LOCUS       NM_024373               1884 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus polypeptide N-acetylgalactosaminyltransferase 1
            (Galnt1), mRNA.
ACCESSION   NM_024373 XM_006254471
VERSION     NM_024373.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1884)
  AUTHORS   Raman,J., Guan,Y., Perrine,C.L., Gerken,T.A. and Tabak,L.A.
  TITLE     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferases: completion of the family tree
  JOURNAL   Glycobiology 22 (6), 768-777 (2012)
   PUBMED   22186971
  REMARK    Erratum:[Glycobiology. 2015 Apr;25(4):465. doi:
            10.1093/glycob/cwv003.. PMID: 25715345]
REFERENCE   2  (bases 1 to 1884)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 1884)
  AUTHORS   Zhang,Y., Iwasaki,H., Wang,H., Kudo,T., Kalka,T.B., Hennet,T.,
            Kubota,T., Cheng,L., Inaba,N., Gotoh,M., Togayachi,A., Guo,J.,
            Hisatomi,H., Nakajima,K., Nishihara,S., Nakamura,M., Marth,J.D. and
            Narimatsu,H.
  TITLE     Cloning and characterization of a new human
            UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that
            is specifically expressed in neurons and synthesizes GalNAc
            alpha-serine/threonine antigen
  JOURNAL   J Biol Chem 278 (1), 573-584 (2003)
   PUBMED   12407114
REFERENCE   4  (bases 1 to 1884)
  AUTHORS   Argueso,P., Tisdale,A., Mandel,U., Letko,E., Foster,C.S. and
            Gipson,I.K.
  TITLE     The cell-layer- and cell-type-specific distribution of
            GalNAc-transferases in the ocular surface epithelia is altered
            during keratinization
  JOURNAL   Invest Ophthalmol Vis Sci 44 (1), 86-92 (2003)
   PUBMED   12506059
REFERENCE   5  (bases 1 to 1884)
  AUTHORS   Tenno,M., Saeki,A., Kezdy,F.J., Elhammer,A.P. and Kurosaka,A.
  TITLE     The lectin domain of UDP-GalNAc:polypeptide
            N-acetylgalactosaminyltransferase 1 is involved in O-glycosylation
            of a polypeptide with multiple acceptor sites
  JOURNAL   J Biol Chem 277 (49), 47088-47096 (2002)
   PUBMED   12364335
  REMARK    GeneRIF: the GalNAc-T1 lectin domain plays a critical role in
            enzymatic activity, and GalNAc-T1 has two activities distinguished
            by their sensitivities to inhibition with free GalNAc
REFERENCE   6  (bases 1 to 1884)
  AUTHORS   Tenno,M., Kezdy,F.J., Elhammer,A.P. and Kurosaka,A.
  TITLE     Function of the lectin domain of polypeptide
            N-acetylgalactosaminyltransferase 1
  JOURNAL   Biochem Biophys Res Commun 298 (5), 755-759 (2002)
   PUBMED   12419318
  REMARK    GeneRIF: the lectin domain of GalNAc-T1 has at least two functional
            repeats, allowing the possibility of multivalent interactions with
            GalNAc residues on the acceptor polypeptide during glycosylation
REFERENCE   7  (bases 1 to 1884)
  AUTHORS   Tenno,M., Toba,S., Kezdy,F.J., Elhammer,A.P. and Kurosaka,A.
  TITLE     Identification of two cysteine residues involved in the binding of
            UDP-GalNAc to UDP-GalNAc:polypeptide
            N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
  JOURNAL   Eur J Biochem 269 (17), 4308-4316 (2002)
   PUBMED   12199709
REFERENCE   8  (bases 1 to 1884)
  AUTHORS   Ten Hagen,K.G., Bedi,G.S., Tetaert,D., Kingsley,P.D., Hagen,F.K.,
            Balys,M.M., Beres,T.M., Degand,P. and Tabak,L.A.
  TITLE     Cloning and characterization of a ninth member of the
            UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family,
            ppGaNTase-T9
  JOURNAL   J Biol Chem 276 (20), 17395-17404 (2001)
   PUBMED   11278534
REFERENCE   9  (bases 1 to 1884)
  AUTHORS   Wandall,H.H., Hassan,H., Mirgorodskaya,E., Kristensen,A.K.,
            Roepstorff,P., Bennett,E.P., Nielsen,P.A., Hollingsworth,M.A.,
            Burchell,J., Taylor-Papadimitriou,J. and Clausen,H.
  TITLE     Substrate specificities of three members of the human
            UDP-N-acetyl-alpha-D-galactosamine:Polypeptide
            N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3
  JOURNAL   J Biol Chem 272 (38), 23503-23514 (1997)
   PUBMED   9295285
REFERENCE   10 (bases 1 to 1884)
  AUTHORS   Hagen,F.K., Gregoire,C.A. and Tabak,L.A.
