LOCUS       NM_001013089            1375 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus galactose-1-phosphate uridylyltransferase (Galt),
            mRNA.
ACCESSION   NM_001013089 XM_216372
VERSION     NM_001013089.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1375)
  AUTHORS   Daenzer,J.M.I., Rasmussen,S.A., Patel,S., McKenna,J. 3rd and
            Fridovich-Keil,J.L.
  TITLE     Neonatal GALT gene replacement offers metabolic and phenotypic
            correction through early adulthood in a rat model of classic
            galactosemia
  JOURNAL   J Inherit Metab Dis 45 (2), 203-214 (2022)
   PUBMED   34964137
  REMARK    GeneRIF: Neonatal GALT gene replacement offers metabolic and
            phenotypic correction through early adulthood in a rat model of
            classic galactosemia.
REFERENCE   2  (bases 1 to 1375)
  AUTHORS   Rasmussen,S.A., Daenzer,J.M.I. and Fridovich-Keil,J.L.
  TITLE     A pilot study of neonatal GALT gene replacement using AAV9
            dramatically lowers galactose metabolites in blood, liver, and
            brain and minimizes cataracts in GALT-null rat pups
  JOURNAL   J Inherit Metab Dis 44 (1), 272-281 (2021)
   PUBMED   32882063
  REMARK    GeneRIF: A pilot study of neonatal GALT gene replacement using AAV9
            dramatically lowers galactose metabolites in blood, liver, and
            brain and minimizes cataracts in GALT-null rat pups.
REFERENCE   3  (bases 1 to 1375)
  AUTHORS   Rasmussen,S.A., Daenzer,J.M.I., MacWilliams,J.A., Head,S.T.,
            Williams,M.B., Geurts,A.M., Schroeder,J.P., Weinshenker,D. and
            Fridovich-Keil,J.L.
  TITLE     A galactose-1-phosphate uridylyltransferase-null rat model of
            classic galactosemia mimics relevant patient outcomes and reveals
            tissue-specific and longitudinal differences in galactose
            metabolism
  JOURNAL   J Inherit Metab Dis 43 (3), 518-528 (2020)
   PUBMED   31845342
  REMARK    GeneRIF: A galactose-1-phosphate uridylyltransferase-null rat model
            of classic galactosemia mimics relevant patient outcomes and
            reveals tissue-specific and longitudinal differences in galactose
            metabolism.
REFERENCE   4  (bases 1 to 1375)
  AUTHORS   McCorvie,T.J., Kopec,J., Pey,A.L., Fitzpatrick,F., Patel,D.,
            Chalk,R., Shrestha,L. and Yue,W.W.
  TITLE     Molecular basis of classic galactosemia from the structure of human
            galactose 1-phosphate uridylyltransferase
  JOURNAL   Hum Mol Genet 25 (11), 2234-2244 (2016)
   PUBMED   27005423
REFERENCE   5  (bases 1 to 1375)
  AUTHORS   Obata,Y., Fukumoto,Y., Nakayama,Y., Kuga,T., Dohmae,N. and
            Yamaguchi,N.
  TITLE     The Lyn kinase C-lobe mediates Golgi export of Lyn through
            conformation-dependent ACSL3 association
  JOURNAL   J Cell Sci 123 (Pt 15), 2649-2662 (2010)
   PUBMED   20605918
  REMARK    Erratum:[J Cell Sci. 2010 Aug 1;123(Pt 15):2681]
REFERENCE   6  (bases 1 to 1375)
  AUTHORS   Reichardt,J.K., Packman,S. and Woo,S.L.
  TITLE     Molecular characterization of two galactosemia mutations:
            correlation of mutations with highly conserved domains in
            galactose-1-phosphate uridyl transferase
  JOURNAL   Am J Hum Genet 49 (4), 860-867 (1991)
   PUBMED   1897530
REFERENCE   7  (bases 1 to 1375)
  AUTHORS   Rogers,S. and Segal,S.
  TITLE     Modulation of rat tissue galactose-1-phosphate uridyltransferase by
            uridine and uridine triphosphate
  JOURNAL   Pediatr Res 30 (3), 222-226 (1991)
   PUBMED   1945559
REFERENCE   8  (bases 1 to 1375)
  AUTHORS   Rogers,S.R., Bovee,B.W., Saunders,S.L. and Segal,S.
  TITLE     Activity of hepatic galactose-metabolizing enzymes in the pregnant
            rat and fetus
  JOURNAL   Pediatr Res 25 (2), 161-166 (1989)
   PUBMED   2537489
REFERENCE   9  (bases 1 to 1375)
  AUTHORS   Solov'eva,N.A., Morozkova,T.S. and Salganik,R.I.
  TITLE     [Development of a rat subline with symptoms of hereditary
            galactosemia and study of its biochemical characteristics]
  JOURNAL   Genetika 11 (5), 63-71 (1975)
   PUBMED   1240812
REFERENCE   10 (bases 1 to 1375)
  AUTHORS   Bertoli,D. and Segal,S.
  TITLE     Developmental aspects and some characteristics of mammalian
            galactose 1-phosphate uridyltransferase
  JOURNAL   J Biol Chem 241 (17), 4023-4029 (1966)
   PUBMED   5920808
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098756.1.
