LOCUS       NM_001047851            4088 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus galactosamine (N-acetyl)-6-sulfatase (Galns),
            mRNA.
ACCESSION   NM_001047851 XM_001079394 XM_226546
VERSION     NM_001047851.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4088)
  AUTHORS   Bertolin,J., Sanchez,V., Ribera,A., Jaen,M.L., Garcia,M., Pujol,A.,
            Sanchez,X., Munoz,S., Marco,S., Perez,J., Elias,G., Leon,X.,
            Roca,C., Jimenez,V., Otaegui,P., Mulero,F., Navarro,M., Ruberte,J.
            and Bosch,F.
  TITLE     Treatment of skeletal and non-skeletal alterations of
            Mucopolysaccharidosis type IVA by AAV-mediated gene therapy
  JOURNAL   Nat Commun 12 (1), 5343 (2021)
   PUBMED   34504088
  REMARK    GeneRIF: Treatment of skeletal and non-skeletal alterations of
            Mucopolysaccharidosis type IVA by AAV-mediated gene therapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4088)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
REFERENCE   3  (bases 1 to 4088)
  AUTHORS   Zito,E., Fraldi,A., Pepe,S., Annunziata,I., Kobinger,G., Di
            Natale,P., Ballabio,A. and Cosma,M.P.
  TITLE     Sulphatase activities are regulated by the interaction of
            sulphatase-modifying factor 1 with SUMF2
  JOURNAL   EMBO Rep 6 (7), 655-660 (2005)
   PUBMED   15962010
  REMARK    Erratum:[EMBO Rep. 2016 Dec;17 (12 ):1901. PMID: 27909074]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000313.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001047851.3.
            
            On Sep 14, 2022 this sequence version replaced NM_001047851.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN000741.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               JACYVU010000313.1  27707457-27707669   c
            214-337             JACYVU010000313.1  27701777-27701900   c
            338-412             JACYVU010000313.1  27700839-27700913   c
            413-515             JACYVU010000313.1  27700083-27700185   c
            516-659             JACYVU010000313.1  27696789-27696932   c
            660-726             JACYVU010000313.1  27695282-27695348   c
            727-854             JACYVU010000313.1  27695048-27695175   c
            855-994             JACYVU010000313.1  27694208-27694347   c
            995-1098            JACYVU010000313.1  27691877-27691980   c
            1099-1235           JACYVU010000313.1  27688633-27688769   c
            1236-1338           JACYVU010000313.1  27687851-27687953   c
            1339-1460           JACYVU010000313.1  27682027-27682148   c
            1461-1578           JACYVU010000313.1  27678180-27678297   c
            1579-4088           JACYVU010000313.1  27674009-27676518   c
FEATURES             Location/Qualifiers
     source          1..4088
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..4088
                     /gene="Galns"
                     /note="galactosamine (N-acetyl)-6-sulfatase"
                     /db_xref="GeneID:292073"
                     /db_xref="RGD:1565391"
     exon            1..213
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1665
                     /gene="Galns"
                     /EC_number="3.1.6.4"
                     /note="N-acetylgalactosamine-6-sulfatase;
                     N-acetylgalactosamine-6-sulfate sulfatase; chondroitinase;
                     galNAc6S sulfatase; chondroitinsulfatase;
                     galactose-6-sulfate sulfatase; galactosamine
                     (N-acetyl)-6-sulfate sulfatase"
