LOCUS       NM_057100               2560 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus growth arrest specific 6 (Gas6), mRNA.
ACCESSION   NM_057100
VERSION     NM_057100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2560)
  AUTHORS   Aydin,N., Ouliass,B., Ferland,G. and Hafizi,S.
  TITLE     Modification of Gas6 Protein in the Brain by a Functional
            Endogenous Tissue Vitamin K Cycle
  JOURNAL   Cells 13 (10), 873 (2024)
   PUBMED   38786095
  REMARK    GeneRIF: Modification of Gas6 Protein in the Brain by a Functional
            Endogenous Tissue Vitamin K Cycle.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2560)
  AUTHORS   Huang,M., Liu,M., Huang,D., Ma,Y., Ye,G., Wen,Q., Li,Y., Deng,L.,
            Qi,Q., Liu,T., Liu,X., Chen,M., Ye,W. and Zhang,D.
  TITLE     Tumor perivascular cell-derived extracellular vesicles promote
            angiogenesis via the Gas6/Axl pathway
  JOURNAL   Cancer Lett 524, 131-143 (2022)
   PUBMED   34678434
  REMARK    GeneRIF: Tumor perivascular cell-derived extracellular vesicles
            promote angiogenesis via the Gas6/Axl pathway.
REFERENCE   3  (bases 1 to 2560)
  AUTHORS   Ma,L., Cao,Y., Zhang,L., Li,K., Yan,L., Pan,Y. and Zhu,J.
  TITLE     Celastrol mitigates high glucose-induced inflammation and apoptosis
            in rat H9c2 cardiomyocytes via miR-345-5p/growth arrest-specific 6
  JOURNAL   J Gene Med 22 (9), e3201 (2020)
   PUBMED   32307774
  REMARK    GeneRIF: Celastrol mitigates high glucose-induced inflammation and
            apoptosis in rat H9c2 cardiomyocytes via miR-345-5p/growth
            arrest-specific 6.
REFERENCE   4  (bases 1 to 2560)
  AUTHORS   Shan,S., Liu,Z., Guo,T., Wang,M., Tian,S., Zhang,Y., Wang,K.,
            Zheng,H., Zhao,X., Zuo,P., Wang,Y., Li,D. and Liu,C.
  TITLE     Growth arrest-specific gene 6 transfer promotes mesenchymal stem
            cell survival and cardiac repair under hypoxia and ischemia via
            enhanced autocrine signaling and paracrine action
  JOURNAL   Arch Biochem Biophys 660, 108-120 (2018)
   PUBMED   30365934
  REMARK    GeneRIF: Growth arrest-specific gene 6 transfer promotes
            mesenchymal stem cell survival and cardiac repair under hypoxia and
            ischemia via enhanced autocrine signaling and paracrine action
REFERENCE   5  (bases 1 to 2560)
  AUTHORS   Wu,G., McBride,D.W. and Zhang,J.H.
  TITLE     Axl activation attenuates neuroinflammation by inhibiting the
            TLR/TRAF/NF-kappaB pathway after MCAO in rats
  JOURNAL   Neurobiol Dis 110, 59-67 (2018)
   PUBMED   29196212
  REMARK    GeneRIF: recombinant Gas6 reduced the neurological deficits by
            inhibiting neuroinflammation via the TLR/TRAF/NF-kappaB signaling
            pathway after middle cerebral artery occlusion (MCAO) in rats
REFERENCE   6  (bases 1 to 2560)
  AUTHORS   Ohashi,K., Nagata,K., Toshima,J., Nakano,T., Arita,H., Tsuda,H.,
            Suzuki,K. and Mizuno,K.
  TITLE     Stimulation of sky receptor tyrosine kinase by the product of
            growth arrest-specific gene 6
  JOURNAL   J Biol Chem 270 (39), 22681-22684 (1995)
   PUBMED   7559388
REFERENCE   7  (bases 1 to 2560)
  AUTHORS   Godowski,P.J., Mark,M.R., Chen,J., Sadick,M.D., Raab,H. and
            Hammonds,R.G.
  TITLE     Reevaluation of the roles of protein S and Gas6 as ligands for the
            receptor tyrosine kinase Rse/Tyro 3
  JOURNAL   Cell 82 (3), 355-358 (1995)
   PUBMED   7634325
REFERENCE   8  (bases 1 to 2560)
  AUTHORS   Nakano,T., Higashino,K., Kikuchi,N., Kishino,J., Nomura,K.,
            Fujita,H., Ohara,O. and Arita,H.
