LOCUS       NM_001008282            1486 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus galactokinase 1 (Galk1), mRNA.
ACCESSION   NM_001008282 XM_213528
VERSION     NM_001008282.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1486)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 1486)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 1486)
  AUTHORS   Sangiuolo F, Magnani M, Stambolian D and Novelli G.
  TITLE     Biochemical characterization of two GALK1 mutations in patients
            with galactokinase deficiency
  JOURNAL   Hum Mutat 23 (4), 396 (2004)
   PUBMED   15024738
REFERENCE   4  (bases 1 to 1486)
  AUTHORS   Yager C, Ning C, Reynolds R, Leslie N and Segal S.
  TITLE     Galactitol and galactonate accumulation in heart and skeletal
            muscle of mice with deficiency of galactose-1-phosphate
            uridyltransferase
  JOURNAL   Mol Genet Metab 81 (2), 105-111 (2004)
   PUBMED   14741191
REFERENCE   5  (bases 1 to 1486)
  AUTHORS   Timson DJ and Reece RJ.
  TITLE     Sugar recognition by human galactokinase
  JOURNAL   BMC Biochem 4, 16 (2003)
   PUBMED   14596685
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1486)
  AUTHORS   Ai Y, Basu M, Bergsma DJ and Stambolian D.
  TITLE     Comparison of the enzymatic activities of human galactokinase GALK1
            and a related human galactokinase protein GK2
  JOURNAL   Biochem Biophys Res Commun 212 (2), 687-691 (1995)
   PUBMED   7542884
REFERENCE   7  (bases 1 to 1486)
  AUTHORS   Rogers,S. and Segal,S.
  TITLE     Changing activities of galactose-metabolizing enzymes during
            perfusion of suckling-rat liver
  JOURNAL   Am J Physiol 240 (3), E333-E339 (1981)
   PUBMED   6259949
REFERENCE   8  (bases 1 to 1486)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   9  (bases 1 to 1486)
  AUTHORS   McBreen,P., Orkwiszewski,K.G., Chern,C.J., Mellman,W.J. and
            Croce,C.M.
  TITLE     Synteny of the genes for thymidine kinase and galactokinase in the
            mouse and their assignment to mouse chromosome 11
  JOURNAL   Cytogenet Cell Genet 19 (1), 7-13 (1977)
   PUBMED   196814
REFERENCE   10 (bases 1 to 1486)
  AUTHORS   Mishkin,J.D., Taylor,B.A. and Mellman,W.J.
  TITLE     Glk: a locus controlling galactokinase activity in the mouse
  JOURNAL   Biochem Genet 14 (7-8), 635-640 (1976)
   PUBMED   186024
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085919.1.
            
            On Dec 16, 2004 this sequence version replaced XM_213528.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085919.1, FQ219172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1486
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1486
                     /gene="Galk1"
                     /gene_synonym="Galk; Glk"
                     /note="galactokinase 1"
                     /db_xref="GeneID:287835"
                     /db_xref="RGD:1305375"
     exon            1..192
                     /gene="Galk1"
                     /gene_synonym="Galk; Glk"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1206
                     /gene="Galk1"
                     /gene_synonym="Galk; Glk"
                     /EC_number="2.7.1.6"
                     /codon_start=1
                     /product="galactokinase"
                     /protein_id="NP_001008283.1"
                     /db_xref="GeneID:287835"
                     /db_xref="RGD:1305375"
