LOCUS       NM_012958               2283 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Rattus norvegicus galanin receptor 1 (Galr1), mRNA.
ACCESSION   NM_012958
VERSION     NM_012958.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2283)
  AUTHORS   Shi,H., Fang,Y., Huang,L., Gao,L., Lenahan,C., Okada,T.,
            Travis,Z.D., Xie,S., Tang,H., Lu,Q., Liu,R., Tang,J., Cheng,Y. and
            Zhang,J.H.
  TITLE     Activation of Galanin Receptor 1 with M617 Attenuates Neuronal
            Apoptosis via ERK/GSK-3beta/TIP60 Pathway After Subarachnoid
            Hemorrhage in Rats
  JOURNAL   Neurotherapeutics 18 (3), 1905-1921 (2021)
   PUBMED   34086200
  REMARK    GeneRIF: Activation of Galanin Receptor 1 with M617 Attenuates
            Neuronal Apoptosis via ERK/GSK-3beta/TIP60 Pathway After
            Subarachnoid Hemorrhage in Rats.
            Erratum:[Neurotherapeutics. 2024 Apr;21(3):e00358. doi:
            10.1016/j.neurot.2024.e00358.. PMID: 38641459]
REFERENCE   2  (bases 1 to 2283)
  AUTHORS   Yang,Y., Li,Y., Liu,B., Li,C., Liu,Z., Deng,J., Luo,H., Li,X.,
            Wu,J., Li,H., Wang,C.Y., Zhao,M., Wu,H., Lallemend,F.,
            Svenningsson,P., Hokfelt,T.G.M. and Xu,Z.D.
  TITLE     Involvement of Scratch2 in GalR1-mediated depression-like behaviors
            in the rat ventral periaqueductal gray
  JOURNAL   Proc Natl Acad Sci U S A 118 (24) (2021)
   PUBMED   34108238
  REMARK    GeneRIF: Involvement of Scratch2 in GalR1-mediated depression-like
            behaviors in the rat ventral periaqueductal gray.
REFERENCE   3  (bases 1 to 2283)
  AUTHORS   Randesi,M., Levran,O., van den Brink,W., Blanken,P., van Ree,J.M.,
            Ott,J. and Kreek,M.J.
  TITLE     Further evidence for the association of GAL, GALR1 and NPY1R
            variants with opioid dependence
  JOURNAL   Pharmacogenomics 21 (13), 903-917 (2020)
   PUBMED   32757697
REFERENCE   4  (bases 1 to 2283)
  AUTHORS   Bai,Y.F., Ma,H.T., Liu,L.N., Li,H., Li,X.X., Yang,Y.T., Xue,B.,
            Wang,D. and Xu,Z.D.
  TITLE     Activation of galanin receptor 1 inhibits locus coeruleus neurons
            via GIRK channels
  JOURNAL   Biochem Biophys Res Commun 503 (1), 79-85 (2018)
   PUBMED   29852172
  REMARK    GeneRIF: The inhibitory effect of galanin on locus coeruleus
            neurons is mediated by GALR1 via Gi/o proteins, which activate GIRK
            channels.
REFERENCE   5  (bases 1 to 2283)
  AUTHORS   Li,S.Y., Huo,M.L., Wu,X.Y., Huang,Y.Q., Wang,L., Zhang,X.,
            Jiang,Y.M., Zhang,M.L., Wang,L.L. and Yu,L.C.
  TITLE     Involvement of galanin and galanin receptor 1 in nociceptive
            modulation in the central nucleus of amygdala in normal and
            neuropathic rats
  JOURNAL   Sci Rep 7 (1), 15317 (2017)
   PUBMED   29127424
  REMARK    GeneRIF: These results illustrated that galanin induced
            antinociception in CeA in normal rats and rats with neuropathy, and
            there is an up-regulation of GalR1 expression in rats with
            neuropathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2283)
  AUTHORS   Wang,S., Hashemi,T., Fried,S., Clemmons,A.L. and Hawes,B.E.
