LOCUS       NM_001011899            3405 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus phosphoribosylglycinamide formyltransferase,
            phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole
            synthetase (Gart), mRNA.
ACCESSION   NM_001011899 XM_213651
VERSION     NM_001011899.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3405)
  AUTHORS   Zhang D, Yue Y, Jiang S, Li A, Guo A, Wu X, Xia X, Cheng H, Zhang
            J, Tao T and Gu X.
  TITLE     GART expression in rat spinal cord after injury and its role in
            inflammation
  JOURNAL   Brain Res 1564, 41-51 (2014)
   PUBMED   24709117
  REMARK    GeneRIF: After spinal cord injury, GART expression was increased in
            astrocytes, correlated with the highly expressed proliferating cell
            nuclear antigen. Knockdown of GART expression in astrocytes
            revealed that it plays a role in pro-inflammatory factors.
REFERENCE   2  (bases 1 to 3405)
  AUTHORS   Stover PJ and Field MS.
  TITLE     Trafficking of intracellular folates
  JOURNAL   Adv Nutr 2 (4), 325-331 (2011)
   PUBMED   22332074
  REMARK    Review article
REFERENCE   3  (bases 1 to 3405)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 3405)
  AUTHORS   Zhang Y, Desharnais J, Greasley SE, Beardsley GP, Boger DL and
            Wilson IA.
  TITLE     Crystal structures of human GAR Tfase at low and high pH and with
            substrate beta-GAR
  JOURNAL   Biochemistry 41 (48), 14206-14215 (2002)
   PUBMED   12450384
REFERENCE   5  (bases 1 to 3405)
  AUTHORS   Brodsky G, Barnes T, Bleskan J, Becker L, Cox M and Patterson D.
  TITLE     The human GARS-AIRS-GART gene encodes two proteins which are
            differentially expressed during human brain development and
            temporally overexpressed in cerebellum of individuals with Down
            syndrome
  JOURNAL   Hum Mol Genet 6 (12), 2043-2050 (1997)
   PUBMED   9328467
REFERENCE   6  (bases 1 to 3405)
  AUTHORS   Hards,R.G., Graw,S.L. and Patterson,D.
  TITLE     Purification of mammalian glycinamide ribonucleotide (GAR)
            synthetase
  JOURNAL   Adv Exp Med Biol 195 Pt B, 315-319 (1986)
   PUBMED   3532702
REFERENCE   7  (bases 1 to 3405)
  AUTHORS   Deacon,R., Chanarin,I., Lumb,M. and Perry,J.
  TITLE     Role of folate dependent transformylases in synthesis of purine in
            bone marrow of man and in bone marrow and liver of rats
  JOURNAL   J Clin Pathol 38 (12), 1349-1352 (1985)
   PUBMED   4078017
REFERENCE   8  (bases 1 to 3405)
  AUTHORS   Daubner,S.C. and Benkovic,S.J.
  TITLE     Characterization of mammalian phosphoribosylglycineamide
            formyltransferase from transformed cells
  JOURNAL   Cancer Res 45 (10), 4990-4997 (1985)
   PUBMED   4027981
REFERENCE   9  (bases 1 to 3405)
  AUTHORS   Deacon,R., Perry,J., Lumb,M. and Chanarin,I.
  TITLE     Effect of cobalamin inactivation on folate-dependent
            transformylases involved in purine synthesis in rats
  JOURNAL   Biochem J 227 (1), 67-71 (1985)
   PUBMED   3994693
REFERENCE   10 (bases 1 to 3405)
  AUTHORS   Dominguez,J. and Ordonez,L.A.
