LOCUS       NM_019172               1422 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus galanin receptor 2 (Galr2), mRNA.
ACCESSION   NM_019172
VERSION     NM_019172.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1422)
  AUTHORS   Borroto-Escuela,D., Serrano-Castro,P., Sanchez-Perez,J.A.,
            Barbancho-Fernandez,M.A., Fuxe,K. and Narvaez,M.
  TITLE     Enhanced neuronal survival and BDNF elevation via long-term
            co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors
            (NPY1R): potential therapeutic targets for major depressive
            disorder
  JOURNAL   Expert Opin Ther Targets 28 (4), 295-308 (2024)
   PUBMED   38622072
  REMARK    GeneRIF: Enhanced neuronal survival and BDNF elevation via
            long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1
            receptors (NPY1R): potential therapeutic targets for major
            depressive disorder.
REFERENCE   2  (bases 1 to 1422)
  AUTHORS   El-Saka,M.H., Abo El Gheit,R.E., El Saadany,A., Alghazaly,G.M.,
            Marea,K.E. and Madi,N.M.
  TITLE     Effect of spexin on renal dysfunction in experimentally obese rats:
            potential mitigating mechanisms via galanin receptor-2
  JOURNAL   Arch Physiol Biochem 129 (4), 933-942 (2023)
   PUBMED   33632048
  REMARK    GeneRIF: Effect of spexin on renal dysfunction in experimentally
            obese rats: potential mitigating mechanisms via galanin receptor-2.
REFERENCE   3  (bases 1 to 1422)
  AUTHORS   Chen,S.H., Lue,J.H., Hsiao,Y.J., Lai,S.M., Wang,H.Y., Lin,C.T.,
            Chen,Y.C. and Tsai,Y.J.
  TITLE     Elevated galanin receptor type 2 primarily contributes to
            mechanical hypersensitivity after median nerve injury
  JOURNAL   PLoS One 13 (6), e0199512 (2018)
   PUBMED   29928003
  REMARK    GeneRIF: activation of GalR2, probably through NPY or nitric oxide,
            induces c-Fos expression in the cuneate nucleus and transmits
            mechanical allodynia sensations to the thalamus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1422)
  AUTHORS   Zhang,M.L., Wang,H.B., Fu,F.H. and Yu,L.C.
  TITLE     Involvement of galanin and galanin receptor 2 in nociceptive
            modulation in anterior cingulate cortex of normal rats and rats
            with mononeuropathy
  JOURNAL   Sci Rep 7, 45930 (2017)
   PUBMED   28378856
  REMARK    GeneRIF: Both the galanin and galanin receptor 2 mRNA expression
            and content increased significantly in anterior cingulate cortex
            (ACC) in rats with mononeuropathy than that in normal rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1422)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   6  (bases 1 to 1422)
  AUTHORS   Fathi,Z., Cunningham,A.M., Iben,L.G., Battaglino,P.B., Ward,S.A.,
            Nichol,K.A., Pine,K.A., Wang,J., Goldstein,M.E., Iismaa,T.P. and
            Zimanyi,I.A.
  TITLE     Cloning, pharmacological characterization and distribution of a
            novel galanin receptor
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 348 (1998)
   PUBMED   9473722
REFERENCE   7  (bases 1 to 1422)
  AUTHORS   Fathi,Z., Cunningham,A.M., Iben,L.G., Battaglino,P.B., Ward,S.A.,
            Nichol,K.A., Pine,K.A., Wang,J., Goldstein,M.E., Iismaa,T.P. and
            Zimanyi,I.A.
  TITLE     Cloning, pharmacological characterization and distribution of a
            novel galanin receptor
  JOURNAL   Brain Res Mol Brain Res 51 (1-2), 49-59 (1997)
   PUBMED   9427506
  REMARK    Erratum:[Brain Res Mol Brain Res 1998 Jan;53(1-2):348]
REFERENCE   8  (bases 1 to 1422)
  AUTHORS   Smith,K.E., Forray,C., Walker,M.W., Jones,K.A., Tamm,J.A., Bard,J.,
            Branchek,T.A., Linemeyer,D.L. and Gerald,C.
  TITLE     Expression cloning of a rat hypothalamic galanin receptor coupled
            to phosphoinositide turnover
  JOURNAL   J Biol Chem 272 (39), 24612-24616 (1997)
   PUBMED   9305929
REFERENCE   9  (bases 1 to 1422)
  AUTHORS   Wang,S., Hashemi,T., He,C., Strader,C. and Bayne,M.
  TITLE     Molecular cloning and pharmacological characterization of a new
            galanin receptor subtype
  JOURNAL   Mol Pharmacol 52 (3), 337-343 (1997)
   PUBMED   9281594
REFERENCE   10 (bases 1 to 1422)
  AUTHORS   Howard,A.D., Tan,C., Shiao,L.L., Palyha,O.C., McKee,K.K.,
            Weinberg,D.H., Feighner,S.D., Cascieri,M.A., Smith,R.G., Van Der
            Ploeg,L.H. and Sullivan,K.A.
