LOCUS       NM_001005888            2054 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus galactosylceramidase (Galc), mRNA.
ACCESSION   NM_001005888 XM_234366
VERSION     NM_001005888.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Meyer Sauteur,P.M., de Bruijn,A.C.J.M., Graca,C., Tio-Gillen,A.P.,
            Estevao,S.C., Hoogenboezem,T., Hendriks,R.W., Berger,C.,
            Jacobs,B.C., van Rossum,A.M.C., Huizinga,R. and Unger,W.W.J.
  TITLE     Antibodies to Protein but Not Glycolipid Structures Are Important
            for Host Defense against Mycoplasma pneumoniae
  JOURNAL   Infect Immun 87 (2), e00663-18 (2019)
   PUBMED   30396892
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2054)
  AUTHORS   Meyer Sauteur,P.M., Huizinga,R., Tio-Gillen,A.P., Drenthen,J.,
            Unger,W.W.J., Jacobs,E., van Rossum,A.M.C. and Jacobs,B.C.
  TITLE     Intrathecal antibody responses to GalC in Guillain-Barre syndrome
            triggered by Mycoplasma pneumoniae
  JOURNAL   J Neuroimmunol 314, 13-16 (2018)
   PUBMED   29301655
REFERENCE   3  (bases 1 to 2054)
  AUTHORS   Andres Benito,P., Dominguez Gonzalez,M. and Ferrer,I.
  TITLE     Altered gene transcription linked to astrocytes and
            oligodendrocytes in frontal cortex in Creutzfeldt-Jakob disease
  JOURNAL   Prion 12 (3-4), 216-225 (2018)
   PUBMED   30009661
REFERENCE   4  (bases 1 to 2054)
  AUTHORS   Meyer Sauteur,P.M., Huizinga,R., Tio-Gillen,A.P., Roodbol,J.,
            Hoogenboezem,T., Jacobs,E., van Rijn,M., van der Eijk,A.A.,
            Vink,C., de Wit,M.C., van Rossum,A.M. and Jacobs,B.C.
  TITLE     Mycoplasma pneumoniae triggering the Guillain-Barre syndrome: A
            case-control study
  JOURNAL   Ann Neurol 80 (4), 566-580 (2016)
   PUBMED   27490360
REFERENCE   5  (bases 1 to 2054)
  AUTHORS   Ang,C.W., Tio-Gillen,A.P., Groen,J., Herbrink,P., Jacobs,B.C., Van
            Koningsveld,R., Osterhaus,A.D., Van der Meche,F.G. and van
            Doorn,P.A.
  TITLE     Cross-reactive anti-galactocerebroside antibodies and Mycoplasma
            pneumoniae infections in Guillain-Barre syndrome
  JOURNAL   J Neuroimmunol 130 (1-2), 179-183 (2002)
   PUBMED   12225900
REFERENCE   6  (bases 1 to 2054)
  AUTHORS   Whitfield,P.D., Sharp,P.C., Taylor,R. and Meikle,P.
  TITLE     Quantification of galactosylsphingosine in the twitcher mouse using
            electrospray ionization-tandem mass spectrometry
  JOURNAL   J Lipid Res 42 (12), 2092-2095 (2001)
   PUBMED   11734583
REFERENCE   7  (bases 1 to 2054)
  AUTHORS   Matsuda,J., Vanier,M.T., Saito,Y., Tohyama,J., Suzuki,K. and
            Suzuki,K.
  TITLE     A mutation in the saposin A domain of the sphingolipid activator
            protein (prosaposin) gene results in a late-onset, chronic form of
            globoid cell leukodystrophy in the mouse
  JOURNAL   Hum Mol Genet 10 (11), 1191-1199 (2001)
   PUBMED   11371512
REFERENCE   8  (bases 1 to 2054)
  AUTHORS   Sakai,N., Inui,K., Tatsumi,N., Fukushima,H., Nishigaki,T.,
            Taniike,M., Nishimoto,J., Tsukamoto,H., Yanagihara,I., Ozono,K. and
            Okada,S.
  TITLE     Molecular cloning and expression of cDNA for murine
            galactocerebrosidase and mutation analysis of the twitcher mouse, a
            model of Krabbe's disease
  JOURNAL   J Neurochem 66 (3), 1118-1124 (1996)
   PUBMED   8769874
REFERENCE   9  (bases 1 to 2054)
  AUTHORS   Shigematsu,H., Morimoto,S., Kishimoto,Y., Weiler,S., Tomich,J.,
            Barranger,J., Shinohara,M., Yeager,A.M. and O'Brien,J.S.
  TITLE     Saposins (sphingolipid activator proteins) in the twitcher mutant
            mouse
  JOURNAL   J Neurochem 55 (5), 1659-1662 (1990)
   PUBMED   2120388
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY386370.1.
