LOCUS       NM_033237                699 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus galanin and GMAP prepropeptide (Gal), mRNA.
ACCESSION   NM_033237
VERSION     NM_033237.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 699)
  AUTHORS   Xiao,K., Song,L., Hu,Y., He,W., Hou,F., Yan,P., Xu,J., Wang,K.,
            Tao,Y., Li,D. and Xie,L.
  TITLE     Novel Role of miR-18a-5p and Galanin in Rat Lung Ischemia
            Reperfusion-Mediated Response
  JOURNAL   Oxid Med Cell Longev 2021, 6621921 (2021)
   PUBMED   34497682
  REMARK    GeneRIF: Novel Role of miR-18a-5p and Galanin in Rat Lung Ischemia
            Reperfusion-Mediated Response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 699)
  AUTHORS   Borroto-Escuela,D.O., Pita-Rodriguez,M., Fores-Pons,R.,
            Barbancho,M.A., Fuxe,K. and Narvaez,M.
  TITLE     Galanin and neuropeptide Y interactions elicit antidepressant
            activity linked to neuronal precursor cells of the dentate gyrus in
            the ventral hippocampus
  JOURNAL   J Cell Physiol 236 (5), 3565-3578 (2021)
   PUBMED   33044017
  REMARK    GeneRIF: Galanin and neuropeptide Y interactions elicit
            antidepressant activity linked to neuronal precursor cells of the
            dentate gyrus in the ventral hippocampus.
REFERENCE   3  (bases 1 to 699)
  AUTHORS   Etemadi,L., Pettersson,L.M.E. and Danielsen,N.
  TITLE     UVB irradiation induces contralateral changes in galanin, substance
            P and c-fos immunoreactivity in rat dorsal root ganglia, dorsal
            horn and lateral spinal nucleus
  JOURNAL   Peptides 136, 170447 (2021)
   PUBMED   33212101
  REMARK    GeneRIF: UVB irradiation induces contralateral changes in galanin,
            substance P and c-fos immunoreactivity in rat dorsal root ganglia,
            dorsal horn and lateral spinal nucleus.
REFERENCE   4  (bases 1 to 699)
  AUTHORS   Li,S.Y., Huo,M.L., Wu,X.Y., Huang,Y.Q., Wang,L., Zhang,X.,
            Jiang,Y.M., Zhang,M.L., Wang,L.L. and Yu,L.C.
  TITLE     Involvement of galanin and galanin receptor 1 in nociceptive
            modulation in the central nucleus of amygdala in normal and
            neuropathic rats
  JOURNAL   Sci Rep 7 (1), 15317 (2017)
   PUBMED   29127424
  REMARK    GeneRIF: Involvement of galanin and galanin receptor 1 in
            nociceptive modulation in the central nucleus of amygdala in normal
            and neuropathic rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 699)
  AUTHORS   Zhang,M.L., Wang,H.B., Fu,F.H. and Yu,L.C.
  TITLE     Involvement of galanin and galanin receptor 2 in nociceptive
            modulation in anterior cingulate cortex of normal rats and rats
            with mononeuropathy
  JOURNAL   Sci Rep 7, 45930 (2017)
   PUBMED   28378856
  REMARK    GeneRIF: Both the galanin and galanin receptor 2 mRNA expression
            and content increased significantly in anterior cingulate cortex
            (ACC) in rats with mononeuropathy than that in normal rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 699)
  AUTHORS   Belai,A., Calcutt,N.A., Carrington,A.L., Diemel,L.T.,
            Tomlinson,D.R. and Burnstock,G.
  TITLE     Enteric neuropeptides in streptozotocin-diabetic rats; effects of
            insulin and aldose reductase inhibition
  JOURNAL   J Auton Nerv Syst 58 (3), 163-169 (1996)
   PUBMED   8738309
REFERENCE   7  (bases 1 to 699)
  AUTHORS   Dunning,B.E. and Ahren,B.
