LOCUS       NM_019173               1163 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus galanin receptor 3 (Galr3), mRNA.
ACCESSION   NM_019173 XM_346807
VERSION     NM_019173.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1163)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   2  (bases 1 to 1163)
  AUTHORS   Kim,D.K., Yun,S., Son,G.H., Hwang,J.I., Park,C.R., Kim,J.I.,
            Kim,K., Vaudry,H. and Seong,J.Y.
  TITLE     Coevolution of the spexin/galanin/kisspeptin family: Spexin
            activates galanin receptor type II and III
  JOURNAL   Endocrinology 155 (5), 1864-1873 (2014)
   PUBMED   24517231
REFERENCE   3  (bases 1 to 1163)
  AUTHORS   Loktev,A.V. and Jackson,P.K.
  TITLE     Neuropeptide Y family receptors traffic via the Bardet-Biedl
            syndrome pathway to signal in neuronal primary cilia
  JOURNAL   Cell Rep 5 (5), 1316-1329 (2013)
   PUBMED   24316073
REFERENCE   4  (bases 1 to 1163)
  AUTHORS   Holm,L., Theodorsson,E., Hokfelt,T. and Theodorsson,A.
  TITLE     Effects of intracerebroventricular galanin or a galanin receptor
            2/3 agonist on the lesion induced by transient occlusion of the
            middle cerebral artery in female rats
  JOURNAL   Neuropeptides 45 (1), 17-23 (2011)
   PUBMED   20974494
  REMARK    GeneRIF: Data show that a galanin or a galanin receptor R2/3
            agonist doubles the size of the ischemic lesion following middle
            cerebral artery occlusion in rats.
REFERENCE   5  (bases 1 to 1163)
  AUTHORS   Barreda-Gomez,G., Giralt,M.T. and Rodriguez-Puertas,R.
  TITLE     G protein-coupled galanin receptor distribution in the rat central
            nervous system
  JOURNAL   Neuropeptides 39 (3), 153-156 (2005)
   PUBMED   15944004
  REMARK    GeneRIF: the efficacy of galanin to induce an effective coupling of
            its receptors to G proteins could be different depending on the
            brain area
REFERENCE   6  (bases 1 to 1163)
  AUTHORS   Waters,S.M. and Krause,J.E.
  TITLE     Distribution of galanin-1, -2 and -3 receptor messenger RNAs in
            central and peripheral rat tissues
  JOURNAL   Neuroscience 95 (1), 265-271 (2000)
   PUBMED   10619483
REFERENCE   7  (bases 1 to 1163)
  AUTHORS   Kolakowski,L.F. Jr., O'Neill,G.P., Howard,A.D., Broussard,S.R.,
            Sullivan,K.A., Feighner,S.D., Sawzdargo,M., Nguyen,T., Kargman,S.,
            Shiao,L.L., Hreniuk,D.L., Tan,C.P., Evans,J., Abramovitz,M.,
            Chateauneuf,A., Coulombe,N., Ng,G., Johnson,M.P., Tharian,A.,
            Khoshbouei,H., George,S.R., Smith,R.G. and O'Dowd,B.F.
  TITLE     Molecular characterization and expression of cloned human galanin
            receptors GALR2 and GALR3
  JOURNAL   J Neurochem 71 (6), 2239-2251 (1998)
   PUBMED   9832121
REFERENCE   8  (bases 1 to 1163)
  AUTHORS   Smith,K.E., Walker,M.W., Artymyshyn,R., Bard,J., Borowsky,B.,
            Tamm,J.A., Yao,W.J., Vaysse,P.J., Branchek,T.A., Gerald,C. and
            Jones,K.A.
  TITLE     Cloned human and rat galanin GALR3 receptors. Pharmacology and
            activation of G-protein inwardly rectifying K+ channels
  JOURNAL   J Biol Chem 273 (36), 23321-23326 (1998)
   PUBMED   9722565
REFERENCE   9  (bases 1 to 1163)
  AUTHORS   Wang,S., He,C., Hashemi,T. and Bayne,M.