            
            On Oct 22, 2004 this sequence version replaced XM_234366.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY386370.1, FQ223346.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2054
                     /gene="Galc"
                     /note="galactosylceramidase"
                     /db_xref="GeneID:314360"
                     /db_xref="RGD:1359384"
     exon            1..190
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..2050
                     /gene="Galc"
                     /EC_number="3.2.1.46"
                     /note="galactocerebrosidase"
                     /codon_start=1
                     /product="galactocerebrosidase precursor"
                     /protein_id="NP_001005888.1"
                     /db_xref="GeneID:314360"
                     /db_xref="RGD:1359384"
                     /translation="MTAAAGSASRVAVPLLLCAMLAPSGAYELDDSDGLGLEFDGIGA
                     VSGGGATSRLLVNYPEPYRSEILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMH
                     YELDENYFRGYEWWLMKEAKKRNPNIILMGLPWSFPGWLGKGFSWPYVNLQLTAFYIV
                     RWILGAKHYHDLDIDYIGIWNERPFDANYIKELRKMLDYEGLQRVRIIASDNLWEPIS
                     SSVLLDQELWKVVDVIGAHYPGTYTVWNAKMSGKKLWSSEDFSTVNSNVGAGCWGRIL
                     NQNYINGNMTATIAWNLVASYYEELPYGRSGLMTAQEPWSGHYVVASPIWVSAHTTQF
                     TQPGWYYLKTVGHLEKGGSYVALTDGLGNFTIIVETMSRQHSMCIRPYLPYYNVSRQL
                     ATFILKGSLKEIQELQVWYTKLGTTPEKLHFKQLETLWLLDGSGSFSLELEEDEMFTL
                     TTLTTGHKGSYRPPPKSQPFPTSYKDDFNVEYPLFSEAPNFADQTGVFEYYTNNEDLE
                     HRFTLRQVLNQRPITWAADASSTISVIGDHHWSNMTVQCDVYIETPRTGGVFIAGRVN
                     KGGILIRTASGVFFWIFANGSYRVTADLGGWITYASGHADVTAKRWYTLTLGIKGYLA
                     SGMLNGKILWENVPVKYPGHGWAAIGTHTFEFAQFDNFHVEAAR"
     exon            191..259
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            260..323
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            324..437
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            438..577
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            578..616
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            617..747
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            748..903
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1028
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1156
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1246
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1333
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1484
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1662
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1826
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1903
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2054
                     /gene="Galc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taacagccga cctaaggctt cccagcaacg ccaagcaaaa gtcatgaccg ccgccgcggg
       61 ctcggcgagc cgtgtcgcgg tgcccttgtt gttgtgcgcg atgctggcgc ccagcggcgc
      121 ctacgagcta gacgactccg acgggctggg cctggagttc gatggcatcg gcgcagtcag
      181 cggcggcggg gcaacctccc ggcttctagt aaattaccca gagccctatc gttctgaaat
      241 actggattat ctatttaagc caaacttcgg tgcctctctg catattctaa aagtggaaat
      301 aggtggcgat ggacaaacaa cagacggcac tgaaccctcc cacatgcact atgagctaga
      361 tgagaattat ttccgaggct atgagtggtg gctaatgaag gaagctaaga agaggaaccc
      421 aaatattata cttatggggt tgccatggtc attccctgga tggctgggca aaggcttcag
      481 ttggccttat gtaaatcttc agctgactgc cttctatatt gtgagatgga ttttgggtgc
      541 caagcattat catgacctgg acattgatta tattgggata tggaatgaaa ggccgtttga
      601 tgccaactat ataaaggaat taagaaaaat gcttgattat gaaggtctcc agcgagtgag
      661 aatcatagca agtgataatc tctgggagcc aatttcctct tctgtgctgc ttgaccagga
      721 gctctggaag gtggttgatg ttataggagc tcattatccc ggaacctaca cagtctggaa
      781 tgcaaagatg tcagggaaga agctttggtc gtcggaagac tttagcactg tcaacagtaa
      841 tgttggcgca ggctgttggg gtcgcatatt gaaccagaat tacatcaacg gcaatatgac
      901 cgccacaatt gcttggaatt tggtggctag ttactatgaa gaattgccct atggacgaag
      961 tggattgatg acagcccagg agccgtggag tggacattat gtagtagcat ctcctatctg
     1021 ggtatcagct catacaactc aatttactca accaggctgg tattacctga agacagttgg
     1081 ccatctagag aaaggaggaa gctatgtagc tctgactgat ggcttgggga atttcaccat
     1141 catcgttgaa actatgagtc gtcaacattc tatgtgtata cggccatatc taccgtatta
     1201 taatgtctca cgtcagctgg ccaccttcat tctaaagggg tctttgaaag aaatacaaga
     1261 gctgcaggtg tggtacacca agcttggaac aacaccagag aaacttcatt ttaaacaact
     1321 ggaaactcta tggctccttg acggcagcgg cagtttctca ctggaactgg aggaggatga
     1381 gatgttcaca ctcaccactc tgaccacagg gcacaaaggc agctaccgtc cccctcccaa
     1441 gtcacagccc ttcccaacca gctataagga tgatttcaac gttgagtacc cattatttag
     1501 tgaagctccg aattttgctg atcagaccgg cgtgttcgag tactacacga ataacgaaga
     1561 ccttgagcat cgcttcacac tgcgccaagt tctcaaccaa cgacctatta cctgggccgc
     1621 ggatgcctcc agcacgatca gtgtcatagg cgatcaccac tggagcaaca tgactgtgca
     1681 gtgtgatgtt tacatagaga ctcctcggac tggcggtgtg ttcattgctg gaagagtgaa
     1741 taaaggtggt atcttgatca gaactgcttc aggagttttc ttctggattt ttgcaaatgg
     1801 ctcttacaga gttacagccg acctgggtgg gtggataaca tatgcttcag gacatgctga
     1861 cgttacagca aagcgatggt atacactcac cttaggcatt aagggttatc tcgcctctgg
     1921 tatgttgaac ggcaagatcc tgtgggaaaa tgtgcccgtg aaatacccag ggcatggctg
     1981 ggctgcgatc ggaacgcata ccttcgagtt tgcgcagttt gacaactttc atgtggaagc
     2041 tgctcgctaa tatt
//