  TITLE     Tissue-specific reduction of galanin content in the pancreas in
            alloxan diabetes in the mouse
  JOURNAL   Acta Physiol Scand 149 (2), 215-219 (1993)
   PUBMED   7505518
REFERENCE   8  (bases 1 to 699)
  AUTHORS   Hyde,J.F., Engle,M.G. and Maley,B.E.
  TITLE     Colocalization of galanin and prolactin within secretory granules
            of anterior pituitary cells in estrogen-treated Fischer 344 rats
  JOURNAL   Endocrinology 129 (1), 270-276 (1991)
   PUBMED   1711463
REFERENCE   9  (bases 1 to 699)
  AUTHORS   Kaplan,L.M., Spindel,E.R., Isselbacher,K.J. and Chin,W.W.
  TITLE     Tissue-specific expression of the rat galanin gene
  JOURNAL   Proc Natl Acad Sci U S A 85 (4), 1065-1069 (1988)
   PUBMED   2448788
REFERENCE   10 (bases 1 to 699)
  AUTHORS   Vrontakis,M.E., Peden,L.M., Duckworth,M.L. and Friesen,H.G.
  TITLE     Isolation and characterization of a complementary DNA (galanin)
            clone from estrogen-induced pituitary tumor messenger RNA
  JOURNAL   J Biol Chem 262 (35), 16755-16758 (1987)
   PUBMED   2445750
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J03624.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03624.1, CB576282.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..699
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..699
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /note="galanin and GMAP prepropeptide"
                     /db_xref="GeneID:29141"
                     /db_xref="RGD:61954"
     exon            1..144
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..519
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /note="galanin peptides; galanin prepropeptide;
                     galanin/GMAP prepropeptide"
                     /codon_start=1
                     /product="galanin peptides preproprotein"
                     /protein_id="NP_150240.1"
                     /db_xref="GeneID:29141"
                     /db_xref="RGD:61954"
                     /translation="MARGSVILLAWLLLVATLSATLGLGMPTKEKRGWTLNSAGYLLG
                     PHAIDNHRSFSDKHGLTGKRELPLEVEEGRLGSVAVPLPESNIVRTIMEFLSFLHLKE
                     AGALDSLPGIPLATSSEDLEQS"
     exon            145..225
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /inference="alignment:Splign:2.1.0"
     exon            226..280
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /inference="alignment:Splign:2.1.0"
     exon            281..370
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /inference="alignment:Splign:2.1.0"
     exon            371..448
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /inference="alignment:Splign:2.1.0"
     exon            449..699
                     /gene="Gal"
                     /gene_synonym="Galn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagggatcc tcgtgcgctt ccctacgccg ctgatctgcg ccatgcagtg agcgaccctc
       61 gcgcccgcca ctctacgcca cgcctggacg gagacacttg gacctgcact aaccagctac
      121 gcccggttcc caccactgct caagatggcc aggggcagcg ttatcctgct agcctggctc
      181 ctgttggttg caaccctgtc agccactctg gggctcggga tgccaacaaa ggagaagaga
      241 ggctggaccc tgaacagcgc tggctacctt ctgggcccac atgccattga caaccacaga
      301 tcatttagcg acaagcatgg cctcacaggc aagagggagt taccactgga agtggaggaa
      361 gggagactag gaagtgttgc tgtgcccctg cctgagagca atatcgtccg cactataatg
      421 gagtttctca gtttcttgca ccttaaagag gccggggccc tcgacagcct gcctggcatc
      481 cccttggcca cctcctcaga agacctagag cagtcctgag accacaccca ctgtgcacct
      541 gtgtcctctg ctataattta aagtcattct aggctaaaaa gaatcttccg ccaactcctc
      601 aagccaacac tttgttctct gctttgatgc tgagttatta caattaagat gttttgattg
      661 gagtaattat attgtgtgac ataataaaaa ctagcaagt
//