  TITLE     Developmental changes in the folate-dependent enzymes of de novo
            purine biosynthesis in rat brain
  JOURNAL   J Neurochem 38 (3), 625-630 (1982)
   PUBMED   7057182
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473989.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001011899.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3405
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3405
                     /gene="Gart"
                     /note="phosphoribosylglycinamide formyltransferase,
                     phosphoribosylglycinamide synthetase,
                     phosphoribosylaminoimidazole synthetase"
                     /db_xref="GeneID:288259"
                     /db_xref="RGD:1308717"
     exon            1..70
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            71..254
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..3142
                     /gene="Gart"
                     /codon_start=1
                     /product="trifunctional purine biosynthetic protein
                     adenosine-3"
                     /protein_id="NP_001011899.2"
                     /db_xref="GeneID:288259"
                     /db_xref="RGD:1308717"
                     /translation="MAARVLVIGSGGREHTLAWKLAQSPHVKQVLVAPGNAGTASAGK
                     ISNAAVSINDHTALARFCKDEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAAL
                     LESSKKFAKEFMDRHGVPTAQWRAFTSPEDACSFIMSADFPALVVKASGLAAGKGVIV
                     AKSKAEACEAVQEIMQEKSFGAAGETVVVEELLEGEEVSCLCFTDGKTVAPMPPAQDH
                     KRLLDGDRGPNTGGMGAYCPAPQVPKDLLVKIKNTILQRTVDGMQQEGVPYTGILYAG
                     IMLTKDGPKVLEFNCRFGDPECQVILPLLKSDLYEVIQSTFDGLLSESPPVWLENHSA
                     VTVVMASGGYPGAYTKGVEITGFPEAQALGLQVFHAGTALKDAKVVTSGGRVLTVTAV
                     RENLMSALDEARKGLAALKFEGAVYRKDIGFRAVAFLQRPRGLTYKDSGVDIAAGNML
                     VKKIQPLAKATSRPGCSVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNK
                     HDSIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSTTEAVVAGIAAACRQAGCAL
                     LGGETAEMPDMYPPGEYDLAGFAVGAMERHQKLPQLERIAEGDAVIGVASSGLHSNGF
                     SLVRKIVERSSLQYSSPAPGGCGDQTLGDLLLTPTRIYSHSLLPIIRSGRVKAFAHIT
                     GGGLLENIPRVLPRKLGVDLDAYTWRVPKVFSWLQQEGQLSEEEMARTFNCGVGAALV
                     VSKDQTEQILHDIRQHQEDAWVIGSVVECPEDSPRVRVKNLIETMQTKGSVVTNGFLR
                     SNFPSQQKKARVAVLISGTGSNLQALIDSTRDPKSSSHIVLVISNKAAVAGLDRAERA
                     GIPTRVINHKLYKSRVEFDNAVDHVLEEFSVDIVCLAGFMRILSGPFVRKWDGKMLNI
                     HPSLLPSFKGSNAHEQVLEAGVTITGCTVHFVAEDVDAGQIILQEAVPVQRDDTVATL
                     SERVKAAEHKIFPAALQLVASGAVQLGEDGKIHWAREQ"
     exon            255..350
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            351..525
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            526..637
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            638..706
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            707..832
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            833..920
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1006
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1175
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1407
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1502
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1612
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1811
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2063
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2216
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2423
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2561
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2692
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2834
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2950
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3405
                     /gene="Gart"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcccgggg ccaacttccg gcgagtgcga gtggcgggtg cgaatgcgag ctgcgtggcc
       61 gggcttgcag gtttcatttg gcttctgaat tcctgcttcg gagacaacaa tggcagcccg
