LOCUS       NM_017007               3198 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Rattus norvegicus glutamate decarboxylase 1 (Gad1), mRNA.
ACCESSION   NM_017007
VERSION     NM_017007.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3198)
  AUTHORS   Anfimova,P.A., Pankrasheva,L.G., Emanuilov,A.I., Moiseev,K.Y. and
            Maslyukov,P.M.
  TITLE     Expression of GAD65/67 and VGLUT2 in Mediobasal Nuclei of Rat
            Hypothalamus during Aging
  JOURNAL   Bull Exp Biol Med 176 (2), 232-234 (2023)
   PUBMED   38194067
  REMARK    GeneRIF: Expression of GAD65/67 and VGLUT2 in Mediobasal Nuclei of
            Rat Hypothalamus during Aging.
REFERENCE   2  (bases 1 to 3198)
  AUTHORS   Liu,D., Fujihara,K., Yanagawa,Y., Mushiake,H. and Ohshiro,T.
  TITLE     Gad1 knock-out rats exhibit abundant spike-wave discharges in EEG,
            exacerbated with valproate treatment
  JOURNAL   Front Neurol 14, 1243301 (2023)
   PUBMED   37830095
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3198)
  AUTHORS   Sirchi,M.M., Motaghi,S., Hosseininasab,N.S., Abbasnejad,M.,
            Esmaili-Mahani,S. and Sepehri,G.
  TITLE     Age-related changes in glutamic acid decarboxylase 1 gene
            expression in the medial prefrontal cortex and ventral hippocampus
            of fear-potentiated rats subjected to isolation stress
  JOURNAL   Behav Brain Res 453, 114630 (2023)
   PUBMED   37586565
  REMARK    GeneRIF: Age-related changes in glutamic acid decarboxylase 1 gene
            expression in the medial prefrontal cortex and ventral hippocampus
            of fear-potentiated rats subjected to isolation stress.
REFERENCE   4  (bases 1 to 3198)
  AUTHORS   Zeng,C., Lei,D., Lu,Y., Huang,Q., Wu,Y., Yang,S. and Wu,Y.
  TITLE     Parvalbumin in the metabolic pathway of glutamate and
            gamma-aminobutyric acid: Influence on expression of GAD65 and GAD67
  JOURNAL   Arch Biochem Biophys 734, 109499 (2023)
   PUBMED   36587827
  REMARK    GeneRIF: Parvalbumin in the metabolic pathway of glutamate and
            gamma-aminobutyric acid: Influence on expression of GAD65 and
            GAD67.
REFERENCE   5  (bases 1 to 3198)
  AUTHORS   Singla,R., Mishra,A., Joshi,R., Sarma,P., Kumar,R., Kaur,G.,
            Sharma,A.R., Jain,A., Prakash,A., Bhatia,A. and Medhi,B.
  TITLE     Homotaurine ameliorates the core ASD symptomatology in VPA rats
            through GABAergic signaling: Role of GAD67
  JOURNAL   Brain Res Bull 190, 122-133 (2022)
   PUBMED   36113682
  REMARK    GeneRIF: Homotaurine ameliorates the core ASD symptomatology in VPA
            rats through GABAergic signaling: Role of GAD67.
REFERENCE   6  (bases 1 to 3198)
  AUTHORS   Michelsen,B.K., Petersen,J.S., Boel,E., Moldrup,A., Dyrberg,T. and
            Madsen,O.D.
  TITLE     Cloning, characterization, and autoimmune recognition of rat islet
            glutamic acid decarboxylase in insulin-dependent diabetes mellitus
  JOURNAL   Proc Natl Acad Sci U S A 88 (19), 8754-8758 (1991)
   PUBMED   1924335
REFERENCE   7  (bases 1 to 3198)
  AUTHORS   Martin,D.L., Martin,S.B., Wu,S.J. and Espina,N.
  TITLE     Regulatory properties of brain glutamate decarboxylase (GAD): the
            apoenzyme of GAD is present principally as the smaller of two
            molecular forms of GAD in brain
  JOURNAL   J Neurosci 11 (9), 2725-2731 (1991)
   PUBMED   1880546
REFERENCE   8  (bases 1 to 3198)
  AUTHORS   Bond,R.W., Wyborski,R.J. and Gottlieb,D.I.
  TITLE     Developmentally regulated expression of an exon containing a stop
            codon in the gene for glutamic acid decarboxylase
  JOURNAL   Proc Natl Acad Sci U S A 87 (22), 8771-8775 (1990)
   PUBMED   2247446
REFERENCE   9  (bases 1 to 3198)
  AUTHORS   Wyborski,R.J., Bond,R.W. and Gottlieb,D.I.
