LOCUS       NM_001401406            3695 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus growth arrest-specific 2 like 1 (Gas2l1), mRNA.
ACCESSION   NM_001401406 XM_006251340
VERSION     NM_001401406.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3695)
  AUTHORS   van de Willige,D., Hummel,J.J., Alkemade,C., Kahn,O.I., Au,F.K.,
            Qi,R.Z., Dogterom,M., Koenderink,G.H., Hoogenraad,C.C. and
            Akhmanova,A.
  TITLE     Cytolinker Gas2L1 regulates axon morphology through
            microtubule-modulated actin stabilization
  JOURNAL   EMBO Rep 20 (11), e47732 (2019)
   PUBMED   31486213
  REMARK    GeneRIF: The microtubule-binding tail region of Gas2L1 directs its
            actin-stabilizing activity towards the axon. We propose that Gas2L1
            acts as an actin regulator, the function of which is spatially
            modulated by microtubules.
REFERENCE   2  (bases 1 to 3695)
  AUTHORS   Stroud,M.J., Nazgiewicz,A., McKenzie,E.A., Wang,Y., Kammerer,R.A.
            and Ballestrem,C.
  TITLE     GAS2-like proteins mediate communication between microtubules and
            actin through interactions with end-binding proteins
  JOURNAL   J Cell Sci 127 (Pt 12), 2672-2682 (2014)
   PUBMED   24706950
REFERENCE   3  (bases 1 to 3695)
  AUTHORS   Gamper,I., Koh,K.R., Ruau,D., Ullrich,K., Bartunkova,J., Piroth,D.,
            Hacker,C., Bartunek,P. and Zenke,M.
  TITLE     GAR22: a novel target gene of thyroid hormone receptor causes
            growth inhibition in human erythroid cells
  JOURNAL   Exp Hematol 37 (5), 539-548 (2009)
   PUBMED   19375645
REFERENCE   4  (bases 1 to 3695)
  AUTHORS   Goriounov,D., Leung,C.L. and Liem,R.K.
  TITLE     Protein products of human Gas2-related genes on chromosomes 17 and
            22 (hGAR17 and hGAR22) associate with both microfilaments and
            microtubules
  JOURNAL   J Cell Sci 116 (Pt 6), 1045-1058 (2003)
   PUBMED   12584248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Feb 11, 2022 this sequence version replaced XM_006251340.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.49522.1,
                                           SRR26643285.39131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000014.1  84175414-84175514   c
            102-754             JAXUCZ010000014.1  84174037-84174689   c
            755-862             JAXUCZ010000014.1  84172733-84172840   c
            863-959             JAXUCZ010000014.1  84172555-84172651   c
            960-1131            JAXUCZ010000014.1  84172295-84172466   c
            1132-3695           JAXUCZ010000014.1  84169398-84171961   c
FEATURES             Location/Qualifiers
     source          1..3695
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3695
                     /gene="Gas2l1"
                     /note="growth arrest-specific 2 like 1"
                     /db_xref="GeneID:360973"
                     /db_xref="RGD:1311206"
     exon            1..101
                     /gene="Gas2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            102..754
                     /gene="Gas2l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2158