  TITLE     Vascular smooth muscle cell-derived, Gla-containing
            growth-potentiating factor for Ca(2+)-mobilizing growth factors
  JOURNAL   J Biol Chem 270 (11), 5702-5705 (1995)
   PUBMED   7890695
REFERENCE   9  (bases 1 to 2560)
  AUTHORS   Varnum,B.C., Young,C., Elliott,G., Garcia,A., Bartley,T.D.,
            Fridell,Y.W., Hunt,R.W., Trail,G., Clogston,C., Toso,R.J. et al.
  TITLE     Axl receptor tyrosine kinase stimulated by the vitamin K-dependent
            protein encoded by growth-arrest-specific gene 6
  JOURNAL   Nature 373 (6515), 623-626 (1995)
   PUBMED   7854420
REFERENCE   10 (bases 1 to 2560)
  AUTHORS   Manfioletti,G., Brancolini,C., Avanzi,G. and Schneider,C.
  TITLE     The protein encoded by a growth arrest-specific gene (gas6) is a
            new member of the vitamin K-dependent proteins related to protein
            S, a negative coregulator in the blood coagulation cascade
  JOURNAL   Mol Cell Biol 13 (8), 4976-4985 (1993)
   PUBMED   8336730
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070881.1.
            
            On Apr 14, 2007 this sequence version replaced NM_057100.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070881.1, SRR8487227.294424.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132279, SAMD00132281
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2560
                     /gene="Gas6"
                     /note="growth arrest specific 6"
                     /db_xref="GeneID:58935"
                     /db_xref="RGD:61913"
     exon            1..209
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2155
                     /gene="Gas6"
                     /note="growth arrest-specific protein 6; GPF; GAS-6;
                     growth-potentiating factor; AXL receptor tyrosine kinase
                     ligand"
                     /codon_start=1
                     /product="growth arrest-specific protein 6 precursor"
                     /protein_id="NP_476441.2"
                     /db_xref="GeneID:58935"
                     /db_xref="RGD:61913"
                     /translation="MPPPPGPTAALGTALLLLLLASESSHTVLLRAREAAQFLRPRQR
                     RAYQVFEEAKQGHLERECVEEVCSKEEAREVFENDPETDYFYPRYQECMRKYGRPEDK
                     NPNFATCVKNLPDQCTPNPCDKKGTQLCQDLMGNFFCLCKDGWGGRLCDKDVNECSQK
                     NGGCSQVCHNKPGSFQCACHSGFSLQSDNKSCQDIDECTDSDTCGDARCKNLPGSYSC
                     LCDKGYTYSSKEKTCQDVDECQQDRCEQTCVNSPGSYTCHCNGRGGLKLSPDMDTCED
                     ILPCVPFSMAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFA
                     GGRSDSTWIVLGFRAGRLELQLRYNGVGRITSSGPTINHGMWQTISVEELDRNLVIKV
                     NKDAVMKIAVAGGLFQLERGLYHLNLTVGGIPFKESDLVQPINPRLDGCMRSWNWLNG
                     EDSAIQETVKANTKMQCFSVTERGSFFPGNGFAFYSLNYTRTSLDVGTETTWEVEVVA
                     RIRPATDTGVLMALVGDKDVVLLSVALVDYHSTKKLKKQLVVLAVENVALALMEIKVC
                     DSQEHTVTVSLRDGEATLEVDGTKGQSEVSTAQLQERLDLLKTRLQGSVLTFVGGLPD
                     VQVTSTPVTAFYRGCMTLEVNGKTLDLDTASYKHSDITSHSCPPVEHVTA"
     exon            210..376
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     exon            377..401
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     exon            402..464
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     exon            465..587
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     exon            588..710
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     exon            711..833
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     exon            834..955
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1074
