LOCUS       NM_022633                682 bp    mRNA    linear   ROD 16-FEB-2024
DEFINITION  Rattus norvegicus galanin-like peptide (Galp), mRNA.
ACCESSION   NM_022633
VERSION     NM_022633.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 682)
  AUTHORS   Wada,A., Wong,P.F., Hojo,H., Hasegawa,M., Ichinose,A., Llanes,R.,
            Kubo,Y., Senba,M. and Ichinose,Y.
  TITLE     Alarin but not its alternative-splicing form, GALP (Galanin-like
            peptide) has antimicrobial activity
  JOURNAL   Biochem Biophys Res Commun 434 (2), 223-227 (2013)
   PUBMED   23537644
REFERENCE   2  (bases 1 to 682)
  AUTHORS   Mohr,M.A., Leathley,E. and Fraley,G.S.
  TITLE     Hypothalamic galanin-like peptide rescues the onset of puberty in
            food-restricted weanling rats
  JOURNAL   J Neuroendocrinol 24 (11), 1412-1422 (2012)
   PUBMED   22681480
  REMARK    GeneRIF: Hypothalamic galanin-like peptide rescues the onset of
            puberty in food-restricted weanling rats.
REFERENCE   3  (bases 1 to 682)
  AUTHORS   Taylor,A., Madison,F.N. and Fraley,G.S.
  TITLE     Galanin-like peptide stimulates feeding and sexual behavior via
            dopaminergic fibers within the medial preoptic area of adult male
            rats
  JOURNAL   J Chem Neuroanat 37 (2), 105-111 (2009)
   PUBMED   19124073
  REMARK    GeneRIF: These data suggest that GALP activates feeding and sexual
            behaviors in male rats by stimulating dopaminergic neurons that
            terminate within the mPOA.
REFERENCE   4  (bases 1 to 682)
  AUTHORS   Dungan Lemko,H.M., Clifton,D.K., Steiner,R.A. and Fraley,G.S.
  TITLE     Altered response to metabolic challenges in mice with genetically
            targeted deletions of galanin-like peptide
  JOURNAL   Am J Physiol Endocrinol Metab 295 (3), E605-E612 (2008)
   PUBMED   18775887
REFERENCE   5  (bases 1 to 682)
  AUTHORS   Kawagoe,R., Yamamoto,Y., Kubo,K., Dobashi,K., Asayama,K., Ueta,Y.
            and Shirahata,A.
  TITLE     Postnatal development of galanin-like peptide mRNA expression in
            rat hypothalamus
  JOURNAL   Regul Pept 145 (1-3), 133-140 (2008)
   PUBMED   17950941
  REMARK    GeneRIF: regulatory mechanism of GALP mRNA is different from that
            of the neuropeptide Y and proopiomelanocortin genes during
            postnatal development
REFERENCE   6  (bases 1 to 682)
  AUTHORS   Lawrence,C.B., Williams,T. and Luckman,S.M.
  TITLE     Intracerebroventricular galanin-like peptide induces different
            brain activation compared with galanin
  JOURNAL   Endocrinology 144 (9), 3977-3984 (2003)
   PUBMED   12933672
  REMARK    GeneRIF: Cell activation induced by GALP in the supraoptic
            hypothalamic nucleus and nucleus tractus solitarius was dependent
            on food intake but independent of food consumption in all other
            brain regions.
REFERENCE   7  (bases 1 to 682)
  AUTHORS   Kumano,S., Matsumoto,H., Takatsu,Y., Noguchi,J., Kitada,C. and
            Ohtaki,T.
  TITLE     Changes in hypothalamic expression levels of galanin-like peptide
            in rat and mouse models support that it is a leptin-target peptide
  JOURNAL   Endocrinology 144 (6), 2634-2643 (2003)
   PUBMED   12746327
  REMARK    GeneRIF: hypothalamic GALP gene expression is controlled by leptin
            signals and suggests possible involvement of GALP in the
            reproductive abnormalities of the Zucker obese rat.
REFERENCE   8  (bases 1 to 682)
  AUTHORS   Takenoya,F., Aihara,K., Funahashi,H., Matsumoto,H., Ohtaki,T.,
            Tsurugano,S., Yamada,S., Katoh,S., Kageyama,H., Takeuchi,M. and
            Shioda,S.
