LOCUS       NM_017195               1499 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus growth associated protein 43 (Gap43), mRNA.
ACCESSION   NM_017195
VERSION     NM_017195.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1499)
  AUTHORS   Hu,Y., Sun,Y.F., Yuan,H., Liu,J., Chen,L., Liu,D.H., Xu,Y.,
            Zhou,X.F., Ding,L., Zhang,Z.T., Xiong,L.L., Xue,L.L. and Wang,T.H.
  TITLE     Vof16-miR-185-5p-GAP43 network improves the outcomes following
            spinal cord injury via enhancing self-repair and promoting axonal
            growth
  JOURNAL   CNS Neurosci Ther 30 (4), e14535 (2024)
   PUBMED   38168094
  REMARK    GeneRIF: Vof16-miR-185-5p-GAP43 network improves the outcomes
            following spinal cord injury via enhancing self-repair and
            promoting axonal growth.
REFERENCE   2  (bases 1 to 1499)
  AUTHORS   Li,T., Jia,Y., Fu,J., Fu,Z., Qiao,Z., Liu,X., Lv,T., Tang,R. and
            Yang,G.
  TITLE     P53-induced GAP-43 Upregulation in Primary Cortical Neurons of Rats
  JOURNAL   Protein Pept Lett 31 (3), 229-235 (2024)
   PUBMED   38288820
  REMARK    GeneRIF: P53-induced GAP-43 Upregulation in Primary Cortical
            Neurons of Rats.
REFERENCE   3  (bases 1 to 1499)
  AUTHORS   Jyothi,A.K., Thotakura,B., Priyadarshini,S.C., Patil,S.,
            Poojari,M.S. and Subramanian,M.
  TITLE     Paternal stress alters synaptic density and expression of GAP-43,
            GRIN1, M1 and SYP genes in the hippocampus and cortex of offspring
            of stress-induced male rats
  JOURNAL   Morphologie 107 (356), 67-79 (2023)
   PUBMED   35715368
  REMARK    GeneRIF: Paternal stress alters synaptic density and expression of
            GAP-43, GRIN1, M1 and SYP genes in the hippocampus and cortex of
            offspring of stress-induced male rats.
REFERENCE   4  (bases 1 to 1499)
  AUTHORS   Zhao,H., Liu,Z.D., Zhang,Y.B., Gao,X.Y., Wang,C., Liu,Y. and
            Wang,X.F.
  TITLE     NEP1-40 promotes myelin regeneration via upregulation of GAP-43 and
            MAP-2 expression after focal cerebral ischemia in rats
  JOURNAL   Mol Med Rep 24 (6) (2021)
   PUBMED   34643252
  REMARK    GeneRIF: NEP140 promotes myelin regeneration via upregulation of
            GAP43 and MAP2 expression after focal cerebral ischemia in rats.
            Erratum:[Mol Med Rep. 2023 Mar;27(3):58. doi:
            10.3892/mmr.2023.12945.. PMID: 36695184]
REFERENCE   5  (bases 1 to 1499)
  AUTHORS   Rahmati,M. and Taherabadi,S.J.
  TITLE     The effects of exercise training on Kinesin and GAP-43 expression
            in skeletal muscle fibers of STZ-induced diabetic rats
  JOURNAL   Sci Rep 11 (1), 9535 (2021)
   PUBMED   33953268
  REMARK    GeneRIF: The effects of exercise training on Kinesin and GAP-43
            expression in skeletal muscle fibers of STZ-induced diabetic rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1499)
  AUTHORS   Spencer,S.A., Schuh,S.M., Liu,W.S. and Willard,M.B.
  TITLE     GAP-43, a protein associated with axon growth, is phosphorylated at
            three sites in cultured neurons and rat brain
  JOURNAL   J Biol Chem 267 (13), 9059-9064 (1992)
   PUBMED   1533624
REFERENCE   7  (bases 1 to 1499)
  AUTHORS   Nedivi,E., Basi,G.S., Akey,I.V. and Skene,J.H.
  TITLE     A neural-specific GAP-43 core promoter located between unusual DNA
            elements that interact to regulate its activity
  JOURNAL   J Neurosci 12 (3), 691-704 (1992)
   PUBMED   1532026
REFERENCE   8  (bases 1 to 1499)
  AUTHORS   Houbre,D., Duportail,G., Deloulme,J.C. and Baudier,J.
  TITLE     The interactions of the brain-specific calmodulin-binding protein
            kinase C substrate, neuromodulin (GAP 43), with membrane
            phospholipids
  JOURNAL   J Biol Chem 266 (11), 7121-7131 (1991)
   PUBMED   1826685
REFERENCE   9  (bases 1 to 1499)
  AUTHORS   Rosenthal,A., Chan,S.Y., Henzel,W., Haskell,C., Kuang,W.J.,
            Chen,E., Wilcox,J.N., Ullrich,A., Goeddel,D.V. and Routtenberg,A.