                     /translation="MAAWRPPRVEELLAEARRAFMEEFGAEPELAVSAPGRVNLIGEH
                     TDYNQGLVLPMALELVTVMVGSPRTDGLVSLLTTSKDADEPQRLQFPLPSAQWSLEPG
                     IPQWANYVKGVIQYYPASPLCGFSAVVVSSVPLGGGLSSSASLEVATYAFLQQLCPDS
                     GSIAARAQVCQRAEHSFAGVPCGIMDQLIALLGQKGYALLIDCRSLETSLVPLSDPKL
                     TVLITNSNVRHSLASSEYPIRRRQCEEVAQALGKESLREVRMEELEAGRELMSKEGFR
                     RARHVVSEIRRTAQGAAALSRGDYKAFGRLMVESHYSLRDDYEVSCPELDLLVEAALS
                     VPGVYGSRMTGGGFGGCTVTLLEASVAPLVMHHIQEQYSGTATFYLTQAADGAQVLSL
                     "
     exon            193..382
                     /gene="Galk1"
                     /gene_synonym="Galk; Glk"
                     /inference="alignment:Splign:2.1.0"
     exon            383..502
                     /gene="Galk1"
                     /gene_synonym="Galk; Glk"
                     /inference="alignment:Splign:2.1.0"
     exon            503..638
                     /gene="Galk1"
                     /gene_synonym="Galk; Glk"
                     /inference="alignment:Splign:2.1.0"
     exon            639..820
                     /gene="Galk1"
                     /gene_synonym="Galk; Glk"
                     /inference="alignment:Splign:2.1.0"
     exon            821..971
                     /gene="Galk1"
                     /gene_synonym="Galk; Glk"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1134
                     /gene="Galk1"
                     /gene_synonym="Galk; Glk"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1324
                     /gene="Galk1"
                     /gene_synonym="Galk; Glk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgcgccc cgctgcagac gagcgtcatg gctgcttgga gaccgccccg ggttgaggag
       61 ctgctggccg aggcccggcg ggccttcatg gaggagtttg gagccgagcc ggagctggca
      121 gtgtcggcgc ctggccgcgt caacctcatc ggggagcaca cggattacaa ccagggcctg
      181 gtgctgccca tggctctgga gcttgtgacg gtgatggttg gcagcccccg gacagatggg
      241 cttgtttctc tcctcaccac ttccaaagat gcagacgagc cccagcgact gcagttccca
      301 ctgccctcag cccagtggtc cttggagcct ggaatcccac agtgggccaa ttatgtcaag
      361 ggagtgattc agtattaccc agcttcccct ctctgtggct tcagcgcagt ggtggtcagc
      421 tcagtgcccc tggggggtgg tctttccagc tcagcttctc tggaagtggc cacgtacgcc
      481 ttcctccagc agctctgccc agactcgggg tcaatagccg ctcgggccca ggtgtgtcaa
      541 cgggctgagc acagcttcgc aggggtgccc tgtggcatca tggaccaact catcgcactg
      601 ctggggcaga aaggctatgc gctactcatt gactgcaggt ccctggaaac aagcctggtg
      661 ccgctgtcag accctaagct gaccgtgctc atcaccaact ccaatgtccg ccattccctg
      721 gcctccagcg agtacccgat tcgtcggcgc cagtgtgaag aggtggccca ggccctgggc
      781 aaggagagcc ttcgggaggt gcggatggag gaacttgagg cgggcaggga gctgatgagc
      841 aaggagggtt tccggcgggc ccggcacgtg gttagcgaga tccggcgaac agcccaggga
      901 gcagctgctc tgagccgagg agactataag gcctttggac gtctcatggt ggagagtcac
      961 tattccctca gagatgacta tgaggtgagc tgccctgagc tggacctatt ggttgaggct
     1021 gcgctctctg tgcctggagt ttacggcagt cgcatgacag gcggtggctt cggcggctgc
     1081 actgtcacgt tgctggaggc ctctgttgcc ccccttgtca tgcatcacat acaggagcag
     1141 tacagcggga cagccacctt ctacctcact caagctgccg atggagccca ggtgctgagc
     1201 ttgtgaggtg tccctgcgag tgacgtacgc acaggcgtaa ggcagagagg cagccggtgc
     1261 gtaccggctc tgcttcaggc atcctcctcc catatctggg tgcttaataa acgcgtacct
     1321 cttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1381 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