  TITLE     Molecular cloning and characterization of a new receptor for
            galanin
  JOURNAL   FEBS Lett 405 (3), 285-290 (1997)
   PUBMED   9108306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On May 28, 2015 this sequence version replaced NM_019172.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF008548.1, AF010318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               JAXUCZ010000010.1  102013626-102014022
            398-1422            JAXUCZ010000010.1  102015030-102016054
FEATURES             Location/Qualifiers
     source          1..1422
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1422
                     /gene="Galr2"
                     /gene_synonym="GAL2-R; GALR-2"
                     /note="galanin receptor 2"
                     /db_xref="GeneID:29234"
                     /db_xref="RGD:2657"
     exon            1..397
                     /gene="Galr2"
                     /gene_synonym="GAL2-R; GALR-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1148
                     /gene="Galr2"
                     /gene_synonym="GAL2-R; GALR-2"
                     /codon_start=1
                     /product="galanin receptor type 2"
                     /protein_id="NP_062045.1"
                     /db_xref="GeneID:29234"
                     /db_xref="RGD:2657"
                     /translation="MNGSGSQGAENTSQEGGSGGWQPEAVLVPLFFALIFLVGTVGNA
                     LVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDDWVFGSLLCKAVH
                     FLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLALLFSGPY
                     LSYYRQSQLANLTVCHPAWSAPRRRAMDLCTFVFSYLLPVLVLSLTYARTLRYLWRTV
                     DPVTAGSGSQRAKRKVTRMIIIVAVLFCLCWMPHHALILCVWFGRFPLTRATYALRIL
                     SHLVSYANSCVNPIVYALVSKHFRKGFRKICAGLLRPAPRRASGRVSILAPGNHSGSM
                     LEQESTDLTQVSEAAGPLVPPPALPNCTASSRTLDPAC"
     exon            398..1422
                     /gene="Galr2"
                     /gene_synonym="GAL2-R; GALR-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggagcgg cgtccacttt ggtgatacca tgaatggctc cggcagccag ggcgcggaga
       61 acacgagcca ggaaggcggt agcggcggct ggcagcctga ggcggtcctt gtacccctat
      121 ttttcgcgct catcttcctc gtgggcaccg tgggcaacgc gctggtgctg gcggtgctgc
      181 tgcgcggcgg ccaggcggtc agcaccacca acctgttcat cctcaacctg ggcgtggccg
      241 acctgtgttt catcctgtgc tgcgtgcctt tccaggccac catctacacc ctggacgact
      301 gggtgttcgg ctcgctgctc tgcaaggctg ttcatttcct catctttctc actatgcacg
      361 ccagcagctt cacgctggcc gccgtctccc tggacaggta tctggccatc cgctacccgc
      421 tgcactcccg agagttgcgc acacctcgaa acgcgctggc cgccatcggg ctcatctggg
      481 ggctagcact gctcttctcc gggccctacc tgagctacta ccgtcagtcg cagctggcca
      541 acctgacagt atgccaccca gcatggagcg cacctcgacg tcgagccatg gacctctgca
      601 ccttcgtctt tagctacctg ctgccagtgc tagtcctcag tctgacctat gcgcgtaccc
      661 tgcgctacct ctggcgcaca gtcgacccgg tgactgcagg ctcaggttcc cagcgcgcca
      721 aacgcaaggt gacacggatg atcatcatcg tggcggtgct tttctgcctc tgttggatgc
      781 cccaccacgc gcttatcctc tgcgtgtggt ttggtcgctt cccgctcacg cgtgccactt
      841 acgcgttgcg catcctttca cacctagttt cctatgccaa ctcctgtgtc aaccccatcg
      901 tttacgctct ggtctccaag catttccgta aaggtttccg caaaatctgc gcgggcctgc
      961 tgcgccctgc cccgaggcga gcttcgggcc gagtgagcat cctggcgcct gggaaccata
     1021 gtggcagcat gctggaacag gaatccacag acctgacaca ggtgagcgag gcagccgggc
     1081 cccttgtccc accacccgca cttcccaact gcacagcctc gagtagaacc ctggatccgg
     1141 cttgttaaag gaccaaaggg catctaacag cttctagaca gtgtggcccg aggatccctg
     1201 ggggttatgc ttgaacgtta cagggttgag gctaaagact gaggattgat tgtagggaac
     1261 ctccagttat taaacggtgc ggattgctag agggtggcat agtccttcaa tcctggcacc
     1321 cgaaaagcag atgcaggagc aggagcagga gcaaagccag ccatggagtt tgaggcctgc
     1381 ttgaactacc tgagatccaa taataaaaca tttcatatgc tg
//