            
            On Jul 13, 2005 this sequence version replaced NM_001013089.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098756.1, SRR8487227.319971.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132273, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1375
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1375
                     /gene="Galt"
                     /note="galactose-1-phosphate uridylyltransferase"
                     /db_xref="GeneID:298003"
                     /db_xref="RGD:1306483"
     exon            1..154
                     /gene="Galt"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1212
                     /gene="Galt"
                     /EC_number="2.7.7.12"
                     /note="gal-1-P uridylyltransferase;
                     UDP-glucose--hexose-1-phosphate uridylyltransferase;
                     galactose-1-phosphate uridyl transferase"
                     /codon_start=1
                     /product="galactose-1-phosphate uridylyltransferase"
                     /protein_id="NP_001013107.1"
                     /db_xref="GeneID:298003"
                     /db_xref="RGD:1306483"
                     /translation="MSQSGADPEQRQQASEADAMAATFRASEHQHIRYNPLQDEWVLV
                     SAHRMKRPWQGQVEPQLLKTVPRHDPLNPLCPGATRANGEVNPPYDGTFLFDNDFPAL
                     QPDAPDPGPSDHPLFRVEAARGVCKVMCFHPWSDVTLPLMSVPEIRAVIDAWASVTEE
                     LGAQYPWVQIFENKGAMMGCSNPHPHCQVWASNFLPDIAQREERSQQTYHNQHGKPLL
                     LEYGHQELLRKERLVLTSEYWIVLVPFWAVWPFQTLLLPRRHVQRLPELTPAERDDLA
                     STMKKLLTKYDNLFETSFPYSMGWHGAPMGLKTGATCDHWQLHAHYYPPLLRSATVRK
                     FMVGYEMLAQAQRDLTPEQAAERLRVLPEVHYCLTQKDKETAATA"
     exon            155..324
                     /gene="Galt"
                     /inference="alignment:Splign:2.1.0"
     exon            325..400
                     /gene="Galt"
                     /inference="alignment:Splign:2.1.0"
     exon            401..449
                     /gene="Galt"
                     /inference="alignment:Splign:2.1.0"
     exon            450..579
                     /gene="Galt"
                     /inference="alignment:Splign:2.1.0"
     exon            580..636
                     /gene="Galt"
                     /inference="alignment:Splign:2.1.0"
     exon            637..759
                     /gene="Galt"
                     /inference="alignment:Splign:2.1.0"
     exon            760..892
                     /gene="Galt"
                     /inference="alignment:Splign:2.1.0"
     exon            893..976
                     /gene="Galt"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1131
                     /gene="Galt"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1307
                     /gene="Galt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaaactat ggagtggtga gtttatcccc gtgcactttc ttgacggact ttaggttaat
       61 tcgtgtgacc tcatgtcgca aagcggagcc gatcctgagc agcgccagca ggcttcagag
      121 gcggacgcca tggcagcgac cttccgggcg agcgaacacc agcatattcg ctacaacccg
      181 ctccaggatg agtgggtgtt agtgtcagcc catcgcatga agcggccctg gcaaggacaa
      241 gtggagcccc agcttctgaa gacggtcccc cgccatgacc cactcaaccc tctgtgtccc
      301 ggggccacac gagctaatgg ggaggtgaat cccccctatg atggcacctt cttatttgac
      361 aatgacttcc cggctctgca gcccgatgct ccggatccag gacccagtga ccaccctctc
      421 ttccgagtgg aggccgccag aggagtttgt aaggtcatgt gcttccaccc ctggtcggat
      481 gtgacgctgc cactcatgtc tgtccctgag atccgagctg tcatcgatgc atgggcctca
      541 gtcacagagg aactgggcgc ccagtaccct tgggtgcaga tctttgaaaa caaaggagcc
      601 atgatgggtt gctctaaccc ccatccccac tgccaggttt gggctagcaa tttcctgcca
      661 gatattgccc agcgtgaaga gcgatcccag cagacttatc acaaccagca tggaaagcct
      721 ttattattgg aatatggcca ccaagagctc ctcaggaagg aacgtctggt cctaaccagt
      781 gagtactgga tagttctggt ccccttctgg gcagtgtggc ctttccagac attactgctg
      841 ccccgacggc acgtgcagcg gctacctgag ctgacccctg ctgagcgtga tgatctagcc
      901 tccaccatga agaagctctt gaccaagtat gacaacctgt ttgagacgtc ctttccttac
      961 tccatgggct ggcacggggc tcccatggga ttaaagactg gagccacctg tgaccactgg
     1021 cagctccatg ctcactatta ccccccactc ctgcgatcgg ctactgttcg gaaattcatg
     1081 gttggctatg aaatgcttgc ccaggcccag cgtgacctca ctcccgaaca ggctgcagaa
     1141 agattaaggg tgctccctga ggtacactat tgcctgacgc agaaagacaa ggaaacagca
     1201 gccaccgctt gactgtgacc acagcagggc attgaatctt tgtacccgac agacctggga
     1261 cctggagttc gggcagatgt gacatcaata aaactgtgtc tcatgttaaa aaaaaaaaaa
     1321 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
