LOCUS       NM_001400814            2986 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus growth arrest-specific 1 (Gas1), mRNA.
ACCESSION   NM_001400814 XM_003751637
VERSION     NM_001400814.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2986)
  AUTHORS   Luna-Antonio,B.I., Rodriguez-Munoz,R., Namorado-Tonix,C.,
            Perez-Lopez,A., Sanchez,E.I., Vergara,P., Reyes,J.L. and Segovia,J.
  TITLE     Expression of growth arrest specific 1 (Gas1) in the distal tubules
            and collecting ducts in normal kidney and in the early stages of
            diabetic nephropathy
  JOURNAL   J Mol Histol 53 (6), 925-946 (2022)
   PUBMED   36272046
  REMARK    GeneRIF: Expression of growth arrest specific 1 (Gas1) in the
            distal tubules and collecting ducts in normal kidney and in the
            early stages of diabetic nephropathy.
REFERENCE   2  (bases 1 to 2986)
  AUTHORS   Ayala-Sarmiento,A.E., Estudillo,E., Perez-Sanchez,G.,
            Sierra-Sanchez,A., Gonzalez-Mariscal,L., Martinez-Fong,D. and
            Segovia,J.
  TITLE     GAS1 is present in the cerebrospinal fluid and is expressed in the
            choroid plexus of the adult rat
  JOURNAL   Histochem Cell Biol 146 (3), 325-336 (2016)
   PUBMED   27225491
  REMARK    GeneRIF: The pattern of expression of GAS1 is perivascular in both
            the CP and the liver. In vitro studies show that the fibroblast
            cell line NIH/3T3 expresses one form of GAS1 and releases two
            soluble forms into the supernatant.
REFERENCE   3  (bases 1 to 2986)
  AUTHORS   Chapuis,J., Vingtdeux,V., Campagne,F., Davies,P. and Marambaud,P.
  TITLE     Growth arrest-specific 1 binds to and controls the maturation and
            processing of the amyloid-beta precursor protein
  JOURNAL   Hum Mol Genet 20 (10), 2026-2036 (2011)
   PUBMED   21357679
REFERENCE   4  (bases 1 to 2986)
  AUTHORS   Martinelli,D.C. and Fan,C.M.
  TITLE     A sonic hedgehog missense mutation associated with
            holoprosencephaly causes defective binding to GAS1
  JOURNAL   J Biol Chem 284 (29), 19169-19172 (2009)
   PUBMED   19478089
REFERENCE   5  (bases 1 to 2986)
  AUTHORS   Ohazama,A., Haycraft,C.J., Seppala,M., Blackburn,J., Ghafoor,S.,
            Cobourne,M., Martinelli,D.C., Fan,C.M., Peterkova,R., Lesot,H.,
            Yoder,B.K. and Sharpe,P.T.
  TITLE     Primary cilia regulate Shh activity in the control of molar tooth
            number
  JOURNAL   Development 136 (6), 897-903 (2009)
   PUBMED   19211681
REFERENCE   6  (bases 1 to 2986)
  AUTHORS   Lee,C.S., May,N.R. and Fan,C.M.
  TITLE     Transdifferentiation of the ventral retinal pigmented epithelium to
            neural retina in the growth arrest specific gene 1 mutant
  JOURNAL   Dev Biol 236 (1), 17-29 (2001)
   PUBMED   11456441
REFERENCE   7  (bases 1 to 2986)
  AUTHORS   Lee,K.K., Leung,A.K., Tang,M.K., Cai,D.Q., Schneider,C.,
            Brancolini,C. and Chow,P.H.
  TITLE     Functions of the growth arrest specific 1 gene in the development
            of the mouse embryo
  JOURNAL   Dev Biol 234 (1), 188-203 (2001)
   PUBMED   11356029
REFERENCE   8  (bases 1 to 2986)
  AUTHORS   Ruaro,M.E., Stebel,M., Vatta,P., Marzinotto,S. and Schneider,C.
  TITLE     Analysis of the domain requirement in Gas1 growth suppressing
            activity
  JOURNAL   FEBS Lett 481 (2), 159-163 (2000)
   PUBMED   10996316
REFERENCE   9  (bases 1 to 2986)
  AUTHORS   Stebel,M., Vatta,P., Ruaro,M.E., Del Sal,G., Parton,R.G. and
            Schneider,C.