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1264
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1429
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1598
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1771
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..2000
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2538
                     /gene="Gas6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgagatg tgaccttcac cgccgcttgg ccagaatgac cggagcccgt gtcccgcggc
       61 gtccgcggtt cgcttcagtt tctcgggtgc tttgaccgca cgctcccggg ctcccggccc
      121 gggcctcgcc atgccgccac cgcccgggcc caccgccgcc ctgggcactg cgcttctgct
      181 gctcctgctg gcctccgagt cttcgcacac tgtgctgttg cgggcgcgtg aggcggcgca
      241 gttcctgcgg cccaggcagc gccgcgccta ccaagtcttc gaggaggcca agcagggcca
      301 cctggaacgg gagtgcgtgg aggaggtgtg cagcaaggag gaggctagag aggtgttcga
      361 gaacgacccc gagacggact atttctatcc aagatatcaa gagtgcatga ggaaatatgg
      421 ccggcccgaa gataaaaacc caaatttcgc cacctgtgtt aagaacttac ctgaccaatg
      481 caccccaaac ccctgtgata agaagggcac tcaactctgc caagacctca tgggcaactt
      541 cttctgcttg tgcaaagatg gctggggagg ccggctctgt gacaaagatg tcaacgagtg
      601 tagtcagaag aatgggggct gcagccaggt ctgccataac aaaccaggaa gcttccaatg
      661 tgcctgccac agtggcttct cacttcaatc agacaacaag agctgccaag atatagatga
      721 atgcacagac tcagacacct gtggggatgc gcgttgcaag aaccttccgg gctcctactc
      781 ctgcctctgc gacaaggggt acacttacag ctccaaggag aagacctgcc aagatgtgga
      841 tgagtgccag caggaccgtt gtgagcagac ctgtgtcaac tccccaggca gctatacctg
      901 ccactgtaat gggcgcgggg gcctaaaact gtccccagac atggatacct gtgaggacat
      961 cttaccgtgt gtgcccttca gcatggccaa gagcgtcaag tccttgtacc tgggccgcat
     1021 gttcagcggg acccccgtga ttagactacg cttcaagagg ctccagccta ccaggctgct
     1081 ggccgaattt gacttccgta cttttgaccc tgagggagtc ctcttcttcg ccggaggtcg
     1141 ctcggatagc acctggatcg tcctgggctt cagggctggg cgacttgagt tgcagctacg
     1201 gtacaatggc gttggacgca tcaccagcag tgggccaacc atcaaccacg gcatgtggca
     1261 aacgatctct gtggaagaac tggaccgcaa ccttgtcatc aaggtcaaca aagatgccgt
     1321 gatgaagatt gcggtggctg gggggctgtt ccagctagag agaggcctgt accacctgaa
     1381 tctcactgtg gggggcattc ccttcaagga gagtgacctc gtccagccga ttaaccctcg
     1441 cctggacggg tgcatgagga gctggaactg gctgaatggg gaagacagtg ccattcagga
     1501 aacggtcaag gccaatacaa aaatgcagtg cttctctgtg acagagaggg gctccttctt
     1561 cccggggaat ggatttgcct tctatagcct caactacacc cggacatcgc tggatgtcgg
     1621 cacggaaacc acctgggaag tagaagtcgt ggctcgcatt cgccctgcca ctgacacggg
     1681 ggtgctgatg gcactggtgg gggacaaaga cgtcgtcctc ctctctgtgg ccctggtcga
     1741 ctaccactcc acaaagaagc tcaagaagca gctggtggtc ctggcagttg agaatgttgc
     1801 cctggccctg atggaaatca aggtgtgcga cagccaggaa cacactgtca ctgtctccct
     1861 gcgggatggc gaggccaccc tggaagtgga tggtaccaag ggccagagcg aagtgagcac
     1921 cgcacagctg caggagcgac tggacctgct taagacacgt ctgcaaggct ccgtgctcac
     1981 ctttgtgggg ggcctgccag atgtacaagt gacttccaca cccgtcacgg cgttctaccg
     2041 tggatgcatg actctggagg taaacgggaa gaccctggac ctggatacgg cctcctacaa
     2101 gcacagtgac atcacctccc actcctgccc gcctgtggag cacgtcacag cctagaccga
     2161 gctgcaagag ttctctacac ctaaaagaca cggtgaagca gggtcaggga cacacagcac
     2221 catctcctct cgcatgggcc ctgcaacact ggagcaggtg ggctactgcc tttgtggctt
     2281 tttttttttc cttgagatct ttctttttgc cttgtaatat atctgtacat agtgggactg
     2341 ataccgggtc agcggctgct catgagagag ccgcgaggcc tggtgagagc tggctggaag
     2401 gggctggact ggaggggctg gcggttcgca gcagagcggg actatctgaa gaaaataatt
     2461 ctctattatt tttattacca catgcttctt tctgattcta aaatatggaa aataaaatat
     2521 ttacagaaac ctttttaaaa aaaaaaaaaa aaaaaaaaaa
//
