LOCUS       NM_080783               1425 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus UDP-galactose-4-epimerase (Gale), mRNA.
ACCESSION   NM_080783
VERSION     NM_080783.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Wei,X., Das,J., Fragoza,R., Liang,J., Bastos de Oliveira,F.M.,
            Lee,H.R., Wang,X., Mort,M., Stenson,P.D., Cooper,D.N., Lipkin,S.M.,
            Smolka,M.B. and Yu,H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1425)
  AUTHORS   Timson,D.J.
  TITLE     Functional analysis of disease-causing mutations in human
            UDP-galactose 4-epimerase
  JOURNAL   FEBS J 272 (23), 6170-6177 (2005)
   PUBMED   16302980
REFERENCE   4  (bases 1 to 1425)
  AUTHORS   Schulz,J.M., Watson,A.L., Sanders,R., Ross,K.L., Thoden,J.B.,
            Holden,H.M. and Fridovich-Keil,J.L.
  TITLE     Determinants of function and substrate specificity in human
            UDP-galactose 4'-epimerase
  JOURNAL   J Biol Chem 279 (31), 32796-32803 (2004)
   PUBMED   15175331
REFERENCE   5  (bases 1 to 1425)
  AUTHORS   Yager,C., Ning,C., Reynolds,R., Leslie,N. and Segal,S.
  TITLE     Galactitol and galactonate accumulation in heart and skeletal
            muscle of mice with deficiency of galactose-1-phosphate
            uridyltransferase
  JOURNAL   Mol Genet Metab 81 (2), 105-111 (2004)
   PUBMED   14741191
REFERENCE   6  (bases 1 to 1425)
  AUTHORS   Zeschnigk,M., von Wilcken-Bergmann,B. and Starzinski-Powitz,A.
  TITLE     cDNA from rat cells with reconstitutive galactose-epimerase
            activity in E. coli
  JOURNAL   Nucleic Acids Res 18 (17), 5289 (1990)
   PUBMED   2205840
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097293.1.
            
            On Dec 11, 2007 this sequence version replaced NM_080783.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097293.1, SRR8487231.22112.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1425
                     /gene="Gale"
                     /note="UDP-galactose-4-epimerase"
                     /db_xref="GeneID:114860"
                     /db_xref="RGD:621493"
     exon            1..27
                     /gene="Gale"
                     /inference="alignment:Splign:2.1.0"
     exon            28..153
                     /gene="Gale"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1079
                     /gene="Gale"
                     /EC_number="5.1.3.2"
                     /EC_number="5.1.3.7"
                     /note="galactowaldenase; galactose-4-epimerase, UDP;
                     UDP-GalNAc 4-epimerase; UDP-GlcNAc 4-epimerase;
                     UDP-galactosamine 4-epimerase; UDP-N-acetylglucosamine
                     4-epimerase"
                     /codon_start=1
                     /product="UDP-glucose 4-epimerase"
                     /protein_id="NP_542961.2"
                     /db_xref="GeneID:114860"
                     /db_xref="RGD:621493"
                     /translation="MEEKVLVTGGAGYIGSHTVLELLEAGYSPVVIDNFHNSIRGEDS
                     MPESLRRVQELTGRSVEFEEMDILDQAALQHLFKKHNFKAVIHFAGLKAVGESVQKPL
                     DYYRVNLTGTIQLLEIMRAHGVKSLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKS
                     KFFIEEMIQDLCRADTAWNAVLLRYFNPIGAHASGRIGEDPQGIPNNLMPYVSQVAIG
                     RREALNVFGDDYATEDGTGVRDYIHVVDLAKGHIAALKKLKEQCGCRIYNLGTGTGYS
                     VLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAHEELGWTAALGLDRMCEDLW
                     RWQKQNPSGFGAQA"
     exon            154..269
                     /gene="Gale"
                     /inference="alignment:Splign:2.1.0"
     exon            270..383
                     /gene="Gale"
                     /inference="alignment:Splign:2.1.0"
     exon            384..560
                     /gene="Gale"
                     /inference="alignment:Splign:2.1.0"
     exon            561..674
                     /gene="Gale"
                     /inference="alignment:Splign:2.1.0"
     exon            675..741
                     /gene="Gale"
                     /inference="alignment:Splign:2.1.0"
     exon            742..827
                     /gene="Gale"
                     /inference="alignment:Splign:2.1.0"
     exon            828..905
                     /gene="Gale"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1020
                     /gene="Gale"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1400
                     /gene="Gale"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggagtctg cgctggatcc tctgcaggcg ccatggagga gaaggtgctc gtcacgggcg
       61 gggctggcta catcggtagc cacacagtgt tggagctgct ggaggcgggc tactcgcctg
      121 tggtcatcga caacttccac aattccattc gtggagaaga ctccatgcct gagagcctgc
      181 gccgggtcca ggagctgaca ggccgctctg tggagtttga ggagatggac atcttggacc
      241 aggcagccct acagcacctc tttaagaagc acaattttaa ggctgtcatc cactttgctg
      301 ggctcaaggc tgtgggcgag tcagtgcaga agcctctgga ttactacaga gttaacctaa
      361 cagggaccat ccagctcctg gagatcatga gggcccatgg ggtgaagagt ctggtcttca
      421 gcagctcagc caccgtgtat gggaaccccc agtacctgcc tctggacgag gcccacccca
      481 ccgggggctg taccaacccc tacggcaagt ccaagttctt cattgaagag atgatccagg
      541 acctgtgccg ggcagacacg gcctggaacg ctgtgctgct tcggtacttc aaccccatag
      601 gcgcccatgc ctctggccgc atcggcgaag atcctcaggg tatccccaac aacctcatgc
      661 cctatgtctc ccaggtggca atcgggcgac gagaggccct gaatgtcttt ggtgatgact
      721 acgctacgga ggatgggaca ggtgtgaggg attacattca tgtggtggat ctggccaagg
      781 gccatatagc agccttgaag aagctgaagg agcagtgtgg ttgccggatc tacaacctgg
      841 gcacgggcac aggctattcg gtcctgcaga tggtccaagc catggagaag gcctcaggga
      901 agaagatccc gtacaaggtg gtggcacggc gggaaggcga tgtggcggcc tgttatgcca
      961 accctagcct ggcccatgag gagctgggct ggacagcagc cttggggctg gacaggatgt
     1021 gtgaagatct gtggcgctgg cagaagcaga acccttcagg ctttggggcg caggcctgag
     1081 gctctcctta ccacggacca gaaaagagca gctacctgct ttgcagccgc cacaggaccc
     1141 tacaccctca tgcgctgagg ccaccctacc tcaaaggcca gctgtctctc agccctcccg
     1201 gcaggagacc tctggttcta ctgaccagaa aggagtctgg gtccttccag cctattttcc
     1261 ccagagtcca gcagctcatg tgatccccag agccttgtgg aggccagggg gtctgggacc
     1321 aaagcctccc tcaggcacta acttatacag ctaagattga gctttccaaa gtatttaaaa
     1381 taaaaatgtc ttcttatcaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