  TITLE     Cloning and expressional characterization of a novel galanin
            receptor. Identification of different pharmacophores within galanin
            for the three galanin receptor subtypes
  JOURNAL   J Biol Chem 272 (51), 31949-31952 (1997)
   PUBMED   9405385
REFERENCE   10 (bases 1 to 1163)
  AUTHORS   Amiranoff,B., Lorinet,A.M. and Laburthe,M.
  TITLE     A clonal rat pancreatic delta cell line (Rin14B) expresses a high
            number of galanin receptors negatively coupled to a
            pertussis-toxin-sensitive cAMP-production pathway
  JOURNAL   Eur J Biochem 195 (2), 459-463 (1991)
   PUBMED   1847683
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF073798.1.
            
            On Dec 17, 2003 this sequence version replaced XM_346807.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF073798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN12840132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1163
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1163
                     /gene="Galr3"
                     /note="galanin receptor 3"
                     /db_xref="GeneID:29235"
                     /db_xref="RGD:2658"
     exon            1..21
                     /gene="Galr3"
                     /inference="alignment:Splign:2.1.0"
     exon            22..384
                     /gene="Galr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1138
                     /gene="Galr3"
                     /note="GAL3-R; GALR-3"
                     /codon_start=1
                     /product="galanin receptor type 3"
                     /protein_id="NP_062046.1"
                     /db_xref="GeneID:29235"
                     /db_xref="RGD:2658"
                     /translation="MADIQNISLDSPGSVGAVAVPVIFALIFLLGMVGNGLVLAVLLQ
                     PGPSAWQEPSSTTDLFILNLAVADLCFILCCVPFQAAIYTLDAWLFGAFVCKTVHLLI
                     YLTMYASSFTLAAVSLDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSY
                     YGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLCFLWAAVGPA
                     GAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLAS
                     HCLAYANSCLNPLVYSLASRHFRARFRRLWPCGRRRHRHHHRAHRALRRVQPASSGPA
                     GYPGDARPRGWSMEPRGDALRGGGETRLTLSPRGPQ"
     exon            385..1163
                     /gene="Galr3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccagtac ctaggactga ggaagatggc tgacatccag aacatttcgc tggacagccc
       61 agggagcgta ggggctgtgg cagtgcctgt gatctttgcc ctcatcttcc tgttgggcat
      121 ggtgggcaat gggctggtgt tggctgtgct actgcagcct ggcccaagtg cctggcagga
      181 gccaagcagt accacagatc tcttcatcct caacttggcc gtggccgacc tttgcttcat
      241 cctgtgctgc gtgcccttcc aggcagccat ctacacactg gatgcctggc tctttggggc
      301 tttcgtgtgc aagacggtac atctgctcat ctacctcacc atgtatgcca gcagcttcac
      361 cctggcggcc gtctccctgg acaggtacct ggctgtgcgg cacccactgc gctccagagc
      421 cctgcgcacc ccgcgcaacg cgcgcgccgc cgtggggctc gtgtggctgc tggcggctct
      481 cttttccgcg ccctacctaa gctattacgg cacggtgcgc tacggcgcgc tcgagctctg
      541 cgtgcccgct tgggaggacg cgcggcggcg cgcgctggac gtggccacct tcgccgcggg
      601 ctacctgctg ccggtggccg tggtgagcct ggcctacgga cgcacgctat gtttcctatg
      661 ggccgccgtg ggtcccgcgg gcgcggcggc agcagaggcg cgcagacggg cgaccggccg
      721 ggcgggacgc gccatgctgg cagtggccgc gctctacgcg ctttgctggg gcccgcacca
      781 cgcgctcatc ctctgcttct ggtacggccg cttcgccttc agcccggcca cctacgcctg
      841 tcgcctggcc tcgcactgcc tcgcctacgc caactcctgc cttaacccgc tcgtctactc
      901 gctcgcctcg cgccacttcc gcgcgcgctt ccgccgcctg tggccctgcg gccgtcgccg
      961 ccaccgccac caccaccgcg ctcatcgagc cctccgtcgt gtccagccgg cgtcttcggg
     1021 ccccgccggt tatcccggcg acgccaggcc tcgtggttgg agtatggagc ccagagggga
     1081 tgctctgcgt ggtggtggag agactagact aaccctgtcc cccaggggac ctcaataacc
     1141 ctgcccgctt ggactctgac gtc
//
