LOCUS       NM_024127               1237 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus growth arrest and DNA-damage-inducible, alpha
            (Gadd45a), mRNA.
ACCESSION   NM_024127
VERSION     NM_024127.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1237)
  AUTHORS   Wang,Y., Gao,H., Cao,X., Li,Z., Kuang,Y., Ji,Y. and Li,Y.
  TITLE     Role of GADD45A in myocardial ischemia/reperfusion through
            mediation of the JNK/p38 MAPK and STAT3/VEGF pathways
  JOURNAL   Int J Mol Med 50 (6) (2022)
   PUBMED   36331027
  REMARK    GeneRIF: Role of GADD45A in myocardial ischemia/reperfusion through
            mediation of the JNK/p38 MAPK and STAT3/VEGF pathways.
REFERENCE   2  (bases 1 to 1237)
  AUTHORS   Sun,R.X., Sun,Z.H., Ren,Q., Li,L., Yin,L., Li,F. and Su,X.
  TITLE     Gadd45alpha affects retinal ganglion cell injury in chronic ocular
            hypertension rats by regulating p38MAPK pathway
  JOURNAL   Gene 763, 145030 (2020)
   PUBMED   32755658
  REMARK    GeneRIF: Gadd45alpha affects retinal ganglion cell injury in
            chronic ocular hypertension rats by regulating p38MAPK pathway.
REFERENCE   3  (bases 1 to 1237)
  AUTHORS   Yoshihara,T., Tsuzuki,T., Chang,S.W., Kakigi,R., Sugiura,T. and
            Naito,H.
  TITLE     Exercise preconditioning attenuates hind limb unloading-induced
            gastrocnemius muscle atrophy possibly via the HDAC4/Gadd45 axis in
            old rats
  JOURNAL   Exp Gerontol 122, 34-41 (2019)
   PUBMED   31009659
  REMARK    GeneRIF: The data indicated that a single bout of preconditioning
            exercise prior to hindlimb unloading may exert a protective effect
            in disuse muscle atrophy in old rats and that these effects may be
            partially mediated by the HDAC4/Gadd45alpha axis.
REFERENCE   4  (bases 1 to 1237)
  AUTHORS   Zhou,L., Wang,W., Yang,C., Zeng,T., Hu,M., Wang,X., Li,N., Sun,K.,
            Wang,C., Zhou,J., Ren,M. and Yan,L.
  TITLE     GADD45a Promotes Active DNA Demethylation of the MMP-9 Promoter via
            Base Excision Repair Pathway in AGEs-Treated Keratinocytes and in
            Diabetic Male Rat Skin
  JOURNAL   Endocrinology 159 (2), 1172-1186 (2018)
   PUBMED   29244109
  REMARK    GeneRIF: A mechanism in which GADD45a is required for demethylation
            of the MMP-9 promoter and the induction of diabetic wound healing.
            The inhibition of GADD45a might be a therapeutic strategy for
            diabetic foot ulcers.
REFERENCE   5  (bases 1 to 1237)
  AUTHORS   Lai,C.Y., Hsieh,M.C., Ho,Y.C., Lee,A.S., Wang,H.H., Cheng,J.K.,
            Chau,Y.P. and Peng,H.Y.
  TITLE     Growth Arrest and DNA-damage-inducible Protein 45beta-mediated DNA
            Demethylation of Voltage-dependent T-type Calcium Channel 3.2
            Subunit Enhances Neuropathic Allodynia after Nerve Injury in Rats
  JOURNAL   Anesthesiology 126 (6), 1077-1095 (2017)
   PUBMED   28346321
  REMARK    GeneRIF: Growth arrest and DNA-damage-inducible protein 45 (Gadd45)
            is known to relieve methylation-induced gene silencing by promoting
            DNA demethylation.
REFERENCE   6  (bases 1 to 1237)
  AUTHORS   Tran,H., Brunet,A., Grenier,J.M., Datta,S.R., Fornace,A.J. Jr.,
            DiStefano,P.S., Chiang,L.W. and Greenberg,M.E.
  TITLE     DNA repair pathway stimulated by the forkhead transcription factor
            FOXO3a through the Gadd45 protein
  JOURNAL   Science 296 (5567), 530-534 (2002)
   PUBMED   11964479
  REMARK    GeneRIF: appeared to be a direct target of FOXO3a that mediates
            part of FOXO3a's effects on DNA repair
REFERENCE   7  (bases 1 to 1237)
  AUTHORS   Wang,X.W., Zhan,Q., Coursen,J.D., Khan,M.A., Kontny,H.U., Yu,L.,
            Hollander,M.C., O'Connor,P.M., Fornace,A.J. Jr. and Harris,C.C.
  TITLE     GADD45 induction of a G2/M cell cycle checkpoint
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3706-3711 (1999)
   PUBMED   10097101
REFERENCE   8  (bases 1 to 1237)
  AUTHORS   Takekawa,M. and Saito,H.
