LOCUS       NM_001039030            1602 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus growth arrest specific 8 (Gas8), mRNA.
ACCESSION   NM_001039030 XM_341716
VERSION     NM_001039030.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1602)
  AUTHORS   Abdelhamed,Z., Vuong,S.M., Hill,L., Shula,C., Timms,A., Beier,D.,
            Campbell,K., Mangano,F.T., Stottmann,R.W. and Goto,J.
  TITLE     A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal
            motile cilia development in mice
  JOURNAL   Development 145 (1) (2018)
   PUBMED   29317443
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1602)
  AUTHORS   Jeanson,L., Thomas,L., Copin,B., Coste,A., Sermet-Gaudelus,I.,
            Dastot-Le Moal,F., Duquesnoy,P., Montantin,G., Collot,N.,
            Tissier,S., Papon,J.F., Clement,A., Louis,B., Escudier,E.,
            Amselem,S. and Legendre,M.
  TITLE     Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory
            Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal
            Disorganization
  JOURNAL   Hum Mutat 37 (8), 776-785 (2016)
   PUBMED   27120127
REFERENCE   3  (bases 1 to 1602)
  AUTHORS   Lewis,W.R., Malarkey,E.B., Tritschler,D., Bower,R., Pasek,R.C.,
            Porath,J.D., Birket,S.E., Saunier,S., Antignac,C., Knowles,M.R.,
            Leigh,M.W., Zariwala,M.A., Challa,A.K., Kesterson,R.A., Rowe,S.M.,
            Drummond,I.A., Parant,J.M., Hildebrandt,F., Porter,M.E., Yoder,B.K.
            and Berbari,N.F.
  TITLE     Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia
            Function and Human Disease
  JOURNAL   PLoS Genet 12 (7), e1006220 (2016)
   PUBMED   27472056
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1602)
  AUTHORS   Olbrich,H., Cremers,C., Loges,N.T., Werner,C., Nielsen,K.G.,
            Marthin,J.K., Philipsen,M., Wallmeier,J., Pennekamp,P., Menchen,T.,
            Edelbusch,C., Dougherty,G.W., Schwartz,O., Thiele,H., Altmuller,J.,
            Rommelmann,F. and Omran,H.
  TITLE     Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia
            and Disrupt the Nexin-Dynein Regulatory Complex
  JOURNAL   Am J Hum Genet 97 (4), 546-554 (2015)
   PUBMED   26387594
REFERENCE   5  (bases 1 to 1602)
  AUTHORS   Evron,T., Philipp,M., Lu,J., Meloni,A.R., Burkhalter,M., Chen,W.
            and Caron,M.G.
  TITLE     Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor
            kinase 2 (GRK2) cooperate in the control of Smoothened signaling
  JOURNAL   J Biol Chem 286 (31), 27676-27686 (2011)
   PUBMED   21659505
REFERENCE   6  (bases 1 to 1602)
  AUTHORS   Nishimura,N., Araki,K., Shinahara,W., Nakano,Y., Nishimura,K.,
            Higashio,H. and Sasaki,T.
  TITLE     Interaction of Rab3B with microtubule-binding protein Gas8 in NIH
            3T3 cells
  JOURNAL   Arch Biochem Biophys 474 (1), 136-142 (2008)
   PUBMED   18396146
REFERENCE   7  (bases 1 to 1602)
  AUTHORS   Bekker,J.M., Colantonio,J.R., Stephens,A.D., Clarke,W.T.,
            King,S.J., Hill,K.L. and Crosbie,R.H.
  TITLE     Direct interaction of Gas11 with microtubules: implications for the
            dynein regulatory complex
  JOURNAL   Cell Motil Cytoskeleton 64 (6), 461-473 (2007)
   PUBMED   17366626
REFERENCE   8  (bases 1 to 1602)
  AUTHORS   Colantonio,J.R., Bekker,J.M., Kim,S.J., Morrissey,K.M.,
            Crosbie,R.H. and Hill,K.L.
  TITLE     Expanding the role of the dynein regulatory complex to non-axonemal
            functions: association of GAS11 with the Golgi apparatus
  JOURNAL   Traffic 7 (5), 538-548 (2006)
   PUBMED   16643277
REFERENCE   9  (bases 1 to 1602)
  AUTHORS   Yeh,S.D., Chen,Y.J., Chang,A.C., Ray,R., She,B.R., Lee,W.S.,
            Chiang,H.S., Cohen,S.N. and Lin-Chao,S.
  TITLE     Isolation and properties of Gas8, a growth arrest-specific gene
            regulated during male gametogenesis to produce a protein associated
            with the sperm motility apparatus
  JOURNAL   J Biol Chem 277 (8), 6311-6317 (2002)
   PUBMED   11751847
REFERENCE   10 (bases 1 to 1602)
  AUTHORS   Hill,K.L., Hutchings,N.R., Grandgenett,P.M. and Donelson,J.E.
  TITLE     T lymphocyte-triggering factor of african trypanosomes is
            associated with the flagellar fraction of the cytoskeleton and
            represents a new family of proteins that are present in several
            divergent eukaryotes
  JOURNAL   J Biol Chem 275 (50), 39369-39378 (2000)
   PUBMED   10969087
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099759.1.
