LOCUS       NM_017008               1306 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glyceraldehyde-3-phosphate dehydrogenase (Gapdh),
            mRNA.
ACCESSION   NM_017008 XM_216453
VERSION     NM_017008.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1306)
  AUTHORS   Huo,J., Dong,W., Xu,J., Ma,L. and You,C.
  TITLE     Role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in
            autophagy activation following subarachnoid hemorrhage
  JOURNAL   Exp Neurol 371, 114577 (2024)
   PUBMED   37863305
  REMARK    GeneRIF: Role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
            in autophagy activation following subarachnoid hemorrhage.
REFERENCE   2  (bases 1 to 1306)
  AUTHORS   Khodabandeh,S., Hosseini,A., Khazali,H. and Azizi,V.
  TITLE     Interplay between polycystic ovary syndrome and hypothyroidism on
            serum testosterone, oxidative stress and StAR gene expression in
            female rats
  JOURNAL   Endocrinol Diabetes Metab 5 (5), e359 (2022)
   PUBMED   35871495
REFERENCE   3  (bases 1 to 1306)
  AUTHORS   Sugiyama,K., Miura,J., Shimizu,M., Takashima,A., Matsuda,Y.,
            Kayashima,H., Okamoto,M., Nagashima,T. and Araki,T.
  TITLE     Effects of advanced glycation end products on dental pulp
            calcification
  JOURNAL   Oral Dis 28 (3), 745-755 (2022)
   PUBMED   33539626
REFERENCE   4  (bases 1 to 1306)
  AUTHORS   Mikeladze,M.A., Dutysheva,E.A., Kartsev,V.G., Margulis,B.A.,
            Guzhova,I.V. and Lazarev,V.F.
  TITLE     Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6
            Glioblastoma Cells to Hypoxic Stress
  JOURNAL   Int J Mol Sci 22 (4), 1520 (2021)
   PUBMED   33546324
  REMARK    GeneRIF: Disruption of the Complex between GAPDH and Hsp70
            Sensitizes C6 Glioblastoma Cells to Hypoxic Stress.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1306)
  AUTHORS   Jiang,T., Dai,S., Yi,Y., Liu,Y., Zhang,S., Luo,M., Wang,H. and
            Xu,D.
  TITLE     The combination of hprt and gapdh is the best compound reference
            genes in the fetal rat hippocampus
  JOURNAL   Dev Neurobiol 80 (7-8), 229-238 (2020)
   PUBMED   32875725
  REMARK    GeneRIF: The combination of hprt and gapdh is the best compound
            reference genes in the fetal rat hippocampus.
REFERENCE   6  (bases 1 to 1306)
  AUTHORS   Brand,I.A. and Heinickel,A.
  TITLE     Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa
            Zn(2+)-binding protein (parathymosin)
  JOURNAL   J Biol Chem 266 (31), 20984-20989 (1991)
   PUBMED   1834654
REFERENCE   7  (bases 1 to 1306)
  AUTHORS   Ercolani,L., Florence,B., Denaro,M. and Alexander,M.
  TITLE     Isolation and complete sequence of a functional human
            glyceraldehyde-3-phosphate dehydrogenase gene
  JOURNAL   J Biol Chem 263 (30), 15335-15341 (1988)
   PUBMED   3170585
REFERENCE   8  (bases 1 to 1306)
  AUTHORS   Maehara,Y., Fujiyoshi,T., Takahashi,K., Yamamoto,M. and Endo,H.
  TITLE     1.5 kb mRNA abundantly expressed in rat tumors encodes a 37
            kilodalton protein in vitro
  JOURNAL   Biochem Biophys Res Commun 131 (2), 800-805 (1985)
   PUBMED   2413848
REFERENCE   9  (bases 1 to 1306)
  AUTHORS   Tso,J.Y., Sun,X.H., Kao,T.H., Reece,K.S. and Wu,R.
  TITLE     Isolation and characterization of rat and human
            glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity
            and molecular evolution of the gene
  JOURNAL   Nucleic Acids Res 13 (7), 2485-2502 (1985)
   PUBMED   2987855
REFERENCE   10 (bases 1 to 1306)
  AUTHORS   Fort,P., Marty,L., Piechaczyk,M., el Sabrouty,S., Dani,C.,
            Jeanteur,P. and Blanchard,J.M.
  TITLE     Various rat adult tissues express only one major mRNA species from
            the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
  JOURNAL   Nucleic Acids Res 13 (5), 1431-1442 (1985)
   PUBMED   2987824
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC059110.1.
            
            On Aug 30, 2012 this sequence version replaced NM_017008.3.
