LOCUS       NM_001077640            1059 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus growth arrest and DNA-damage-inducible, gamma
            (Gadd45g), mRNA.
ACCESSION   NM_001077640 XM_001053888 XM_237999
VERSION     NM_001077640.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1059)
  AUTHORS   Wan,X., Yao,B., Ma,Y., Liu,Y., Tang,Y., Hu,J., Li,M., Fu,S.,
            Zheng,X. and Yin,D.
  TITLE     MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury
            by suppressing Gadd45g-mediated apoptotic signaling
  JOURNAL   Biochem Biophys Res Commun 530 (1), 314-321 (2020)
   PUBMED   32828305
  REMARK    GeneRIF: MicroRNA-128-1-5p attenuates myocardial
            ischemia/reperfusion injury by suppressing Gadd45g-mediated
            apoptotic signaling.
REFERENCE   2  (bases 1 to 1059)
  AUTHORS   Kigar,S.L., Chang,L., Hayne,M.R., Karls,N.T. and Auger,A.P.
  TITLE     Sex differences in Gadd45b expression and methylation in the
            developing rodent amygdala
  JOURNAL   Brain Res 1642, 461-466 (2016)
   PUBMED   27086974
  REMARK    GeneRIF: Report of sex differences in the expression of growth
            arrest and DNA damage inducible factor beta (Gadd45b), but not
            family members alpha (a) or gamma (g), in the neonatal and juvenile
            rodent amygdala
REFERENCE   3  (bases 1 to 1059)
  AUTHORS   Gantner,M.L., Hazen,B.C., Conkright,J. and Kralli,A.
  TITLE     GADD45gamma regulates the thermogenic capacity of brown adipose
            tissue
  JOURNAL   Proc Natl Acad Sci U S A 111 (32), 11870-11875 (2014)
   PUBMED   25071184
REFERENCE   4  (bases 1 to 1059)
  AUTHORS   Qiu,W., Che,N., Feng,X., Xia,M., Wang,H., Zhao,D. and Wang,Y.
  TITLE     Apoptosis of glomerular mesangial cells induced by sublytic C5b-9
            complexes in rats with Thy-1 nephritis is dependent on Gadd45 gamma
            upregulation
  JOURNAL   Eur J Immunol 39 (11), 3251-3266 (2009)
   PUBMED   19882653
  REMARK    GeneRIF: Gadd45 gamma gene expression is involved in regulating
            glomerular mesangial cell apoptosis mediated by sublytic C5b-9 in
            Thy-1 nephritis
REFERENCE   5  (bases 1 to 1059)
  AUTHORS   Schrag,J.D., Jiralerspong,S., Banville,M., Jaramillo,M.L. and
            O'Connor-McCourt,M.D.
  TITLE     The crystal structure and dimerization interface of GADD45gamma
  JOURNAL   Proc Natl Acad Sci U S A 105 (18), 6566-6571 (2008)
   PUBMED   18445651
REFERENCE   6  (bases 1 to 1059)
  AUTHORS   Xu,J.H., Qiu,W., Wang,Y.W., Xu,J., Tong,J.X., Gao,L.J., Xu,W.H. and
            Wu,Y.Q.
  TITLE     Gene expression profile and overexpression of apoptosis-related
            genes (NGFI-B and Gadd 45 gamma) in early phase of Thy-1 nephritis
            model
  JOURNAL   Cell Tissue Res 326 (1), 159-168 (2006)
   PUBMED   16736195
REFERENCE   7  (bases 1 to 1059)
  AUTHORS   Morinobu,A., Gadina,M., Strober,W., Visconti,R., Fornace,A.,
            Montagna,C., Feldman,G.M., Nishikomori,R. and O'Shea,J.J.
  TITLE     STAT4 serine phosphorylation is critical for IL-12-induced
            IFN-gamma production but not for cell proliferation
  JOURNAL   Proc Natl Acad Sci U S A 99 (19), 12281-12286 (2002)
   PUBMED   12213961
REFERENCE   8  (bases 1 to 1059)
  AUTHORS   Vairapandi,M., Balliet,A.G., Hoffman,B. and Liebermann,D.A.
  TITLE     GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role
            in S and G2/M cell cycle checkpoints induced by genotoxic stress
  JOURNAL   J Cell Physiol 192 (3), 327-338 (2002)
   PUBMED   12124778
REFERENCE   9  (bases 1 to 1059)
  AUTHORS   Kojima,S., Mayumi-Matsuda,K., Suzuki,H. and Sakata,T.