                     /gene="Gas2l1"
                     /codon_start=1
                     /product="GAS2-like protein 1"
                     /protein_id="NP_001388335.1"
                     /db_xref="GeneID:360973"
                     /db_xref="RGD:1311206"
                     /translation="MADPVAGIAGSAAKSVRPFRSSEAYVEAMKEDLADWLNALYSLG
                     LPGSGDGFLTGLATGTTLCQHANAVTKAARALAAARPTRGVAFQAHSVAPGSFMARDN
                     VASFIGWCRAELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGLLAPRLVQF
                     EQEIERELRATPQASSVPAAEEDVTEIAAAPGAPARTPRMTPNDIRNLDELVREILGK
                     CTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRNHVMVRVGGGWDTLEHYLDKHDPCRC
                     TSSTHRLPQQRTGTFSPQRGSPTPSPRPGSPVPGSERRSSRPEVTPISLRSTKEGPET
                     PLRPRDQLPPLPRSRRYSGDSDSSASSAQSGPMGARSDDSATGSRRERPNHRLTSGLT
                     ASPRRPPTPRSQSRDRLDRGRPRMAPGGRGAQLSASSPARRTRSQNREEQAVLVVRRD
                     RDGQHSWVARGRGGGGSGGSGRSTPQTPRARSPAAPRPSRGPSPGPELAATPASIFRT
                     PLQLDPQQEQQLFRRLEEEFLANARALEAAASHTLMGSAPDHPAPDSAYCSSSSSSSS
                     LSVLGGKCGQPRESGRTANGLPAPRSQALSSSSDEGSPCLAVGRTLDAARSSLAGPEP
                     SLTWARGRMDTQPDRKPSRIPTPRGPRRPSGPTELGAWHALHSVTPRTEPDSSM"
     exon            755..862
                     /gene="Gas2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..959
                     /gene="Gas2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1131
                     /gene="Gas2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..3695
                     /gene="Gas2l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgcctggaa gcagcgagct cgggcggcgc ctgtgtgcgg cggcgcggcc cggctccggc
       61 cccgccgggg cgatgctccc cggggcggcg gggtgagcca gtgactccac tggccccggg
      121 catggcggac ccagtggcgg gcatcgcagg ctccgccgcc aagagtgtgc gacccttccg
      181 atccagtgag gcctatgtgg aagccatgaa ggaagacctg gccgattggc tcaatgcttt
      241 gtatagtcta ggtctacccg gcagtggtga tggcttcctc acggggctgg ccacgggtac
      301 aaccctgtgc cagcatgcca acgctgtcac caaggctgcc cgggctctgg ctgctgcccg
      361 tccaacccga ggtgtggcct tccaggcaca cagtgtggcg cctggctcct tcatggcccg
      421 agacaacgtg gcctctttca tcggctggtg ccgggctgag ctgggcgtgc ctgaagtgct
      481 catgtttgag acagaggacc tggtgctgcg caagaacgag aagagtgtgg tgctgtgcct
      541 gttggaggtt gcccgacgtg gggcacgcct tgggctgctc gccccgaggc tggtacagtt
      601 tgagcaggag attgagcggg agcttcgggc tacccctcag gcctccagcg tccctgctgc
      661 tgaagaggat gtcactgaaa tcgctgctgc accaggggca cctgcccgca caccccgcat
      721 gacgcccaat gacattcgaa acctggacga gctggtaagg gagatcctgg gcaagtgcac
      781 ctgcccagac cagtttccca tgatcaaggt ctccgagggg aagtaccgag tgggagactc
      841 cagcttgctc atctttgtga gggtgctgag gaaccacgtg atggtgcgag tgggcggcgg
      901 ctgggacaca ctggagcact acctagacaa gcatgaccct tgccgctgca cttcttccac
      961 ccaccggctg ccccagcaga gaaccgggac tttctctccg cagaggggat cacccactcc
     1021 tagtccccgc cccggtagcc cagtccctgg aagtgagcgc cggagctccc ggcccgaagt
     1081 aactcccatc agcctgcgaa gcacaaagga ggggcctgag accccactca ggccccgcga
     1141 ccagctgccc cccctccccc gctcccgccg ctactccggg gacagtgact cctcagcctc