  TITLE     The growth suppressing gas1 product is a GPI-linked protein
  JOURNAL   FEBS Lett 481 (2), 152-158 (2000)
   PUBMED   10996315
REFERENCE   10 (bases 1 to 2986)
  AUTHORS   Del Sal,G., Collavin,L., Ruaro,M.E., Edomi,P., Saccone,S.,
            Valle,G.D. and Schneider,C.
  TITLE     Structure, function, and chromosome mapping of the
            growth-suppressing human homologue of the murine gas1 gene
  JOURNAL   Proc Natl Acad Sci U S A 91 (5), 1848-1852 (1994)
   PUBMED   8127893
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jan 27, 2022 this sequence version replaced XM_003751637.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26643285.47987.1,
                                        SRR26643289.39253.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2986              JAXUCZ010000017.1  4487716-4490701
FEATURES             Location/Qualifiers
     source          1..2986
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2986
                     /gene="Gas1"
                     /note="growth arrest-specific 1"
                     /db_xref="GeneID:683470"
                     /db_xref="RGD:1586820"
     exon            1..2986
                     /gene="Gas1"
                     /inference="alignment:Splign:2.1.0"
     CDS             427..1578
                     /gene="Gas1"
                     /codon_start=1
                     /product="growth arrest-specific protein 1"
                     /protein_id="NP_001387743.1"
                     /db_xref="GeneID:683470"
                     /db_xref="RGD:1586820"
                     /translation="MDEDAHARSARNSDKLFQRPRGRHPSLVSAPHRVRRPLLPAMLA
                     ALLGGGGARSGSLPGALLCLMALLQLLGSAPRGSGLAHGRRLICWQALLQCQGEPDCS
                     YAYSQYAEACAPVLAQRGGADAPGPAGAFPSSAASFSPRWRCPSHCISALIQLNHTRR
                     GPALEDCDCAQDEHCRSTKRAIEPCLPRTSSVGPGAGAGSVMGCTEARRRCDRDSRCN
                     LALGRYLAYCGKLFNGLRCTDECRAVIEDMLAVPKAALLNDCVCDGLERPICESVKEN
                     MARLCFGPDASNGPGSSGSDGGLDDYYDEEYDDEQRAGAAGGEQPLDDDDGLARPGGG
                     AAGAGGRGDLPHGPGRRSSSSGSGGHWATRSSWTPFACFLLLLLLGSHL"
ORIGIN      
        1 agccgggctc cgcggatccg ctccccaggc tccgggtctc cgagcagagc cgcacgctcc
       61 gagtttcggg gtcctccctg cgcctggctc ccagaacttc ccggagtgcg gcccaggccc
      121 gggtagaggg ggaggggacc aagcgtcctg gtcgcgggaa ggcgggatgc cagagctgcg
      181 aactgctacg cgctactgag ccgggaacgg aggagccacc ggccacacga ccttctgcag
      241 gcgccttgca ccatgcaccc ccggcgccgc gcgctcctgc agcctcgccg cgtcccccag
      301 ggacggcact gaacgcttcc agccgccgat cggagccgga cctgcgtcgc cgcgcctctc
      361 agggagcccc ggccgcggtg ctggagcaaa cacccgcctc taccagccgc ggggccgccg
      421 gcatggatgg atgaggacgc ccatgccaga agtgcgcgga actcggacaa acttttccag
      481 cggccccgcg gccgccaccc gagcctcgtt tccgctccgc accgcgtccg gcggccgctg
      541 ctgcccgcga tgctagccgc actgctgggc ggcggcggag cccgctcggg gagcttgccg
      601 ggcgccttgc tgtgcctgat ggcgctgctg cagttgctgg gctcggcgcc gcggggctcg