  TITLE     Primary structure and mRNA localization of protein F1, a
            growth-related protein kinase C substrate associated with synaptic
            plasticity
  JOURNAL   EMBO J 6 (12), 3641-3646 (1987)
   PUBMED   3428269
REFERENCE   10 (bases 1 to 1499)
  AUTHORS   Karns,L.R., Ng,S.C., Freeman,J.A. and Fishman,M.C.
  TITLE     Cloning of complementary DNA for GAP-43, a neuronal growth-related
            protein
  JOURNAL   Science 236 (4801), 597-600 (1987)
   PUBMED   2437653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X06338.1, BF560544.1 and BI304179.1.
            
            On Jan 25, 2008 this sequence version replaced NM_017195.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X06338.1, BC127502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1052              X06338.1           1-1052
            1053-1282           BF560544.1         100-329
            1283-1364           X06338.1           1282-1363
            1365-1499           BI304179.1         1-135               c
FEATURES             Location/Qualifiers
     source          1..1499
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1499
                     /gene="Gap43"
                     /gene_synonym="Basp2"
                     /note="growth associated protein 43"
                     /db_xref="GeneID:29423"
                     /db_xref="RGD:62071"
     exon            1..246
                     /gene="Gap43"
                     /gene_synonym="Basp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..897
                     /gene="Gap43"
                     /gene_synonym="Basp2"
                     /note="brain abundant, membrane attached signal protein 2;
                     protein F1; axonal membrane protein GAP-43; growth
                     accentuating protein 43"
                     /codon_start=1
                     /product="neuromodulin"
                     /protein_id="NP_058891.1"
                     /db_xref="GeneID:29423"
                     /db_xref="RGD:62071"
                     /translation="MLCCMRRTKQVEKNDEDQKIEQDGVKPEDKAHKAATKIQASFRG
                     HITRKKLKDEKKGDAPAAEAEAKEKDDAPVADGVEKKEGDGSATTDAAPATSPKAEEP
                     SKAGDAPSEEKKGEGDAAPSEEKAGSAETESAAKATTDNSPSSKAEDGPAKEEPKQAD
                     VPAAVTDAAATTPAAEDAAKAAQPPTETAESSQAEEEKEAVDEAKPKESARQDEGKED
                     PEADQEHA"
     exon            247..811
                     /gene="Gap43"
                     /gene_synonym="Basp2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1483
                     /gene="Gap43"
                     /gene_synonym="Basp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgatcgctg tagaccttac agttgctgct aactgccctg gtgtgtgtga gggagagaga
       61 gggagagaga gggagaggga gggagggagg gagggagagc gcgctagcgc gagagagcga
      121 gtgagcaagc gagcagaaaa gaggtggaga gggggggaat aaggaagaga ggaggaaagg
      181 agagaaggca ggaagaaggc aggggaagat accaccatgc tgtgctgtat gagaagaacc
      241 aaacaggttg aaaagaatga tgaggaccaa aagattgaac aagatggtgt caaaccggag
      301 gataaggctc ataaggctgc aaccaaaatt caggctagct tccgtggaca cataacaagg
      361 aaaaagctca aagacgagaa gaagggtgat gcaccagctg ctgaggccga ggccaaggag
      421 aaggatgatg ctcccgttgc tgatggtgtg gagaagaagg agggagatgg ctctgctact
      481 accgatgcag ccccagccac cagccctaag gctgaggagc ccagcaaggc aggagatgca
      541 ccttctgagg agaagaaggg cgaaggggat gcggcccctt cagaggaaaa ggccggctca
      601 gctgagacag aaagtgctgc taaagctacc actgataact cgccgtcctc caaggccgaa
      661 gatggcccag ccaaggagga gcctaaacaa gccgatgtgc ctgctgctgt cactgatgct
      721 gctgccacca cccctgctgc agaggatgct gccaaggcag cgcagcctcc aacggagact
      781 gcagaaagca gccaagctga ggaggagaaa gaagctgtag atgaagccaa acctaaggaa
      841 agtgcccgac aggatgaggg taaagaagac cccgaggctg accaagaaca tgcctgaact
      901 ttaagaaacg gctttccacg ttgcccccac ctgaaccctg tctctcctgc cctttctcag
      961 atccactctg aagtttcctc tcctgtcctg ctcacgtgtg tgagcctgtc ctctcctacc
     1021 tatgagccct ctctctctgt gtggcaaaca ttaaaaaaaa aaaaaagcag gaaagatccc
     1081 aagtccaaca gtgtggctta aacatttgtt tcttggtgtt gttatggcga gtttttggta
     1141 atgatgatgc agtcatcttg ggaaattctt gcactgtacc ccggtttttt gatctggtgc
     1201 gtgtggccct gtgggagtcc actttcctct ctatttctct ctgttccaag tgtgtgtgtg
     1261 caatgttccg ttctgaggag tccaaaatat taagtgaatt caaaaaacca tttctgtttc
     1321 ctcattttca atgtgatgga atgaacaaaa aggttaaaaa aattaaaaaa aaaacggttt
     1381 gttttaaaaa taaataaata aagcaaatgt gccaattagc gtaacttaag gctgtgaggc
     1441 tcctttttca atctgaatat taataaatca tgagagtaat caaaaaaaaa aaaaaaaaa
//