  TITLE     A family of stress-inducible GADD45-like proteins mediate
            activation of the stress-responsive MTK1/MEKK4 MAPKKK
  JOURNAL   Cell 95 (4), 521-530 (1998)
   PUBMED   9827804
REFERENCE   9  (bases 1 to 1237)
  AUTHORS   Yoshida,T., Okazaki,T., Hughes,P.E., Schneider,E.L. and Mori,N.
  TITLE     Cloning of rat GADD45 gene and induction analysis following
            ionizing radiation in vivo
  JOURNAL   FEBS Lett 380 (1-2), 87-92 (1996)
   PUBMED   8603754
REFERENCE   10 (bases 1 to 1237)
  AUTHORS   Yoshida,T., Schneider,E.L. and Mori,N.
  TITLE     Cloning of the rat Gadd45 cDNA and its mRNA expression in the brain
  JOURNAL   Gene 151 (1-2), 253-255 (1994)
   PUBMED   7828885
  REMARK    Erratum:[Gene. 1995 Dec 12;166(2):343-4. doi:
            10.1016/0378-1119(95)00566-8. PMID: 8543192]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081795.1.
            
            On Mar 27, 2005 this sequence version replaced NM_024127.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081795.1, FQ216523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1237
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q31"
     gene            1..1237
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; Gadd45"
                     /note="growth arrest and DNA-damage-inducible, alpha"
                     /db_xref="GeneID:25112"
                     /db_xref="RGD:2654"
     exon            1..194
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; Gadd45"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..648
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; Gadd45"
                     /note="DDIT-1; DNA damage-inducible transcript 1 protein;
                     growth arrest and DNA-damage-inducible 45 alpha;
                     DNA-damage-inducible transcript 1"
                     /codon_start=1
                     /product="growth arrest and DNA damage-inducible protein
                     GADD45 alpha"
                     /protein_id="NP_077041.2"
                     /db_xref="GeneID:25112"
                     /db_xref="RGD:2654"
                     /translation="MTLEEFSAAEQKIERMDTVGDALEEVLSKARSQRTITVGVYEAA
                     KLLNVDPDNVVLCLLAADEDDDRDVALQIHFTLIRAFCCENDINILRVSNPGRLAELL
                     LLENDKSPAESGGAAQTPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVI
                     NLPER"
     exon            195..296
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; Gadd45"
                     /inference="alignment:Splign:2.1.0"
     exon            297..534
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; Gadd45"
                     /inference="alignment:Splign:2.1.0"
     exon            535..1213
                     /gene="Gadd45a"
                     /gene_synonym="Ddit1; Gadd45"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaggcagct gtgcagtgtt ccccagcgag gctaagcaag aagccggcaa gagcagagac
       61 gcgagggtgg gagccagcgc agagccggcg ccgggcactg tgggggccag gagcagcccg
      121 cgcgccgcgt gagggactcg cacttgcaat atgactttgg aggaattctc ggccgcagag
      181 cagaagatcg aaaggatgga cacggtgggc gatgccctgg aggaagtgct cagcaaggct
      241 cggagtcagc gcaccataac tgtcggcgtg tacgaggcag ccaagctgct caacgtagac
      301 ccggacaacg tggtcctgtg cctgctggct gcggatgaag atgacgaccg ggacgtggct
      361 ctgcagatcc atttcaccct cattcgtgct ttctgttgcg agaacgacat caacatcctg
      421 cgggtcagca acccgggtcg gctggcagag ctgttgctac tggagaacga caagagcccc
      481 gctgagagcg ggggcgctgc gcagaccccg gacttacact gtgtgctggt gacgaaccca
      541 cattcatcac aatggaagga tcctgcctta agtcaactta tttgtttttg ccgggaaagt
      601 cgctacatgg atcagtgggt gccagtgatt aatctccccg aacggtgatt ccccgaacgg
      661 tgatggcatc tgaatggaaa taactgaacc aaattgcact gaagttttga aatacctttg
      721 tagttactca agcagtcact ccccacgctg atgcaaggat tacagaaact gatgtcaagg
      781 ggctgagttc aactacagga gggctaggag atgactttgc agaaggagag agaggtgaga
      841 ctgaaggagg aagctgtgtg gaaacagaaa tccaagtcaa aagggacaaa aaaactacaa
      901 agaactgtgc aagaaagaaa actattaatt taggatggcc gggttacagt aaagtaaacc
      961 aaatattgct ttgttgaaac tttaaatgtg tagcaatatt ttgggtattt tttttggtct
     1021 tcatgccctc aaataaaaga aaagtgaaaa gggttaatca tattttcaag ccacagttta
     1081 atgtattttg atgagatgtt aaattctcag aagttttatt ataaatcgta ctaagttatt
     1141 ttatgatgtg aaaggttatt tatgataaaa cgtttttgaa gcacattatc taaaataaac
     1201 tggtatggaa taaaaaaaaa aaaaaaaaaa aaaaaaa
//