     1201 ctcagcacag agcggcccca tgggtgcccg cagcgacgat tcagccactg gctcccggag
     1261 ggagcggcct aaccaccggc tgacctccgg tctaacggcc tccccgagac ggccgcccac
     1321 ccctcgcagc cagtctcgag accggctgga ccggggacgg cctcgcatgg ccccaggagg
     1381 ccgaggcgct cagctgtcgg cctccagccc cgcacggcgc acccgcagcc agaaccgcga
     1441 ggaacaggcg gtactggtgg tgcgcaggga ccgagacggc cagcactcgt gggtggcccg
     1501 gggcaggggt ggcgggggat cagggggttc tggaaggagt accccgcaga ctccgcgtgc
     1561 ccgcagtcct gcagcaccca ggccttccag gggccccagc ccaggcccag agctagctgc
     1621 cacacccgcc agcatcttcc gcacgcccct gcagcttgac ccacagcagg agcagcagct
     1681 gttcaggcgc ctggaagagg aattcttggc caatgcccgc gccttggagg ctgctgccag
     1741 ccataccctc atgggatcag cccctgacca tccagctccg gactctgctt actgttcatc
     1801 cagctcctca tcttcatcac tcagtgttct gggtggcaaa tgtggccaac ccagggaatc
     1861 aggtcgcaca gccaatgggc tgcctgcgcc ccgcagccaa gctctgtcca gctcttccga
     1921 tgagggcagc ccctgccttg ctgtaggaag gacactggat gcagccagga gttctttggc
     1981 tggcccagag ccctctctga cctgggcaag ggggcggatg gacacacaac cagaccgtaa
     2041 accctcacgc atacccacac ctcggggacc ccgccgccca tcgggaccca cagagcttgg
     2101 ggcttggcat gccctgcatt cggtcacccc aaggaccgag ccagattctt caatgtgatg
     2161 gaccggctcc actgcaccca caccccattc cattttcttt gtggccttaa cctatccttt
     2221 gcatcaggga ctccccttcc atctcttgag caccagacct catgggacca gaccccacgg
     2281 gaccacatgg cacaatggga cacctgttgt acattccggt tcgggggatg agcattgcta
     2341 tttaattact aatattattg aatgccttag aggagaccgg gctagcccgg tgtccagagg
     2401 acctgtggtc cagtaagcag aacctctgac agtaaagtat tgctccagct cctggttttt
     2461 ggggaccgag ccttcattat atgttgggat tctagagtga actgcctgga gaccagacct
     2521 caatgctctg gacctgtcta ttccagaaca agaaaccctt acattgtgcg cttacatttt
     2581 ttgcttttgt ttttattgcc tgctaaggcg tgactttaaa aagtgtctcc agtagccagt
     2641 ctagcagtgg agaggtagag gcaggtgggt ctatgtagtt caatatgagt gctagaagct
     2701 gtatgaatac ttctgatcgc attcatattc aagtcctttc cagctgtgat tgtaacccaa
     2761 taaggtctta gaaaaaaact gatcttgtcc aatgattggg agttggctgg gtccaatcaa
     2821 gatcaaagaa aagcccgttg gccaggagtc tgggtgggag cctgctttca tgaaatttcc
     2881 ctgttcaatc tgatcacatg aggctgcagc gcgctgggtg cagcgccccc tgcagacgca
     2941 gagcgggatg tgcaggacgt gtgcgcacca aagcacaacg tagaagctct cggaagagac
     3001 gcagcacgtg ccaattgtat ttggctgagc actcgaggta gccacagcgc cagccccttc
     3061 gaactagagt ggccagtgca cgacgaggtc cgaagcgcag ccgctgacgg tcccgcttgt
     3121 tgcccaccac caggatgggt gcctctggcg ctcccgccgg cctggaggcc cgatggagat
     3181 gagagacgca gtgctggaga ctccatggcc agaggaaccc acccaatgtg tacaagtgaa
     3241 ggcgggaccc tcctagggcc tgagactccc tggtgtgctg catacctcat acagcaagag
     3301 accctcaagt gggcacaaag tatgctccag aaacaaccag actatacccg ctcccctggc
     3361 aagacctcca cctccagtca agccctcacc tgttttctgc tatgcgttgc ctcagggctt
     3421 tcacataatc gaaactgtcc gggctgcaga tgtcgtagac cagcacaaag gcatccgtgt
     3481 cctgcaagct ccagtcttta gggtccggcc actcctaagg gtagaggctg gggcttacag
     3541 cagaccctcc tactccagtt catccttccc catcacctac caacaacact caggacgcac
     3601 cctcccacag gccagatttc ccagccctgt ctggatcttg tcagtcctta actcccctac
     3661 ttactgggcc tctaattaaa ctactatcca cccaa
//