      661 gggctggcgc acggccgccg cctcatctgc tggcaggcgc tgctgcagtg tcagggagag
      721 ccggactgca gctacgccta cagccagtac gccgaggcgt gtgcgccggt gctcgcacag
      781 cgcggcggag ctgatgctcc tgggcccgcc ggcgccttcc cctcctcggc cgcgtccttc
      841 tcgccgcgct ggcgctgccc gagccactgc atctcggcgc tcatccagct caaccacacg
      901 cgccgcgggc ccgcgctgga ggactgcgac tgcgcgcagg acgaacactg caggtccacc
      961 aagcgcgcca tcgagccctg tctgccgcgc accagcagcg tgggcccggg cgcgggagcg
     1021 ggctcggtca tgggctgcac tgaggcccgg cggcgctgcg accgggacag ccgctgcaac
     1081 ctggcactcg gccgctatct agcctactgc ggcaagcttt tcaacggtct ccgctgcacc
     1141 gacgagtgcc gcgcggtcat cgaggacatg ctggcggtgc ccaaggcggc gctgctcaac
     1201 gactgtgtgt gcgatgggct ggagaggccc atctgcgagt cggtcaagga gaacatggcc
     1261 cgcctgtgct tcggcccaga tgcgagcaac ggtccgggca gcagcggctc ggacgggggc
     1321 ctagacgact actacgacga agaatatgat gacgagcagc gcgctggggc cgcgggcggc
     1381 gagcagcccc tggacgacga cgacggcctt gcgcgcccgg gcggcggcgc tgctggggca
     1441 ggcggacgcg gggacttgcc ccacgggccg gggcgcagga gcagcagcag cggcagtgga
     1501 ggccactggg cgacccgaag ctcctggacc ccgtttgcct gttttctgct gctcctgctg
     1561 cttgggtccc acttgtagcc cccgcgcccc tgctgcaggc tactccaggc cggtacgcac
     1621 gacccagctg attcccgagc agggcacctg tggctcggag accggagatg atcgggagca
     1681 ctgacccaca ctctccgcgg gtagacaggg cccagcccgt accgcaacta ccatgctcgg
     1741 cccttttctg tgcggttttc caggctgcag ataaaaccgg ccgatctata ctgccggctc
     1801 taatctgcag aattcaggac accttgccaa aagcaatgaa ggcctggctg gactcttgtt
     1861 agagtgctga acggtggggg tctttacagt tccagtggac tagggaaagg gatgttgagc
     1921 gaattaggtt tgcaaagggg ccggaacttt tgtttgtctg tttgttctgt tttgttttta
     1981 aacttttttc ctgtgagggg acacatagta ctggtaacga ctttaattgc tcgtgaccac
     2041 tgagaaacac agcaatccta agtaagtaga aaagttccct ttaccgattc attcctgtac
     2101 tcttggtgta gccctcggta acgctgagtg tggagcccgc gattgcctcg ttggggggtc
     2161 cccgaaatta tgactgcaac cttaacccct cacctctaat tttaccgccc ccattctgat
     2221 ccctctgcac cacgtgtctt agagttaagg atccaaaaaa cgctagtcta aagagttacc
     2281 acagtgttga acaatacacg tttttatcct aaagctcggt actgccaact aggaaaacct
     2341 ctatgatgtt tgttctgttg tccttttttt tttttttttt tttcctccac caagaaattc
     2401 taagtttgaa tattgcagag attgactatt gctctgcccc tatcggggtc ctgcaccctg
     2461 gtacgtcgta tataaactgt attaaaactg gggtttctta ccagttgtac tttgtatata
     2521 gaatttttat aaattgtatg cttcagaaaa taatttattt tttaaaaaga aattaaaagt
     2581 cttaaatctg catcactgtt gtatcacacc ccacccctat ccaagaaatg tatagaaaac
     2641 attggtcacc aggaacccac tcctgcagcc catccaagaa atgtatagaa aacattggtc
     2701 accaggaatc cactcccgca gcctatttta ggtgtgccct gtgtagaaga acagacttaa
     2761 aaatgtacag tgtattttac agatttgaag taacgttctt attttcgaga gaatttatgg
     2821 acattgtaga gatgtattaa atgcatttcc aaactgcctt aaacattgta tttttataga
     2881 cctcattttt ttttaaatcc tgtgtttaaa aagaaaaaac tatgactctg tgtattttgg
     2941 gttgttttat tacaaatgca cacatcagta aagagtttaa acactg
//