                     /codon_start=1
                     /product="N-acetylgalactosamine-6-sulfatase precursor"
                     /protein_id="NP_001041316.1"
                     /db_xref="GeneID:292073"
                     /db_xref="RGD:1565391"
                     /translation="MTACSTAIRAQQLLLPVLSALGLLAAGAPQPPNIVLLLMDDMGW
                     GDLGVYGEPSRETPNLDRMAAEGMLFPSFYSANPLCSPSRAALLTGRLPIRNGFYTTN
                     AHARNAYTPQEIMGGIPNSEHLLPELLKKAGYTNKIVGKWHLGHRPQFHPLKHGFDEW
                     FGSPNCHFGPYDNKVKPNIPVYRDWEMVGRFYEEFPINLKTGEANLTQLYLQEALDFI
                     RTQHARQSPFFLYWAIDATHAPVYASKQFLGTSLRGRYGDAVREIDDSVGKILSLLQN
                     LGISKNTFVFFTSDNGAALISAPKEGGSNGPFLCGKQTTFEGGMREPAIAWWPGHIAA
                     GQVSHQLGSIMDLFTTSLSLAGLKPPSDRVIDGLDLLPTMLQGHIIDRPIFYYRGNTL
                     MAVTLGQYKAHLWTWTNSWEEFRQGIDFCPGQNVSGVTTHTQEEHTELPLIFHLGRDP
                     GERFPLRFTSNEYQDALSRTTQVIQQHQKSLVPGQPQLNVCNQAVMNWAPPGCEKLGK
                     CLTPPESVPEKCFWAH"
     exon            214..337
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
     exon            338..412
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
     exon            413..515
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
     exon            516..659
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
     exon            660..726
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
     exon            727..854
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
     exon            855..994
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1098
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1235
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1338
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1460
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1578
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..4088
                     /gene="Galns"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggcaggg cccgccccac actccaaaag gaaccgcggc ccgactggga ctgagtcttg
       61 cttggctctg cagccggagc ttggattgcc atgacggcct gttccacagc gatcagggcc
      121 cagcagctac tgctgccggt actgagtgct ctaggactct tggctgcagg tgctccgcag
      181 ccccccaaca ttgtgctact gctcatggac gatatggggt ggggtgacct gggtgtgtat
      241 ggagaacctt ccagagagac cccaaattta gaccggatgg ctgcagaagg gatgcttttc
      301 ccaagcttct attctgccaa ccctttgtgc tcaccatcta gggcagccct gctcacagga
      361 cggttgccca tccgcaatgg cttctacaca accaacgcac atgcaaggaa tgcttacaca
      421 cctcaggaga tcatgggcgg gatccctaac tcagaacacc tcctgcctga gctcctgaag
      481 aaagcaggct ataccaacaa gatcgtgggc aaatggcatc tgggtcatag accccagttc
      541 caccccctga agcatggatt tgatgagtgg tttggatccc ccaattgtca ttttggacca
      601 tacgacaaca aggtcaagcc caacatccct gtgtacaggg actgggaaat ggttggcaga
      661 ttttatgaag agttcccaat caacctaaag accggggaag ctaacctcac ccaactctac
      721 ttacaagaag ctctggactt catccggaca caacatgcaa ggcagagccc cttcttcctc
      781 tactgggcca tcgacgccac acacgcacca gtgtatgcct caaaacagtt cctgggtacc
      841 agccttcgag ggcgttatgg cgatgctgtc cgggaaatag atgacagtgt tggaaagatc
      901 ctgagccttc tgcagaactt gggcatcagt aagaacacat ttgtcttctt tacgtctgac
      961 aatggtgcag cgctcatctc tgctcccaaa gaaggtggca gcaatggtcc cttcctgtgt
     1021 gggaagcaga ctacgtttga aggcgggatg agggagcctg caatcgcttg gtggccaggg
     1081 cacattgccg caggccaggt cagccaccag ctgggaagca tcatggacct cttcaccacc
     1141 agcctgtccc ttgcaggcct gaagcccccc agtgacaggg taattgatgg ccttgacctc
     1201 ctccccacca tgctccaggg ccacatcata gacaggccca tattttatta ccgtggcaac