  TITLE     Characterization of a cDNA coding for rat glutamic acid
            decarboxylase
  JOURNAL   Brain Res Mol Brain Res 8 (3), 193-198 (1990)
   PUBMED   2170798
REFERENCE   10 (bases 1 to 3198)
  AUTHORS   Julien,J.F., Samama,P. and Mallet,J.
  TITLE     Rat brain glutamic acid decarboxylase sequence deduced from a
            cloned cDNA
  JOURNAL   J Neurochem 54 (2), 703-705 (1990)
   PUBMED   2299361
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017007.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X57573.1, M34445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000003.1  75777452-75777564
            114-256             JAXUCZ010000003.1  75779001-75779143
            257-319             JAXUCZ010000003.1  75782373-75782435
            320-478             JAXUCZ010000003.1  75787607-75787765
            479-721             JAXUCZ010000003.1  75788928-75789170
            722-812             JAXUCZ010000003.1  75794047-75794137
            813-925             JAXUCZ010000003.1  75801048-75801160
            926-1041            JAXUCZ010000003.1  75802626-75802741
            1042-1121           JAXUCZ010000003.1  75802826-75802905
            1122-1176           JAXUCZ010000003.1  75803137-75803191
            1177-1293           JAXUCZ010000003.1  75805569-75805685
            1294-1358           JAXUCZ010000003.1  75806792-75806856
            1359-1437           JAXUCZ010000003.1  75809187-75809265
            1438-1587           JAXUCZ010000003.1  75810633-75810782
            1588-1695           JAXUCZ010000003.1  75813128-75813235
            1696-1785           JAXUCZ010000003.1  75815886-75815975
            1786-3198           JAXUCZ010000003.1  75816687-75818099
FEATURES             Location/Qualifiers
     source          1..3198
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q22"
     gene            1..3198
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /note="glutamate decarboxylase 1"
                     /db_xref="GeneID:24379"
                     /db_xref="RGD:2652"
     exon            1..113
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            114..256
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1959
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /EC_number="4.1.1.15"
                     /note="glutamate decarboxylase 1 variant GAD67NT; GAD-67;
                     67 kDa glutamic acid decarboxylase; Glutamate
                     decarboxylase 1 (brain); glutamic acid decarboxylase 1"
                     /codon_start=1
                     /product="glutamate decarboxylase 1"
                     /protein_id="NP_058703.1"
                     /db_xref="GeneID:24379"
                     /db_xref="RGD:2652"
                     /translation="MASSTPSPATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGL
                     KICGFLQRTNSLEEKSRLVSAFRERQASKNLLSCENSDPGARFRRTETDFSNLFAQDL
                     LPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDH
                     PESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIA
                     PVFVLMEQITLKKMREIIGWSNKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMA
                     AVPKLVLFTSEHSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADLEAKILDAKQKG
                     FVPLYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLSGI
                     ERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDK
                     AIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEPE
                     HTNVCFWYIPQSLRGVPDSPERREKLHRVAPKIKALMMESGTTMVGYQPQGDKANFFR
                     MVISNPAATQSDIDFLIEEIERLGQDL"
     exon            257..319
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            320..478
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            479..721
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            722..812
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            813..925
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1041
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1121
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1176
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1293
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1358
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1437
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1587
