    GeneRIF: plays a role in the development of gastric mucosa, ECL
            cells and A-like cells in newborn and young rats
REFERENCE   7  (bases 1 to 446)
  AUTHORS   Zanner,R., Hapfelmeier,G., Gratzl,M. and Prinz,C.
  TITLE     Intracellular signal transduction during gastrin-induced histamine
            secretion in rat gastric ECL cells
  JOURNAL   Am J Physiol Cell Physiol 282 (2), C374-C382 (2002)
   PUBMED   11788349
REFERENCE   8  (bases 1 to 446)
  AUTHORS   Varro,A., Nemeth,J., Bridson,J., Lee,C., Moore,S. and Dockray,G.J.
  TITLE     Processing of the gastrin precursor. Modulation of phosphorylated,
            sulfated, and amidated products
  JOURNAL   J Biol Chem 265 (35), 21476-21481 (1990)
   PUBMED   1701434
REFERENCE   9  (bases 1 to 446)
  AUTHORS   Fuller,P.J., Stone,D.L. and Brand,S.J.
  TITLE     Molecular cloning and sequencing of a rat preprogastrin
            complementary deoxyribonucleic acid
  JOURNAL   Mol Endocrinol 1 (4), 306-311 (1987)
   PUBMED   3453895
REFERENCE   10 (bases 1 to 446)
  AUTHORS   Schaffer,M.H., Agarwal,K.L. and Noyes,B.E.
  TITLE     Rat gastrin's amino acid sequence determined from the nucleotide
            sequence of the mRNA
  JOURNAL   Peptides 3 (4), 693-696 (1982)
   PUBMED   6897117
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M38653.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M38653.1, BE119715.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117, SAMN12840118
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..446
                     /gene="Gast"
                     /gene_synonym="Gas; PPG34"
                     /note="gastrin"
                     /db_xref="GeneID:25320"
                     /db_xref="RGD:2662"
     exon            1..40
                     /gene="Gast"
                     /gene_synonym="Gas; PPG34"
                     /inference="alignment:Splign:2.1.0"
     exon            41..256
                     /gene="Gast"
                     /gene_synonym="Gas; PPG34"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..360
                     /gene="Gast"
                     /gene_synonym="Gas; PPG34"
                     /codon_start=1
                     /product="gastrin precursor"
                     /protein_id="NP_036981.1"
                     /db_xref="GeneID:25320"
                     /db_xref="RGD:2662"
                     /translation="MPRLCVCMLVLVLALATFSEASWKPRSQLQDASSGPRTNGALEQ
                     HQLEKLGPASHHRRQLGPQGPQHFIADLSKKQRPPMEEEEEAYGWMDFGRRSAEEEDQ
                     YN"
     exon            257..446
                     /gene="Gast"
                     /gene_synonym="Gas; PPG34"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctactgcca caacagttaa ccgttccccc agctctgcag acaagatgcc tcgactgtgt
       61 gtgtgcatgc tagtcttagt gctggctcta gctaccttct cggaagcttc ttggaaacct
      121 cgctcccagc tacaggatgc atcctctgga ccaaggacca atggggccct ggaacagcac
      181 cagctagaaa agctgggccc agcctctcac catcggagac agctggggcc ccaaggtccg
      241 caacacttca tagcagatct gtccaagaaa cagaggccac caatggagga agaagaggaa
      301 gcatacggat ggatggactt tggtcgccgt agcgctgagg aagaagacca gtataactag
      361 caatgctctt ccagagccca gccatctcca gccaccccca gctcagtcct tacaaaacat
      421 attaaaaata aactagcttg caatgt
//
