LOCUS       NM_001191874            2662 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus GRB2 associated regulator of MAPK1 subtype 2
            (Garem2), mRNA.
ACCESSION   NM_001191874 XM_343127
VERSION     NM_001191874.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2662)
  AUTHORS   Prunotto,M., Farina,A., Lane,L., Pernin,A., Schifferli,J.,
            Hochstrasser,D.F., Lescuyer,P. and Moll,S.
  TITLE     Proteomic analysis of podocyte exosome-enriched fraction from
            normal human urine
  JOURNAL   J Proteomics 82, 193-229 (2013)
   PUBMED   23376485
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jul 17, 2010 this sequence version replaced XM_343127.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.34559.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000006.1  31961480-31961591   c
            113-253             JAXUCZ010000006.1  31958453-31958593   c
            254-384             JAXUCZ010000006.1  31953854-31953984   c
            385-1446            JAXUCZ010000006.1  31952286-31953347   c
            1447-1616           JAXUCZ010000006.1  31951378-31951547   c
            1617-2662           JAXUCZ010000006.1  31949877-31950922   c
FEATURES             Location/Qualifiers
     source          1..2662
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..2662
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml"
                     /note="GRB2 associated regulator of MAPK1 subtype 2"
                     /db_xref="GeneID:362801"
                     /db_xref="RGD:1597138"
     CDS             1..2640
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml"
                     /note="protein FAM59B; family with sequence similarity 59,
                     member B; GRB2-associated and regulator of MAPK
                     protein-like; GRB2 associated, regulator of MAPK1-like;
                     GRB2 associated regulator of MAPK1, member 2"
                     /codon_start=1
                     /product="GRB2-associated and regulator of MAPK protein 2"
                     /protein_id="NP_001178803.1"
                     /db_xref="GeneID:362801"
                     /db_xref="RGD:1597138"
                     /translation="MEKLAAGLAGLRWSMGAFPLDLIVSRCRLPTLACLGPGEYAEGV
                     SERDILLIHSCRQWTTVTAHTLEEGHYVIGPKIDIPLQYPGKFKLLEQARDVREPVRY
                     FSSVEEVASVFPDRIFVMEAITFSVKVVSGEFSEDSEVYNFTLHAGDELTLMGQAEIL
                     CAKTTKERSRFTTLLRKLGRAGALAGIGGPGSMGATGGGGGAARPVRGKMPCLICMNH
                     RTNESLSLPFQCQGRFSTRSPLELQMQEGEHTVRAIIERVRLPVNVLVPSRPPRNPYD
                     LHPVREGHCYKLVSIISKTVVLGLALRREGPAPLHFLLLTDTPRFTLPQGLLAGDPRV
                     ERLVRDSASYCRERFDPDEYSTAVREAPAELADDCASPRRARLCLPAPRVPGSVRVPG
                     PPGRLGPALPAPSDSDQEYVSPDWAGAPEPAAACAEIPYEELWVHQGPESLADARARP
                     LTGPDLISFGTVGPPQHEPEAPPPPVPPKSEAVKEECRLLHAPPVPPRGGSSCSRLTG
                     SPPVPPRFPKLQSVHSPSSSLSYYSSGLQDGAGSRSGSGSPSPDAYSLYCYPCTWGDC
                     KASESSSRPPPGPLPSTTTQPPSQASRALAEPLSGRTASLLGADTPAVKNYHSCPPLF
                     KPSRPQKSLAPFGALNPFSGPAHPSGAPAASSSGSTSTSGALATSSPTHSPGPGPQGQ
                     GYSAAPSSSLSSSEWQEPALEPLDPFELGQASPPELELLRCQEPRASGTPGSGHCLSP
                     LGPPKALEPEGLVLRQVPASLSPAALQGPEAGGTLLFLTQGCLEGPPGSPREGVPGAG
                     VRDASSWQPPADLSALSVEEVSRSLRFIGLSEDVVSFFARERIDGSIFVQLSEDILAD
                     DFHLTKLQVKKIMQFIKGWRPKI"
     exon            1..112
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml"
                     /inference="alignment:Splign:2.1.0"
     exon            113..253
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml"
                     /inference="alignment:Splign:2.1.0"
