LOCUS       NM_001008321            1300 bp    mRNA    linear   ROD 09-JAN-2024
DEFINITION  Rattus norvegicus growth arrest and DNA-damage-inducible, beta
            (Gadd45b), mRNA.
ACCESSION   NM_001008321 XM_216846
VERSION     NM_001008321.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1300)
  AUTHORS   Wu S, Guo W, Chen L, Lin X, Tang M, Lin C, Guo H, Zhang T and Gao
            Y.
  TITLE     Downregulation of Gadd45beta alleviates osteoarthritis by
            repressing lipopolysaccharide-induced fibroblast-like synoviocyte
            inflammation, proliferation and migration
  JOURNAL   Int Immunopharmacol 126, 111202 (2024)
   PUBMED   37988908
  REMARK    GeneRIF: Downregulation of Gadd45beta alleviates osteoarthritis by
            repressing lipopolysaccharide-induced fibroblast-like synoviocyte
            inflammation, proliferation and migration.
REFERENCE   2  (bases 1 to 1300)
  AUTHORS   Yin Q, Du T, Yang C, Li X, Zhao Z, Liu R, Yang B and Liu B.
  TITLE     Gadd45b is a novel mediator of depression-like behaviors and
            neuroinflammation after cerebral ischemia
  JOURNAL   Biochem Biophys Res Commun 554, 107-113 (2021)
   PUBMED   33784505
  REMARK    GeneRIF: Gadd45b is a novel mediator of depression-like behaviors
            and neuroinflammation after cerebral ischemia.
REFERENCE   3  (bases 1 to 1300)
  AUTHORS   Tan XD, Liu B, Jiang Y, Yu HJ and Li CQ.
  TITLE     Gadd45b mediates environmental enrichment-induced neurogenesis in
            the SVZ of rats following ischemia stroke via BDNF
  JOURNAL   Neurosci Lett 745, 135616 (2021)
   PUBMED   33421485
  REMARK    GeneRIF: Gadd45b mediates environmental enrichment-induced
            neurogenesis in the SVZ of rats following ischemia stroke via BDNF.
REFERENCE   4  (bases 1 to 1300)
  AUTHORS   Zhang K, Zhang Q, Deng J, Li J, Li J, Wen L, Ma J and Li C.
  TITLE     ALK5 signaling pathway mediates neurogenesis and functional
            recovery after cerebral ischemia/reperfusion in rats via Gadd45b
  JOURNAL   Cell Death Dis 10 (5), 360 (2019)
   PUBMED   31043581
  REMARK    GeneRIF: The results suggest that the ALK5 signaling pathway plays
            a critical role in mediating neural plasticity and neurological
            function recovery via Gadd45b after cerebral ischemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1300)
  AUTHORS   Kazemi S, Mousavi Kani SN, Ghasemi-Kasman M, Aghapour F, Khorasani
            H and Moghadamnia AA.
  TITLE     Nonylphenol induces liver toxicity and oxidative stress in rat
  JOURNAL   Biochem Biophys Res Commun 479 (1), 17-21 (2016)
   PUBMED   27590577
  REMARK    GeneRIF: Data show that nonylphenol (NP) increased serum alkaline
            phosphatase, lead to liver damage and can increase the expression
            of heme oxygenase-1 (HO1) and growth arrest and
            DNA-damage-inducible 45 beta protein (Gadd45b) genes and may modify
            the toxic effects on liver through induction of oxidative stress.
REFERENCE   6  (bases 1 to 1300)
  AUTHORS   Liu B, Suyeoka G, Papa S, Franzoso G and Neufeld AH.
  TITLE     Growth arrest and DNA damage protein 45b (Gadd45b) protects retinal
            ganglion cells from injuries
  JOURNAL   Neurobiol Dis 33 (1), 104-110 (2009)
   PUBMED   18977442
  REMARK    GeneRIF: RGC5 cells, a transformed retinal ganglion (RGC) cell
            line, were used to demonstrate the function of Gadd45b in survival
            of RGC5 in response to paraquat oxidative stress, TNFalpha
            cytotoxicity and glutamate excitotoxicity
REFERENCE   7  (bases 1 to 1300)
  AUTHORS   Larsen CM, Dossing MG, Papa S, Franzoso G, Billestrup N and
            Mandrup-Poulsen T.
  TITLE     Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun
            N-terminal kinase and extracellular signal-regulated kinase and
            decreases IL-1beta-induced apoptosis in insulin-producing INS-1E
            cells
  JOURNAL   Diabetologia 49 (5), 980-989 (2006)
   PUBMED   16528573
  REMARK    GeneRIF: Inadequate induction of Gadd45b, which encodes a novel
            beta cell JNK and ERK inhibitor, may in part explain the
            pro-apoptotic response of beta cells to IL-1beta.
REFERENCE   8  (bases 1 to 1300)
  AUTHORS   Morinobu A, Gadina M, Strober W, Visconti R, Fornace A, Montagna C,
            Feldman GM, Nishikomori R and O'Shea JJ.