  TITLE     Molecular cloning of rat GADD45gamma, gene induction and its role
            during neuronal cell death
  JOURNAL   FEBS Lett 446 (2-3), 313-317 (1999)
   PUBMED   10100865
REFERENCE   10 (bases 1 to 1059)
  AUTHORS   Takekawa,M. and Saito,H.
  TITLE     A family of stress-inducible GADD45-like proteins mediate
            activation of the stress-responsive MTK1/MEKK4 MAPKKK
  JOURNAL   Cell 95 (4), 521-530 (1998)
   PUBMED   9827804
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001077640.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168643.1, DY308875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840124 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               JAXUCZ010000017.1  13530211-13530351   c
            142-243             JAXUCZ010000017.1  13529628-13529729   c
            244-457             JAXUCZ010000017.1  13529312-13529525   c
            458-1059            JAXUCZ010000017.1  13528606-13529207   c
FEATURES             Location/Qualifiers
     source          1..1059
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1059
                     /gene="Gadd45g"
                     /note="growth arrest and DNA-damage-inducible, gamma"
                     /db_xref="GeneID:291005"
                     /db_xref="RGD:1311796"
     exon            1..141
                     /gene="Gadd45g"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..568
                     /gene="Gadd45g"
                     /note="growth arrest and DNA damage inducible;
                     GADD45gamma; growth arrest and DNA-damage-inducible 45
                     gamma"
                     /codon_start=1
                     /product="growth arrest and DNA damage-inducible protein
                     GADD45 gamma"
                     /protein_id="NP_001071108.1"
                     /db_xref="GeneID:291005"
                     /db_xref="RGD:1311796"
                     /translation="MTLEEVRGQDTVPESTARMQGAGKALHELLLSAQRQGCLTAGVY
                     ESAKVLNVDPDNVTFCVLAADEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLA
                     AIVGADDEGGAPGDLHCILISNPNEDTWKDPALEKLSLFCEESRSFNDWVPSITLPE"
     exon            142..243
                     /gene="Gadd45g"
                     /inference="alignment:Splign:2.1.0"
     exon            244..457
                     /gene="Gadd45g"
                     /inference="alignment:Splign:2.1.0"
     exon            458..1059
                     /gene="Gadd45g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggatcgt ctttgggaat ctttacttgc gctcgggttc cctctgcact cttcactttt
       61 ggataacttg ctgttcgtgg atcgcacaat gactctggaa gaagtccgtg gccaggatac
      121 agttccggaa agcacagcca ggatgcaggg cgccgggaaa gcattgcacg aacttctgct
      181 gtcggcgcag cgccagggct gtctgaccgc tggcgtctac gagtccgcca aagtcctgaa
      241 tgtggaccct gacaatgtga ccttttgcgt gctggctgcc gacgaagaag atgagggcga
      301 catagccctg cagatccatt ttacgttgat ccaggcgttc tgctgcgaga acgacattga
      361 catcgtgcgc gtgggagacg tgcagaggct ggcggcgatc gtgggcgccg acgacgaggg
      421 gggcgcgccg ggagacttgc attgcatcct catttcgaac cctaatgaag acacatggaa
      481 ggaccctgcc ttggagaagc tcagtttgtt ctgcgaggag agccgcagct tcaacgactg
      541 ggtgcccagc atcacccttc ccgagtgaca gcctggcagg gaccttggtc tgatcgactt
      601 ggtgacactc tagcgcgctg ctggctctgg agtggccctc cgagggcgct cgagtgcgca
      661 tggagactgg caggcgatgt tgcctggaga gcgaggagcg cggcctccca agaagggggt
      721 ctggcggcag cggggacatc ttgttccgag cccaggactc tgccagtgtc cggagaggct
      781 gctagcacac gaaggcctgg caaggacgtt ggccccaggg ccgggaagaa ccgaccagcg
      841 aggcaggtgt gactcagcaa gcagccttca gtgaaaggag gggaaaggca aggcaggagg
      901 ccgcctggac ttggtacagc tgcaggagag gccactgcag gagcgagccg gacttagcag
      961 actgcactgc tctttcaaaa acggatcccg ggcaatgctt tcattttcta aaggacgcta
     1021 tcgtggaagc tttgaatttc acaataaact tattgaaac
//