  TITLE     Differential intracellular signaling of the GalR1 and GalR2 galanin
            receptor subtypes
  JOURNAL   Biochemistry 37 (19), 6711-6717 (1998)
   PUBMED   9578554
REFERENCE   7  (bases 1 to 2283)
  AUTHORS   Berg,S.F., Dissen,E., Westgaard,I.H. and Fossum,S.
  TITLE     Two genes in the rat homologous to human NKG2
  JOURNAL   Eur J Immunol 28 (2), 444-450 (1998)
   PUBMED   9521051
REFERENCE   8  (bases 1 to 2283)
  AUTHORS   Smith,K.E., Forray,C., Walker,M.W., Jones,K.A., Tamm,J.A., Bard,J.,
            Branchek,T.A., Linemeyer,D.L. and Gerald,C.
  TITLE     Expression cloning of a rat hypothalamic galanin receptor coupled
            to phosphoinositide turnover
  JOURNAL   J Biol Chem 272 (39), 24612-24616 (1997)
   PUBMED   9305929
REFERENCE   9  (bases 1 to 2283)
  AUTHORS   Parker,E.M., Izzarelli,D.G., Nowak,H.P., Mahle,C.D., Iben,L.G.,
            Wang,J. and Goldstein,M.E.
  TITLE     Cloning and characterization of the rat GALR1 galanin receptor from
            Rin14B insulinoma cells
  JOURNAL   Brain Res Mol Brain Res 34 (2), 179-189 (1995)
   PUBMED   8750821
REFERENCE   10 (bases 1 to 2283)
  AUTHORS   Burgevin,M.C., Loquet,I., Quarteronet,D. and Habert-Ortoli,E.
  TITLE     Cloning, pharmacological characterization, and anatomical
            distribution of a rat cDNA encoding for a galanin receptor
  JOURNAL   J Mol Neurosci 6 (1), 33-41 (1995)
   PUBMED   8562318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U30290.2 and JAXUCZ010000018.1.
            
            On Jan 7, 2017 this sequence version replaced NM_012958.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U30290.2, SRR26360194.1863497.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984021, SAMN14984024
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1360              U30290.2           1-1360
            1361-86135382       JAXUCZ010000018.1  1-86134022
            86135383-86136304   U30290.2           1362-2283
FEATURES             Location/Qualifiers
     source          1..2283
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..2283
                     /gene="Galr1"
                     /gene_synonym="Galnr1"
                     /note="galanin receptor 1"
                     /db_xref="GeneID:50577"
                     /db_xref="RGD:2656"
     exon            1..885
                     /gene="Galr1"
                     /gene_synonym="Galnr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1266
                     /gene="Galr1"
                     /gene_synonym="Galnr1"
                     /note="GAL1-R; GALR-1"
                     /codon_start=1
                     /product="galanin receptor type 1"
                     /protein_id="NP_037090.2"
                     /db_xref="GeneID:50577"
                     /db_xref="RGD:2656"
                     /translation="MELAPVNLSEGNGSDPEPPAEPRPLFGIGVENFITLVVFGLIFA
                     MGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVL
                     GAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGFIWA
                     LSIAMASPVAYYQRLFHRDSNQTFCWEHWPNQLHKKAYVVCTFVFGYLLPLLLICFCY
                     AKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHVIHLWAEFGAFPLT
                     PASFFFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCRVCNESPHGDAKEKNR
                     IDTPPSTNCTHV"
     exon            886..951
                     /gene="Galr1"
                     /gene_synonym="Galnr1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..2248
                     /gene="Galr1"
                     /gene_synonym="Galnr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggccaggga agaggatagc gagatcaggc acagcccggg tcactgtcct ctgctgtctt
       61 gccggttgcg ggaggttcta gctggagacg cgcgctctct ccgcgctgtc tagggccatc
      121 ctgtgaccct aggctacctc cagagctggc tttccctggc tggcacaact ctccaaggag
      181 ctccggtcca ttgcacagcg ccccaagggg gtgtctcagt aagtgatgga actggctccg
      241 gtgaacctca gtgaagggaa tgggagcgac cctgaacctc cagcggaacc caggccgctc
      301 ttcggcatcg gcgtggagaa cttcatcacg ctggtggtgt ttggccttat tttcgcgatg
      361 ggcgtgctgg gcaacagcct ggtgatcacc gtgctggcgc gcagcaaacc gggcaagccg
      421 cgcagcacca ccaacctgtt catcctcaac ctgagcatcg cagacctggc ctacctgctc
      481 ttctgcatcc ctttccaggc caccgtgtac gcactgccca cctgggtgct gggcgccttc
      541 atctgcaagt ttatacacta cttcttcacc gtgtccatgc tcgtgagcat cttcaccctg
      601 gccgcgatgt ctgtggatcg ctatgtggcc attgtgcatt cacggcgctc ctcctccctc
      661 agggtgtccc gcaacgcgct gctgggcgtg ggcttcatct gggcgctgtc catcgctatg
      721 gcctcgccgg tggcctacta ccagcgcctt tttcatcggg acagcaacca aaccttctgc
      781 tgggagcact ggcccaacca actccacaag aaggcttacg tggtgtgcac tttcgtcttt
      841 ggttaccttc tgcccttact gctcatctgc ttttgctatg ccaaggttct caatcatctg
      901 cataaaaagt tgaagaacat gtcaaaaaag tcagaggcat ccaagaaaaa gactgcacag
      961 actgtcctgg tggtcgttgt ggtatttggc atatcatggc tgccccatca tgtcatccac
     1021 ctctgggctg agttcggagc attcccgctg accccagctt ccttcttctt cagaatcact
     1081 gcccactgcc tggcatacag caactcctcg gtgaacccca tcatctacgc ctttctctca
     1141 gaaaacttcc ggaaggcgta caagcaagtg ttcaagtgcc gtgtttgcaa tgagtcgccg
     1201 cacggcgatg ctaaagaaaa gaaccgaata gataccccgc cctccaccaa ctgcacccac
     1261 gtgtgaaggt tggccagagc ctcctgtcct ccgctcccat gtgtgttaga gaggggagga
     1321 cacagtgaat tatcaagtaa catggcagct cgttctcctg acagcaattc ctatcattct
     1381 aacaacattc cacagcggtg aaagcacttt gattgtccag ggaactcctc ggtctactga
     1441 agattatttc ccaattttat ttcattttat gattgtattt atgaagcaaa agaaacttcc
     1501 atatagcttc tatcttttaa gggatgaaag tccaacagcg cactgcagat atgttctgat
     1561 ctccatgata caaaccaagt tctaggaagc aatgaagatt atttgaaatc cacattttaa
     1621 ggccagttaa tatagggaaa cagttctctt tcttttaatg atgtagtatt ctagttttga
     1681 aatacatttg tgggcccaga atagtgaatt ttattttact gaacctttgt ggactggcac
     1741 ctcttccgag tcaggggagg cttttcaaag tctgttccca taggtgtaca gagttctgtc
     1801 tgggaacgtg agactcacca agttcatctc aggagatcat tggtgactcc actttgaagt
     1861 aatcctgtgg actaagacac cagggagtct gctgtggacg gctacaaacc tgcctgttgt
     1921 agctttaagg atgttcttgg caaattatta gctgggcctc caaagaaccc aggaaaccag
     1981 tcagccaaca gtttccacgg ggttgaaaac tggacaaaac ttagccacgt agttaatatt
     2041 catgccgcat ggagaaagca ggaaagatgc ttgattccga atgagcaaag acaaaggtat
     2101 cctgtgggag aatagataaa cacttagaga cgtgatgcct tatgcagact tgtaccgaca
     2161 actgtttaat gattgttttc cccaaacatt attccctggg gcaattaatt tagaattaaa
     2221 atcaccacca cgtgacttgc aaatgtaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2281 aaa
//