  TITLE     STAT4 serine phosphorylation is critical for IL-12-induced
            IFN-gamma production but not for cell proliferation
  JOURNAL   Proc Natl Acad Sci U S A 99 (19), 12281-12286 (2002)
   PUBMED   12213961
REFERENCE   9  (bases 1 to 1300)
  AUTHORS   Vairapandi M, Balliet AG, Hoffman B and Liebermann DA.
  TITLE     GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role
            in S and G2/M cell cycle checkpoints induced by genotoxic stress
  JOURNAL   J Cell Physiol 192 (3), 327-338 (2002)
   PUBMED   12124778
REFERENCE   10 (bases 1 to 1300)
  AUTHORS   Takekawa M and Saito H.
  TITLE     A family of stress-inducible GADD45-like proteins mediate
            activation of the stress-responsive MTK1/MEKK4 MAPKKK
  JOURNAL   Cell 95 (4), 521-530 (1998)
   PUBMED   9827804
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085337.1.
            
            On Dec 16, 2004 this sequence version replaced XM_216846.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085337.1, DN947934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093044, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1300
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1300
                     /gene="Gadd45b"
                     /note="growth arrest and DNA-damage-inducible, beta"
                     /db_xref="GeneID:299626"
                     /db_xref="RGD:1309080"
     exon            1..276
                     /gene="Gadd45b"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..715
                     /gene="Gadd45b"
                     /note="growth arrest and DNA-damage-inducible 45 beta"
                     /codon_start=1
                     /product="growth arrest and DNA damage-inducible protein
                     GADD45 beta"
                     /protein_id="NP_001008322.1"
                     /db_xref="GeneID:299626"
                     /db_xref="RGD:1309080"
                     /translation="MTLEELVASDNAVQKMQAVTAAVEQLLVAAQRQDRLTVGVYEAA
                     KLMNVDPDSVVLCLLAIDEEEEDDIALQIHFTLIQSFCCDNDIDIVRVSGMQRLAQLL
                     GEPAETLGTNEARDLHCLLVTNCHTDSWKSQGLVEVASYCEESRGNNQWVPYISLEER
                     "
     exon            277..378
                     /gene="Gadd45b"
                     /inference="alignment:Splign:2.1.0"
     exon            379..601
                     /gene="Gadd45b"
                     /inference="alignment:Splign:2.1.0"
     exon            602..1276
                     /gene="Gadd45b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacccggga tccgtgtcac ctccgtcttc ttggattaat ttcgaggggg atttttttgc
       61 aatcttcttt ttaatcctgc ttttttcttg ggaaagtaag tcccaccgcc tccggaaagc
      121 ctcggacact tctggtcgcg cgggaaggtt tttacctctt gggttcggat ctggacgagt
      181 gctttgcctt ggggatcttc cgtgggggtc cgctgtgaag tgtgactgaa tcatgaccct
      241 ggaagagctg gtggcgagcg acaacgcggt tcagaagatg caggcggtga ctgcggcggt
      301 ggagcagctg ctggtggccg cgcagcgtca ggatcgcctc accgtggggg tgtacgaggc
      361 ggccaaactg atgaatgtgg accccgacag cgtggtcttg tgcctgctgg ccatagacga
      421 agaagaggag gatgatattg ctctgcaaat tcacttcacc ctgatccaat cgttctgctg
      481 cgacaatgac attgacatcg tcagggtatc aggcatgcaa aggctggcgc agctcctggg
      541 tgagccggca gagactctag gcacaaacga ggcccgagac ctgcactgcc tcctggtcac
      601 gaactgtcat acagattcct ggaaaagcca aggcttggtg gaggtggcca gttactgtga
      661 agagagcaga ggcaataacc agtgggtccc ctatatctct ctggaggaac gctgaggccc
      721 actctaaaca cctaaagcaa ctgttgagtt gctgtcccct aaaaaaatta aataaaatac
      781 atatttgaca gcgccccctc attccccaga acaatccctc aaaagctacc ctacccgtga
      841 taccttccgg gaggggcgga gtcaccgaga ctgagacgag gagaggggag tgtgcgcccg
      901 cccgccccct gggctatgga gccaggagcc agcaccacag gtggtcgcca agacaggaag
      961 gaggggacct caggctggag gagacagaga ctttagagcc aaggcctggc aatcatgcag
     1021 ccagcctctg cacgcagcag cagacggtct ggacaccgcc gcaggggtgg ggcgaggcgt
     1081 cccccacccc gctggacagt gaactgtgcg taactcagcg gagggcggcg accctcgacg
     1141 cgggagccgg gactcgagcc cgggacttcg cagctaaggc acatctactt tagtattgtg
     1201 ctgagcaaga cagatcgctt gcatattttt taaaaatttc tactacagag acattccaat
     1261 aaactggtta agccttaaaa aaaaaaaaaa aaaaaaaaaa
//