      121 agttcttgta atcggtagtg gaggaaggga acacaccctg gcctggaaac tcgcacaatc
      181 ccctcatgtc aaacaagtgc tggttgcccc aggaaatgca ggcacagctt ctgctgggaa
      241 gatctccaat gctgctgtct ccatcaatga tcacactgct ctcgctcggt tctgcaaaga
      301 tgaaaagatt gaactcgtag ttgttggacc agaggcccct ctggctgcag ggattgttgg
      361 ggacctgact tctgcaggag tgcgatgctt tggccccacg gcacaagcag ctctactgga
      421 gtccagtaaa aagtttgcca aagagtttat ggaccgacat ggcgtcccaa ctgcacagtg
      481 gcgggcattc accagccctg aagacgcctg cagctttatt atgagcgcgg actttcctgc
      541 tttggttgtg aaggccagtg gccttgcagc agggaagggg gtgattgtgg cgaagagcaa
      601 agctgaagcc tgcgaagctg ttcaggagat catgcaagaa aagtcatttg gagcagccgg
      661 tgaaactgtt gtcgtggagg agcttctgga aggggaagaa gtgtcttgcc tgtgcttcac
      721 tgatgggaag acagtggccc caatgccccc agcacaagac cataagcgat tgctggatgg
      781 agatcgggga cccaacactg gaggaatggg agcctactgc cctgcacctc aggttcctaa
      841 ggatttgtta gtaaaaatta aaaacacaat tcttcagaga acagtagatg gcatgcagca
      901 ggagggggtg ccgtacacag gaattcttta tgctggtata atgctgacca aagatggccc
      961 aaaagttttg gagtttaatt gccgttttgg tgatccagaa tgccaggtca tcctcccact
     1021 tcttaaaagt gacctttatg aagtgattca gtccaccttt gatggcctgc tgagcgagtc
     1081 tccgcctgtt tggctagaaa accacagtgc cgtaactgtt gtcatggcga gtggagggta
     1141 tcctggagcc tacaccaagg gtgtggagat tacagggttt cctgaggccc aagctttagg
     1201 actgcaggtc tttcatgcag gcactgctct taaagatgcc aaagtggtga ccagcggggg
     1261 cagagtcctc acagtgacag ctgtccggga aaatctcatg tcagcccttg atgaggccag
     1321 gaagggactc gctgctctaa agtttgaggg agcagtttac cgaaaggaca ttggcttccg
     1381 tgctgtggcc ttcctccagc ggcccagggg cctgacctac aaggactctg gagtagacat
     1441 tgcagctgga aatatgctgg ttaagaaaat tcagccttta gccaaagcta cctccagacc
     1501 aggctgcagt gttgaccttg ggggctttgc tggtcttttt gatttgaaag cagctggttt
     1561 caaagatcct cttctggcct ctggaacaga cggtgttgga actaaactaa agattgccca
     1621 gctgtgcaat aagcatgact ccatcggtca ggatctggtt gcgatgtgcg tgaacgacat
     1681 cctcgcacaa ggagcagagc ccctcttctt ccttgactac ttttcctgtg gaaaacttga
     1741 ccttagtaca actgaggctg tggttgctgg aattgctgca gcttgccgac aggctgggtg
     1801 tgctctccta ggtggggaga cagcagagat gcccgacatg tacccccctg gagagtatga
     1861 tcttgccgga tttgctgttg gtgctatgga gagacaccag aagctccctc agctagaaag
     1921 gatcgccgaa ggagatgccg ttattggagt ggcttcatct ggtcttcaca gcaatggctt
     1981 tagccttgtg aggaaaattg tggagaggtc ttcactccag tactcctctc cagcaccggg
     2041 tggttgtgga gatcagactt taggggactt acttctaact ccaaccagga tctacagcca
     2101 ttcactgctg cctatcatac gttcaggacg tgtcaaagct tttgctcata ttactggagg
     2161 tggattgctg gaaaacatcc ccagagtcct ccctcggaag cttggagtag atttagatgc
     2221 ctatacctgg agggtcccca aggtcttctc atggctacag caagaaggac agctctctga
     2281 agaagaaatg gccaggacat tcaactgtgg ggttggagct gccctggtgg tatcaaagga
     2341 ccaaacagag cagattctcc atgacattcg gcagcaccag gaagacgcct gggtgatagg
     2401 cagtgtcgtt gagtgtcccg aagattcccc tcgtgtcaga gttaagaatc tgattgaaac
     2461 catgcaaaca aaggggtcag tggtgacaaa cggcttcctg agaagtaatt tccctagcca
     2521 gcaaaagaaa gcaagagtgg ctgtcctaat atctggaaca gggtcgaacc tccaggcact
     2581 catagacagc actcgggatc caaaaagctc ctcacacatc gttcttgtca tctccaacaa
     2641 agctgcagtt gctggcttag accgagcaga gcgagctggc attcccacca gggtgattaa
     2701 tcataagtta tataaaagtc gtgtcgagtt tgacaacgca gttgaccatg tcctggaaga
     2761 gttctcagta gacatagtct gtctcgcagg attcatgagg atcctctctg gcccgtttgt
     2821 cagaaaatgg gatgggaaaa tgctcaacat ccacccgtcc ttgctccctt cttttaaggg
     2881 ttcaaatgct cacgagcagg ttctggaggc tggagtcacc attactgggt gcaccgtaca
     2941 ctttgtagct gaagacgtag atgccgggca aatcatccta caggaagctg tccctgtgca
     3001 gagggacgac actgttgcaa cactgtctga acgcgtcaag gcagcagaac ataagatatt
     3061 tcctgcagcc ctccaactag tggccagtgg ggctgtgcag ctgggagaag acggcaagat
     3121 ccactgggcc agagagcagt agcccgtcct gagcaggagg gccagtgccg agagagaagc
     3181 agggcttgct gggtgccttt tcttctcttt ttcttcccca gagctgagga ccaaacccag
     3241 agccttgcac ttgctagcaa gcactctacc actgagctaa atccccagcc ctgctgggtg
     3301 ccttttcatc gtggccatgg cccaaactta tatacctgct agtaaaaagt ctttaatcct
     3361 taccagccgc catgttttta ataaataggt tcattaaaaa caaaa
//