     1261 acactgatgg cagtcactct tggccagtac aaagcacacc tctggacttg gaccaactcc
     1321 tgggaggagt tcagacaggg cattgacttc tgccccgggc agaatgtttc aggagtcaca
     1381 acccacaccc aggaagagca cacggagcta cccctgatct tccacctggg acgtgaccca
     1441 ggggagagat tcccactcag gttcaccagc aatgagtacc aggatgccct cagcaggacc
     1501 acccaggtca tccagcaaca ccaaaagtct ttggtccctg gacagcccca gctcaatgtg
     1561 tgtaaccagg ctgtcatgaa ttgggcgcct ccaggctgtg aaaaactagg gaagtgtctg
     1621 acacctcctg agtctgtccc cgagaagtgt ttctgggccc attagccaag accgagatcg
     1681 ccagacagcc agcccgcccc cacaggagcc cggaaggcct ctgcctgggg acggatggat
     1741 ggaagccacc agctgccctt gccctcccat cactggatgg gcggcccctg caaccagtaa
     1801 caaggctcca agactgcccc tcccggagcc ccgaccctgg agtccgttct ctggcactgt
     1861 ggcccttctt gccaactgga tactgaaaaa gaagaggctc tcctgccccg gtggccttgg
     1921 tcaccatgcg tgttccagcc cggtgtctga agcgctgtca ctttgccacc tcactgtccc
     1981 tgcatacatt tcaaccttgt agacaaaagt gagggtttca gcgtgatgcc aaggagccac
     2041 catcttcctg gccatccgtc ctcagcccca ggcggccaac cccctgagcc accctgcctc
     2101 ttttcccact ggttacaaac aaaagacaag gagcacattt tccagtcaag gcgatgctgt
     2161 caccacccca tggagatagg aaaacgatat cctaaatttc tggccctggc tcagtgcact
     2221 gtggggccac ttcttttttt tttttttttt tttggttctt tttttcggag ctggggaccg
     2281 aacccagggc cttgcacttc ctaggcaagc gctctaccac tgagctaaat ccccagcccc
     2341 tgtggggcca cttctatacc tgccacctgc cagtcatgtg ctccacataa cctcctcatc
     2401 ctatctctga aggctcgtgg gagctgtcca ccatgaacag gtttgcacat ctgggcaaca
     2461 gctgcagtgc caaagctgag ctgtaaggtt gggaactgag ggtgaagaga ttgagtgaga
     2521 ataaggaaca ggagggagcc tcaggttttt tttttttttt ttggtttttt gttttttttt
     2581 tggttctttt tttcggagct ggggaccgaa cccaggtcct tgcgcttcct aggtaagcgc
     2641 tctaccactg agctaaatcc ccagccccgg agcctcagtt ttgtttgggg gttggttgtc
     2701 tgcttgtttg ttttaataca aggtctctct gtgtagccct ggctcttctg gaacttactc
     2761 tgtggaatag gctggccttg aactcagaga tctgcctgcc tcctcctcgt cgagcactgg
     2821 gattaaaggc ctgtgccatc atggccacct atcctggttt ttacactaga gattatgatg
     2881 ggagactgtg ttagatgtcc gtgtacctat ggcatgaacg ttccctgggg agacagaaac
     2941 atgtgctcca gataagattc caatggccgc ctaaaggaac catttcatcc aatgagttca
     3001 ttgcttacaa gaacaggaat gacccccaaa gcagctccat cgcccgactg aaaagtctca
     3061 gcccagaatg gatgacaagc tccctctaac agaggctccc ttcagttagc cgtcccccct
     3121 gcacatatac tccagtgcct ccacagatca cctcggatgg aagaactgcc gctcacaggg
     3181 agggtccggg aagcactggt tagaagccac tggaccttcc ccacacctcc attgatgaag
     3241 cataggtcaa tctgcagggt gtcctttgag taatcacaac tgccctgaag atgataatgg
     3301 ctattatacg caagaggacg gtcttccaca ccattacctg tagactcagg taccgtgcta
     3361 ggaaggtaga tctccgttct gtctctggct atctggatct tatggtcccc accccaaaac
     3421 gaggacgcat tctgttgcaa tgcacaggag tatctgtggc ttcagagtat gcattcctta
     3481 ccccgccatg cgaccctgat tccttctccc gcactcccac tctagcccat acacaatgca
     3541 cttccactta tagacctgag agtatccatt aaactccctt cctggctaat tccaggaaag
     3601 cagggacgaa tctcaggccc ctcgcactgc gcgccggagc acagtacacg gagcgaaggg
     3661 acgcgaggcc aaaccatgcc aggggacctg ggcaagaccg gtccctgctc cctcaggtcc
     3721 agacggctgg ccccggggaa agcctgactg gaaaggcgtg ggggaggcaa aaccaaagaa
     3781 aagggtgatg acaggacgcc catccccttt ccacccatct atctttgagg tagggatgct
     3841 tgtgtttagg cagctcaaga aatttaaccc cggggctgga gagatggctc agcggttaag
     3901 agcactgact gctcttccaa aggtcatgag ttcaaatccc agcaaccaca tggtggctca
     3961 caaccatctg taacgagatc cgatgccctc ttctgctgtg tctgaaggca gcagctacag
     4021 tgtactcgtc atatataaaa tgaataaata aaatcttaaa aaaaaaagaa atttaacccc
     4081 aggttttc
//