            
            On Jan 12, 2006 this sequence version replaced XM_341716.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099759.1, SRR8487231.62694.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132297
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1602
                     /gene="Gas8"
                     /note="growth arrest specific 8"
                     /db_xref="GeneID:361438"
                     /db_xref="RGD:1307817"
     exon            1..26
                     /gene="Gas8"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1460
                     /gene="Gas8"
                     /note="growth arrest-specific protein 8; GAS-8; GAS-11;
                     growth arrest-specific protein 11"
                     /codon_start=1
                     /product="dynein regulatory complex subunit 4"
                     /protein_id="NP_001034119.1"
                     /db_xref="GeneID:361438"
                     /db_xref="RGD:1307817"
                     /translation="MAPKRRGKKGKAKGNAVVDGVAPEDMSKEQVEEHVARIREELDR
                     EREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKV
                     KHLLYEHQNNLAEVKTEGTVVMKLAQKEHRAQEGALRKDMRVLKVELKEQELANEVVI
                     KNLRLKQAEEITKMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTEIHEVEERKNGQ
                     ISTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEEYLEREMAEVSLQN
                     KRLAEPLQRAKEEMSEMQKRLGNHERDKQILACTKARLKVTEKELKDLKWEHEILEQR
                     FIKVQQEREELYRKFTAAIQEVQQKTGFKNLVLERKLQALNAAVEKREVQFNEVLAAS
                     NLDPTALTLVSRKLEDVLESKNTTIKDLQYELARVCKAHNDLLRTYEAKLLAFGIPLD
                     NVGFKPLETAVIGQTLGQGPAGLVGAPT"
     exon            27..113
                     /gene="Gas8"
                     /inference="alignment:Splign:2.1.0"
     exon            114..311
                     /gene="Gas8"
                     /inference="alignment:Splign:2.1.0"
     exon            312..518
                     /gene="Gas8"
                     /inference="alignment:Splign:2.1.0"
     exon            519..573
                     /gene="Gas8"
                     /inference="alignment:Splign:2.1.0"
     exon            574..779
                     /gene="Gas8"
                     /inference="alignment:Splign:2.1.0"
     exon            780..947
                     /gene="Gas8"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1034
                     /gene="Gas8"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1244
                     /gene="Gas8"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1310
                     /gene="Gas8"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1576
                     /gene="Gas8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggtgctg cactgctgcc atcatggcac ccaaaaggag agggaagaaa gggaaagcca
       61 aagggaatgc agtcgttgat ggggtcgcac cagaggacat gtccaaggag caggtggagg
      121 aacatgtcgc ccgcatccgg gaggagctgg accgggagcg ggaggagcgc aactactttc
      181 agctggagcg ggacaaaatc cacaccttct gggagatcac gcggaggcag ctggaggaga
      241 agaaggctga gctgcgcaac aaagaccggg agatggagga ggccgaggag aggcaccagg
      301 tggagatcaa ggtttacaag cagaaagtga agcaccttct gtacgaacac cagaacaatc
      361 tggcagaggt gaagactgag ggcaccgtgg tcatgaagct ggcccagaag gagcaccgcg
      421 cccaagaggg cgctctgcgc aaggacatgc gcgtgctgaa agtggagctg aaggagcagg
      481 agctggctaa cgaggtggtg ataaagaacc tgcgtctgaa acaagccgag gagatcacca
      541 agatgcgaaa tgactttgaa aggcaagttc gagaaatcga ggccaaatat gataaaaaga
      601 tgaagatgct tcgagacgag cttgacctgc ggagaaagac tgagatccac gaggtggagg
      661 agaggaagaa cgggcagatc agtacgctga tgcagcgtca tgaggaggcc ttcactgaca
      721 tcaaaaacta ctacaatgac atcactctca acaacctggc cctcatcaat tccctcaagg
      781 agcagatgga ggatatgagg aagaaggagg agtacctgga gagggagatg gcggaggtgt
      841 ctctgcagaa caagcggctg gctgagccgc tgcagagagc caaggaggag atgagcgaga
      901 tgcagaagag actggggaac catgagaggg acaagcagat cctggcctgt acgaaggcac
      961 gtttgaaggt cactgagaag gagctgaagg acctgaagtg ggagcatgag atcctggagc
     1021 agaggttcat caaggtgcag caggagaggg aagagctcta tcggaagttc actgcagcca
     1081 tccaggaggt gcagcagaag acaggcttca agaacctggt gctggagcgt aagctgcagg
     1141 cactgaatgc tgctgtggag aagagagagg tgcagttcaa tgaggtgctg gctgcctcca
     1201 acctggaccc tacagcacta acacttgtgt ctcgcaaact tgaggacgtt ctagagtcga
     1261 agaataccac catcaaggac ttgcagtatg agctggcccg agtctgcaag gcccacaacg
     1321 acctgttgcg tacatatgag gcaaagttat tggccttcgg gatccccctg gacaatgtgg
     1381 ggttcaagcc cctggagaca gcagtgattg gacagacact gggacagggc cctgcaggac
     1441 ttgtgggtgc gccgacatag ccatctacag cagcctgcag cttgtcagtt actctgcccc
     1501 tctcccctgg gaattcacac cctgcacaag ttttgttttg aacacttaac aaacaccaat
     1561 gaaagttttt gcatgaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