     exon            254..384
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml"
                     /inference="alignment:Splign:2.1.0"
     exon            385..1446
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1616
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..2662
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagaagc tggcggccgg gcttgccggg ctgcgctgga gcatgggcgc tttcccgctg
       61 gacctcatcg tcagccgctg tcgcctgccc acgctcgcct gcctcgggcc aggggagtat
      121 gctgagggtg tcagtgaacg agatatcctg ctgatccact cctgccgcca gtggaccaca
      181 gtgaccgccc ataccctgga ggagggccac tacgtcattg gacccaagat tgacatcccc
      241 ctgcagtacc caggcaaatt caagctcctg gagcaggctc gggatgtgcg ggagccggtg
      301 agatacttca gcagtgtgga ggaggtggcc agtgtcttcc ctgaccgaat ctttgtgatg
      361 gaagccatca ccttcagtgt caaggtggtg tcaggcgagt tcagcgagga cagcgaggtg
      421 tacaacttca cactgcacgc aggcgacgag ctcactctca tgggtcaggc cgagattctg
      481 tgcgccaaga caaccaaaga gcgctcgcgc ttcaccacgc tcctgcgcaa gttgggccgt
      541 gcaggggcct tggctggaat cggcggtccc gggagtatgg gggccacagg aggtggcggc
      601 ggggccgcca ggcccgtcag aggcaagatg ccctgtctca tctgcatgaa ccaccgcacc
      661 aacgagagcc tgagcctgcc cttccaatgc cagggccgct ttagcacgcg cagccctctg
      721 gagctacaaa tgcaggaggg cgagcacacg gtgcgcgcca tcatcgagcg cgtgaggctt
      781 ccggtgaacg tgctggtacc cagccggccg ccgcgcaacc cttacgacct acaccctgtg
      841 cgggagggcc actgctataa gctggtcagc atcatctcca agaccgtggt gctggggctg
      901 gcgctgcgcc gtgagggtcc ggcgccactg cacttcctgc tgctcaccga cacgccgcgc
      961 ttcactctgc cgcagggtct gctggccggg gacccgcgcg tcgagcgcct ggtgcgcgac
     1021 agcgcctcct actgtcgcga gcgcttcgat ccggacgagt actccactgc tgtgcgcgag
     1081 gcgcccgcgg agctcgcgga cgattgcgcc agtccgcgcc gtgcgcgcct ctgcctgccc
     1141 gcgccgcgtg ttcccgggtc tgtccgtgtg cctggaccgc cgggtcgcct gggtcctgcc
     1201 ctgccagcac cgagcgacag cgaccaggag tacgtgagcc ctgattgggc gggtgcgccc
     1261 gagcccgcgg ccgcgtgcgc cgagatcccc tacgaggagc tgtgggtgca ccaaggcccc
     1321 gaaagcctcg ccgacgcccg tgcacggccg ctgacagggc cggatctcat ctcttttggg
     1381 accgtggggc ccccacagca tgaaccagag gcaccaccgc ctcctgtccc ccccaaatct
     1441 gaggcggtga aggaagagtg ccgcctgctt cacgccccgc ctgtgcctcc taggggtggc
     1501 agcagctgca gtaggctcac aggcagccct ccagtgccgc cccgcttccc caagctgcag
     1561 tctgtccact caccgagctc cagtctctcg tactattcct ctggcctgca ggatggggca
     1621 ggatcccgca gtggcagtgg ttccccgtca ccggatgcat actctctcta ttgctaccct
     1681 tgcacctggg gagattgtaa agccagcgag tcctctagtc gcccgccacc aggaccccta
     1741 ccttctacca ccacccagcc gcccagtcag gcctcaagag ccctagcaga gcctttgagt
     1801 ggtcgaaccg cctccctctt gggagctgac accccagcgg ttaagaacta ccatagctgc
     1861 ccgcctctgt ttaaaccctc acgtccccag aagtcccttg ctccctttgg tgcactcaac
     1921 ccattctctg ggcctgccca cccttcaggt gctccagcgg cctcctcctc tgggtccaca
     1981 tccacttcgg gtgccctggc tacctccagc cccacacact ccccaggccc aggcccacag
     2041 ggccaaggtt actcagctgc tccctcctcc tccttgtcct cctctgagtg gcaggagcca
     2101 gcgctggagc ccctggaccc gtttgagctg gggcaggcca gtcctcctga gctggagctg
     2161 ctccgctgcc aggagcccag agcttcgggg acacctgggt ctggacattg cctttcccca
     2221 cttggtccgc ccaaggcctt agagccggaa ggtttggtgc tgaggcaggt ccctgcctca
     2281 ctgtcaccag ctgccttgca ggggcccgag gcaggaggaa ccctcctctt tcttacccaa
     2341 gggtgcctgg aagggcctcc tggcagccca cgggagggcg tcccaggtgc cggagtccgg
     2401 gatgcttcct cctggcagcc accagcagac ttatctgccc tctccgtgga agaggtctca
     2461 cggagcctgc gcttcatcgg gctctcagag gacgtggtga gcttctttgc ccgagaacgc
     2521 attgacggaa gcatctttgt gcagctcagt gaggacatct tggctgatga ctttcatctt
     2581 accaagcttc aggtcaagaa gatcatgcag ttcatcaaag gttggagacc caagatctga
     2641 accgtctggc cagctgctgc ac
//