  TITLE     Cloning and sequence homology of a rat UDP-GalNAc:polypeptide
            N-acetylgalactosaminyltransferase
  JOURNAL   Glycoconj J 12 (6), 901-909 (1995)
   PUBMED   8748168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Dec 2, 2020 this sequence version replaced
            XM_006254471.3, NM_024373.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.53483.1,
                                           SRR26643299.62073.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000018.1  15798922-15798976
            56-297              JAXUCZ010000018.1  15802957-15803198
            298-472             JAXUCZ010000018.1  15810182-15810356
            473-639             JAXUCZ010000018.1  15816414-15816580
            640-847             JAXUCZ010000018.1  15821577-15821784
            848-1018            JAXUCZ010000018.1  15824526-15824696
            1019-1136           JAXUCZ010000018.1  15826384-15826501
            1137-1317           JAXUCZ010000018.1  15828659-15828839
            1318-1457           JAXUCZ010000018.1  15829745-15829884
            1458-1556           JAXUCZ010000018.1  15837154-15837252
            1557-1691           JAXUCZ010000018.1  15838082-15838216
            1692-1884           JAXUCZ010000018.1  15841476-15841668
FEATURES             Location/Qualifiers
     source          1..1884
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..1884
                     /gene="Galnt1"
                     /note="polypeptide N-acetylgalactosaminyltransferase 1"
                     /db_xref="GeneID:79214"
                     /db_xref="RGD:620358"
     exon            1..55
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            56..297
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1838
                     /gene="Galnt1"
                     /EC_number="2.4.1.41"
                     /note="galNAc-T1; pp-GaNTase 1; polypeptide GalNAc
                     transferase 1; protein-UDP acetylgalactosaminyltransferase
                     1; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 1; polypeptide GalNAc
                     transferase T1;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 1 (GalNAc-T1)"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 1"
                     /protein_id="NP_077349.1"
                     /db_xref="GeneID:79214"
                     /db_xref="RGD:620358"
                     /translation="MRKFAYCKVVLATSLVWVLLDMFLLLYFSECNKCEEKKERGLPA
                     GDVLELVQKPHEGPGEMGKPVVIPKEDQEKMKEMFKINQFNLMASEMIAFNRSLPDVR
                     LEGCKTKVYPDSLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDASER
                     DFLKRPLESYVKKLKVPVHVIRMEQRSGLIRARLKGAAVSKGQVITFLDAHCECTVGW
                     LEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMD
                     RRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTL
                     EIVTCSHVGHVFRKATPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVD
                     YGDISSRVGLRHKLQCKPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNMARKE
                     NEKVGIFNCHGMGGNQVFSYTANKEIRTDDLCLDVSKLNGPVTMLKCHHLKGNQLWEY
                     DPVKLTLQHVNSNQCLDKATEEDSQVPSIRDCTGSRSQQWLLRNVTLPEIF"
     exon            298..472
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..639
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..847
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1018
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1136
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1317
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1457
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1556
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1691
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1884
                     /gene="Galnt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtttgag acatgtggat ttgtgatatg aagtcatttg aaaaactcct ttggggatat
       61 gactgtgatt tctgatgaaa ccagattgga ataattttca tgatatttgt atatttatat
      121 atatatattt taaaatttta catttgactt aaagtgccat gagaaaattt gcatattgca
      181 aggtggttct agccacctcc ttggtttggg tactcttgga tatgttcctg ctgctttact
      241 tcagtgaatg caacaaatgt gaagagaaga aggagcgagg gcttcctgct ggggatgttc
      301 tagagctggt gcagaagcct cacgaaggtc ctggagaaat gggaaaacca gtcgtcattc
      361 ctaaagagga tcaggaaaag atgaaagaga tgttcaaaat caaccagttc aacctaatgg
      421 cgagtgagat gattgcattc aacagatcct taccagacgt gaggctagag gggtgtaaaa
      481 caaaagtgta cccagatagc cttcctacga caagcgtggt gattgtcttt cacaatgagg
      541 catggagcac cctcctgcga acagtccaca gtgtcattaa ccgctcacca agacacatga
      601 tagaagagat tgttcttgta gacgatgcca gcgaaagaga ctttttgaaa agacctctag
      661 agagttatgt gaaaaagctt aaagtgccag ttcatgtaat tcgaatggaa caacgttctg
      721 ggttgatcag agctagatta aaaggagctg ctgtgtccaa aggccaagtg atcaccttct
      781 tagatgctca ctgcgagtgc acagtagggt ggctggagcc tctgttagcc cggatcaaac
      841 atgacaggag gacagtggtg tgtcctatca tcgatgtgat cagtgatgac acttttgagt
      901 acatggcggg ctctgatatg acctatggtg gattcaactg gaagctcaat ttccgttggt
      961 atcctgttcc ccaacgagaa atggacagaa ggaaaggtga ccggactctt cctgtcagaa
     1021 cacctacaat ggctggaggc ctgttttcaa tagacagaga ttactttcag gaaattggaa
     1081 catatgatgc tggaatggat atttggggag gagaaaacct agaaatttcc tttaggattt
     1141 ggcagtgtgg agggactctg gaaatagtga cgtgctccca cgttggccat gtgtttcgga
     1201 aagctacgcc gtacacgttc ccgggtggca cggggcagat catcaacaag aataacagac
     1261 ggctcgcgga ggtgtggatg gatgaattca agaatttctt ctacataatt tctccaggtg
     1321 ttacaaaggt agattatggt gatatatcat caagagtcgg tctgagacat aaactacagt
     1381 gcaagccttt ctcttggtac ctagaaaata tttatcccga ttctcaaatt cctcgtcact
     1441 atttctcatt gggagagata cgaaatgtgg aaacaaatca atgtctagat aacatggcta
     1501 gaaaagagaa tgaaaaggtt ggaattttta attgtcatgg tatgggaggc aatcaggttt
     1561 tctcttacac tgccaacaaa gaaattagaa cagatgacct ttgtttggac gtttccaaac
     1621 ttaatggccc agttaccatg ctcaaatgcc accacctaaa aggcaaccag ctctgggagt
     1681 atgacccagt gaaattaacc ctgcagcatg tgaacagtaa ccagtgcctg gataaagcca
     1741 cagaagagga cagccaggtg cccagcatca gagactgcac tggaagccgg tcccagcagt
     1801 ggcttcttcg aaatgtcacc cttccagaaa tattctgaga ccaaattaca acaaagaaag
     1861 gattgactgg gctacctcag cata
//