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1695
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1785
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..3198
                     /gene="Gad1"
                     /gene_synonym="Gad67"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcagccc cggggtgaca cccagcacgt acgtctgtgg cagagcaaag ccaagcgggg
       61 gacgcttcgc ggaggagtcg cgggagggtc cagctccctg tggctgaatc gagcccgttc
      121 ctgcgcccag accgcggggg acacttgaac agtagagacc ccaagaccac cgagctgatg
      181 gcatcttcca cgccttcgcc tgcaacctcc tcgaacgcgg gagcggatcc taatactacc
      241 aacctgcgtc ctacaacata tgatacttgg tgtggcgtag cccatggatg caccagaaaa
      301 ctgggcctga agatctgtgg cttcttgcaa aggaccaata gcctggaaga gaagagtcgt
      361 cttgtgagtg ccttcaggga gaggcaggcc tccaagaacc tgctttcctg tgaaaacagt
      421 gaccctggtg cccgcttccg gcgcacagag acggacttct ccaacctgtt tgctcaagat
      481 ctgcttccag ctaagaacgg ggaggagcaa actgtgcagt tcttactgga ggtggttgac
      541 atactcctca actatgtccg caagacgttt gatcgctcca ccaaggtttt ggacttccac
      601 cacccacacc agttgctgga aggcatggaa ggttttaatt tggagctgtc tgaccacccc
      661 gagtctctgg agcagatcct ggttgactgt agagacaccc taaagtacgg ggttcgcaca
      721 ggtcaccctc ggtttttcaa ccagctctct actggtttgg atatcattgg tttagctggc
      781 gaatggctga catcaactgc caataccaat atgttcacat atgaaattgc acccgtgttt
      841 gttcttatgg aacagattac acttaagaag atgcgagaga tcattggatg gtcaaataaa
      901 gatggtgatg ggatattttc tcctggggga gccatatcca acatgtacag catcatggcg
      961 gctcggtaca agtactttcc agaagtgaaa acaaaaggca tggcggctgt gcccaaactg
     1021 gtcctcttca cctcagaaca cagtcactat tccataaaga aggctggggc tgcgcttggc
     1081 tttggaactg acaatgtgat cctgataaag tgcaatgaaa gggggaagat aattccagct
     1141 gatttagagg caaaaattct tgatgccaaa caaaagggat ttgttcccct ttatgtcaat
     1201 gcaaccgcag gcacgactgt ttatggagcg tttgatccga tccaggagat tgcagacata
     1261 tgtgagaaat acaacctttg gctgcatgtg gatgctgcct ggggtggtgg gctgctcatg
     1321 tcccggaagc atcgccacaa actcagcggc atagaaaggg ccaattcagt cacctggaac
     1381 cctcacaaga tgatgggtgt gctgctccag tgttctgcca tcctggtcaa ggaaaagggt
     1441 atactccaag gatgcaacca gatgtgtgca ggctacctct tccagccaga caagcagtat
     1501 gacgtctcct acgatacagg ggacaaggcg attcagtgtg gccgccatgt ggacatcttc
     1561 aagttctggc tgatgtggaa agcaaagggc actgtgggat ttgaaaatca gatcaacaaa
     1621 tgcctggagc tggctgaata cctctatgcc aagattaaaa acagagaaga gtttgagatg
     1681 gttttcaatg gtgagcctga gcacacaaat gtctgtttct ggtacatacc acaaagcctc
     1741 cgaggggttc cagacagccc tgagcgacga gaaaaactac acagggtggc tcccaagatc
     1801 aaagccctga tgatggagtc aggaacaacc atggttggtt accagcctca aggggacaag
     1861 gccaacttct tccggatggt catctccaac ccagccgcca cccagtctga catcgatttc
     1921 ctcatcgagg aaatagagag gttgggtcaa gatctgtaat cccccccccc cctttgcaga
     1981 accgtaatca ccggccatag ccctgcccct ctggcaccct agaacgcagc tctgtcagta
     2041 gttgacacac ctaggccatt tcactgaagg aaattataat ctcttaaaga atatttgtca
     2101 catctcacgt aagcttgttt gttagaatta gcgggaaatg atgttctttt aaaaaaattg
     2161 cacattagaa acacagtata tatgtacagt tatatatata tatatacctc tctctatgta
     2221 ctatgtatgt atagtgaatg tggcttagtc ctagaccaca gcatgtcgct cgctcccagg
     2281 gaattagcct cacccccagc aattactaag aggctaacca tctcgcaagc aactgcagga
     2341 cagatggtac ccccactgca gtgtcctagg gacccaggga aaggccgttg ctgggagcct
     2401 accgccctgc tagagctgtc cccacctgaa tggatggatg atggatggta ggaagtacca
     2461 gtagatgaca aatgtcacac cctccctgtt agtgccctgc taggggatat agtagcagag
     2521 tctttgtcac aattgtgctg ttgctgcgtt ttagagatta atctgtgtaa actgtacatt
     2581 accgttgtct atctttgggc agggggaagt gcatataatg atttaattgt acgtcagtga
     2641 gatatttgct tatttatatt caaatatata tcatgttaaa gagacatctt gtattttctt
     2701 cccatttgta atgtatctta tttatatatt aatggagtaa gttctggata ctgtttatgg
     2761 tattttcgtg catttgtgag ccaaagagaa aagatgaaaa ttagtgagac ttgcatttat
     2821 atttgagtgc ccttaacata atgatttgaa cacatgtgta ctgtctggaa acgaattctg
     2881 atactgtaca tagagtggcg ttatggaaat cttgcttcag tagcctttgc tcttctcttt
     2941 cccccctcag gctgtacgtc aggtgttctc aaagcttttc tagtaactgt tgaaaaataa
     3001 tgactagatc tcctgtaatt ttgtagtagt atatgaccaa tctctgtgac tcgcttagct
     3061 gaaacctaag gctatgtttc cgaagatctc cgatacactg accagtccca caagtgtttt
     3121 tgaagacatg aaacccacac tgtgcattta gagtatgcaa gaagaatata aataaaataa
     3181 aaaaatattc tccatgaa
//