  TITLE     Galanin-like peptide is target for regulation by orexin in the rat
            hypothalamus
  JOURNAL   Neurosci Lett 340 (3), 209-212 (2003)
   PUBMED   12672543
  REMARK    GeneRIF: This is the first study to demonstrate close apposition of
            galanin-like peptide (GALP)-immunoreactive cell bodies and GALP
            neurons expressing OX1-receptors in direct contact with orexin
            (OX1)-immunoreactive terminals in the arcuate nucleus.
REFERENCE   9  (bases 1 to 682)
  AUTHORS   Krasnow,S.M., Fraley,G.S., Schuh,S.M., Baumgartner,J.W.,
            Clifton,D.K. and Steiner,R.A.
  TITLE     A role for galanin-like peptide in the integration of feeding, body
            weight regulation, and reproduction in the mouse
  JOURNAL   Endocrinology 144 (3), 813-822 (2003)
   PUBMED   12586757
  REMARK    GeneRIF: present observations are consistent with the argument that
            galanin-like peptide (GALP) is a downstream effector of leptin's
            actions within the central nervous system
REFERENCE   10 (bases 1 to 682)
  AUTHORS   Ohtaki,T., Kumano,S., Ishibashi,Y., Ogi,K., Matsui,H., Harada,M.,
            Kitada,C., Kurokawa,T., Onda,H. and Fujino,M.
  TITLE     Isolation and cDNA cloning of a novel galanin-like peptide (GALP)
            from porcine hypothalamus
  JOURNAL   J Biol Chem 274 (52), 37041-37045 (1999)
   PUBMED   10601261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000026.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_022633.3.
            
            On Nov 26, 2020 this sequence version replaced NM_022633.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF188491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840113, SAMN12840117
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JACYVU010000026.1  2444376-2444462     c
            88-209              JACYVU010000026.1  2443487-2443608     c
            210-258             JACYVU010000026.1  2434247-2434295     c
            259-339             JACYVU010000026.1  2429763-2429843     c
            340-417             JACYVU010000026.1  2427626-2427703     c
            418-682             JACYVU010000026.1  2425364-2425628     c
FEATURES             Location/Qualifiers
     source          1..682
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..682
                     /gene="Galp"
                     /note="galanin-like peptide"
                     /db_xref="GeneID:64568"
                     /db_xref="RGD:620187"
     exon            1..87
                     /gene="Galp"
                     /inference="alignment:Splign:2.1.0"
     exon            88..209
                     /gene="Galp"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..473
                     /gene="Galp"
                     /codon_start=1
                     /product="galanin-like peptide precursor"
                     /protein_id="NP_072155.1"
                     /db_xref="GeneID:64568"
                     /db_xref="RGD:620187"
                     /translation="MACSKHLVLFLTILLSLAETPDSAPAHRGRGGWTLNSAGYLLGP
                     VLHLSSKANQGRKTDSALEILDLWKAIDGLPYSRSPRMTKRSMGETFVKPRTGDLRIV
                     DKNVPDEEATLNL"
     exon            210..258
                     /gene="Galp"
                     /inference="alignment:Splign:2.1.0"
     exon            259..339
                     /gene="Galp"
                     /inference="alignment:Splign:2.1.0"
     exon            340..417
                     /gene="Galp"
                     /inference="alignment:Splign:2.1.0"
     exon            418..682
                     /gene="Galp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggacaactg ggattacaga tgtgcatccc tgcaaccggc tgccacacaa gttctgggat
       61 ctgaactcct ggcctcaaac ttgccagcat tccttagctg tatgccgtgc ttttccagtt
      121 ccaggatggc ctgctccaag catctggtcc tcttcctcac catcttgcta agcctcgcag
      181 aaacaccaga ctctgcacct gctcacaggg gacgaggagg ctggaccctc aatagtgctg
      241 gttacctcct gggtcctgtc ctccaccttt cctcaaaggc caaccagggc aggaagacag
      301 actcagctct tgagatccta gacctgtgga aggccataga tgggctccct tattcccgct
      361 ctccaaggat gaccaaaagg tcaatgggag aaacgtttgt caagccgagg actggagatc
      421 tgcgcatagt ggacaagaat gttccggatg aagaagccac cctgaactta tagagagtta
      481 gccctagctc actcctacgt ttccagctca ccgcctctcc ccccaccccc gcccccagaa
      541 gcgctctgaa caccctttct aagtctaaga ccttacaact atattcccta atctcactaa
      601 gacatgttgt gatatttaaa gagttattct gcccagctcc ggaaaaaaaa aaaaaaaaaa
      661 aaaaagagtt attctgacgt aa
//