            
            Summary: This gene encodes a member of the
            glyceraldehyde-3-phosphate dehydrogenase protein family. A similar
            protein in human and mouse has been identified as a moonlighting
            protein based on its ability to perform mechanistically distinct
            functions. The encoded protein was originally identified as a key
            glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P)
            into 3-phospho-D-glyceroyl phosphate. Subsequent studies in human
            and mouse have assigned a variety of additional functions to the
            protein including nitrosylation of nuclear proteins. Many
            pseudogenes similar to this locus are found throughout the rat
            genome. [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DY317204.1, CR754152.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            multifunctional gene product(s) :: inferred from conservation
            RefSeq Select criteria          :: based on conservation,
                                               expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1306              BC059110.1         2-1307
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1306
                     /gene="Gapdh"
                     /gene_synonym="BARS-38; Gapd"
                     /note="glyceraldehyde-3-phosphate dehydrogenase"
                     /db_xref="GeneID:24383"
                     /db_xref="RGD:2661"
     exon            1..57
                     /gene="Gapdh"
                     /gene_synonym="BARS-38; Gapd"
                     /inference="alignment:Splign:2.1.0"
     exon            58..98
                     /gene="Gapdh"
                     /gene_synonym="BARS-38; Gapd"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1077
                     /gene="Gapdh"
                     /gene_synonym="BARS-38; Gapd"
                     /EC_number="1.2.1.12"
                     /note="38 kDa BFA-dependent ADP-ribosylation substrate;
                     peptidyl-cysteine S-nitrosylase GAPDH"
                     /codon_start=1
                     /product="glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="NP_058704.1"
                     /db_xref="GeneID:24383"
                     /db_xref="RGD:2661"
                     /translation="MVKVGVNGFGRIGRLVTRAAFSCDKVDIVAINDPFIDLNYMVYM
                     FQYDSTHGKFNGTVKAENGKLVINGKPITIFQERDPANIKWGDAGAEYVVESTGVFTT
                     MEKAGAHLKGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIVSNASCTTNCLAPLAK
                     VIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKV
                     IPELNGKLTGMAFRVPTPNVSVVDLTCRLEKPAKYDDIKKVVKQAAEGPLKGILGYTE
                     DQVVSCDFNSNSHSSTFDAGAGIALNDNFVKLISWYDNEYGYSNRVVDLMAYMASKE"
     exon            99..305
                     /gene="Gapdh"
                     /gene_synonym="BARS-38; Gapd"
                     /inference="alignment:Splign:2.1.0"
     exon            306..396
                     /gene="Gapdh"
                     /gene_synonym="BARS-38; Gapd"
                     /inference="alignment:Splign:2.1.0"
     exon            397..594
                     /gene="Gapdh"
                     /gene_synonym="BARS-38; Gapd"
                     /inference="alignment:Splign:2.1.0"
     exon            595..825
                     /gene="Gapdh"
                     /gene_synonym="BARS-38; Gapd"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1007
                     /gene="Gapdh"
                     /gene_synonym="BARS-38; Gapd"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1276
                     /gene="Gapdh"
                     /gene_synonym="BARS-38; Gapd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggctctct gctcctccct gttctagaga cagccgcatc ttcttgtgca gtgccagcct
       61 cgtctcatag acaagatggt gaaggtcggt gtgaacggat ttggccgtat cggacgcctg
      121 gttaccaggg ctgccttctc ttgtgacaaa gtggacattg ttgccatcaa cgaccccttc
      181 attgacctca actacatggt ctacatgttc cagtatgact ctacccacgg caagttcaac
      241 ggcacagtca aggctgagaa tgggaagctg gtcatcaacg ggaaacccat caccatcttc
      301 caggagcgag atcccgctaa catcaaatgg ggtgatgctg gtgctgagta tgtcgtggag
      361 tctactggcg tcttcaccac catggagaag gctggggctc acctgaaggg tggggccaaa
      421 agggtcatca tctccgcccc ttccgctgat gcccccatgt ttgtgatggg tgtgaaccac
      481 gagaaatatg acaactccct caagattgtc agcaatgcat cctgcaccac caactgctta
      541 gcccccctgg ccaaggtcat ccatgacaac tttggcatcg tggaagggct catgaccaca
      601 gtccatgcca tcactgccac tcagaagact gtggatggcc cctctggaaa gctgtggcgt
      661 gatggccgtg gggcagccca gaacatcatc cctgcatcca ctggtgctgc caaggctgtg
      721 ggcaaggtca tcccagagct gaacgggaag ctcactggca tggccttccg tgttcctacc
      781 cccaatgtat ccgttgtgga tctgacatgc cgcctggaga aacctgccaa gtatgatgac
      841 atcaagaagg tggtgaagca ggcggccgag ggcccactaa agggcatcct gggctacact
      901 gaggaccagg ttgtctcctg tgacttcaac agcaactccc attcttccac ctttgatgct
      961 ggggctggca ttgctctcaa tgacaacttt gtgaagctca tttcctggta tgacaatgaa
     1021 tatggctaca gcaacagggt ggtggacctc atggcctaca tggcctccaa ggagtaagaa
     1081 accctggacc acccagccca gcaaggatac tgagagcaag agagaggccc tcagttgctg
     1141 aggagtcccc atcccaactc agcccccaac actgagcatc tccctcacaa ttccatccca
     1201 gaccccataa caacaggagg ggcctgggga gccctccctt ctctcgaata ccatcaataa
     1261 agttcgctgc accctcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
